Objective
The epithelium plays a significant role in resistance to infection in mammals, and is made up of a single layer of elongated, column-shaped cells that line the stomach and colon. This single layer of epithelial cells restricts the entry of toxins and pathogens, while selectively absorbing nutrients that sustain the body. Pathogens have devised multiple mechanisms to destroy the integrity of the intestinal epithelial barrier, compromising the normal absorption of water in the intestine and thereby causing diarrheal disease. The World Health Organization estimates that in 2005 alone 1.8 million people died from diarrheal diseases. CELLTOX is a novel type of biosensor for the detection of enteric pathogens and toxins, based on the principle of using live epithelial cells grown on an organic electrochemical transistor (OECT), which provides a very sensitive and convenient means of measuring ionic transport. When the epithelial cells form a monolayer, the integrity of the cell monolayer prohibits ion transport keeping the transistor in the ON state. Assault of the cells by an enteric pathogen or toxin will lead to a disruption of the cell monolayer and enable ion migration into the polymer, switching the transistor OFF. This novel “canary in a coal mine” platform will constitute a broad first-line diagnostic for gastrointestinal disease, with applications for food and water safety. It will lead to sensors that are fast, portable, inexpensive and label-free. Future use of different cell lines (eg. bronchial, dermal, etc.) with this platform will lead to a host of sensors for applications in medical diagnostics, agriculture, and environmental protection. This multidisciplinary project encompasses the disciplines of organic electronics, cell biology and microbiology, and will contribute to the successful and lasting reintegration of the applicant back to Europe.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences cell biology
- natural sciences chemical sciences polymer sciences
- natural sciences biological sciences zoology mammalogy
- natural sciences biological sciences microbiology
- medical and health sciences clinical medicine gastroenterology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-RG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
42023 SAINT ETIENNE CEDEX
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.