Objective
Synthesis and development of novel DNA base pairs that are orthogonal in their recognition properties compared to the natural base pairs are avidly pursued by scientists. Such novel base pairs are investigated as tools in biotechnology and in designing novel genetic systems. Interest in artificial base pairs continues because of their application in materials research and nanosciences. Likewise charge transfer (CT) through the DNA duplex has received considerable attention and is being explored in fundamental and applied research. The objective of this project is to synthesize and study DNA containing more than one phenanthrenyl-pair (dPhen-R) in a duplex DNA. This would provide the first example of electron transfer through a duplex containing multiple phenanthrenyl (dPhen-R) base replacements. Substitutions (R) on the ring will influence the redox potential of the aromatic system. This will also influence the electron transfer efficiency. This project will also pursue the synthesis of a base-pairing nucleobase analogue capable of acting as an electron acceptor. This electron acceptor will report on electron transfer by a fluorescent response and increase the stability of the duplex. The optimized DNA-based architecture will then be attached to a gold surface in order to observe direct electron transfer by nanoelectrochemistry. It is envisioned that this novel DNA architecture and future designs may be applied in DNA based biosensors and in the area of DNA nanomaterials.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors biosensors
- natural sciences biological sciences genetics DNA
- engineering and technology nanotechnology nano-materials
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IIF-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
3012 Bern
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.