Obiettivo A detailed knowledge of basic mechanisms by which ionizing radiation induces cancer and genetic disorders is essential for informed judgements to be made in radiation protection. The identification of most of the genes involved in the DNA damage responses to radiation and the generation of knockout mice defective in these processes provide the basis for further improvement of our understanding of the mechanisms of the different DNA damage response pathways and their interactions. To achieve these goals we will exploit new technologies and utilise different organisms. To understand the consequences of deficiencies in radiation responses in man we will analyse the defects in damage response mechanisms in rare radiosensitive individuals. The tools and concepts that we will develop will assist in the understanding of genetic changes and radiation carcinogenesis in man and will ultimately help to extrapolate to the effects of low doses and low dose-rates. Campo scientifico natural sciencesbiological sciencesgeneticsDNAnatural sciencesphysical sciencesnuclear physicsmedical and health sciencesclinical medicineoncology Programma(i) FP5-EAECTP C - Research and training programme (Euratom) in the field of nuclear energy (1998 to 2002) Argomento(i) 2.1.3.-1.1. - Risk estimates for exposures at low dose and low dose rate Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore LEIDEN UNIVERSITY Contributo UE Nessun dato Indirizzo Wassenaarseweg 72 2300 RA LEIDEN Paesi Bassi Mostra sulla mappa Costo totale Nessun dato Partecipanti (6) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto ERASMUS UNIVERSITEIT ROTTERDAM Paesi Bassi Contributo UE Nessun dato Indirizzo Dr. Molewaterplein 50 3000 DR ROTTERDAM Mostra sulla mappa Costo totale Nessun dato GSF-RESEARCH CENTER FOR ENVIRONMENT AND HEALTH Germania Contributo UE Nessun dato Indirizzo Ingolstädter Landstrasse 1 85764 Neuherberg Mostra sulla mappa Costo totale Nessun dato INSTITUT CURIE Francia Contributo UE Nessun dato Indirizzo Rue d'Ulm 26 75248 PARIS Mostra sulla mappa Costo totale Nessun dato MEDICAL RESEARCH COUNCIL Regno Unito Contributo UE Nessun dato Indirizzo Sussex University BN1 9RR Falmer, Brighton Mostra sulla mappa Costo totale Nessun dato MEDICAL RESEARCH COUNCIL Regno Unito Contributo UE Nessun dato Indirizzo Harwell OX11 0RD Didcot Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF SUSSEX Regno Unito Contributo UE Nessun dato Indirizzo Falmer BN1 9RR BRIGHTON / FALMER Mostra sulla mappa Costo totale Nessun dato