Overcoming the frontiers of biomolecular studies on human history and adaptation using palaeoproteomics

Project Information

BACKWARD

Grant agreement ID: 101021361

DOI

10.3030/101021361

EC signature date 13 August 2021

Start date 1 January 2022

End date 31 December 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 499 276,00

EU contribution

€ 2 499 276,00

Coordinated by

KOBENHAVNS UNIVERSITET
Denmark

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (13)

Assessing the Potential of Ancient Protein Sequences in the Study of Hominid Evolution

Author(s): Ioannis Patramanis, Laurits Skov, Enrico Cappellini, Fernando Racimo
Published in: Genome Biology and Evolution, Issue 18, 2026, ISSN 1759-6653
Publisher: Oxford University Press
DOI: 10.1093/gbe/evag035

Phylogenetic Signal in Primate Tooth Enamel Proteins and its Relevance for Paleoproteomics

Author(s): Ricardo Fong-Zazueta, Johanna Krueger, David M Alba, Xènia Aymerich, Robin M D Beck, Enrico Cappellini, Guillermo Carrillo-Martin, Omar Cirilli, Nathan Clark, Omar E Cornejo, Kyle Kai-How Farh, Luis Ferrández-Peral, David Juan, Joanna L Kelley, Lukas F K Kuderna, Jordan Little, Joseph D Orkin, Ryan S Paterson, Harvinder Pawar, Tomas Marques-Bonet, Esther Lizano
Published in: Genome Biology and Evolution, Issue 17, 2025, ISSN 1759-6653
Publisher: Oxford University Press
DOI: 10.1093/gbe/evaf007

The Japanese Archipelago sheltered cave lions, not tigers, during the Late Pleistocene

Author(s): Xin Sun, Lanhui Peng, Takumi Tsutaya, Qigao Jiangzuo, Yoshikazu Hasegawa, Yuxin Hou, Yu Han, Yan Zhuang, Nuno Filipe Gomes Martins, Jazmin Ramos Madrigal, Alberto J. Taurozzi, Meaghan Mackie, Gaudry Trochė, Jesper V. Olsen, Enrico Cappellini, Stephen J. O’Brien, M. Thomas P. Gilbert, Nobuyuki Yamaguchi, Shu-Jin Luo
Published in: Proceedings of the National Academy of Sciences, Issue 123, 2026, Page(s) e2523901123, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2523901123

Results from an Australopithecus africanus dental enamel fragment confirm the potential of palaeoproteomics for South African Plio-Pleistocene fossil sites

Author(s): Palesa P. Madupe, Fazeelah Munir, Marc Dickinson, Alberto J. Taurozzi, Meaghan Mackie, Mirriam Tawane, Catherine Mollereau, Nomawethu Hlazo, Kirsty Penkman, Lauren Schroeder, Clément Zanolli, Jesper V. Olsen, Rebecca R. Ackermann, Enrico Cappellini
Published in: South African Journal of Science, Issue 121, 2025, ISSN 1996-7489
Publisher: Academy of Science of South Africa
DOI: 10.17159/sajs.2025/18571

Enamel proteins reveal biological sex and genetic variability in southern African <i>Paranthropus</i>

Author(s): Palesa P. Madupe, Claire Koenig, Ioannis Patramanis, Patrick L. Rüther, Nomawethu Hlazo, Meaghan Mackie, Mirriam Tawane, Johanna Krueger, Alberto J. Taurozzi, Gaudry Troché, Job Kibii, Robyn Pickering, Marc R. Dickinson, Yonatan Sahle, Dipuo Kgotleng, Charles Musiba, Fredrick Manthi, Liam Bell, Michelle DuPlessis, Catherine Gilbert, Bernhard Zipfel, Lukas F. K. Kuderna, Esther Lizano, Frido Welk
Published in: Science, Issue 388, 2025, Page(s) 969-973, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.adt9539

Geometric morphometrics and paleoproteomics enlighten the paleodiversity of Pongo

Author(s): Jülide Kubat, Ryan Paterson, Ioannis Patramanis, Graeme Barker, Fabrice Demeter, Arnaud Filoux, Ottmar Kullmer, Meaghan Mackie, Tomas Marques-Bonet, Nguyen Thi Mai Huong, Nguyen Anh Tuan, Sytha Pheng, Jessica Rippengal, Friedemann Schrenk, Viengkeo Souksavatdy, Lim Tze Tshen, Athiwat Wattanapituksakul, Wei Wang, Clément Zanolli, Enrico Cappellini, Anne-Marie Bacon
Published in: PLOS ONE, Issue 18, 2024, Page(s) e0291308, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0291308

PaleoProPhyler: a reproducible pipeline for phylogenetic inference using ancient proteins

Author(s): Ioannis Patramanis, Jazmín Ramos-Madrigal, Enrico Cappellini, Fernando Racimo
Published in: Peer Community Journal, Issue 3, 2023, ISSN 2804-3871
Publisher: PCI
DOI: 10.24072/pcjournal.344

SPIN enables high throughput species identification of archaeological bone by proteomics

Author(s): Patrick Leopold Rüther, Immanuel Mirnes Husic, Pernille Bangsgaard, Kristian Murphy Gregersen, Pernille Pantmann, Milena Carvalho, Ricardo Miguel Godinho, Lukas Friedl, João Cascalheira, Alberto John Taurozzi, Marie Louise Schjellerup Jørkov, Michael M. Benedetti, Jonathan Haws, Nuno Bicho, Frido Welker, Enrico Cappellini & Jesper Velgaard Olsen
Published in: nature communications, Issue 13, 2022, Page(s) Article number: 2458, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-30097-x

Phylogenetically informative proteins from an Early Miocene rhinocerotid

Author(s): Ryan S. Paterson, Meaghan Mackie, Alessio Capobianco, Nicola S. Heckeberg, Danielle Fraser, Beatrice Demarchi, Fazeelah Munir, Ioannis Patramanis, Jazmín Ramos-Madrigal, Shanlin Liu, Abigail D. Ramsøe, Marc R. Dickinson, Chloë Baldreki, Marisa Gilbert, Raffaele Sardella, Luca Bellucci, Gabriele Scorrano, Michela Leonardi, Andrea Manica, Fernando Racimo, Eske Willerslev, Kirsty E. H. Penkman, Je
Published in: Nature, Issue 643, 2025, Page(s) 719-724, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-025-09231-4

Deep-time phylogenetic inference by paleoproteomic analysis of dental enamel

Author(s): Alberto J. Taurozzi, Patrick L. Rüther, Ioannis Patramanis, Claire Koenig, Ryan Sinclair Paterson, Palesa P. Madupe, Florian Simon Harking, Frido Welker, Meaghan Mackie, Jazmín Ramos-Madrigal, Jesper V. Olsen, Enrico Cappellini
Published in: Nature Protocols, Issue 19, 2024, Page(s) 2085-2116, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-024-00975-3

Automated High-Throughput Biological Sex Identification from Archeological Human Dental Enamel Using Targeted Proteomics

Author(s): Claire Koenig, Patricia Bortel, Ryan S. Paterson, Barbara Rendl, Palesa P. Madupe, Gaudry B. Troché, Nuno Vibe Hermann, Marina Martínez de Pinillos, María Martinón-Torres, Sandra Mularczyk, Marie Louise Schjellerup Jørkov, Christopher Gerner, Fabian Kanz, Ana Martinez-Val, Enrico Cappellini, Jesper V. Olsen
Published in: Journal of Proteome Research, Issue 23, 2024, Page(s) 5107-5121, ISSN 1535-3893
Publisher: American Chemical Society
DOI: 10.1021/acs.jproteome.4c00557

A male Denisovan mandible from Pleistocene Taiwan

Author(s): Takumi Tsutaya, Rikai Sawafuji, Alberto J. Taurozzi, Zandra Fagernäs, Ioannis Patramanis, Gaudry Troché, Meaghan Mackie, Takashi Gakuhari, Hiroki Oota, Cheng-Hsiu Tsai, Jesper V. Olsen, Yousuke Kaifu, Chun-Hsiang Chang, Enrico Cappellini, Frido Welker
Published in: Science, Issue 388, 2025, Page(s) 176-180, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.ads3888

Human‐like enamel growth in <i>Homo naledi</i>

Author(s): Patrick Mahoney, Gina McFarlane, Alberto J. Taurozzi, Palesa P. Madupe, Mackie C. O'Hara, Keneiloe Molopyane, Enrico Cappellini, John Hawks, Matthew M. Skinner, Lee Berger
Published in: American Journal of Biological Anthropology, Issue 184, 2024, ISSN 2641-4597
Publisher: John Wiley & Sons
DOI: 10.1002/ajpa.24893

Other (2)

Enamel proteins reveal biological sex and genetic variability within southern African Paranthropus

Author(s): Palesa P. Madupe, Claire Koenig, Ioannis Patramanis, Patrick L. Rüther, Nomawethu Hlazo, Meaghan Mackie, Mirriam Tawane, Johanna Krueger, Alberto J. Taurozzi, Gaudry Troché, Job Kibii, Robyn Pickering, Marc Dickinson, Yonatan Sahle, Dipuo Kgotleng, Charles Musiba, Fredrick Manthi, Liam Bell, Michelle DuPlessis, Catherine Gilbert, Bernhard Zipfel, Lukas F. K. Kuderna, Esther Lizano, Frido Welker,
Published in: bioRxiv, Issue 2023.07.03.547326, 2023
Publisher: bioRxiv.org
DOI: 10.1101/2023.07.03.547326

Automated high-throughput biological sex identification from archaeological human dental enamel using targeted proteomics

Author(s): Claire Koenig, Patricia Bortel, Ryan S. Paterson, Barbara Rendl, Palesa P. Madupe, Gaudry B. Troché, Nuno Vibe Hermann, Marina Martínez de Pinillos, María Martinón-Torres, Sandra Mularczyk, Marie Louise Schjellerup Jørkov, Christopher Gerner, Fabian Kanz, Ana Martinez-Val, Enrico Cappellini, Jesper V. Olsen
Published in: bioRxiv, 2024
Publisher: bioRxiv.org
DOI: 10.1101/2024.02.20.581140

Conference proceedings (2)

Preliminary palaeoproteomic insights into the Plio-Pleistocene australopiths from South Africa

Author(s): Madupe, Palesa; Rüther, Patrick Leopold; Hlazo, Nomawethu; Mackie, Meaghan; Patramanis, Ioannis; Taurozzi, Alberto; Tawane, Mirriam; Schroeder, Lauren; Racimo, Fernando; Zanolli, Clément; Olsen, Jesper; Ackermann, Rebecca; Cappellini, Enrico
Published in: https://www.eshe.eu/pastmeeting/2022/, Issue 1, 2023
Publisher: HAL open Science
DOI: 10.48738/2022.iss2.809

Preliminary palaeoproteomic insights into the Plio-Pleistocene australopiths from South Africa

Author(s): Madupe, Palesa; Rüther, Patrick Leopold; Hlazo, Nomawethu; Mackie, Meaghan; Patramanis, Ioannis; Taurozzi, Alberto; Tawane, Mirriam; Schroeder, Lauren; Racimo, Fernando; Zanolli, Clément; Olsen, Jesper; Ackermann, Rebecca; Cappellini, Enrico
Published in: 12th Annual Meeting of the European Society for the Study of Human Evolution Abstracts Tübingen, 22-24 September 2022, Issue Vol. 2022 No. 2 (2022): PaleoAnthropology - Published Oct 27, 2022, 2022, Page(s) 530, ISSN 1545-0031
Publisher: Paleoanthropology Society & European Society for the study of Human Evolution