Cel Two unconventional concepts of skin contraction are presented that could change the current paradigm of wound healing. The overall objective is to clarify the underlying processes and to develop new therapies to prevent excessive scarring, ameliorate patients lives and reduce medical health care expenses. Specific emphasis lies on the role of Matrix metalloproteinases (MMP) and keratinocytes. Previous internationally acknowledged work of the PI resulted in these challenging concepts. The project will take place at the Medical School Hannover with its vast scientific infrastructure perfectly suited for this type of pioneer research. Unconventional is the concept that MMP lead to contrary cell responses. By degrading matrix molecules, MMP induce cell disassembly and migration. Only MMP-3 and -7 cleave cadherins and induce adhesion. MMP-3 deficient mice showed normal wound epithelialisation without contraction. Presumably by controlled proteolysis of intercellular molecules, cell adhesivity increases. Firm adhesion complexes provide stable anchorage sites for force generation. Selective MMP-3 inhibition would reduce contraction without impairing epithelialisation. The concept of the epithelial role in contraction differs from the paradigm and marks a beyond the state-of-art approach in wound healing. Keratinocytes at the air-liquid interphase close wounds by reepithelialisation and surface minimization. Hence, reduction of surface tension would decrease epidermal contraction. Alveolar surface tension is reduced by surfactants in preterm infants. Assuming that epidermal wounds could profit of surfactants is a high risk high gain approach of tackling hypertrophic scarring, but if successful it would revolutionize burn wound therapy. Program(-y) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) ERC-SG-LS9 - ERC Starting Grant - Applied life sciences and biotechnology Zaproszenie do składania wniosków ERC-2009-StG Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-SG - ERC Starting Grant Instytucja przyjmująca UNIVERSITAET BREMEN Wkład UE € 888 894,42 Adres Bibliothekstrasse 1 28359 Bremen Niemcy Zobacz na mapie Region Bremen Bremen Bremen, Kreisfreie Stadt Rodzaj działalności Higher or Secondary Education Establishments Kierownik naukowy Ursula Mirastschijski (Dr.) Kontakt administracyjny Silke Reinold (Ms.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Beneficjenci (3) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko UNIVERSITAET BREMEN Niemcy Wkład UE € 888 894,42 Adres Bibliothekstrasse 1 28359 Bremen Zobacz na mapie Region Bremen Bremen Bremen, Kreisfreie Stadt Rodzaj działalności Higher or Secondary Education Establishments Kierownik naukowy Ursula Mirastschijski (Dr.) Kontakt administracyjny Silke Reinold (Ms.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych CONSTRUCTOR UNIVERSITY BREMEN GGMBH Zakończenie uczestnictwa Niemcy Wkład UE Brak danych Adres CAMPUS RING 1 28725 Bremen Zobacz na mapie Region Bremen Bremen Bremen, Kreisfreie Stadt Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Ronald Kieschnick (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych MEDIZINISCHE HOCHSCHULE HANNOVER Niemcy Wkład UE € 410 945,58 Adres Carl-Neuberg-Strasse 1 30625 Hannover Zobacz na mapie Region Niedersachsen Hannover Region Hannover Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Frank Dittrich (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych