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Advanced bioinformatics for genome and metagenome analyses and discovery of novel biocatalists from extremophiles: implications for improving industrial bioprocesses

Objective

The aim of this proposal is to acquire new insights about the mechanisms of environmental adaptation, particularly for cold-adapted organisms, and to discover novel metabolic pathways and enzymes with potential industrial value. We intend to accomplish this goal by establishing a collaboration and a knowledge-exchange network between industrial and academic partners aiming at developing bioinformatic tools for genomic analysis and biotechnology tools for directed evolution. The partners present high complementarity: UNICAM holds genomic sequences from psychrophilic and mesophilic ciliates that need to be annotated and analysed. Sabanci provides environmental samples for the isolation and characterization of new extremophiles. CAMBRIDGE provides the know-how for the discovery of new metabolic pathways valuable for understanding environmental adaptation. BMR Genomics and COMSATS possess all the facilities for genome sequencing and annotation and bioinformatic expertise with the purpose of developing new tools to analyse genomes of microorganisms from extreme environment. UNIMIB owns the facilities for the heterologous expression of gene sequences in bacteria and yeasts and technologies to assess and implement the properties of novel enzymes towards industrial application. We are confident that the establishment of the international research network proposed, with its synergistic effects, will significantly contribute to push all the involved laboratories to the top level in the field of production of active biomolecules and in the discovery of mechanisms of molecular adaptation under extreme environmental conditions. These discoveries may help the manufacturing of a new generation of ordinary facilities, as cleaning agents, biofuels, with a significant impact on the everyday life of European citizens.

Fields of science (EuroSciVoc)

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Programme(s)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) H2020-MSCA-RISE-2014

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Coordinator

UNIVERSITA DEGLI STUDI DI CAMERINO
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 81 000,00
Address
PIAZZA CAVOUR 19F
62032 Camerino
Italy

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Region
Centro (IT) Marche Macerata
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 81 000,00

Participants (5)

Partners (1)

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