Objective
Inhibition of heparanase overexpressed by tumours, preventing not only the release and activation of angiogenic growth factors stored by heparan sulfate (HS) proteoglycans but also the disruption of the basement membrane and the extracellular matrix is regarded as a very promising strategy to develop anticancer drugs. This project aims at:
a) mapping the binding sites of heparanase for HS;
b) determining the structural requirements of HS-like polysaccharides for interaction with the enzyme as substrates and as inhibitors;
c) improving the heparanase-inhibiting properties of polysaccharides by generating specific sulfation patterns optimised on biological activity (inhibition of heparanase, antimetastatic-antiangiogenic activity).
These aims will be pursued through a study of the inhibition of heparanase with natural and synthetic HS-like oligo/polysaccharides, glycomimetics, and its in vivo effects.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
20133 MILANO
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.