PARVOVIRUS BASED LINEAR ANIMAL VECTORS FOR PRODUCTION OF VACCINES AND OTHER USEFUL PROTEINS

Projektinformationen

ID Finanzhilfevereinbarung: BAP*0121

Startdatum 1 Juli 1986

Enddatum 31 Dezember 1989

Finanziert unter

• Multiannual research action programme (EEC) in the field of biotechnology (BAP), 1985-1989

Gesamtkosten € 0,00

EU-Beitrag Keine Daten

Koordiniert durch

UNIVERSITE LIBRE DE BRUXELLES
Belgium

Exploitable results

Genetic modification of parvovirus

Modification of the genomes of parvoviruses H-1 and MVM, attempting to make them suitable linear vectors, has resulted in: production of recombinant parvoviruses showing transduction specificity for oncogene-transformed cells and having potential for cancer gene therapy; programmed cell killing by means of inducible clones of parvoviral genes encoding nonstructural proteins; demonstration and unravelling of the oncolytic activity of parvoviruses, raising prospects of anticancer applications.