Objective
It has been estimated a threefold increase in the number of obese people in Europe since the 1980’s. Currently, EU
countries spend an average of 7% of their public health budgets on diseases linked to obesity. The socio-economic impact of
obesity epidemic cannot be overrated. European societal needs require desperately a shift forward in the field of obesity
research to be able to build new therapeutics strategies. Recent scientific evidences point toward a role of epigenetic
changes as major contributor in the obesity etiology. In the last decades, a huge amount of data clearly link epigenetic
dysregulation to obesity onset. Yet, it remains unclear whether epigenetic dysregulation contributes meaningfully to obesity
epidemic. Because weight gain only occurs when energy intake exceed energy expenditure, burning off excess fuel
represent an attractive path to reduce obesity when diet and exercise are not enough. My preliminary data indicate the
histone methyltransferases Suv420h1 and Suv420h2 as pivotal players in metabolism regulation. By using knockout mice
specifically in brown adipose tissue, this project aims at dissecting the role of Suv420h proteins in the etiology of
obesity. I will combine in vivo and in vitro analyses and genome wide studies to: 1) dissect the role of Suv420h proteins
in the epigenetic regulation of the pathways controlling weight balance in response to nutritional or environmental stimuli; 2) identify genes involved in the generation, maintenance or transmission of the epigenetic memory of exposure; 3) provide useful markers or therapeutic targets to treat obesity and metabolic diseases. My results have the potential to translate into therapeutics. This research will contribute to provide new clinical targets against obesity. The Experienced Researcher will emerge from the project with new skills, and the capability to lead her own research group.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health
- natural sciences biological sciences biochemistry biomolecules lipids
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
- medical and health sciences health sciences nutrition obesity
- natural sciences biological sciences genetics epigenetics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-SE - Society and Enterprise panel
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2016
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
20132 Milano
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.