Safe and sUstainable by desigN Strategies for HIgh performance multi-component NanomatErials

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

5 QSAR models to predict (eco)toxicity with a focus on mixture effects

Report describing QSAR models for prediction of (mixture) toxicity.

Machine learning modelling to support MCNMs grouping and read-across

Report describing the machine learning models to support grouping of MCNMs and read-across of information for S&SbD and risk assessment purposes (WP4).

The SUNSHINE Open & FAIR database

Report describing the SUNSHINE project database and its content in terms of the experimental data (WP2) and model estimations (WP3) from project.

Tool for read-across of information

Extension of the open source CEFIC LRI AMBIT read-across tool for MCNMs based on a previous development for NMs in the GRACIOUS project.

1 Atomistic and coarse-grained models of MCNMs

Report describing molecular models of carbonbased nanocomposites CNRS metal and metal oxides UNIGE as well as continuum models characterising properties of different materials NTUA

From Safe by Design (SbD) to Sustainable and Safe by Design (S&SbD)

Report on the development of the S&SbD concept as a potential tool for meeting policy ambitions for sustainability and Circular Economy.

Unique properties and interactions of MCNMs

The report will include an inventory of the unique properties and interactions of MCNMs that may lead to eg mixture effects and the MCNMspecific information requirements for grouping and readacross Task 41

Final report on the impact of the collaboration with USA, Asia Pacific and South Africa

At the end of the project, a final report describing the achievements of the collaboration between SUNSHINE and USA, Asia Pacific and Africa, together with the dissemination activities in collaboration with WP8 and the impact assessment of the collaboration will be submitted.

Blueprint for the development of trusted environments

Blueprint for the development of trusted environments to facilitate dialogue between innovators and regulators at an early stage of the innovation process using a learning by doing approach with industrial case studies. The objective is to shorten the time of the S&SbD-modified MCNM products to the market.

Foresight framework as a tool for Regulatory Preparedness for MCNMs

Adaptation of the NANoREG foresight conceptual framework for MCNMs to support the effectiveness of Regulatory Preparedness.

Background analysis of how MCNMs are covered in legislation

Report reviewing how MCNMs are addressed/covered by regulations and Guidance documents and whether there are gaps with regard to MCNMs that SUNSHINE can address.

Grouping hypotheses for MCNMs and corresponding IATA

The deliverable will include the grouping hypotheses (Task 4.3), including also the hypotheses based on the Mode of Action (Sub-Task 4.3.2), and the corresponding IATA (Sub-Task 4.3.3).

Demonstration of the grouping and read-across approaches in case studies

This report will include the results of applying the similarity assessment, grouping and read-across approaches to case studies. It will also include a critical analysis of the relevance and robustness of the grouping hypotheses and IATA to address MCNMs.

Progress reports on the implementation of international collaboration

These reports (internal Month 24) will describe the actions taken to facilitate international collaboration, especially with the USA, and the obtained results.

Recommendations on how the knowledge, tools and data generated in SUNSHINE can inform adaptation of regulatory guidance and standard guidelines to address MCNMs

Report including recommendations on how the scientific knowledge, tools and data generated in SUNSHINE can be taken into account by regulators and standardisation bodies for the adaptation, if needed, of current regulatory guidance, test methods and standards relevant for MCNMs.

Roles and conditions to get the SIA for MCNMs to work in practice

Report on the system of people, roles and conditions needed to get the SIA for MCNMs to work in practice.

4 SUNSHINE e-learning platform

A collection of training material (e.g. webinars, guidance documents) will be developed and made publicly available.

Project Website

A project website will be developed published by M3 of the project and constantly updated

Publications

Roadmap towards safe and sustainable advanced and innovative materials. (Outlook for 2024-2030)

Author(s): Flemming R. Cassee, Eric A.J. Bleeker, Cyrille Durand, Thomas Exner, Andreas Falk, Steffi Friedrichs, Elisabeth Heunisch, Martin Himly, Sabine Hofer, Norbert Hofstätter, Danail Hristozov, Penny Nymark, Anna Pohl, Lya G. Soeteman-Hernández, Blanca Suarez-Merino, Eugenia Valsami-Jones, Monique Groenewold
Published in: Computational and Structural Biotechnology Journal, Issue 25, 2024, Page(s) 105-126, ISSN 2001-0370
Publisher: Elsevier
DOI: 10.1016/j.csbj.2024.05.018

Using Integrated Approaches to Testing and Assessment to streamline Grouping and Read-Across of solid nanomaterials

Author(s): V Stone, A Oomen, H Johnston, D Hristozov, O Schmidt, T Stoeger, S Aparicio, U Vogel, W Wohlleben, F Murphy
Published in: Toxicology Letters, Issue Volume 384, Supplement 1, September 2023, 2023, Page(s) Pages S.13 - S.14, ISSN 1879-3169
Publisher: Elsevier

Characterizing the hard and soft nanoparticle-protein corona with multilayer adsorption

Author(s): Oriol Vilanova, Alberto Martinez-Serra, Marco P. Monopoli, Giancarlo Franzese
Published in: Frontiers in Nanotechnology, Issue 6, 2025, ISSN 2673-3013
Publisher: Frontiers Media SA
DOI: 10.3389/fnano.2024.1531039

Understanding the impact of silica nanoparticles in cancer cells through physicochemical and biomolecular characterizations

Author(s): Asia Saorin, Alberto Martinez-Serra, Germán Jose Paparoni-Bruzual, Michele Crozzolin, Vincenzo Lombardi, Michele Back, Pietro Riello, Marco P. Monopoli, Flavio Rizzolio
Published in: Materials Advances, Issue 5, 2024, Page(s) 5106-5117, ISSN 2633-5409
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/d4ma00084f

Regulatory preparedness for multicomponent nanomaterials: Current state, gaps and challenges of REACH

Author(s): Neil Hunt, Vikram Kestens, Kirsten Rasmussen, Elena Badetti, Lya G. Soeteman-Hernández, Agnes G. Oomen, Willie Peijnenburg, Danail Hristozov, Hubert Rauscher
Published in: NanoImpact, Issue 37, 2025, Page(s) 100538, ISSN 2452-0748
Publisher: Elsevier
DOI: 10.1016/j.impact.2024.100538

Predicting environmental concentrations of nanomaterials for exposure assessment - a review

Author(s): Arturo A. Keller; Yuanfang Zheng; Antonia Praetorius; Joris T.K. Quik; Bernd Nowack
Published in: NanoImpact, Issue Volume 33, January 2024, 100496, 2024, ISSN 2452-0748
Publisher: Elsevier
DOI: 10.1016/j.impact.2024.100496

A structure–activity approach towards the toxicity assessment of multicomponent metal oxide nanomaterials

Author(s): G. P. Gakis, I. G. Aviziotis, C. A. Charitidis
Published in: Nanoscale, 2023, ISSN 2040-3372
Publisher: RSC
DOI: 10.1039/d3nr03174h

Screening level approach to support companies in making safe and sustainable by design decisions at the early stages of innovation

Author(s): Lisa Pizzol; Arianna Livieri; Beatrice Salieri; Lucian Farcal; Lya G. Soeteman-Hernández; Hubert Rauscher; Alex Zabeo; Magda Blosi; Anna Luisa Costa; Willie Peijnenburg; Stella Stoycheva; Neil Hunt; Maria José López-Tendero; Cástor Salgado; Julian J. Reinosa; Jose F. Fernández; Danail Hristozov
Published in: Crossref, Issue 1, 2023, ISSN 2666-7894
Publisher: Elsevier
DOI: 10.1016/j.cesys.2023.100132

Chronic toxicity of core–shell SiC/TiO 2 (nano)-particles to Daphnia magna under environmentally relevant food rations in the presence of humic acid

Author(s): Kornelia Serwatowska, Tom A. P. Nederstigt, Willie J. G. M. Peijnenburg, Martina G. Vijver
Published in: Nanotoxicology, Issue 18, 2024, Page(s) 107-118, ISSN 1743-5390
Publisher: Informa Healthcare
DOI: 10.1080/17435390.2024.2321873

Next Generation Risk Assessment approaches for advanced nanomaterials: Current status and future perspectives

Author(s): Danail Hristozov, Elena Badetti, Paolo Bigini, Andrea Brunelli, Susan Dekkers, Luisa Diomede, Shareen H. Doak, Wouter Fransman, Agnieszka Gajewicz-Skretna, Elisa Giubilato, Laura Gómez-Cuadrado, Roland Grafström, Arno C. Gutleb, Sabina Halappanavar, Roland Hischier, Neil Hunt, Alberto Katsumiti, Ali Kermanizadeh, Antonio Marcomini, Elisa Moschini, Agnes Oomen, Lisa Pizzol, Carlos Rumbo, Otmar Sc
Published in: NanoImpact, Issue 35, 2025, Page(s) 100523, ISSN 2452-0748
Publisher: Elsevier BV
DOI: 10.1016/j.impact.2024.100523

Safe-by-design assessment of an SiO2@ZnO multi-component nanomaterial used in construction

Author(s): A. Brunelli, A. Serrano-Lotina, M. A. Bañares, V. Alcolea-Rodriguez, M. Blosi, A. Costa, S. Ortelli, W. Peijnenburg, C. Fito, E. G. Fernandez, J. S. Hermosilla, L. G. Soeteman-Hernández, I. Garmendia Aguirre, H. Rauscher, F. Murphy, V. Stone, J. Balbuena, J. M. L. Cormano, L. Pizzol, D. Hristozov, A. Marcomini, E. Badetti
Published in: Environmental Science: Nano, Issue 12, 2025, Page(s) 762-776, ISSN 2051-8153
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4en00352g

Life cycle thinking and safe-and-sustainable-by-design approaches for the battery innovation landscape

Author(s): Lya G. Soeteman-Hernández, Carlos Felipe Blanco, Maarten Koese, Adrienne J.A.M. Sips, Cornelle W. Noorlander, Willie J.G.M. Peijnenburg
Published in: iScience, Issue 26, 2025, Page(s) 106060, ISSN 2589-0042
Publisher: Elsevier BV
DOI: 10.1016/j.isci.2023.106060

Protocols for isolation and characterization of nanoparticle biomolecular corona complexes

Author(s): Mahmoud G. Soliman, Alberto Martinez-Serra, Marko Dobricic, Duong N. Trinh, Jack Cheeseman, Daniel I. R. Spencer, Marco P. Monopoli
Published in: Frontiers in Toxicology, Issue 6, 2024, ISSN 2673-3080
Publisher: Frontiers Media SA
DOI: 10.3389/ftox.2024.1393330

In Vitro Cytokinesis Block Micronucleus (CBMN) Assay to Evaluate the Genotoxicity of Multicomponent Nanomaterials – a Tiered Testing Approach

Author(s): Angela Saccardo, Stephen J Evans, Mariajose Lopez Tendero, José Balbuena, José M L Cormano, Gareth J S Jenkins, Martin J D Clift, Shareen H Doak
Published in: Annals of work exposures and health, Issue Volume 67, Issue Supplement_1 May 2023, 2023, ISSN 2398-7316
Publisher: British Occupational Hygiene Society
DOI: 10.1093/annweh/wxac087.146

Review and Prospects on the Ecotoxicity of Mixtures of Nanoparticles and Hybrid Nanomaterials

Author(s): Fan Zhang; Zhuang Wang; Willie J. G. M. Peijnenburg; Martina G. Vijver
Published in: Environmental Science and Technology, Issue 56(22), 2022, Page(s) 15238 - 15250, ISSN 1520-5851
Publisher: ACS
DOI: 10.1021/acs.est.2c03333

Author(s): Veronica Di Battista, ORCID logo ‡ab Karla R. Sanchez-Lievanos, ORCID logo ‡ac Nina Jeliazkova, ORCID logo d Fiona Murphy,e Georgia Tsiliki,fg Alex Zabeo,h Agnieszka Gajewicz-Skretna, ORCID logo i Alicja Mikołajczyk, ORCID logo ij Danail Hristozov,k Vicki Stone,e Otmar Schmid,l Neil Hunt,m Agnes G. Oomenno and Wendel Wohlleben ORCID logo *a
Published in: Environmental Science: Nano, Issue 1/2024, 2024, ISSN 2051-8161
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3en00338h

Form-Specific Prospective Environmental Risk Assessment of Graphene-Based Materials in European Freshwater

Author(s): Hyunjoo Hong, Bernd Nowack
Published in: Environmental Science & Technology, Issue 58, 2024, Page(s) 21750-21759, ISSN 0013-936X
Publisher: American Chemical Society
DOI: 10.1021/acs.est.4c05153

Membrane Phase Drives the Assembly of Gold Nanoparticles on Biomimetic Lipid Bilayers

Author(s): Jacopo Cardellini, Lucrezia Caselli, Enrico Lavagna, Sebastian Salassi, Heinz Amenitsch, Martino Calamai, Costanza Montis, Giulia Rossi, Debora Berti
Published in: J. Phys. Chem., Issue C 2022, 126, 9, 2021, ISSN 1932-7455
Publisher: American Chemical Society
DOI: 10.1021/acs.jpcc.1c08914

Identification of emerging safety and sustainability issues of advanced materials: Proposal for a systematic approach

Author(s): Willie J.G.M. Peijnenburg; Agnes G. Oomen; Lya G. Soeteman-Hernández; Monique Groenewold; Adriënne J.A.M. Sips; Cornelle W. Noorlander; J.A.B. Kettelarij; Eric A.J. Bleeker
Published in: NanoImpact, Issue 1, 2021, ISSN 2452-0748
Publisher: Science Direct
DOI: 10.1016/j.impact.2021.100342

Correction: Development of a transferable coarse-grained model of polydimethylsiloxane

Author(s): Sonia Cambiaso; Fabio Rasera; Giulia Rossi; Davide Bochicchio
Published in: Soft Matter, Issue 42, 2022, 2022, ISSN 2048-769X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2sm90137d

“Advanced materials” and the challenges on the horizon for testing their (eco)toxicity and assessing their hazard

Author(s): Fazel Abdolahpur Monikh; Willie Peijnenburg; Agnes G. Oomen; Eugenia Valsami-Jones; Vicki Stone; Raine Kortet; Jarkko Akkanen; Peng Zhang; Jukka Kekäläinen; Alena Sevcu; Jussi V. K. Kukkonen
Published in: Environmental Science: Advance, Issue 2/2023, 2023, Page(s) 162-170, ISSN 2754-7000
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2va00128d

How to formulate hypotheses and IATAs to support grouping and read-across of nanoforms

Author(s): Fiona A. Murphy, Helinor J. Johnston, Susan Dekkers, Eric A. J. Bleeker, Agnes G. Oomen, Teresa F. Fernandes, Kirsten Rasmussen, Paula Jantunen, Hubert Rauscher, Neil Hunt, Luisana di Cristos, Hedwig M. Braakhuis, Andrea Haase, Danail Hristozov, Wendel Wohlleben, Stefania Sabella, Vicki Stone
Published in: ALTEX - Alternatives to Animal Experimentation, 2023, ISSN 0378-4274
Publisher: Elsevier BV
DOI: 10.14573/altex.2203241

Understanding the role of biomolecular coronas in human exposure to nanomaterials

Author(s): Mahmoud G. Soliman, Alberto Martinez-Serra, Giulia Antonello, Marko Dobricic, Terence Wilkins, Tommaso Serchi, Ivana Fenoglio, Marco P. Monopoli
Published in: Environmental Science: Nano, Issue 11, 2024, Page(s) 4421-4448, ISSN 2051-8153
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4en00488d

A Conceptual Framework for Safe-and-Sustainable-by-Design to Support Sustainable Business Model Innovation and New Product Development

Author(s): Stella Stoycheva, Willie Peijnenburg, Beatrice Salieri, Vrishali Subramanian, Agnes G. Oomen, Lisa Pizzol, Magda Blosi, Anna Costa, Shareen H. Doak, Vicki Stone, Arianna Livieri, Vikram Kestens, Irantzu Garmendia, Hubert Rauscher, Neil Hunt, Danail Hristozov, Lya G. Soeteman-Hernández
Published in: Sustainability & Circularity NOW, Issue 02, 2025, ISSN 2940-1852
Publisher: Thieme
DOI: 10.1055/a-2498-8902

Safe-and-sustainable-by-design chemicals and advanced materials: a paradigm shift towards prevention-based risk governance is needed

Author(s): Danail Hristozov; Alex Zabeo; Lya G. Soeteman-Hernández; Lisa Pizzol; Stella Stoycheva
Published in: Crossref, Issue 4, 2023, ISSN 2666-7894
Publisher: RSC
DOI: 10.1039/d3su00045a

Status, implications and challenges of European safe and sustainable by design paradigms applicable to nanomaterials and advanced materials

Author(s): Irini Furxhi; Anna Costa; Socorro Vázquez-Campos; Carlos Fito-López; Danail Hristozov; Juan Antonio Tamayo Ramos; Susanne Resch; Margherita Cioffi; Steffi Friedrichs; Cris Rocca; Eugenia Valsami-Jones; Iseult Lynch; Sánchez Jiménez Araceli; Lucian Farcal
Published in: Crossref, Issue 4, 2023, ISSN 2666-7894
Publisher: RSC
DOI: 10.1039/d2su00101b

Development of a transferable coarse-grained model of polydimethylsiloxane

Author(s): Sonia Cambiaso; GIULIA ROSSI; Fabio Rasera Figueiredo; Davide Bochicchio
Published in: Soft Matter, Issue 40, 2022, 2022, ISSN 2048-769X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2sm00939k

An overview on dispersion procedures and testing methods for the ecotoxicity testing of nanomaterials in the marine environment

Author(s): Andrea Brunelli, Virginia Cazzagon, Eleonora Faraggiana, Cinzia Bettiol, Marco Picone, Antonio Marcomini, Elena Badetti
Published in: Science of The Total Environment, Issue 921, 2024, Page(s) 171132, ISSN 0048-9697
Publisher: Elsevier BV
DOI: 10.1016/j.scitotenv.2024.171132

Identification of the safe(r) by design alternatives for nanosilver-enabled wound dressings

Author(s): V. Cazzagon; E. Giubilato; A. Bonetto; M. Blosi; I. Zanoni; A. L. Costa; C. Vineis; A. Varesano; A. Marcomini; D. Hristozov; E. Semenzin; E. Badetti
Published in: Frontiers in Bioengineering and Biotechnology, 2022, ISSN 2296-4185
Publisher: Frontiers Media SA
DOI: 10.3389/fbioe.2022.987650

A Martini Coarse Grained Model of Citrate-Capped Gold Nanoparticles Interacting with Lipid Bilayers.

Author(s): Sebastian Salassi; Lucrezia Caselli; Jacopo Cardellini; Enrico Lavagna; Costanza Montis; Debora Berti; Giulia Rossi
Published in: Journal of Chemical Theory and Computation, Issue 1, 2021, ISSN 1549-9618
Publisher: American Chemical Society
DOI: 10.1021/acs.jctc.1c00627

Socio-Economic Life Cycle-Based Framework for Safe and Sustainable Design of Engineered Nanomaterials and Nano-Enabled Products

Author(s): Stella Stoycheva, Alex Zabeo, Lisa Pizzol, Danail Hristozov
Published in: MDPI Sustainability, 2022, ISSN 2071-1050
Publisher: MDPI Open Access Publishing
DOI: 10.3390/su14095734

Martini 3 coarse-grained models for carbon nanomaterials

Author(s): Roshan Shrestha, Riccardo Alessandri, Martin Vögele, Paulo Souza, Siewert-Jan Marrink, Luca Monticelli
Published in: 2024
Publisher: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv-2024-6s1wj

Roadmap Safe and Sustainable Advanced and Innovative Materials 2024-2030

Author(s): Flemming R. Cassee; Eric A.J. Bleeker; Cyrille Durand; Thomas Exner; Andreas Falk; Danail Hristozov; Sabine Hofer; Norbert Hofstätter; Steffi Friedrichs; Elisabeth Heunisch; Martin Himly; Penny Nymark; Anna Pohl; Lya G. Soeteman-Hernández; Blanca Suarez-Merino; Eugenia Valsami-Jones; Monique Groenewold
Published in: Roadmap Safe and Sustainable Advanced and Innovative Materials, 2024
Publisher: SUNSHINE
DOI: 10.5281/zenodo.11191095

INISS-Nano: revised concept and action plan (International Network Initiative on Safe and Sustainable Nanotechnologies)

Author(s): Falk, Andreas; Pogany, Alexander; Aungkavattana, Pavadee; Bañares, Miguel A.; Beitollahi, Ali; Bim, Vinicius; Briffa, Sophie; Bochon, Anthony; Cassee, Flemming; Doridot, Fernand; Exner, Thomas; Farias, Patricia M.A.; Favre, Georges; Franzese, Giancarlo; Friedrichs, Steffi; Hristozov, Danail; Hunt, Neil; Indaraprasirt, Ramjitti; Karim, Md. E.; Khandelwal, Neha; Malsch, Ineke; Marcoulaki, Effie; Ma
Published in: INISS-nano, Issue 2, 2022
Publisher: INISS-Nano
DOI: 10.5281/zenodo.6818049

International Network Initiative on Safe and Sustainable Nanotechnologies (INISS-nano)

Author(s): Falk, Andreas
Published in: Open Aire, Issue 1, 2021, ISSN 2452-0748
Publisher: Zenodo
DOI: 10.5281/zenodo.5004929

Roadmap Safe and Sustainable Advanced and Innovative Materials 2024-2030

Author(s): Flemming R. Cassee; Eric A.J. Bleeker; Cyrille Durand; Thomas Exner; Andreas Falk; Danail Hristozov; Sabine Hofer; Norbert Hofstätter; Steffi Friedrichs; Elisabeth Heunisch; Martin Himly; Penny Nymark; Anna Pohl; Lya G. Soeteman-Hernández; Blanca Suarez-Merino; Eugenia Valsami-Jones; Monique Groenewold
Published in: Issue 19, 2024
Publisher: SUNSHINE
DOI: 10.5281/zenodo.11147296

INISS-Nano: revised concept and action plan (International Network Initiative on Safe and Sustainable Nanotechnologies)

Author(s): Falk, Andreas; Pogany, Alexander; Aungkavattana, Pavadee; Bañares, Miguel A.; Beitollahi, Ali; Bim, Vinicius; Briffa, Sophie; Bochon, Anthony; Cassee, Flemming; Doridot, Fernand; Exner, Thomas; Farias, Patricia M.A.; Favre, Georges; Franzese, Giancarlo; Friedrichs, Steffi; Hristozov, Danail; Hunt, Neil; Indaraprasirt, Ramjitti; Karim, Md. E.; Khandelwal, Neha; Malsch, Ineke; Marcoulaki, Effie; Ma
Published in: Issue 5, 2023, ISSN 2666-7894
Publisher: Zenodo
DOI: 10.5281/zenodo.7877359

NMBP-16 Ambassadors - Cooperation as cornerstone of our success

Author(s): Alfaro Serrano, Beatriz; Resch, Susanne; Hristozov, Danail; Schmid, Otmar; Stöger, Tobias; Rumbo, Carlos
Published in: 2024
Publisher: SUNSHINE - HARMLESS - DIAGONAL
DOI: 10.5281/zenodo.13908183

Using Integrated Approaches to Testing and Assessment to streamline Grouping and Read-Across of solid nanomaterials

Author(s): V Stone, A Oomen, H Johnston, D Hristozov, O Schmidt, T Stoeger, S Aparicio, U Vogel, W Wohlleben, F Murphy
Published in: Toxicology Letters, 2023, ISSN 0378-4274
Publisher: Elsevier
DOI: 10.1016/s0378-4274(23)00296-5

Searching for OpenAIRE data...

Deliverables

Publications

Share this page Share this page on social networks

Download Download the content of the page