Objective
Obesity is a worldwide epidemic with major health consequences. One devastating consequence of obesity is ovarian failure and infertility in women. Obesity causes endocrine dysfunction that compromises particularly the female gamete, the oocyte. Importantly, maternal obesity also affects the offspring, predisposing children to obesity and type 2 diabetes.
In the present proposal we will build on the unique expertise of the host lab and research experience of the postdoctoral fellow to address how maternal obesity promotes epigenetic changes in the oocyte and affects early embryonic development.
The proposal will exploit the synergies between two laboratories in a multidisciplinary research setting. The candidate has a background in reproductive medicine and endocrinology, with 5 years of postdoctoral experience over which the candidate has been producing a relevant body of preliminary data on obesity and ovarian failure. The partner laboratory in Poland will contribute know-how and animal models for the study of obesity, as well as support from the local team. The host laboratory will provide methods and access to state-of-the-art facilities for epigenetic analysis.
Our results, will enable us to clearly understand: (i) the extent to which the oocyte is vulnerable to maternal obesity; (ii) if epigenetic changes established in the oocyte interfere with early embryonic development. We will analyse the oocyte and early embryo epigenome and transcriptome of mouse strains with different susceptibilities to obesity and diet-induced obesity protocols representative of our social dietary habits.
We will critically assess the potential health consequences of maternal obesity for the offspring. Ultimately, the knowledge generated through this proposal will lead to the public sector being better informed and new political and pharmacological strategies can be conceived for the improvement of female fertility and prevention of disease in offspring.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine gynaecology reproductive medicine
- natural sciences biological sciences developmental biology
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences clinical medicine embryology
- medical and health sciences health sciences nutrition obesity
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2016
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
CB22 3AT Cambridge
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.