Objective
Optogenetics is an emerging new method in biology for the non-invasive control of neuronal behaviour with light. NeurOLED will develop and validate a novel, biocompatible light source that provides unprecedented high-resolution, real-time optogenetic control of neurons. At the heart of the new devices are organic light-emitting diodes (OLEDs) that are brought into direct contact with neuronal cells. Using microscopic patterning, we will create dense arrays of OLEDs that can stimulate the firing of individual live neurons. Initial proof-of-principle experiments will use the new OLED light source to study neuronal networks in vitro. To fully exploit the potential of OLEDs in optogenetics, neuronal networks will ultimately be investigated in vivo. We will examine the neuronal network that is responsible for locomotion in the model organism Drosophila melanogaster. To maximize spatial resolution in vivo, the light penetration depth in tissue will be optimized by systematic optical design of the spectral and angular emission characteristics of the OLEDs. Furthermore, stacked multi-colour OLEDs will be used to achieve both activation and deactivation of single neurons at very high speed and precision. Atomic layer deposition will be used as an innovative thin-film encapsulation technology to develop OLEDs that can withstand aqueous environments and can thus be brought into direct contact with neurons and biological tissue. Compared to current state-of-the-art optogenetic light sources, OLEDs will significantly advance control of neuronal behaviour thus paving the way to a better understanding of neural networks.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences neurobiology
- natural sciences chemical sciences organic chemistry
- agricultural sciences agriculture, forestry, and fisheries agriculture horticulture fruit growing
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences computer and information sciences artificial intelligence computational intelligence
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2015
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
KY16 9AJ St Andrews
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.