Objective A detailed knowledge of basic mechanisms by which ionizing radiation induces cancer and genetic disorders is essential for informed judgements to be made in radiation protection. The identification of most of the genes involved in the DNA damage responses to radiation and the generation of knockout mice defective in these processes provide the basis for further improvement of our understanding of the mechanisms of the different DNA damage response pathways and their interactions. To achieve these goals we will exploit new technologies and utilise different organisms. To understand the consequences of deficiencies in radiation responses in man we will analyse the defects in damage response mechanisms in rare radiosensitive individuals. The tools and concepts that we will develop will assist in the understanding of genetic changes and radiation carcinogenesis in man and will ultimately help to extrapolate to the effects of low doses and low dose-rates. Fields of science natural sciencesbiological sciencesgeneticsDNAnatural sciencesphysical sciencesnuclear physicsmedical and health sciencesclinical medicineoncology Programme(s) FP5-EAECTP C - Research and training programme (Euratom) in the field of nuclear energy (1998 to 2002) Topic(s) 2.1.3.-1.1. - Risk estimates for exposures at low dose and low dose rate Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator LEIDEN UNIVERSITY EU contribution No data Address Wassenaarseweg 72 2300 RA LEIDEN Netherlands See on map Total cost No data Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all ERASMUS UNIVERSITEIT ROTTERDAM Netherlands EU contribution No data Address Dr. Molewaterplein 50 3000 DR ROTTERDAM See on map Total cost No data GSF-RESEARCH CENTER FOR ENVIRONMENT AND HEALTH Germany EU contribution No data Address Ingolstädter Landstrasse 1 85764 Neuherberg See on map Total cost No data INSTITUT CURIE France EU contribution No data Address Rue d'Ulm 26 75248 PARIS See on map Total cost No data MEDICAL RESEARCH COUNCIL United Kingdom EU contribution No data Address Sussex University BN1 9RR Falmer, Brighton See on map Total cost No data MEDICAL RESEARCH COUNCIL United Kingdom EU contribution No data Address Harwell OX11 0RD Didcot See on map Total cost No data UNIVERSITY OF SUSSEX United Kingdom EU contribution No data Address Falmer BN1 9RR BRIGHTON / FALMER See on map Total cost No data