Objective
The goal of this proposal is to provide accurate, up-to-date data on occupational exposure to wood dust, and to assess associations between such exposure and molecular alterations of Sino-nasal cancers, and biological mechanisms of pulmonary inflammation. Data on overall levels of European exposure will be obtained from European exposure databases and exposure registers as well as by monitoring wood dust levels in workplaces. Sino-nasal cancer cases and their exposure histories will be collected and paraffin-embedded tissue samples examined for p53 and K-transmutations. DNA damage induced by wood dust will be studied in exposed human cells. Molecular mechanisms of wood dust-induced pulmonary inflammation will be studied with experimental animals and cell cultures, and with nasal epithelial cells obtained from wood dust exposed subjects. Data from exposure assessment and the toxicological endpoints will be compiled for risk assessment. The study ultimately aims to provide exposure and mechanism-bases data for setting occupational limit values to improve safety at workplaces.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences computer and information sciences databases
- humanities history and archaeology history
- natural sciences biological sciences genetics DNA
- medical and health sciences clinical medicine oncology
- agricultural sciences agriculture, forestry, and fisheries forestry
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
00250 HELSINKI
Finland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.