Objetivo The objective of the proposal is to use cytogenetic methods to examine fundamental aspects of variations in radiosensitivity between individuals. The proposal exploits recent advances in using the G2 assay in lymphocytes to identify normally responding and hypersensitive individuals amongst cohorts of healthy subjects and cancer patients. Current evidence suggests that G2 sensitivity is a marker of predisposition to cancer. Suitable normal and sensitive subjects will have small skin biopsiestaken and from these fibroblast cultures will be initiated. These will provide a stock of cells that will be irradiated in vi tro and examined for induced chromosomal damage. Particular emphasis will be placed on the presence of stable aberrations detected by using the fluorescence in situ hybridisation method on mitotic preparations. The data will be examined for both quantitative and qualitative differences in chromosomal responses between individuals that may correlate with their known radiosensitivity and disease status. Programa(s) EAEC-NFS 2 - Specific research and training programme in the field of nuclear safety and safeguards, 1994-1998 Tema(s) 040102 - Repair of, and recovery from, DNA damage and radiation sensitivity Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador National Radiological Protection Board (NRPB) Aportación de la UE Sin datos Dirección Chilton OX11 0RQ Didcot Reino Unido Ver en el mapa Coste total Sin datos Participantes (2) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo Christie Hospital NHS Trust Reino Unido Aportación de la UE Sin datos Dirección Wilmslow Road Didsbury M20 9BX Manchester Ver en el mapa Coste total Sin datos FUNDACION CENTRO ONCOLOGICO DE GALICIA JOSE ANTONIO QUIROGA Y PINEYRO España Aportación de la UE Sin datos Dirección S/N,Avenida de Montserrat S/N 15006 LA CORUNA Ver en el mapa Coste total Sin datos
