Obiettivo Two unconventional concepts of skin contraction are presented that could change the current paradigm of wound healing. The overall objective is to clarify the underlying processes and to develop new therapies to prevent excessive scarring, ameliorate patients lives and reduce medical health care expenses. Specific emphasis lies on the role of Matrix metalloproteinases (MMP) and keratinocytes. Previous internationally acknowledged work of the PI resulted in these challenging concepts. The project will take place at the Medical School Hannover with its vast scientific infrastructure perfectly suited for this type of pioneer research. Unconventional is the concept that MMP lead to contrary cell responses. By degrading matrix molecules, MMP induce cell disassembly and migration. Only MMP-3 and -7 cleave cadherins and induce adhesion. MMP-3 deficient mice showed normal wound epithelialisation without contraction. Presumably by controlled proteolysis of intercellular molecules, cell adhesivity increases. Firm adhesion complexes provide stable anchorage sites for force generation. Selective MMP-3 inhibition would reduce contraction without impairing epithelialisation. The concept of the epithelial role in contraction differs from the paradigm and marks a beyond the state-of-art approach in wound healing. Keratinocytes at the air-liquid interphase close wounds by reepithelialisation and surface minimization. Hence, reduction of surface tension would decrease epidermal contraction. Alveolar surface tension is reduced by surfactants in preterm infants. Assuming that epidermal wounds could profit of surfactants is a high risk high gain approach of tackling hypertrophic scarring, but if successful it would revolutionize burn wound therapy. Programma(i) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) ERC-SG-LS9 - ERC Starting Grant - Applied life sciences and biotechnology Invito a presentare proposte ERC-2009-StG Vedi altri progetti per questo bando Meccanismo di finanziamento ERC-SG - ERC Starting Grant Istituzione ospitante UNIVERSITAET BREMEN Contributo UE € 888 894,42 Indirizzo Bibliothekstrasse 1 28359 Bremen Germania Mostra sulla mappa Regione Bremen Bremen Bremen, Kreisfreie Stadt Tipo di attività Higher or Secondary Education Establishments Ricercatore principale Ursula Mirastschijski (Dr.) Contatto amministrativo Silke Reinold (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Beneficiari (3) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto UNIVERSITAET BREMEN Germania Contributo UE € 888 894,42 Indirizzo Bibliothekstrasse 1 28359 Bremen Mostra sulla mappa Regione Bremen Bremen Bremen, Kreisfreie Stadt Tipo di attività Higher or Secondary Education Establishments Ricercatore principale Ursula Mirastschijski (Dr.) Contatto amministrativo Silke Reinold (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato CONSTRUCTOR UNIVERSITY BREMEN GGMBH Partecipazione conclusa Germania Contributo UE Nessun dato Indirizzo CAMPUS RING 1 28725 Bremen Mostra sulla mappa Regione Bremen Bremen Bremen, Kreisfreie Stadt Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Ronald Kieschnick (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato MEDIZINISCHE HOCHSCHULE HANNOVER Germania Contributo UE € 410 945,58 Indirizzo Carl-Neuberg-Strasse 1 30625 Hannover Mostra sulla mappa Regione Niedersachsen Hannover Region Hannover Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Frank Dittrich (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato