Advanced High Aspect Ratio and Multicomponent materials: towards comprehensive intelLigent tEsting and Safe by design Strategies

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Performance evaluation and guidance documentation

Part one of the deliverable will describe the principles and ideas of the safe innovations approach (SIA). The report will point out pivotal information to assess the risk potential of hybrid and multicomponent nanomaterials, instruments and methods for each stage of the SIA.Part two of the deliverable will be a documentation scheme for a pre-regulatory safety dossier, suitable for risk communication and regulatory purposes. It will be the final report on the Safe Innovations approach, delivered at the end of the project duration and will report relevant standardisation actions regarding SbD.

Bioaccumulation and persistency evaluation of selected NMs

Report describing the bioaccumulation at the entry-point of the trophic chain, according to the data obtained for algae and daphnia, and the possibilities of biomagnification according to the data obtained for fish. Since persistency of the NMs plays a key role in bioaccumulation by determining the availability of NMs for organisms, the report will incorporate the results of the persistency studies.

Overview of relevant AOPs to inform NAM choice of KEs

Report summarizing relevant AOPs and selection of candidate Key Events and Adverse Outcomes suitable forNAM in WP3

Open access repository of mRNA single cell response

Open access repository of mRNA single cell response profiles detected in lung tissue flowing pulmonary exposure. Report on the comparison of lung single cell response profiles of (intubated ventilated) inhalation and instillation exposed rodents.

Sector-specific categorisation scheme of multi-component nanomaterials based on specific concerns, the suitability of SbD concepts, the SIA and elements of the DSS tool for decision steps in innovation management at SME and industry

The categorisation scheme will use all sector-specific criteria to maximize the effectiveness of the SbD process for different sectors, including the categories established by appropriate risk matrices, and will thus lower the hurdle of SbD implementation in industry and SME.

Testing of the HARMLESS guidance and DSS tool that lead to SbD target specifications, which were implemented and their effectiveness to safer innovation verified

This deliverable summarises the results of the implementation of the HARMLESS SbD strategies on three case studies with experimental verification into real industrial practice, including lessons learnt for future SbD schemes. An interim report is provided to WP4, WP5 by M34

HARMLESS database with extensions to handle advanced materials

The report will include description of HARMLESS-eNanoMapper database setup, content and ontology annotations, and the implemented approach of advanced materials representation.

Final HARMLESS DSS and user manual

The final HARMLESS DSS with manual will be made online available to end-users and stakeholders. The finalized HARMLESS DSS will now incorporate the finalized interfaces and functionality based on the second use experience of the system by end-users performing case studies and stakeholder feedback.

Data Management Plan

Data management plan (initial M6, intermediate M19 and final M43)

Pubblicazioni

A Screening Approach to the Safe‐and‐Sustainable‐by‐Design Development of Advanced Insulation Materials

Autori: Veronica Di Battista, Carla Ribalta, Klaus Vilsmeier, Dilpreet Singh, Philip Demokritou, Eva Günther, Keld Alstrup Jensen, Susan Dekkers, Veronique Adam, Wendel Wohlleben
Pubblicato in: Small, Numero 20, 2024, ISSN 1613-6810
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202311155

Development of handling energy factors for use of dustiness data in exposure assessment modelling

Autori: Ana Sofia Fonseca, Carla Ribalta, Neeraj Shandilya, Wouter Fransman, Keld Alstrup Jensen
Pubblicato in: Annals of Work Exposures and Health, Numero 68, 2024, Pagina/e 295-311, ISSN 2398-7308
Editore: Oxford University Press (OUP)
DOI: 10.1093/annweh/wxae009

Autori: Veronica Di Battista, Karla R. Sanchez-Lievanos, Nina Jeliazkova, Fiona Murphy, Georgia Tsiliki, Alex Zabeo, Agnieszka Gajewicz-Skretna, Alicja Mikołajczyk, Danail Hristozov, Vicki Stone, Otmar Schmid, Neil Hunt, Agnes G. Oomenno and Wendel Wohlleben
Pubblicato in: Environ. Sci.: Nano, 2024, Advance ArticleEnvironmental science: Nano, on the special issue on Advanced Materials, 2024, ISSN 2051-8153
Editore: Royal Society of Chemistry
DOI: 10.1039/d3en00338h

Breathing-induced stretch enhances the efficacy of an inhaled and orally delivered anti-fibrosis drug in vitro

Autori: Doryab, A., Heydarian, M., Yildirim, A.Ö., Hilgendorff, A., Behr, J., Schmid, O.,
Pubblicato in: Journal of Drug Delivery Science and Technology, Numero 85, 2023, Pagina/e still ePub, ISSN 1773-2247
Editore: Editions de Sante
DOI: 10.1016/j.jddst.2023.104316

evaluating use and performance

Autori: Krans, N A; Ammar, A; Nymark, P; Willighagen, E L; Bakker, M I; Quik, J T K
Pubblicato in: NanoImpact, Numero 24520748, 2022, ISSN 2452-0748
Editore: Elservier BV
DOI: 10.1016/j.impact.2022.100402

Bridging Smart Nanosystems with Clinically Relevant Models and Advanced Imaging for Precision Drug Delivery

Autori: Qiaoxia Zhou, Qiongliang Liu, Yan Wang, Jie Chen, Otmar Schmid, Markus Rehberg, Lin Yang
Pubblicato in: Advanced Science, 2024, ISSN 2198-3844
Editore: Wiley Online Library
DOI: 10.1002/advs.202308659

Carbonaceous particle exposure triggered accumulation of Osteopontin/SPP1+ macrophages contributes to emphysema development

Autori: Lianyong Han, Verena Haefner, Ali Önder Yildirim, Heiko Adler, Tobias Stoeger
Pubblicato in: MedComm, Numero 6, 2025, ISSN 2688-2663
Editore: Wiley
DOI: 10.1002/mco2.70061

Towards Computer-Aided Graphene Covered TiO2-Cu/(CuxOy) Composite Design for the Purpose of Photoinduced Hydrogen Evolution

Autori: Łukasz Lewandowski; Agnieszka Gajewicz-Skretna; Tomasz Klimczuk; Grzegorz Trykowski; Kostiantyn Nikiforow; Wojciech Lisowski; Anna Gołąbiewska; Adriana Zaleska-Medynska
Pubblicato in: Catalysts Numero 6, Numero 2, 2021, ISSN 2073-4344
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/catal11060698

Oxide-Perovskites for Automotive Catalysts Biotransform and Induce Multicomponent Clearance and Hazard

Autori: Veronica Di Battista, Pernille Høgh Danielsen, Agnieszka Gajewicz-Skretna, Andrzej Kedziorski, Svenja B. Seiffert, Lan Ma-Hock, Trine Berthing, Alicja Mortensen, Andreas Sundermann, Lars Michael Skjolding, Ulla Vogel, Anders Baun, Wendel Wohlleben
Pubblicato in: ACS Nano, Numero 18, 2024, Pagina/e 32672-32693, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.4c10135

Single-walled vs. Multi-walled Carbon Nanotubes: Influence of Physico-Chemical Properties on Toxicogenomics Responses of Mouse Lungs

Autori: Silvia A. Solorio-Rodriguez, Andrew Williams, Sarah Søs Poulsen, Kristina B. Knudsen, Keld Alstrup Jensen, Per A. Clausen, Pernille Høgh Danielsen, Håkan Wallin, Ulla Vogel, Sabina Halappanavar
Pubblicato in: "NanoMaterials - Special Numero ""Safety and Toxicity of Carbon Nanotubes""", Numero 13, 2023, Pagina/e 1059, ISSN 2079-4991
Editore: MDPI
DOI: 10.3390/nano13061059

Meta‐Analysis of Integrated Proteomic and Transcriptomic Data Discerns Structure–Activity Relationship of Carbon Materials with Different Morphologies

Autori: Verónica I. Dumit; Yuk‐Chien Liu; Aileen Bahl; Pekka Kohonen; Roland C. Grafström; Penny Nymark; Christine Müller‐Graf; Andrea Haase; Mario Pink
Pubblicato in: Advanced Science, Numero 2, 2023, ISSN 1613-6829
Editore: Wiley Online Library
DOI: 10.1002/advs.202306268

Referee report. For: ELIXIR and Toxicology: a community in development [version 1; peer review: 1 approved, 1 approved with reservations]

Autori: Eide, Marta
Pubblicato in: ELIXIR, Numero 3, 2023, ISSN 2229-712X
Editore: F1000 Research
DOI: 10.5256/f1000research.78265.r124031

High-throughput screening data generation, scoring and FAIRification: a case study on nanomaterials

Autori: Gergana Tancheva, Vesa Hongisto, Konrad Patyra, Luchesar Iliev, Nikolay Kochev, Penny Nymark, Pekka Kohonen, Nina Jeliazkova, Roland Grafström
Pubblicato in: Journal of Cheminformatics, Numero 17, 2025, Pagina/e 59, ISSN 1758-2946
Editore: Chemistry Central
DOI: 10.1186/s13321-025-01001-8

Toxicity of carbon nanomaterials: A model to predict ROS production from easily measurable surface characteristics

Autori: V. Malmborg, D.A. Elam, V. Di Battista, J. Rissler, P.A. Clausen, U. Vogel, W. Wohlleben, N.R. Jacobsen
Pubblicato in: Carbon, Numero 234, 2025, Pagina/e 119997, ISSN 0008-6223
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.carbon.2025.119997

Editorial: Exploring impacts of combined exposures to particles and chemicals on immune reactions across living organisms

Autori: Diana Boraschi, Albert Duschl, Iseult Lynch and Tobias Stoeger
Pubblicato in: Frontiers in Toxicology, Numero 5, 2023, Pagina/e still ePub, ISSN 2673-3080
Editore: Frontiers in Toxicology
DOI: 10.3389/ftox.2023.1148374

An inter-laboratory effort to harmonize the cell-delivered in vitro dose of aerosolized materials

Autori: Bannuscher, A., Schmid, O., et al. Doryab, A., et al. Clift, M.J.D., Rothen-Rutishauser, B.
Pubblicato in: NanoImpact, Numero 28, 2022, Pagina/e 100439, ISSN 2452-0748
Editore: ScienceDirect
DOI: 10.1016/j.impact.2022.100439

Predicting the morphology-driven pathogenicity of nanofibers through proteomic profiling

Autori: Tobias Stobernack, Antje Vennemann, Dirk Broßell, Oliver Gräb, Mario Pink, Andrea Haase, Martin Wiemann, Verónica I. Dumit
Pubblicato in: Nano Today, Numero 65, 2025, Pagina/e 102812, ISSN 1748-0132
Editore: Elsevier BV
DOI: 10.1016/j.nantod.2025.102812

HARMLESS Early Warning System for Advanced Materials

Autori: Julia Prinz, Gregor Nagel, Susan Dekkers, Eugene P. van Someren, Véronique Adam, Veronica Di Battista, Blanca Suarez‐Merino, Wendel Wohlleben, Michael Persson, Anders Baun, Otmar Schmid, Andrea Haase
Pubblicato in: Advanced Sustainable Systems, 2025, Pagina/e 2500217, ISSN 2366-7486
Editore: Wiley
DOI: 10.1002/adsu.202500217

Everything falls apart: How solids degrade and release nanomaterials, composite fragments, and microplastics

Autori: Wendel Wohlleben, Nathan Bossa, Denise M. Mitrano, Keana Scott
Pubblicato in: NanoImpact, Numero 34, 2024, Pagina/e 100510, ISSN 2452-0748
Editore: Elsevier BV
DOI: 10.1016/j.impact.2024.100510

P19-68 Identification of physico-chemical properties of 79 nanomaterials that are predictive of inflammation and genotoxicity following pulmonary exposure in mice

Autori: P.H. Danielsen, K.A. Jensen, U. Vogel
Pubblicato in: Toxicology Letters, Numero 399, 2024, Pagina/e S281-S282, ISSN 0378-4274
Editore: Elsevier BV
DOI: 10.1016/j.toxlet.2024.07.677

The oxidative potential of nanomaterials: an optimized high-throughput protocol and interlaboratory comparison for the ferric reducing ability of serum (FRAS) assay

Autori: Nienke Ruijter, Matthew Boyles, Hedwig Braakhuis, Rafael Ayerbe Algaba, Morgan Lofty, Veronica di Battista, Wendel Wohlleben, Flemming R. Cassee, Ana Candalija
Pubblicato in: Nanotoxicology, Numero 18, 2024, Pagina/e 724-738, ISSN 1743-5390
Editore: Informa Healthcare
DOI: 10.1080/17435390.2024.2438116

ELIXIR and Toxicology: a community in development

Autori: Marvin Martens; Rob Stierum; Emma L. Schymanski; Chris T. Evelo; Reza Aalizadeh; Hristo Aladjov; Kasia Arturi; Karine Audouze; Pavel Babica; Karel Berka; Jos Bessems; Ludek Blaha; Evan E Bolton; Montserrat Cases; Dimitrios Damalas; Kirtan Dave; Marco Dilger; Thomas Exner; Daan P. Geerke; Roland C. Grafström; Alasdair J. G. Gray; John M. Hancock; Henner Hollert; Nina Jeliazkova; Danyel Jennen; Fab
Pubblicato in: ELIXIR and Toxicology: a community in development, 2021, ISSN 2046-1402
Editore: F1000 Research Ltd.
DOI: 10.12688/f1000research.74502.1

Advancing Nanomaterial Toxicology Screening Through Efficient and Cost‐Effective Quantitative Proteomics

Autori: Tobias Stobernack, Nils Dommershausen, Víctor Alcolea‐Rodríguez, Rico Ledwith, Miguel A. Bañares, Andrea Haase, Mario Pink, Verónica I. Dumit
Pubblicato in: Small Methods, Numero 8, 2024, Pagina/e 2400420, ISSN 2366-9608
Editore: Wiley
DOI: 10.1002/smtd.202400420

Behaviour of advanced materials in environmental aquatic media – dissolution kinetics and dispersion stability of perovskite automotive catalysts

Autori: Veronica Di Battista; Kai Werle; Lars Michael Skjolding; Wendel Wohlleben; Anders Baun
Pubblicato in: Environmental science: Nano, on the special issue on Advanced Materials, Numero 2, 2023, ISSN 2754-7000
Editore: RSC - The Royal Society of Chemistry
DOI: 10.1039/d3en00685a

Towards characterization of cell culture conditions for reliable proteomic analysis: in vitro studies on A549, differentiated THP-1, and NR8383 cell lines

Autori: Rico Ledwith, Tobias Stobernack, Antje Bergert, Aileen Bahl, Mario Pink, Andrea Haase, Verónica I. Dumit
Pubblicato in: Archives of Toxicology, Numero 98, 2024, Pagina/e 4021-4031, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-024-03858-4

Next Generation Risk Assessment approaches for advanced nanomaterials: Current status and future perspectives

Autori: Danail Hristozov, Elena Badetti, Paolo Bigini, Andrea Brunelli, Susan Dekkers, Luisa Diomede, Shareen H. Doak, Wouter Fransman, Agnieszka Gajewicz-Skretna, Elisa Giubilato, Laura Gómez-Cuadrado, Roland Grafström, Arno C. Gutleb, Sabina Halappanavar, Roland Hischier, Neil Hunt, Alberto Katsumiti, Ali Kermanizadeh, Antonio Marcomini, Elisa Moschini, Agnes Oomen, Lisa Pizzol, Carlos Rumbo, Otmar Sc
Pubblicato in: NanoImpact, Numero 35, 2025, Pagina/e 100523, ISSN 2452-0748
Editore: Elsevier BV
DOI: 10.1016/j.impact.2024.100523

Roadmap towards safe and sustainable advanced and innovative materials. (Outlook for 2024-2030)

Autori: Flemming R. Cassee, Eric A.J. Bleeker, Cyrille Durand, Thomas Exner, Andreas Falk, Steffi Friedrichs, Elisabeth Heunisch, Martin Himly, Sabine Hofer, Norbert Hofstätter, Danail Hristozov, Penny Nymark, Anna Pohl, Lya G. Soeteman-Hernández, Blanca Suarez-Merino, Eugenia Valsami-Jones, Monique Groenewold
Pubblicato in: Computational and Structural Biotechnology Journal, Numero 25, 2024, Pagina/e 105-126, ISSN 2001-0370
Editore: Elsevier BV
DOI: 10.1016/j.csbj.2024.05.018

Acute, controlled inhalation of thin graphene oxide nanosheets in humans with null cardiorespiratory effects

Autori: Ulla Vogel
Pubblicato in: Nature Nanotechnology, Numero 19, 2024, Pagina/e 582-583, ISSN 1748-3387
Editore: Nature Publishing Group
DOI: 10.1038/s41565-024-01639-9

Bioinformatics and machine learning to support nanomaterial grouping

Autori: Aileen Bahl, Sabina Halappanavar, Wendel Wohlleben, Penny Nymark, Pekka Kohonen, Håkan Wallin, Ulla Vogel, Andrea Haase
Pubblicato in: Nanotoxicology, Numero 18, 2024, Pagina/e 373-400, ISSN 1743-5390
Editore: Informa Healthcare
DOI: 10.1080/17435390.2024.2368005

Status, implications and challenges of European safe and sustainable by design paradigms applicable to nanomaterials and advanced materials

Autori: Irini Furxhi, Anna Costa, Socorro Vázquez-Campos, Carlos Fito-López, Danail Hristozov, Juan Antonio Tamayo Ramos, Susanne Resch, Margherita Cioffi, Steffi Friedrichs, Cris Rocca, Eugenia Valsami-Jones, Iseult Lynch, Sánchez Jiménez Aracelil, Lucian Farcal
Pubblicato in: RSC Sustainability, 2023, ISSN 2753-8125
Editore: The Royal Society of Chemistry
DOI: 10.1039/d2su00101b

Transferability and reproducibility of exposed air-liquid interface co-culture lung models

Autori: Hedwig M, Braakhuis; Eric R, Gremmer; Anne, Bannuscher; Barbara, Drasler; Sandeep, Keshavan; Barbara, Rothen-Rutishauser; Barbara, Birk; Andreas, Verlohner; Robert, Landsiedel; Kirsty, Meldrum; Shareen H, Doak; Martin J D, Clift; Johanna Samulin, Erdem; Oda A H, Foss; Shanbeh, Zienolddiny-Narui; Tommaso, Serchi; Elisa, Moschini; Pamina, Weber; Sabina, Burla; Pramod, Kumar; Otmar, Schmid; Edwin, Zw
Pubblicato in: NanoImpact, Numero 4, 2023, ISSN 2452-0748
Editore: ScienceDirect
DOI: 10.1016/j.impact.2023.100466

COPD basal cells are primed towards secretory to multiciliated cell imbalance driving increased resilience to environmental stressors

Autori: Mircea Gabriel Stoleriu, Meshal Ansari, Maximilian Strunz, Andrea Schamberger, Motaharehsadat Heydarian, Yaobo Ding, Carola Voss, Juliane Josephine Schneider, Michael Gerckens, Gerald Burgstaller, Alejandra Castelblanco, Teresa Kauke, Jan Fertmann, Christian Schneider, Juergen Behr, Michael Lindner, Elvira Stacher-Priehse, Martin Irmler, Johannes Beckers, Oliver Eickelberg, Benjamin Schubert, Stef
Pubblicato in: Thorax, Numero 79, 2024, Pagina/e 524-537, ISSN 0040-6376
Editore: BMJ Publishing Group
DOI: 10.1136/thorax-2022-219958

LungVis 1.0: an automatic AI-powered 3D imaging ecosystem unveils spatial profiling of nanoparticle delivery and acinar migration of lung macrophages

Autori: Lin Yang, Qiongliang Liu, Pramod Kumar, Arunima Sengupta, Ali Farnoud, Ruolin Shen, Darya Trofimova, Sebastian Ziegler, Neda Davoudi, Ali Doryab, Ali Önder Yildirim, Markus E. Diefenbacher, Herbert B. Schiller, Daniel Razansky, Marie Piraud, Gerald Burgstaller, Wolfgang G. Kreyling, Fabian Isensee, Markus Rehberg, Tobias Stoeger, Otmar Schmid
Pubblicato in: Nature Communications, Numero 15, 2024, Pagina/e 10138, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-54267-1

A template wizard for the cocreation of machine-readable data-reporting to harmonize the evaluation of (nano)materials

Autori: Nina Jeliazkova, Eleonora Longhin, Naouale El Yamani, Elise Rundén-Pran, Elisa Moschini, Tommaso Serchi, Ivana Vinković Vrček, Michael J. Burgum, Shareen H. Doak, Mihaela Roxana Cimpan, Ivan Rios-Mondragon, Emil Cimpan, Chiara L. Battistelli, Cecilia Bossa, Rositsa Tsekovska, Damjana Drobne, Sara Novak, Neža Repar, Ammar Ammar, Penny Nymark, Veronica Di Battista, Anita Sosnowska, Tomasz Puzyn,
Pubblicato in: Nature Protocols, Numero 19, 2024, Pagina/e 2642-2684, ISSN 1754-2189
Editore: Nature Publishing Group
DOI: 10.1038/s41596-024-00993-1

Dynamic QSAR modeling for predicting in vivo genotoxicity and inflammation induced by nanoparticles and advanced materials: a time-dose-property/response approach

Autori: Michalina Miszczak, Kabiruddin Khan, Pernille Høgh Danielsen, Keld Alstrup Jensen, Ulla Vogel, Roland Grafström, Agnieszka Gajewicz-Skretna
Pubblicato in: Journal of Nanobiotechnology, Numero 23, 2025, Pagina/e 420, ISSN 1477-3155
Editore: BioMed Central
DOI: 10.1186/s12951-025-03510-y

Advanced materials earliest assessment (AMEA)

Autori: Wendel Wohlleben, Michael Persson, Blanca Suarez-Merino, Anders Baun, Veronica Di Battista, Susan Dekkers, Eugene P. van Someren, Dirk Broßell, Burkhard Stahlmecke, Martin Wiemann, Otmar Schmid, Andrea Haase
Pubblicato in: Environmental Science: Nano, Numero 11, 2024, Pagina/e 2948-2967, ISSN 2051-8153
Editore: Royal Society of Chemistry
DOI: 10.1039/d3en00831b

Effect of Exposure Concentration and Growth Conditions on the Association of Cerium Oxide Nanoparticles with Green Algae

Autori: Aiga Mackevica; Lyndsey Hendriks; Olga Meili-Borovinskaya; Anders Baun; Lars Michael Skjolding
Pubblicato in: Nanomaterials , vol. 13 , no. 17, Numero 2, 2023, ISSN 2079-4991
Editore: MDPI
DOI: 10.3390/nano13172468

Release of particulate matter from nano-enabled building materials (NEBMs) across their lifecycle: Potential occupational health and safety implications

Autori: Dilpreet Singh, Antonella Marrocco, Wendel Wohlleben, Hae-Ryung Park, Avantika R. Diwadkar, Blanca E. Himes, Quan Lu, David C. Christiani, Philip Demokritou
Pubblicato in: Journal of Hazarous Materials, Numero 03043894, 2022, ISSN 0304-3894
Editore: Elsevier BV
DOI: 10.1016/j.jhazmat.2021.126771

Prospective environmental risk screening of seven advanced materials based on production volumes and aquatic ecotoxicity

Autori: Rickard Arvidsson; Gregory Peters; Steffen Foss Hansen; Anders Baun
Pubblicato in: NanoImpact, Numero 24520748, 2022, ISSN 2452-0748
Editore: Elsevier BV
DOI: 10.1016/j.impact.2022.100393

Physicochemical properties of 26 carbon nanotubes as predictors for pulmonary inflammation and acute phase response in mice following intratracheal lung exposure

Autori: Pernille Høgh Danielsen, Sarah Søs Poulsen, Kristina Bram Knudsen, Per Axel Clausen, Keld Alstrup Jensen, Håkan Wallin, Ulla Vogel
Pubblicato in: Environmental Toxicology and Pharmacology, Numero 107, 2025, Pagina/e 104413, ISSN 1382-6689
Editore: Elsevier BV
DOI: 10.1016/j.etap.2024.104413

A novel quantitative read-across tool designed purposefully to fill the existing gaps in nanosafety data

Autori: Mainak Chatterjee; Arkaprava Banerjee; Priyanka De; Agnieszka Gajewicz-Skretna; Kunal Roy
Pubblicato in: Environmental Science: Nano, Numero 1, 2021, ISSN 2051-8153
Editore: Royal Society of Chemistry
DOI: 10.1039/d1en00725d

highlights from the Basic and Translational Science Assembly

Autori: Sara Cuevas Ocaña; Natalia El-Merhie; Merian E. Kuipers; Mareike Lehmann; Sara Rolandsson Enes; Carola Voss; Lareb S.N. Dean; Matthew Loxham; Agnes W. Boots; Suzanne M. Cloonan; Catherine M. Greene; Irene H. Heijink; Audrey Joannes; Arnaud A. Mailleux; Nahal Mansouri; Niki L. Reynaert; Anne M. van der Does; Darcy E. Wagner; Niki Ubags
Pubblicato in: Erj Open Research, Numero 2, 2023, ISSN 2312-0541
Editore: European Respiratory Society
DOI: 10.1183/23120541.00561-2022

Lung Organoids for Hazard Assessment of Nanomaterials

Autori: Miriam T. Kastlmeier; Eva M. Guenther; Tobias Stoeger; Carola Voss
Pubblicato in: Int. J. Mol. Sci. 23:15666 (2022), Numero 4, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232415666

A refined dose metric for nanotoxicology based on surface site reactivity for oxidative potential of engineered nanomaterials

Autori: Victor Alcolea-Rodriguez, Felice C. Simeone, Verónica I. Dumit, Lara Faccani, Victoria Toledo, Andrea Haase, Nicolas Coca-López, Raquel Portela, Miguel A. Bañares
Pubblicato in: Nanoscale Advances, Numero 7, 2025, Pagina/e 2929-2941, ISSN 2516-0230
Editore: Royal Society of Chemistry (RSC)
DOI: 10.1039/d5na00104h

As microscopic materials proliferate, ensuring they are safe is a priority

Autori: Otmar Schmid et al.
Pubblicato in: 2023
Editore: Horizon Magazine

Bioaccumulation and persistency evaluation of selected NMs

Autori: Anders Baun, Fides Hensel, Aiga Mackevica, Lars M. Skjolding (DTU) Veronica Di Battista, Wendel Wohlleben (BASF) Mona Connolly, José M. Navas (INIA)
Pubblicato in: 2023
Editore: CORDIS

Cell circuits underlying nanomaterial specific respiratory toxicology

Autori: Carola Voss, Lianyong Han, Meshal Ansari, Maximilian Strunz, Verena Haefner, Carol Ballester-Lopez, Ilias Angelidis, Christoph H. Mayr, Trine Berthing, Thomas Conlon, Qiongliang Liu, Hongyu Ren, Qiaoxia Zhou, Otmar Schmid, Ali Önder Yildirim, Markus Rehberg, Ulla Vogel, Janine Gote-Schniering, Fabian J. Theis, Herbert B. Schiller, Tobias Stoeger
Pubblicato in: 2024
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.02.10.579746

HARMLESS database with extensions to handle advanced materials

Autori: Lead beneficiary for this Deliverable: IDEA
Pubblicato in: 2023
Editore: CORDIS

Roadmap Safe and Sustainable Advanced and Innovative Materials 2024-2030

Autori: Flemming R. Cassee; Eric A.J. Bleeker; Cyrille Durand; Thomas Exner; Andreas Falk; Danail Hristozov; Sabine Hofer; Norbert Hofstätter; Steffi Friedrichs; Elisabeth Heunisch; Martin Himly; Penny Nymark; Anna Pohl; Lya G. Soeteman-Hernández; Blanca Suarez-Merino; Eugenia Valsami-Jones; Monique Groenewold
Pubblicato in: Numero 6, 2024
Editore: NanoSafetyCluster
DOI: 10.5281/zenodo.11147296

INISS-Nano: revised concept and action plan (International Network Initiative on Safe and Sustainable Nanotechnologies)

Autori: Andreas Falk; Pogany, Alexander; Aungkavattana, Pavadee; Bañares, Miguel A.; Beitollahi, Ali; Bim, Vinicius; Briffa, Sophie; Bochon, Anthony; Cassee, Flemming; Doridot, Fernand; Exner, Thomas; Farias, Patricia M.A.; Favre, Georges; Franzese, Giancarlo; Friedrichs, Steffi; Hristozov, Danail; Hunt, Neil; Indaraprasirt, Ramjitti; Karim, Md. E.; Khandelwal, Neha; Malsch, Ineke; Marcoulaki, Effie; Mar
Pubblicato in: INISS-nano, 2022
Editore: Concept Paper
DOI: 10.5281/zenodo.6818049

Automatic workflow for HTS data FAIRification, preprocessing and Tox5 in-vitro toxicity scoring (Version 2)

Autori: Tancheva, Gergana; Nymark, Penny; Hongisto, Vesa; Kochev, Nikolay; Jeliazkova, Nina
Pubblicato in: 2024
Editore: Zenodo
DOI: 10.5281/zenodo.10517627

Bayesian Network Models to combine and update models using incomplete data

Autori: Tanja Krone, Xavier Pinho, Eugene van Someren, Susan Dekkers
Pubblicato in: 2023
Editore: Zenodo
DOI: 10.5281/zenodo.10420899

Orange3-ToxFAIRy visual guide (Widget usage examples)

Autori: Gergana Tancheva, Vesa Hongisto, Konrad Patyra, Luchesar Iliev, Nikolay Kochev, Penny Nymark, Pekka Kohonen, Nina Jeliazkova, Roland Grafström
Pubblicato in: 2024
Editore: Zenodo
DOI: 10.5281/zenodo.13685297

Factsheet on ToxFAIRy: The HARMLESS software solution for automated toxicity scoring and FAIRification of data

Autori: Tancheva, Gergana, Hongisto, Vesa, Jeliazkova, Nina, Alfaro Serrano, Beatriz
Pubblicato in: 2024
Editore: Zenodo
DOI: 10.5281/zenodo.14526121

Safe-and-Sustainable-by-Design Approach and Decision Support System for Advanced Materials

Autori: Susan Dekkers, Veronique Adam, Veronica De Battista, Andrea Haase, Julia Prinz, Gregor Nagel, Wouter Fransman, Michael Persson, Blanca Suarez-Merino, Wendel Wohlleben, Otmar Schmid, Eugene van Someren
Pubblicato in: 2025
Editore: Authorea
DOI: 10.22541/au.174077018.85147151/v1

Factsheet on the HARMLESS Case Study on Catalysts: Oxide-perovskites for automotive catalysts

Autori: Di Battista, Veronica, Wohlleben, Wendel, Alfaro Serrano, Beatriz
Pubblicato in: 2024
Editore: Zenodo
DOI: 10.5281/zenodo.13861859

HARMLESS Workshop on SSbD for SMEs: AdMa in Product Development

Autori: Otmar Schmid, Michael Persson, Blanca Suarez Merino, Susan Dekkers, Nina Jeliazkova, Beatriz Alfaro Serrano
Pubblicato in: 2023
Editore: Zenodo
DOI: 10.5281/zenodo.7974563

Decision Support System for Safe-and-Sustainable-by-Design Advanced Materials: Case study demonstration

Autori: Veronique Adam, Veronica Di Battista, Fabienne Testard, Michael Persson, Daniel Persson, Dorra Gargouri, Arianna Filoramo, Roland Grafström, Pekka Kohonen, Vesa Hongisto, Mona Conolly, José Maria Navas, Lars Michael Skjolding, Agnieszka Gajewicz-Skretna, Pernille Høgh Danielsen, Ulla Vogel, Keld Alstrup Jensen, Eugene van Someren, Susan Dekkers, Otmar Schmid, Wendel Wohlleben, Blanca Suarez Mer
Pubblicato in: 2025
Editore: Authorea
DOI: 10.22541/au.173991289.98651419/v1

Advanced Materials Assessment Schemes HARMLESS - OECD Working Party on Manufactured Nanomaterials (WPMN) Workshop Report

Autori: Blanca Suarez-Merino (TEMAS Solutions GmbH); Nathan Bossa (TEMAS Solutions GmbH); Susan Dekkers (TNO); Anders Baun (DTU); Otmar Schmid (HMGU); Wendel Wohlleben (BASF SE); Andrea Haase (BfR) and Agnes Oomen (RIVM)
Pubblicato in: 2023
Editore: OECD

INISS-Nano: revised concept and action plan (International Network Initiative on Safe and Sustainable Nanotechnologies) - Version 3.0

Autori: Andreas Falk et al.
Pubblicato in: 2023
Editore: Zenodo
DOI: 10.5281/zenodo.7877359

HAMLESS Deliverable 2.3 – Bioaccumulation and persistency evaluation of selected NMs

Autori: Lars M. Skjolding, Fides Hensel, Aiga Mackevica, Anders Baun (DTU), Veronica Di Battista, Wendel Wohlleben (BASF), Mona Connolly, José M.Navas (INIA-CSIC)
Pubblicato in: 2024
Editore: Zenodo
DOI: 10.5281/zenodo.14105537

Deliverable 1.1 HARMLESS database with extensions to handle advanced materials

Autori: Jeliazkova, Nina; Wohlleben, Wendel
Pubblicato in: 2023
Editore: Zenodo
DOI: 10.5281/zenodo.14097538

HARMLESS Final Webinar (11.03.2025)

Autori: Schmid, Otmar; Suarez-Merino, Blanca; Dekkers, Susan; Grafström, Roland; Dumit, Verónica; Gajewicz-Skretna, Agnieszka; Baun, Anders; Jeliazkova, Nina; Haase, Andrea; Alfaro Serrano, Beatriz
Pubblicato in: 2025
Editore: Zenodo
DOI: 10.5281/zenodo.15196793

Factsheet on the HARMLESS Decision Support System for SSbD of Advanced Materials

Autori: Dekkers, Susan; van Someren, Eugene; Adam, Veronique; Di Battista, Veronica; Haase, Andrea; Prinz, Julia; Nagel, Gregor; Fransman, Wouter; Persson, Michael; Suarez-Merino, Blanca; Wohlleben, Wendel; Schmid, Otmar; Alfaro Serrano, Beatriz
Pubblicato in: 2025
Editore: Zenodo
DOI: 10.5281/zenodo.15356395

Roadmap Safe and Sustainable Advanced and Innovative Materials 2024-2030 (Version v5) - Preprint

Autori: Flemming R. Cassee, Eric A.J. Bleeker, Cyrille Durand, Thomas Exner, Andreas Falk, Danail Hristozov, Sabine Hofer, Norbert Hofstätter, Steffi Friedrichs, Elisabeth Heunisch, Martin Himly, Penny Nymark, Anna Pohl, Lya G. Soeteman-Hernández, Blanca Suarez-Merino, Eugenia Valsami-Jones, Monique Groenewold
Pubblicato in: 2024
Editore: Zenodo
DOI: 10.5281/zenodo.11191095

Overview of relevant AOPs to inform NAM choice of KEs

Autori: Lead beneficiary for this Deliverable: NRCWE
Pubblicato in: 2022
Editore: CORDIS

HARMLESS Deliverable 2.1 - Overview of relevant AOPs to inform NAM choice of KEs

Autori: Ulla Vogel
Pubblicato in: 2024
Editore: Zenodo
DOI: 10.5281/zenodo.10556303

Open access repository of mRNA single cell response

Autori: Lead beneficiary for this Deliverable: HMGU
Pubblicato in: 2024
Editore: CORDIS

In-vitro High-throughput screening data

Data entry template for High Throughput Screening (HTS) metadata, with links to data files - part of eNanoMapper Template Wizard

Autori: Tancheva, Gergana
Pubblicato in: 2024
Editore: Zenodo
DOI: 10.5281/zenodo.14260137

HARMLESS Deliverable D2.4 - Open access repository of mRNA single cell response

Autori: """Voss, Carola, Han, Lianyong, Ansari, Meshal, Strunz, Maximilian, Haefner, Verena, Ballester-Lopez, Carol, Angelidis, Ilias, Mayr, Christoph H., Berthing, Trine, Conlon, Thomas, Lui, Qiongliang, Ren, Hongyu, Zhou, Qiaoxia, Schmid, Otmar, Yildirim, Ali Önder, Rehberg, Markus, Vogel, Ulla, Gote-Schniering, Janine, Theis, Fabian J., Stöger, Tobias, Schiller, Herbert B."""
Pubblicato in: 2024
Editore: Zenodo
DOI: 10.5281/zenodo.13950977

Factsheet on the HARMLESS Case Study on Catalysts: Oxide-perovskites for automotive catalysts

Autori: Di Battista, Veronica; Wohlleben, Wendel; Alfaro Serrano, Beatriz
Pubblicato in: Numero 3, 2025
Editore: Zenodo
DOI: 10.5281/zenodo.14611300

From principles to reality. FAIR implementation in the nanosafety community

Autori: Dumit, Verónica I.; Ammar, Ammar; Bakker, Martine; Bañares, Miguel A.; Bossa, Cecilia; Costa, Anna; Cowie, Hilary; Drobne, Damjana; Exner, Thomas E.; Farcal, Lucian; Friedrichs, Steffi; Furxhi, Irini; Grafström, Roland; Haase, Andrea; Himly, Martin; Jeliazkova, Nina; Lynch, Iseult; Maier, Dieter; Noorlander, Cornelle W.; Shin, Hyun Kil; Soler-Illia, Galo J.A.A.; Suarez-Merino, Blanca; Willighag
Pubblicato in: Numero 2, 2023
Editore: Zenodo
DOI: 10.1016/j.nantod.2023.101923

Factsheet on the HARMLESS Case Study on Agriculture: Imogolites for agriculture & environmental plant protection

Autori: """Testard, Fabienne; Filoramo, Arianna; Gargouri, Dorra; Picot, Pierre; Alfaro Serrano, Beatriz"""
Pubblicato in: 2025
Editore: Zenodo
DOI: 10.5281/zenodo.14976837

International Network Initiative on Safe and Sustainable Nanotechnologies (INISS-nano)

Autori: Falk, Andreas
Pubblicato in: INISS-nano, 2021
Editore: Concept Paper
DOI: 10.5281/zenodo.5004929

SKIG Report 2023-2024 - Report of the Society for the Advancement of AOPs Knowledgebase Interest Group

Autori: WITTWEHR Clemens ; AUDOUZE Karine ; BURGDORF Tanja ; CLERBAUX Laure-Alix ; COEREK Emre; DEMUYNCK Emmanuel ; EXNER Thomas ; FILIPOVSKA Julija ; FRITSCHE Ellen ; GERIS Liesbet ; HENCH Virginia ; JELIAZKOVA Nina ; KARSCHNIK Travis; KUCHOVSKA Eliska ; MAIA LADEIRA Luiz Carlos ; MALINOWSKA Julia ; MARINOV Evgeni; MARTENS Marvin ; MERTENS Birgit ; NYMARK Penny ; SCHAFFERT Alexandra ; STAUMONT Bernard ;
Pubblicato in: SKIG Report - JRC publication, 2025, ISBN 978-92-68-25041-9
Editore: Publications Office of the European Union
DOI: 10.2760/7749010

Nanomaterialien: Unbedenklich oder Grund zur Sorge?

Autori: Otmar Schmid et al.
Pubblicato in: 2024
Editore: APA Science

Factsheet on ToxFAIRy: The HARMLESS software solution for automated toxicity scoring and FAIRification of data

Autori: Tancheva, Gergana; Hongisto, Vesa; Jeliazkova, Nina; Alfaro Serrano, Beatriz
Pubblicato in: Numero 3, 2025
Editore: Zenodo
DOI: 10.5281/zenodo.14526122

Automatic workflow for in vitro high-throughput screening data FAIRification, preprocessing and scoring.

Autori: Tancheva, Gergana; Nymark, Penny; Hongisto, Vesa; Kochev, Nikolay; Jeliazkova, Nina; Patyra, Konrad; Iliev, Luchesar; Grafström, Roland
Pubblicato in: Numero 5, 2023
Editore: QSAR 2023
DOI: 10.5281/zenodo.8029959

HARMLESS SSbD Approach and Decision Support System for Advanced Nanomaterials

Autori: Dekkers, Susan, Adam, Véronique, Di Battista, Veronica, Fransman, Wouter, Suarez-Merino, Blanca, Wohlleben, Wendel, van Someren, Eugene
Pubblicato in: 2024
Editore: Zenodo
DOI: 10.5281/zenodo.14279205

Engineered nanomaterial-relevant AOPs; network creation and identification of key nodes for adverse outcomes

Autori: Pousen, Sarah Søs; Baun, Anders; Stöger, Tobias; Navas, José María; Connolly, Mona; Vogel, Ulla B.
Pubblicato in: Numero 1, 2022
Editore: “Nano-week” & NanoCommons Final Conference
DOI: 10.5281/zenodo.6806067

NMBP-16 Ambassadors - Cooperation as cornerstone of our success

Autori: Alfaro Serrano, Beatriz; Resch, Susanne; Hristozov, Danail; Schmid, Otmar; Stöger, Tobias; Rumbo, Carlos
Pubblicato in: 2024
Editore: Zenodo
DOI: 10.5281/zenodo.13908183

HARMLESS webinar on SSbD: DSS demo with AdMa case study

Autori: Otmar Schmid, Blanca Suárez Merino, Veronica Di Battista, Eugene van Someren, & Susan Dekkers, Beatriz Alfaro and Wendel Wohlleben
Pubblicato in: 2024
Editore: Zenodo
DOI: 10.5281/zenodo.11459527

Automatic workflow for in vitro high-throughput screening data FAIRification, preprocessing and scoring: A case study on nanomaterials (Version 3)

Autori: Tancheva, Gergana; Nymark, Penny; Hongisto, Vesa; Kochev, Nikolay; Jeliazkova, Nina; Patyra, Konrad; Iliev, Luchesar; Grafström, Roland; Kohonen, Pekka
Pubblicato in: 2024
Editore: Zenodo
DOI: 10.5281/zenodo.13986392

AOP training session

Autori: Vogel, Ulla; Poulsen, Sarah Søs
Pubblicato in: 2022
Editore: NanoWeek 2022 and NanoCommons Final Conference
DOI: 10.5281/zenodo.6806125

HARMLESS Decision Support System

Autori: Eugene van Someren; Neeraj Shandilya; Remy Franken; Xavier Pinho; Tanja Krone; Robin van Stokkum; Gino Kalkman; Erik Lemcke; Ioannis Tolios; Wouter Fransman; Susan Dekkers
Pubblicato in: Numero 2, 2023
Editore: nanoSAFE 2023 Conference
DOI: 10.5281/zenodo.8099067

Conceptual Design of the HARMLESS Decision Support System

Autori: van Someren, Eugene; Shandilya, Neeraj; Franken, Remy; Krone, Tanja; van Stokkum, Robin; Suarez-Merino, Blanca; Adam, Véronique; Salieri, Beatrice; Wohlleben, Wendel; Kalkman, Gino; van Barneveld, Mark; Tolios, Ioannis; Rubingh, Carina; Krishnan, Shaji; Fransman, Wouter; Dekkers, Susan
Pubblicato in: Numero 2, 2022
Editore: “Nano-week” & NanoCommons Final Conference
DOI: 10.5281/zenodo.6806190

Reactive bases of nanomaterial toxicity

Autori: Alcolea Rodríguez, Víctor
Pubblicato in: reponame:Docta Complutense, Numero 2, 2024
Editore: UNIVERSIDAD COMPLUTENSE DE MADRID

The Impact of Carbon Nanotube Properties on Lung Pathologies and Atherosclerosis Through Acute Inflammation: a New AOP‐Anchored <i>in Silico</i> NAM

Autori: Sattibabu Merugu, Karolina Jagiello, Agnieszka Gajewicz‐Skretna, Sabina Halappanavar, Andrew Willliams, Ulla Vogel, Tomasz Puzyn
Pubblicato in: Small, Numero 21, 2025, ISSN 1613-6810
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202501185

Nanoparticle-Exposure-Triggered Virus Reactivation Induces Lung Emphysema in Mice

Autori: Lianyong Han, Verena Haefner, Youjia Yu, Bing Han, Hongyu Ren, Martin Irmler, Johannes Beckers, Qiongliang Liu, Annette Feuchtinger, Ali Oender Yildirim, Heiko Adler and Tobias Stoeger
Pubblicato in: ACS Nano, 17, 21, 21056-21072, 2023, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.3c04111

Reply to: Prospects and challenges for FAIR toxicogenomics data

Autori: Roland Grafström; Andrea Haase; Pekka Kohonen; Nina Jeliazkova; Penny Nymark
Pubblicato in: Nature Nanotechnology, Numero 17, 2022, Pagina/e 19-20, ISSN 1748-3387
Editore: Nature Publishing Group
DOI: 10.1038/s41565-021-01050-8

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