Objectif Two unconventional concepts of skin contraction are presented that could change the current paradigm of wound healing. The overall objective is to clarify the underlying processes and to develop new therapies to prevent excessive scarring, ameliorate patients lives and reduce medical health care expenses. Specific emphasis lies on the role of Matrix metalloproteinases (MMP) and keratinocytes. Previous internationally acknowledged work of the PI resulted in these challenging concepts. The project will take place at the Medical School Hannover with its vast scientific infrastructure perfectly suited for this type of pioneer research. Unconventional is the concept that MMP lead to contrary cell responses. By degrading matrix molecules, MMP induce cell disassembly and migration. Only MMP-3 and -7 cleave cadherins and induce adhesion. MMP-3 deficient mice showed normal wound epithelialisation without contraction. Presumably by controlled proteolysis of intercellular molecules, cell adhesivity increases. Firm adhesion complexes provide stable anchorage sites for force generation. Selective MMP-3 inhibition would reduce contraction without impairing epithelialisation. The concept of the epithelial role in contraction differs from the paradigm and marks a beyond the state-of-art approach in wound healing. Keratinocytes at the air-liquid interphase close wounds by reepithelialisation and surface minimization. Hence, reduction of surface tension would decrease epidermal contraction. Alveolar surface tension is reduced by surfactants in preterm infants. Assuming that epidermal wounds could profit of surfactants is a high risk high gain approach of tackling hypertrophic scarring, but if successful it would revolutionize burn wound therapy. Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) ERC-SG-LS9 - ERC Starting Grant - Applied life sciences and biotechnology Appel à propositions ERC-2009-StG Voir d’autres projets de cet appel Régime de financement ERC-SG - ERC Starting Grant Institution d’accueil UNIVERSITAET BREMEN Contribution de l’UE € 888 894,42 Adresse Bibliothekstrasse 1 28359 Bremen Allemagne Voir sur la carte Région Bremen Bremen Bremen, Kreisfreie Stadt Type d’activité Higher or Secondary Education Establishments Chercheur principal Ursula Mirastschijski (Dr.) Contact administratif Silke Reinold (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Bénéficiaires (3) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire UNIVERSITAET BREMEN Allemagne Contribution de l’UE € 888 894,42 Adresse Bibliothekstrasse 1 28359 Bremen Voir sur la carte Région Bremen Bremen Bremen, Kreisfreie Stadt Type d’activité Higher or Secondary Education Establishments Chercheur principal Ursula Mirastschijski (Dr.) Contact administratif Silke Reinold (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée CONSTRUCTOR UNIVERSITY BREMEN GGMBH Participation terminée Allemagne Contribution de l’UE Aucune donnée Adresse CAMPUS RING 1 28725 Bremen Voir sur la carte Région Bremen Bremen Bremen, Kreisfreie Stadt Type d’activité Higher or Secondary Education Establishments Contact administratif Ronald Kieschnick (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée MEDIZINISCHE HOCHSCHULE HANNOVER Allemagne Contribution de l’UE € 410 945,58 Adresse Carl-Neuberg-Strasse 1 30625 Hannover Voir sur la carte Région Niedersachsen Hannover Region Hannover Type d’activité Higher or Secondary Education Establishments Contact administratif Frank Dittrich (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée