Comparative INsect CHRONobiology

Project Information

CINCHRON

Grant agreement ID: 765937

DOI 10.3030/765937

Project closed

EC signature date 29 August 2017

Start date 1 June 2018

End date 30 November 2022

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 3 809 005,92

EU contribution € 3 809 005,92

Coordinated by

UNIVERSITY OF LEICESTER
United Kingdom

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (39)

Silkworm strain sensitivity to infections in different LD determined
Effects of clock mutations on diapause (morph morphology) in aphids

Report on effects of clock mutations on diapause in aphids

Entrainment profile of flies with only the ocelli-expressed Rh2 rhodopsin

Entrainment profile of flies with only the ocelliexpressed Rh2 rhodopsin

Entrainment profile of flies with only Rh2 and no Hiscl1 or flies with only Rh2 and no ort
Silkmoth Transcriptome analysis

Silkmoth Transcriptome analysis reported

Nasonia functional analysis of period knock-out

Nasonia functional analysis of period knock-out described (M18). D3.13 Nasonia functional analysis of other candidate clock genes on behaviour described

Nasonia functional analysis of other candidate clock genes on behaviour

Nasonia functional analysis of other candidate clock genes on behaviour described

Circadian neuronal network responding to different manipulations

Report describing how circadian neuronal network responds to different genetic and environmental manipulations

Circadian behaviour and clock gene expression in pea aphids

Report on circadian behaviour and clock gene expression in pea aphids

Effects of bumblebee clock mutants on circadian and other behaviour

Report effects of bumblebee clock mutants on circadian rhythms in locomotor activity suncompass navigation and timing visits to flowers by bumblebee foragers

Effects of Ucp4c knock-out on metabolic physiology of larvae and disruptions in other signalling pathways

Report effects of Ucp4c knock-outs on metabolic physiology of larvae and disruptions in other signalling pathways

Diapause, circadian rhythms and gene expression in D. ezoana clock mutants

Report of diapause circadian rhythms and gene expression in D ezoana clock mutants

Identification of regulatory elements in light responsive genes
Description of how stress affects behaviour, synaptic plasticity and longevity of flies in when ho is manipulated genetically

Description of how stress affects behaviour synaptic plasticity and longevity of flies when ho is manipulated genetically

Nasonia circannual clock gene fluctuations and expression patterns

Nasonia circannual clock gene fluctuations and expression patterns described

Role of antioxidants on ho, clock gene expression, cell death, in normal conditions and under environmental stress

Role of antioxidants sulphorafan on ho clock gene expression cell death in normal conditions and under environmental stress

Circadian clock gene expression and diapause in aphids

Report of circadian clock gene expression and diapause in aphids

Rescue of the phenotype using UAS-Rh5

Rescue of the phenotype using UAS-Rh5.

Locomotor profile and sleep of flies with different combinations of Rhodopsins and histamine receptors (ort and HisCl1) in LD 12:12 as well as short and long photoperiods

Locomotor profile and sleep of flies with different combinations of Rhodopsins and histamine receptors ort and HisCl1 in LD 1212 as well as short and long photoperiods

Neuronal basis for temperature compensation

Report describing neuronal basis for temperature compensation

Effects of clock mutations on the health and performance of nurses

Report effects of clock mutations on the health and performance of nurses which are typically active aroundtheclock with no or attenuated circadian rhythms

Upc4c expression in pest species

Report of Upc4c expression in pest species

Analyse other Rhodopsin mutants in temperature entrainment

Analyse other Rhodopsin mutants in temperature entrainment including a line lacking all Rhodopsins generated by the Rouyer lab

Immunohistological and in situ expression patterns of clock and neuropeptide genes in pea aphids described

Immunohistological and in situ expression patterns of pea aphids described

Effects of mutagenesis on neuropeptide and clock genes on linden bug

Effects of knockdown and CRISPRCas9 mutagenesis on neuropeptide and clock genes on linden bug behaviour and diapause reported

ho expression pattern in the brain of Drosophila during 24 h cycle in LD 12:12

Description of ho expression pattern in the brain of Drosophila during 24 h cycle in LD 12:12

Effects of Ucp4c inhibitors on pest species

Effects of Ucp4c inhibitors on pest species described

Analyse the behaviour of Rh5 mutants

Analyse the behaviour of Rh5 mutants.

Characterization of the temporal expression profiles of UCP4C in laboratory and natural fruit fly lines sampled at different latitudes

Characterization of the temporal expression profiles of UCP4C at different temperatures in laboratory and natural fruit fly lines sampled at different latitudes

Identification of clock cells controlling cyclic expression of ho mRNA and protein
Candidate photoreceptor function in the circadian clock and their expression pattern in Bombus terrestris

Report describing the candidate photoreceptor function in the circadian clock and their expression pattern in Bombus terrestris

Effects of photoperiod on linden bug reproductive behaviour

Report of effects of photoperiod on linden bug reproductive behaviour

Identification of light-sensitive genes in Nasonia

Identification of lightsensitive genes in Nasonia M20 D29 Identification of regulatory elements in light responsive genes

Polymorphism and gene expression linked to latitudinal variation

Report describing the linking of polymorphism and gene expression patterns to latitudinal variation in behavioural circadian light response

Mapping protein interactions between clock proteins in Bombus terrestris

Report describing mapping clock protein interactions in Bombus terrestris

D. ezoana diapause and clock gene expression under different photoperiods

Report of D. ezoana diapause and clock gene expression under different photoperiods.

Molecular analysis of clock protein synchronisation

Molecular analysis of clock protein synchronisation in clock neurons of Rhodopsin mutants that affect behavioural temperature entrainment

Expression peptides of relevant neuropeptides in linden bug

Expression peptides of relevant neuropeptides described in linden bugs

Characterization of mutant silkworms for productivity and sensitivity to infections

Websites, patent fillings, videos etc. (1)

Websites (external and internal for data sharing)

Other (3)

Publication of scientific and popular press papers
Exploitation plan draft
Overall dissemination strategy including Dissemination and Communication plan

Publications

Peer reviewed articles (16)

Circadian rhythms and the liver

Author(s): Rodolfo Costa, Chiara Mangini, Esther D. Domenie, Lisa Zarantonello, Sara Montagnese
Published in: Liver international, 2022, ISSN 1478-3223
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/liv.15501

Mitochondrial Cytochrome c Oxidase Defects Alter Cellular Homeostasis of Transition Metals

Author(s): Michele Brischigliaro, Denis Badocco, Rodolfo Costa, Carlo Viscomi, Massimo Zeviani, Paolo Pastore, Erika Fernandez-Vizarra
Published in: Frontiers in Cell and Developmental Biology, Issue 2296634X, 2022, ISSN 2296-634X
Publisher: Frontiers
DOI: 10.3389/fcell.2022.892069

Regulation of heme oxygenase and its cross-talks with apoptosis and autophagy under different conditions in Drosophila

Author(s): Terence Al L. Abaquita, MIlena Damulewicz, Debarati Bhattacharya, Elzbieta Pyza
Published in: Antioxidants, 2021, ISSN 2076-3921
Publisher: MDPI
DOI: 10.3390/antiox10111716

The Circadian Clock in Lepidoptera

Author(s): Daniel Brady; Alessio Saviane; Silvia Cappellozza; Federica Sandrelli
Published in: Frontiers in Physiology, Issue 3, 2021, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.776826

The role of astrocytes in generating circadian rhythmicity in health and disease

Author(s): Rodolfo Costa, Sara Montagnese
Published in: Journal of Neurochemistry, Issue 14714159, 2021, ISSN 1471-4159
Publisher: Wiley
DOI: 10.1111/jnc.15312

Antibodies Against the Clock Proteins Period and Cryptochrome Reveal the Neuronal Organization of the Circadian Clock in the Pea Aphid

Author(s): Colizzi, Francesca Sara; Beer, Katharina; Cuti, Paolo; Deppisch, Peter; Martínez Torres, David; Yoshii, Taishi; Helfrich-Förster, Charlotte
Published in: Frontiers in Physiology, Issue 3, 2021, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.705048

Mesencephalic astrocyte-derived neurotrophic factor regulates morphology of pigment-dispersing factor-positive clock neurons and circadian neuronal plasticity in Drosophila melanogaster

Author(s): Wojciech Krzeptowski, Lucyna Walkowicz, Ewelina Krzeptowska Edyta Motta, Kacper Witek, Joanna Szramel, Terence Al Abaquita,
Published in: Frontiers in Physiology, 2021, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.705183

Progress in the characterization of insulin-like peptides in aphids: Immunohistochemical mapping of ILP4

Author(s): Paolo Cuti, Miquel Barberà, Jan A. Veenstra, David Martínez-Torres
Published in: Insect Biochemistry and Molecular Biology, Issue 136, 2021, Page(s) 103623, ISSN 0965-1748
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.ibmb.2021.103623

Peripheral Sensory Organs Contribute to Temperature Synchronization of the Circadian Clock in Drosophila melanogaster

Author(s): Rebekah George, Ralf Stanewsky
Published in: Frontiers in Physiology, Issue 1664042X, 2021, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.622545

Insect Cecropins, Antimicrobial Peptides with Potential Therapeutic Applications

Author(s): Daniel Brady, Alessandro Grapputo, Ottavia Romoli, Federica Sandrelli
Published in: International Journal of Molecular Sciences, Issue 20/23, 2019, Page(s) 5862, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20235862

Temperature synchronization of the Drosophila circadian clock protein PERIOD is controlled by the TRPA channel PYREXIA

Author(s): Sanne Roessingh, Mechthild Rosing, Martina Marunova, Maite Ogueta, Rebekah George, Angelique Lamaze, Ralf Stanewsky
Published in: Communications Biology, Issue 2/1, 2019, ISSN 2399-3642
Publisher: Springer Nature group
DOI: 10.1038/s42003-019-0497-0

Light and Temperature Synchronizes Locomotor Activity in the Linden Bug, Pyrrhocoris apterus

Author(s): Magdalena Maria Kaniewska, Hana Vaněčková, David Doležel, Joanna Kotwica-Rolinska
Published in: Frontiers in Physiology, Issue 11, 2020, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.00242

An Efficient Workflow for Screening and Stabilizing CRISPR/Cas9-Mediated Mutant Lines in Bombyx mori

Author(s): Daniel Brady, Alessio Saviane, Silvia Cappellozza, Federica Sandrelli
Published in: Methods and Protocols, Issue 4/1, 2021, Page(s) 4, ISSN 2409-9279
Publisher: MDPI
DOI: 10.3390/mps4010004

A natural timeless polymorphism allowing circadian clock synchronization in “white nights”

Author(s): Angelique Lamaze, Chenghao Chen, Solene Leleux, Min Xu, Rebekah George & Ralf Stanewsky
Published in: Nature communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-29293-6

Natural alleles of the clock gene timeless differentially affect life-history traits in Drosophila

Author(s): Gabriele Andreatta, Sara Montagnese, Rodolfo Costa
Published in: Frontiers in Physiology, 2022, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2022.1092951

Toward a Molecular Approach to Chronotype Assessment

Author(s): Alberto Biscontin, Lisa Zarantonello, Antonella Russo, Rodolfo Costa, Sara Montagnese
Published in: Journal of Biological Rhythms, Issue 07487304, 2022, ISSN 0748-7304
Publisher: Sage Science Press
DOI: 10.1177/07487304221099365

Other (1)

The ticking of the biological clock

Author(s): Valeria Zonato, Charalambos Kyriacou
Published in: EU Research, Issue 27524736, 2022, ISSN 2752-4736
Publisher: Blazon Publishing and Media Ltd