Objective
Understanding how brain function emerges through the assembly of specific neuronal circuits is one of the main challenges in neuroscience. In the cerebral cortex, excitatory glutamatergic pyramidal cells and inhibitory interneurons constitute the main cellular elements of neuronal circuits. Interneuron deficits seem to underlie a variety of neurodevelopmental and psychiatric disorders in humans, but our current knowledge of the mechanisms controlling their precise integration into cortical circuits remains very limited. I aim to determine the mechanisms mediating the allocation of interneurons born in the caudal ganglionic eminence (CGE) into circuits composed of pyramidal neurons and interneurons in the cerebral cortex. The first goal of this project is to distinguish whether pyramidal cells or medial ganglionic eminence (MGE) interneurons influence the allocation of CGE interneurons in the superficial layers of the cortex. To this end, I will use a set of transgenic mouse models to specifically disrupt the normal lamination of pyramidal cells or MGE interneurons in the superficial or deep layers of the cortex and evaluate its effect on the allocation of CGE interneurons. Next, I will identify genes encoding transmembrane or secreted proteins responsible for the proper laminar allocation of CGE interneurons. This will be done both via a candidate-based approach and an unbiased screen involving fluorescence-activated cell sorting and RNA sequencing, followed by differential expression analysis. Functional analysis of candidate genes will be assessed via gain and loss of function experiments using in utero electroporation or retroviral infection prior to mutant mouse analysis. Together, these experiments will allow the dissection of the mechanisms underlying the precise integration of CGE interneurons into cortical circuits and contribute to our understanding of the etiology of several neurodevelopmental and psychiatric disorders.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences neurobiology
- medical and health sciences clinical medicine psychiatry
- natural sciences mathematics pure mathematics mathematical analysis functional analysis
- natural sciences biological sciences genetics RNA
- natural sciences chemical sciences electrochemistry bioelectrochemistry electroporation
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
WC2R 2LS London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.