International Human Microbiome Coordination and Support Action

Project Information

IHMCSA

Grant agreement ID: 964590

DOI

10.3030/964590

Project closed

EC signature date 22 January 2021

Start date 1 May 2021

End date 30 April 2024

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 1 999 370,00

EU contribution

€ 1 999 370,00

Coordinated by

INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (17)

Ethical and policy issues in microbiome research and symbiosis monitoring

D7.1 Ethical and policy issues in microbiome research and symbiosis monitoring (M24)Report on evidence-based tools for microbiome-oriented self-care and medical decisions aids based on international standards on metagenomics data production and validation, resulting in a Mutual learning protocol to empower early-stage researchers to explore and address ethical and policy issues in microbiome research. EUR

White paper and recommendations on the human microbiome addressing gaps, emerging fields and political priorities

D4.3 White paper and recommendations on the human microbiome addressing gaps, emerging fields and political priorities, UCC (M36)

Recommendations for responsible research and innovation rules in the field of microbiome

D7.3 Recommendations for responsible research and innovation rules in the field of microbiome EUR (M36)

Report proposing initiatives for unified repositories for processed data

D3.2 Report proposing initiatives for unified repositories for processed data, UNITN (M30)

Consensus opinion paper (submission) on new approaches for intervention studies

D5.3 Consensus opinion paper (submission) on new approaches for intervention studies. UP (M30).

Policies and regulations for self-management tools

D7.2 Policies and regulations for self-management tools. PRI (M36)1) Report on the different policies needed in order to ensure appropriate regulation and control of ethical issues surrounding self-management tools, and 2) Report on the adaptation of ICH and EMA guidelines on pharmacogenomic biomarkers to microbiome-specific aspects and recommendation to the EMA

Report on the Delphi consultation: Questionnaire & analysis of the. consultation answers

D5.1 Report on the Delphi consultation: Questionnaire & analysis of the. consultation answers

Consensus opinion paper (submission) on preclinical models for microbiome research with focus on causality

D5.2 Consensus opinion paper (submission) on preclinical models for microbiome research with focus on causality

Report on clinical endpoints metadata

D1.2 Report on clinical endpoints metadata, EF-CLIF (M36)

Sustainability plan including toolbox

D8.2 Sustainability plan including toolbox (EUFIC, M30)

Communication and dissemination plan

D81 Communication and dissemination plan EUFIC M6

Report on interoperability

D2.2 Report on interoperability, INRAE (M36)

Report on the highlights of communication and dissemination efforts with KPI indicators

D8.3 Report on the highlights of communication and dissemination efforts with KPI indicators (EUFIC, M36)

Report on human microbiome data

D2.1 Report on human microbiome data, UCPH (M24)

Report on recommendations for microbiome analysis standards

D3.1 Report on recommendations for microbiome analysis standards, UCPH (M30)

Roadmap proposal for a European Microbiome-Dedicated Surveillance Network

D7.4 Roadmap proposal for a European Microbiome-Dedicated Surveillance Network EUR (M36)

Position paper (submission) on biomarker identification, preanalytical & analytical validation

D6.2 Position paper (submission) on biomarker identification, preanalytical & analytical validation. LNS (M30)

Publications

Peer reviewed articles (31)

Editorial: Acute-on-chronic liver failure: systemic inflammation and immunosuppression.

Author(s): Tyc O, Shi Y, Fan YC, Trebicka J, Xiang X
Published in: Frontiers in Immunology, Issue 2023 Aug 15, 2023, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2023.1260749

Targeted decrease of portal hepatic pressure gradient improves ascites control after TIPS

Author(s): Alexander Queck, Louise Schwierz, Wenyi Gu, Philip G. Ferstl, Christian Jansen, Frank E. Uschner, Michael Praktiknjo, Johannes Chang, Maximilian J. Brol, Filippo Schepis, Manuela Merli, Christian P. Strassburg, Jennifer Lehmann, Carsten Meyer, Jonel Trebicka
Published in: Hepatology, 2022, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.32676

"""Human-microbes symbiosis inhealth and disease, on earth andbeyond planetary boundaries"""

Author(s): Dore J & Ortega-Ugalde S
Published in: Frontiers in Astronomy and Space Sciences, Issue 2023 Sept, 2023, ISSN 2296-987X
Publisher: Frontiers Media
DOI: 10.3389/fspas.2023.1180522

Editorial: Portal Hypertension in Cirrhosis: From Pathogenesis to Novel Treatments

Author(s): Chandana B. Herath, Peter W. Angus, and Jonel Trebicka
Published in: Frontiers in Physiology, 2022, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2022.864083

Stage of fibrosis is not a predictive determinant of weight loss in patients undergoing bariatric surgery

Author(s): Brol MJ, Drebber U, Yu X, Schierwagen R, Gu W, Plamper A, Klein S, Odenthal M, Uschner FE, Praktiknjo M, Trebicka J, Rheinwalt KP
Published in: Surgery for Obesity and Related Diseases, Issue 2024, 2024, ISSN 1550-7289
Publisher: Elsevier BV
DOI: 10.1016/j.soard.2024.02.006

Recent advances in the prevention and treatment of decompensated cirrhosis and acute-on-chronic liver failure (ACLF) and the role of biomarkers

Author(s): Trebicka J, Hernaez R, Shawcross DL, Gerbes AL
Published in: Gut, Issue 2024 Mar 25, 2024, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2023-330584

Blood Endotoxin Levels as Biomarker of Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis

Author(s): Soppert, Josefin; Brandt, Elisa Fabiana; Heussen, Nicole Maria; Barzakova, Emona; Blank, Lars M.; Küpfer, Lars; Hornef, Mathias; Trebicka, Jonel; Jankowski, Joachim; Berres, Marie-Luise; Noels, Heidi
Published in: Clinical Gastroenterology and Hepatology, Issue 7, 2023, Page(s) 2746-2758, ISSN 1542-3565
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.cgh.2022.11.030

Pathogenetic mechanisms and therapeutic approaches of acute-to-chronic liver failure

Author(s): Schierwagen, Robert; Gu, Wenyi; Brieger, Angela; Brüne, Bernhard; Ciesek, Sandra; Đikić, Ivan; Dimmeler, Stefanie; Geisslinger, Gerd; Greten, Florian R.; Hermann, Eva; Hildt, Eberhard; Kempf, Volkhard A. J.; Klein, Sabine; Koch, Ina; Mühl, Heiko; Müller, Volker; Peiffer, Kai-Henrik; Kestner, Roxane-Isabelle; Piiper, Albrecht; Rohde, Gernot; Scholich, Klaus; Schulz, Marcel H.; Storf, Holger; T
Published in: American journal of physiology. Cell physiology, Issue 8, 2023, ISSN 0363-6143
Publisher: American Physiological Society
DOI: 10.1152/ajpcell.00101.2023

Atorvastatin for patients with cirrhosis. A randomized, placebo-controlled trial. 

Author(s): Kronborg TM, Schierwagen R, Trošt K, Gao Q, Moritz T, Bendtsen F, Gantzel RH, Andersen ML, Teisner AS, Grønbæk H, Hobolth L, Møller S, Trebicka J, Kimer N
Published in: Hepatology Communications, Issue 2023 Dec 1, 2023, ISSN 2471-254x
Publisher: Wolters Kluwer Health
DOI: 10.1097/hc9.0000000000000332

The Role of Hypoxia-Inducible Factor 1 Alpha in Acute-on-Chronic Liver Failure. 

Author(s): Mücke MM, El Bali N, Schwarzkopf KM, Uschner FE, Kraus N, Eberle L, Mücke VT, Bein J, Beyer S, Wild PJ, Schierwagen R, Klein S, Zeuzem S, Welsch C, Trebicka J, Brieger A
Published in: International Journal of Molecular Sciences, Issue 2024 Jan 26, 2024, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25031542

The rationale and study design of two phase II trials examining the effects of BI 685509, a soluble guanylyl cyclase activator, on clinically significant portal hypertension in patients with compensated cirrhosis

Author(s): Reiberger, Thomas; Berzigotti, Annalisa; Trebicka, Jonel; Ertle, Judith; Gashaw, Isabella; Swallow, Ros; Tomisser, Andrea
Published in: Trials, Issue 10, 2023, ISSN 1745-6215
Publisher: BioMed Central
DOI: 10.1186/s13063-023-07291-3

Acute-On-Chronic Liver Failure: Current Interventional Treatment Options and Future Challenges

Author(s): Markus Kimmann; Jonel Trebicka
Published in: Journal of Personalized Medicine, Vol 13, Iss 7, p 1052 (2023), Issue 11, 2023, ISSN 2075-4426
Publisher: MDPI
DOI: 10.3390/jpm13071052

Use and outcome of TIPS in hospitalized patients in Germany: A Nationwide study (2007-2018). 

Author(s): Gu W, Zeleke Y, Hortlik H, Schaaf L, Uschner FE, Schulz M, Tischendorf M, Peiffer KH, Brol MJ, Kimmann M, Vogl T, Köhler M, Meyer C, Gerbes A, Rössle M, Laleman W, Zipprich A, Steib C, Praktiknjo M, Trebicka J; German TIPS Working Group.
Published in: Hepatology Communications, Issue 2023 Sep 15, 2023, ISSN 2471-254x
Publisher: Wolters Kluwer Health
DOI: 10.1097/hc9.0000000000000237

Custom scoring based on ecological topology of gut microbiota associated with cancer immunotherapy outcome

Author(s): Lisa Derosa, Valerio Iebba, Carolina Alves Costa Silva, Gianmarco Piccinno, Guojun Wu, Leonardo Lordello, Bertrand Routy, Naisi Zhao, Cassandra Thelemaque, Marine Fidelle, Meriem Messaoudene, Andrew Maltez Thomas, Gerard Zalcman, Sylvie Friard, Julien Mazieres, Clarisse Audigier-Valette, Denis Moro-Sibilot, François Goldwasser, Arnaud Scherpereel, Hervé Pegliasco, François Ghiringhelli, Nicol
Published in: Cell, 2024, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2024.05.029

Gut Microbiota-Related Biomarkers in Immuno-oncology

Author(s): Carolina Alves Costa Silva, Marine Fidelle, Andrew A. Almonte, Lisa Derosa, Laurence Zitvogel
Published in: Ann. Rev. Pharmacol, 2024, ISSN 0362-1642
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-pharmtox-061124-102218

Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis

Author(s): Sandra Torres; Cristina Ortiz; Nadine Bachtler; Wenyi Gu; Leon D. Grünewald; Nico Kraus; Robert Schierwagen; Christoph Hieber; Caroline Meier; Olaf Tyc; Maximilian Joseph Brol; Frank Erhard Uschner; Bart Nijmeijer; Christoph Welsch; Marie‐Luise Berres; Carmen Garcia‐Ruiz; Jose Carlos Fernandez‐Checa; Christian Trautwein; Thomas J. Vogl; Stefan Zeuzem; Jonel Trebicka; Sabine Klein
Published in: Hepatology, 2022, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.32746

Sympathetic nervous activation, mitochondrial dysfunction and outcome in acutely decompensated cirrhosis: the metabolomic prognostic models (CLIF-C MET)

Author(s): Emmanuel Weiss; Carlos de la Peña-Ramirez; Ferran Aguilar; Juan-Jose Lozano; Cristina Sánchez-Garrido; Patricia Sierra; Pedro Izquierdo-Bueno Martin; Juan Manuel Diaz; François Fenaille; Florence A Castelli; Thierry Gustot; Wim Laleman; Agustín Albillos; Carlo Alessandria; Marco Domenicali; Paolo Caraceni; Salvatore Piano; Faouzi Saliba; Stefan Zeuzem; Alexander L Gerbes; Julia A Wendon; Chris
Published in: Gut, Issue 6, 2023, Page(s) 1581-1591, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2022-328708

Epidemiology of liver transplantation and post-LT complications in Germany: nationwide study (2005-2018). 

Author(s): Gu W, Schaaf L, Hortlik H, Zeleke Y, Brol MJ, Schnitzbauer AA, Bechstein WO, Zeuzem S, Queck A, Peiffer KH, Tischendorf M, Pascher A, Laleman W, Praktiknjo M, Schulz MS, Uschner FE, Rennebaum F, Trebicka J
Published in: European Journal of Gastroenterology & Hepatology, Issue 2023 Nov 1, 2023, Page(s) 1289-1297, ISSN 0954-691X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/meg.0000000000002640

“Love is a microbe too” : Microbiome dialectics

Author(s): Hub Zwart
Published in: Endeavour, Issue 46, 2022, Page(s) 100816, ISSN 0160-9327
Publisher: Elsevier BV
DOI: 10.1016/j.endeavour.2022.100816

From animal models to gut-on-chip: the challenging journey to capture inter-individual variability in chronic digestive disorders

Author(s): Kriaa A, Mariaule V, De Rudder C, Jablaoui A, Sokol H, Wilmes P, Maguin E, Rhimi M.
Published in: Gut Microbes, Issue 2024 Jan-Dec;16(1):2333434, 2024, ISSN 1949-0984
Publisher: Taylor and Francis
DOI: 10.1080/19490976.2024.2333434

Design of a proteolytic module for improved metabolic modeling of Bacteroides caccae.

Author(s): Paulay A, Grimaud GM, Caballero R, Laroche B, Leclerc M, Labarthe S, Maguin E
Published in: mSystems, Issue 2024 Apr 16;9(4):e0015324, 2024, ISSN 0021-9193
Publisher: American Society for Microbiology
DOI: 10.1128/msystems.00153-24

The non-selective Rho-kinase inhibitors Y-27632 and Y-33075 decrease contraction but increase migration in murine and human hepatic stellate cells

Author(s): Bachtler, Nadine; Torres, Sandra; Ortiz, Cristina; Schierwagen, Robert; Tyc, Olaf; Hieber, Christoph; Berres, Marie-Luise; Meier, Caroline; Kraus, Nico; Zeuzem, Stefan; Nijmeijer, Bart; Pronk, Sebas; Trebicka, Jonel; Klein, Sabine
Published in: PLoS ONE, Vol 18, Iss 1, p e0270288 (2023), Issue 7, 2023, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0270288

Opportunities and barriers for omics-based biomarker discovery in steatotic liver diseases

Author(s): Thiele M, Villesen IF, Niu L, Johansen S, Sulek K, Nishijima S, Van Espen L, Keller M, Israelsen M, Suvitaival T, de Zawadzki A, Juel HB, Brol MJ, Stinson SE, Huang Y, Alvarez Silva MC, Kuhn M, Anastasiadou E, Leeming DJ, Karsdal M, Matthijnssens J, Arumugam M, Dalgaard LT, Legido-Quigley C, Mann M, Trebicka J, Bork P, Jensen LJ, Hansen T, Krag A; MicrobLiver and GALAXY consortia; GALAXY consortiu
Published in: Journal of Hepatology, Issue 2024 Mar 27, 2024, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2024.03.035

Beta-blockers in patients with liver cirrhosis: Pragmatism or perfection? 

Author(s): Sauerbruch T, Hennenberg M, Trebicka J, Schierwagen R
Published in: Frontiers in Medicine, Issue 2023 Jan 9, 2023, ISSN 2296-858X
Publisher: Frontiers Media
DOI: 10.3389/fmed.2022.1100966

Genetic variation in<i>TERT</i>modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study

Author(s): Buch, Stephan; Innes, Hamish; Lutz, Philipp Ludwig; Nischalke, Hans Dieter; Marquardt, Jens U; Fischer, Janett; Weiss, Karl Heinz; Rosendahl, Jonas; Marot, Astrid; Krawczyk, Marcin; Casper, Markus; Lammert, Frank; Eyer, Florian; Vogel, Arndt; Marhenke, Silke; von Felden, Johann; Sharma, Rohini; Atkinson, Stephen Rahul; McQuillin, Andrew; Nattermann, Jacob; Schafmayer, Clemens; Franke, Andre; Stras
Published in: Gut, Issue 8, 2023, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2022-327196

Personalised human albumin in patients with cirrhosis and ascites: design and rationale for the ALB-TRIAL - a randomised clinical biomarker validation trial. 

Author(s): Torp N, Israelsen M, Coenraad M, Papp M, Shawcross D, Korenjak M, Angeli P, Laleman W, Juanola A, Gines P, Trebicka J, Krag A; MICROB-PREDICT Consortium.
Published in: BMJ Open, Issue 2024 Feb 14, 2024, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2023-079309

Modeling microbiota-associated human diseases: from minimal models to complex systems

Author(s): Doriane Aguanno, Amira Metwaly, Olivia I. Coleman, Dirk Haller
Published in: Microbiome Research Reports, 2022, ISSN 2771-5965
Publisher: OAE Publishing Inc.
DOI: 10.20517/mrr.2022.01

Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies

Author(s): Kennedy KM, de Goffau MC, Perez-Muñoz ME, Arrieta M-C, Bäckhed F, Bork P, Braun T, Bushman FD, Dore J, de Vos WM, Earl AM, Eisen JA, Elovitz MA, Ganal-Vonarburg SC, Gänzle MG, Garrett WS, Hall LJ, Hornef MW, Huttenhower C, Konnikova L, Lebeer S, Macpherson AJ, Massey RC, McHardy AC, Koren O, Lawley TD, Ley RE, O’Mahony L, O’Toole PW, Pamer EG, Parkhill J, Raes J, Rattei T, Salonen A, Segal
Published in: Nature, Issue 2023 Jan, 2023, Page(s) 639-649, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-05546-8

Operating under pressure: Is there a place for preoperative TIPS? 

Author(s): Praktiknjo M, Trebicka J.
Published in: JHEP Reports, Issue 2024 Feb 9, 2024, ISSN 2589-5559
Publisher: Elsevier B.V.
DOI: 10.1016/j.jhepr.2024.101034

Myostatin is associated with the presence and development of acute-on-chronic liver failure. 

Author(s): Ruiz-Margáin A, Pohlmann A, Lanzerath S, Langheinrich M, Campos-Murguía A, Román-Calleja BM, Schierwagen R, Klein S, Uschner FE, Brol MJ, Torre-Delgadillo A, Flores-García NC, Praktiknjo M, Macías Rodríguez RU, Trebicka J
Published in: JHEP Reports, Issue 2023 Apr 14, 2023, ISSN 2589-5559
Publisher: Elsevier BV
DOI: 10.1016/j.jhepr.2023.100761

Microbiome risk profiles as biomarkers for inflammatory and metabolic disorders

Author(s): Amira Metwaly, Sandra Reitmeier, Dirk Haller
Published in: Nature Reviews Gastroentrology & Hepatology, 2022, ISSN 1759-5045
Publisher: Nature Publishing Group
DOI: 10.1038/s41575-022-00581-2