A Clinical Phase IIB trial with 2OHOA in patients with newly-diagnosed malignant glioma.

Informacje na temat projektu

CLINGLIO

Identyfikator umowy o grant: 755179

DOI

10.3030/755179

Projekt został zamknięty

Data podpisania przez KE 27 Listopada 2017

Data rozpoczęcia 1 Grudnia 2017

Data zakończenia 31 Maja 2022

Finansowanie w ramach

SOCIETAL CHALLENGES - Health, demographic change and well-being

Koszt całkowity

€ 6 155 125,00

Wkład UE

€ 6 155 125,00

6 155 125,00

Koordynowany przez

LAMINAR PHARMACEUTICALS SA
Spain

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

First regulatory approval of final version of study protocol

Approvals required for invitation / enrolment of first subject in at least one clinical centre: Ethic Committee, Competent Authority and National Data Protection Authority). Registration in Primary Registries in the WHO Registry Network (EU Clinical Trials Register (EU-CTR)).

Study team TCs, newsletters progress/issues reports

According to the communication plan specified in CT project plan (D4.2).Last publicaction will take place on month 36. We expect deliveries also in monots 6, 12, 24 and 30.

Protocols and laboratory manual for miRNAS, mRNA expression and RNAseq
Statistical protocols
Report on the status of posting results

Report on the status of posting results in the study registryies including timelines when final posting of results is scheduled after end of funding period To be scheduled for the time of expected results

Sample protocols for liquid biopsy biomarkers
Protocols for protein biomarker determinations

Protocols for protein biomarker determinations (GFAP, mTOR, pAkt, SMS1, SMS2, etc.).

Consititution of the different management bodies

Constitution of the different management bodies

Role of the membrane lipid composition and lipid genes in glioma cell proliferation

Expression and analysis and patient survival; (ii) Lipidomic and proteomic analysis of proliferating and quiescent glioma (U118) cells; (iii) potential biomarker determinations

SMS1 and SMS2 molecular modelling

(i) determination of SMS1 structure , (ii) determination of SMS2 structure, (iii) determination of SMS1-2OHOA and SMS2-2OHOA interactions, and (iv) determination of the structure and interaction with 2OHOA for specific mutants selected from other experiments in this WP

Publikacje

Study of the Interaction of a Novel Semi-Synthetic Peptide with Model Lipid Membranes

Autorzy: Lucia Sessa, Simona Concilio, Peter Walde, Tom Robinson, Petra S. Dittrich, Amalia Porta, Barbara Panunzi, Ugo Caruso, Stefano Piotto
Opublikowane w: Membranes, Numer 10/10, 2020, Strona(/y) 294, ISSN 2077-0375
Wydawca: Molecular Diversity Preservation International
DOI: 10.3390/membranes10100294

Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues

Autorzy: Doralicia Casares, Pablo V. Escribá, Catalina Ana Rosselló
Opublikowane w: International Journal of Molecular Sciences, Numer 20/9, 2019, Strona(/y) 2167, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20092167

The Opposing Contribution of SMS1 and SMS2 to Glioma Progression and Their Value in the Therapeutic Response to 2OHOA

Autorzy: Paula Fernández-García, Catalina A. Rosselló, Raquel Rodríguez-Lorca, Roberto Beteta-Göbel, Javier Fernández-Díaz, Victoria Lladó, Xavier Busquets, Pablo V. Escribá
Opublikowane w: Cancers, Numer 11/1, 2019, Strona(/y) 88, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers11010088

The triacylglycerol, hydroxytriolein, inhibits triple negative mammary breast cancer cell proliferation through a mechanism dependent on dihydroceramide and Akt

Autorzy: Francisca Guardiola-Serrano, Roberto Beteta-Göbel, Raquel Rodríguez-Lorca, Maitane Ibarguren, David J. López, Silvia Terés, María Alonso-Sande, Mónica Higuera, Manuel Torres, Xavier Busquets, Pablo V. Escribá
Opublikowane w: Oncotarget, Numer 10/26, 2019, ISSN 1949-2553
Wydawca: Impact Journals
DOI: 10.18632/oncotarget.26824

Minerval (2-hydroxyoleic acid) causes cancer cell selective toxicity by uncoupling oxidative phosphorylation and compromising bioenergetic compensation capacity

Autorzy: Wessal Massalha, Mark Markovits, Edward Pichinuk, Yael Feinstein-Rotkopf, Mark Tarshish, Kumudesh Mishra, Victoria Llado, Miguel Weil, Pablo V. Escriba, Or Kakhlon
Opublikowane w: Bioscience Reports, Numer 39/1, 2019, Strona(/y) BSR20181661, ISSN 0144-8463
Wydawca: Kluwer Academic Publishers
DOI: 10.1042/bsr20181661

The Implications for Cells of the Lipid Switches Driven by Protein–Membrane Interactions and the Development of Membrane Lipid Therapy

Autorzy: Manuel Torres, Catalina Ana Rosselló, Paula Fernández-García, Victoria Lladó, Or Kakhlon, Pablo Vicente Escribá
Opublikowane w: International Journal of Molecular Sciences, Numer 21/7, 2020, Strona(/y) 2322, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21072322

Prawa własności intelektualnej

ALPHA-DERIVATIVES OF CIS-MONOUNSATURATED FATTY ACIDS INTENDED FOR USE AS A DRUG

Numer wniosku/publikacji: EP 09831504
Data: 2009-12-04
Wnioskodawca/wnioskodawcy: UNIVERSITAT DE LES ILLES BALEARS

USE OF HYDROXYOLEIC ACID AND SIMILAR COMPOUNDS IN THE PRODUCTION OF MEDICAMENTS

Numer wniosku/publikacji: EP 02783094
Data: 2002-10-09
Wnioskodawca/wnioskodawcy: UNIVERSITAT DE LES ILLES BALEARS