Objective
Diffusion Tensor Imaging (DTI) is a central tool in brain research and in the clinical neurological diagnosis. Despite its popularity in research and in clinical applications, the biophysical mechanisms underlying DTI are not fully understood. For example, with respect to essential parameters such as the amplitude of change of the apparent displacement post insults, the orientation of maximal change and its timing, theoretical models of displacement fail to describe the kinetics of water displacement following insults. Moreover, it was suggested that neuronal activity can directly modify the diffusion weighted MR signal to provide functional images with high temporal and spatial resolution. Our working hypothesis is that water displacement that occurs due to active cellular mechanisms, contributes significantly to the signal measured in DTI. We are interested in quantifying the contribution of various cellular events to the signal measured in DTI, where a pivotal mechanism that will explored is the suggested water displacement that is linked with neuronal activation. To address the limits of detectability of neuronal excitation via MR, we suggest employing a three-source, multi-modal system: MRI, electrical potential mapping and fluorescence microscopy of neuronal organotypic cell cultures. The use of organotypic cultures bypasses major sources of physiological artifacts such as blood flow and pulsation. MRI is performed with a low-field open MRI system. Electrical recordings will be performed simultaneously with a multi-electrode array system that will provide 2-D ‘imaging’ of neuronal electrical activity and optical microscopy will allow imaging of Calcium release. This multi-modal imaging system will allow testing previously proposed mechanisms of neural detection by MRI and will provide a test-bed to enable us to develop new ones.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- natural sciences physical sciences optics microscopy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-RG
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
69978 Tel Aviv
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.