Objective
UTI is one of the most common bacterial infections, affecting >150 million individuals annually, worldwide. Unexpectedly, UTI is also the most common complication after stroke, occurring in up to 40% of patients. This suggests a dysregulation between the bladder and the brain, however this has never been studied. In other mucosal organs, neurons are in direct contact with tissue-resident macrophages and modulate their function during infection. Indeed, stroke causes striking changes to the immune compartment, including macrophages, in peripheral organs. As a result, stroke patients experience increased susceptibility to infection, alongside systemic inflammation, which is associated with neurological decline. In this project, I will investigate bladder macrophages in homeostasis and during acute stroke recovery. I will assess the impact of stroke on bladder immune cell-nerve crosstalk, including bladder macrophages and susceptibility to UTI.
Specifically, I hypothesize that changes in macrophage-nerve crosstalk after stroke alters macrophage response to infection, leading to systemic inflammation and subsequent neurological decline. In collaboration with The University of Edinburgh, I will use a model of ischemic stroke in the lab of Dr Laura McCulloch to test this hypothesis. During this project, I will use state-of-the-art technologies such as spatial transcriptomics, 3D-imaging and spectral flow cytometry. Training at the University of Edinburgh, alongside in the host lab, will provide me with a unique set of skills combining the disciplines of immunology, microbiology and neurobiology. The expertise I will acquire in this project are in line with my career goals to become an independent researcher, and provide me with the tools to address a novel question in a largely unstudied area with clinical importance.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine neurology stroke
- natural sciences biological sciences microbiology
- medical and health sciences basic medicine physiology homeostasis
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75654 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.