Objetivo Two unconventional concepts of skin contraction are presented that could change the current paradigm of wound healing. The overall objective is to clarify the underlying processes and to develop new therapies to prevent excessive scarring, ameliorate patients lives and reduce medical health care expenses. Specific emphasis lies on the role of Matrix metalloproteinases (MMP) and keratinocytes. Previous internationally acknowledged work of the PI resulted in these challenging concepts. The project will take place at the Medical School Hannover with its vast scientific infrastructure perfectly suited for this type of pioneer research. Unconventional is the concept that MMP lead to contrary cell responses. By degrading matrix molecules, MMP induce cell disassembly and migration. Only MMP-3 and -7 cleave cadherins and induce adhesion. MMP-3 deficient mice showed normal wound epithelialisation without contraction. Presumably by controlled proteolysis of intercellular molecules, cell adhesivity increases. Firm adhesion complexes provide stable anchorage sites for force generation. Selective MMP-3 inhibition would reduce contraction without impairing epithelialisation. The concept of the epithelial role in contraction differs from the paradigm and marks a beyond the state-of-art approach in wound healing. Keratinocytes at the air-liquid interphase close wounds by reepithelialisation and surface minimization. Hence, reduction of surface tension would decrease epidermal contraction. Alveolar surface tension is reduced by surfactants in preterm infants. Assuming that epidermal wounds could profit of surfactants is a high risk high gain approach of tackling hypertrophic scarring, but if successful it would revolutionize burn wound therapy. Programa(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) ERC-SG-LS9 - ERC Starting Grant - Applied life sciences and biotechnology Convocatoria de propuestas ERC-2009-StG Consulte otros proyectos de esta convocatoria Régimen de financiación ERC-SG - ERC Starting Grant Institución de acogida UNIVERSITAET BREMEN Aportación de la UE € 888 894,42 Dirección Bibliothekstrasse 1 28359 Bremen Alemania Ver en el mapa Región Bremen Bremen Bremen, Kreisfreie Stadt Tipo de actividad Higher or Secondary Education Establishments Investigador principal Ursula Mirastschijski (Dr.) Contacto administrativo Silke Reinold (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Beneficiarios (3) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo UNIVERSITAET BREMEN Alemania Aportación de la UE € 888 894,42 Dirección Bibliothekstrasse 1 28359 Bremen Ver en el mapa Región Bremen Bremen Bremen, Kreisfreie Stadt Tipo de actividad Higher or Secondary Education Establishments Investigador principal Ursula Mirastschijski (Dr.) Contacto administrativo Silke Reinold (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos CONSTRUCTOR UNIVERSITY BREMEN GGMBH La participación finalizó Alemania Aportación de la UE Sin datos Dirección CAMPUS RING 1 28725 Bremen Ver en el mapa Región Bremen Bremen Bremen, Kreisfreie Stadt Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Ronald Kieschnick (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos MEDIZINISCHE HOCHSCHULE HANNOVER Alemania Aportación de la UE € 410 945,58 Dirección Carl-Neuberg-Strasse 1 30625 Hannover Ver en el mapa Región Niedersachsen Hannover Region Hannover Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Frank Dittrich (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos