NEXT GENERATION TOOLS FOR GENOME-CENTRIC MULTIMODAL DATA INTEGRATION IN PERSONALISED CARDIOVASCULAR MEDICINE

Project Information

NextGen

Grant agreement ID: 101136962

DOI

10.3030/101136962

EC signature date 1 December 2023

Start date 1 January 2024

End date 31 December 2027

Funded under

• Health

Total cost

€ 7 601 771,25

EU contribution

€ 7 601 770,00

Coordinated by

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

Periodic Reporting for period 1 - NextGen (NEXT GENERATION TOOLS FOR GENOME-CENTRIC MULTIMODAL DATA INTEGRATION IN PERSONALISED CARDIOVASCULAR MEDICINE)

Reporting period: 2024-01-01 to 2025-06-30

Summary of the context and overall objectives of the project

The overall objective of NextGen is to build novel and synergistic tools to enable portable multimodal, multiomic and clinically-oriented research in high-impact areas of cardiovascular medicine. NextGen tools will benefit researchers, innovators and healthcare professionals by identifying and overcoming health data linkage barriers in exemplar use cases which are complex or intractable with existing technology. Consequently, it will benefit patients, providing faster diagnosis, and better treatments (including personalised medicine). A comprehensive gap analysis of the existing landscape, factoring in ongoing initiatives will ensure NextGen deliverables are forward-looking and complementary. In particular, the NextGen embedded governance framework and robust regulatory processes will ensure secure multi-jurisdictional phenotype and genomic data access aligned with initiatives including “1+ Million Genomes” and European Health Data Space.

Work performed from the beginning of the project to the end of the period covered by the report and main results achieved so far

The project remains on track. Significant progress has been made in decentralized data management, architecture design, federated analytics, multimodal integration, governance, and stakeholder engagement. Pathfinder and MVP services have been deployed, laying the foundation for cross-jurisdictional interoperability, privacy-preserving data sharing, and sustainable exploitation of project results.

Progress beyond the state of the art and expected potential impact (including the socio-economic impact and the wider societal implications of the project so far)

FF