Objective
Marine ecosystems are centrally important to the biology of the planet but they are at risk. The number of disease outbreaks in marine organisms is increasing, most likely caused by climate change and eutrophication. It is also established that these anthropogenic effects alter the interactions between hosts and their microbiome, specifically leading to a breakdown of host-symbiont relationships and to shifts in the diversity of host-associated microbes.
It is not clear however, how this is causally connected to the increased emergence of pathogens under environmental stress. This research project will establish this link by directly testing whether pathogens evolve from resident bacteria within the host-associated microbial community or whether shifts in the original microbial community facilitate the invasion by pathogens. This will be studied in a model system consisting of the sea anemone Nematostella vectensis as host, and its associated microbes, with a focus on vibrios. After the host-specific Vibrio population structure in the wild has been determined, WP1, experiments will be conducted in the laboratory testing the stability of the host-microbiome relationship under a range of environmental stressors. The role of the microbiome in protecting against the invasion of pathogens will directly be tested, WP2. In WP3, pathogen evolution will be followed in real time. Effects of the microbiome on interactions with (non-)pathogens will be separated from host effects. Particular attention will be given to the changes in the genome of vibrios, which can be connected to an increase in virulence, and to changes in gene-expression of both, hosts and the microbiome.
This multidisciplinary approach, combining the strength of microbial ecology, experimental evolution, and genomic studies, will significantly contribute to our understanding of host-microbe interactions, particularly focusing on the selective forces and ecological conditions that promote pathogen emergence.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences zoology mammalogy cetology
- natural sciences biological sciences ecology ecosystems
- natural sciences earth and related environmental sciences hydrology limnology
- natural sciences earth and related environmental sciences atmospheric sciences climatology climatic changes
- natural sciences biological sciences zoology invertebrate zoology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-RI - RI – Reintegration panel
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
24118 Kiel
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.