A Clinical Phase IIB trial with 2OHOA in patients with newly-diagnosed malignant glioma.

Leistungen

First regulatory approval of final version of study protocol

Approvals required for invitation / enrolment of first subject in at least one clinical centre: Ethic Committee, Competent Authority and National Data Protection Authority). Registration in Primary Registries in the WHO Registry Network (EU Clinical Trials Register (EU-CTR)).

Protocols and laboratory manual for miRNAS, mRNA expression and RNAseq
Statistical protocols
Report on the status of posting results

Report on the status of posting results in the study registryies including timelines when final posting of results is scheduled after end of funding period To be scheduled for the time of expected results

Sample protocols for liquid biopsy biomarkers
Protocols for protein biomarker determinations

Protocols for protein biomarker determinations (GFAP, mTOR, pAkt, SMS1, SMS2, etc.).

Consititution of the different management bodies

Constitution of the different management bodies

Public Web Site and Project Presentation

Design and maintenance of dedicated project web site with an offering of the typical electronic dissemination facilities

SMS1 and SMS2 molecular modelling

(i) determination of SMS1 structure , (ii) determination of SMS2 structure, (iii) determination of SMS1-2OHOA and SMS2-2OHOA interactions, and (iv) determination of the structure and interaction with 2OHOA for specific mutants selected from other experiments in this WP

Clinical Trial registration number

EudraCT

Veröffentlichungen

Study of the Interaction of a Novel Semi-Synthetic Peptide with Model Lipid Membranes

Autoren: Lucia Sessa, Simona Concilio, Peter Walde, Tom Robinson, Petra S. Dittrich, Amalia Porta, Barbara Panunzi, Ugo Caruso, Stefano Piotto
Veröffentlicht in: Membranes, Ausgabe 10/10, 2020, Seite(n) 294, ISSN 2077-0375
Herausgeber: Molecular Diversity Preservation International
DOI: 10.3390/membranes10100294

Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues

Autoren: Doralicia Casares, Pablo V. Escribá, Catalina Ana Rosselló
Veröffentlicht in: International Journal of Molecular Sciences, Ausgabe 20/9, 2019, Seite(n) 2167, ISSN 1422-0067
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20092167

The Opposing Contribution of SMS1 and SMS2 to Glioma Progression and Their Value in the Therapeutic Response to 2OHOA

Autoren: Paula Fernández-García, Catalina A. Rosselló, Raquel Rodríguez-Lorca, Roberto Beteta-Göbel, Javier Fernández-Díaz, Victoria Lladó, Xavier Busquets, Pablo V. Escribá
Veröffentlicht in: Cancers, Ausgabe 11/1, 2019, Seite(n) 88, ISSN 2072-6694
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11010088

The triacylglycerol, hydroxytriolein, inhibits triple negative mammary breast cancer cell proliferation through a mechanism dependent on dihydroceramide and Akt

Autoren: Francisca Guardiola-Serrano, Roberto Beteta-Göbel, Raquel Rodríguez-Lorca, Maitane Ibarguren, David J. López, Silvia Terés, María Alonso-Sande, Mónica Higuera, Manuel Torres, Xavier Busquets, Pablo V. Escribá
Veröffentlicht in: Oncotarget, Ausgabe 10/26, 2019, ISSN 1949-2553
Herausgeber: Impact Journals
DOI: 10.18632/oncotarget.26824

Minerval (2-hydroxyoleic acid) causes cancer cell selective toxicity by uncoupling oxidative phosphorylation and compromising bioenergetic compensation capacity

Autoren: Wessal Massalha, Mark Markovits, Edward Pichinuk, Yael Feinstein-Rotkopf, Mark Tarshish, Kumudesh Mishra, Victoria Llado, Miguel Weil, Pablo V. Escriba, Or Kakhlon
Veröffentlicht in: Bioscience Reports, Ausgabe 39/1, 2019, Seite(n) BSR20181661, ISSN 0144-8463
Herausgeber: Kluwer Academic Publishers
DOI: 10.1042/bsr20181661

The Implications for Cells of the Lipid Switches Driven by Protein–Membrane Interactions and the Development of Membrane Lipid Therapy

Autoren: Manuel Torres, Catalina Ana Rosselló, Paula Fernández-García, Victoria Lladó, Or Kakhlon, Pablo Vicente Escribá
Veröffentlicht in: International Journal of Molecular Sciences, Ausgabe 21/7, 2020, Seite(n) 2322, ISSN 1422-0067
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21072322

Rechte des geistigen Eigentums

ALPHA-DERIVATIVES OF CIS-MONOUNSATURATED FATTY ACIDS INTENDED FOR USE AS A DRUG

Antrags-/Publikationsnummer: EP 09831504
Datum: 2009-12-04
Antragsteller: UNIVERSITAT DE LES ILLES BALEARS

USE OF HYDROXYOLEIC ACID AND SIMILAR COMPOUNDS IN THE PRODUCTION OF MEDICAMENTS

Antrags-/Publikationsnummer: EP 02783094
Datum: 2002-10-09
Antragsteller: UNIVERSITAT DE LES ILLES BALEARS

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