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PORTABLE PLATFORM FOR THE ASSESSMENT OF MICROVASCULAR HEALTH IN COVID-19 PATIENTS AT THE INTENSIVE CARE

Project description

New portable solution for scarce ICU resources

Healthcare systems around the world have been overwhelmed by the surge in seriously ill COVID-19 patients who require intensive care unit (ICU) admission. While exact rates differ per EU Member State, 3–12 % of the infected population need mechanical ventilation. The personalisation of treatment will allow for the more targeted rationing of scarce ICU resources. With this in mind, the EU-funded VASCOVID project is developing a portable, non-invasive and real-time health monitoring platform that combines time-resolved near-infrared spectroscopy and diffuse correlation spectroscopy. The solution will enable the large-scale testing of new treatment procedures and therapies, targeting microvascular impairment. Moreover, it will reduce the incidence of extubation failure (reintubation within seven days) in ICUs.

Objective

As COVID-19 spreads worldwide, the surge in patients requiring intensive care unit (ICU) admission has been overwhelming to the healthcare systems. Critical care triage to allow the rationing of scarce ICU resources is needed but is hindered due to lack of personalization. The management of acute respiratory failure and hemodynamics is critical at the ICU. In fact, of the seven million COVID-19 cases (end of May 2020) 3-12% required mechanical ventilation which forms the primary target of VASCOVID where we focus on; (1) patient stratification derived from endothelial function evaluation, and, (2) evaluation of cardiopulmonary interactions that personalizes conservative ventilation strategies in order to avoid ventilator-induced lung injury and readiness to wean from the ventilator. VASCOVID will deploy and mature our portable, non-invasive and real-time health monitoring platform for this purpose. This platform combines two bio-photonics technologies, time-resolved near-infrared spectroscopy and diffuse correlation spectroscopy, and is the fruit of long-term collaboration between core project partners in two European projects (BabyLux and LUCA) where high technology readiness level have been achieved for neuro-monitoring and thyroid cancer screening. VASCOVID will adapt the platform to meet the needs of a typical ICU dealing with COVID-19 and other patients requiring ventilation, as well as to leverage large-scale testing of new treatment procedures and therapies aimed to address microvascular impairment and to reduce extubation failure on ICU patients weaning out of mechanical ventilation life-support. The platform is easy to deploy, cost-effective and provides real-time fast results and its transition to clinical practice will be eased through this project by pushing CE certification. Our inter-disciplinary consortium is well-suited for these activities and will interact closely with our on-going clinical study spanning four countries and a dozen hospitals.

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Keywords

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Programme(s)

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Topic(s)

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Funding Scheme

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IA - Innovation action

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) H2020-SC1-PHE-CORONAVIRUS-2020-2

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Coordinator

FUNDACIO INSTITUT DE CIENCIES FOTONIQUES
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 607 972,69
Address
AVINGUDA CARL FRIEDRICH GAUSS 3
08860 Castelldefels
Spain

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 620 255,46

Participants (7)

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