Obiettivo The objective of the proposal is to use cytogenetic methods to examine fundamental aspects of variations in radiosensitivity between individuals. The proposal exploits recent advances in using the G2 assay in lymphocytes to identify normally responding and hypersensitive individuals amongst cohorts of healthy subjects and cancer patients. Current evidence suggests that G2 sensitivity is a marker of predisposition to cancer. Suitable normal and sensitive subjects will have small skin biopsiestaken and from these fibroblast cultures will be initiated. These will provide a stock of cells that will be irradiated in vi tro and examined for induced chromosomal damage. Particular emphasis will be placed on the presence of stable aberrations detected by using the fluorescence in situ hybridisation method on mitotic preparations. The data will be examined for both quantitative and qualitative differences in chromosomal responses between individuals that may correlate with their known radiosensitivity and disease status. Programma(i) EAEC-NFS 2 - Specific research and training programme in the field of nuclear safety and safeguards, 1994-1998 Argomento(i) 040102 - Repair of, and recovery from, DNA damage and radiation sensitivity Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore National Radiological Protection Board (NRPB) Contributo UE Nessun dato Indirizzo Chilton OX11 0RQ Didcot Regno Unito Mostra sulla mappa Costo totale Nessun dato Partecipanti (2) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto Christie Hospital NHS Trust Regno Unito Contributo UE Nessun dato Indirizzo Wilmslow Road Didsbury M20 9BX Manchester Mostra sulla mappa Costo totale Nessun dato FUNDACION CENTRO ONCOLOGICO DE GALICIA JOSE ANTONIO QUIROGA Y PINEYRO Spagna Contributo UE Nessun dato Indirizzo S/N,Avenida de Montserrat S/N 15006 LA CORUNA Mostra sulla mappa Costo totale Nessun dato
