Molecular Machines with Integrated Parts

Informazioni relative al progetto

MolMacIP

ID dell’accordo di sovvenzione: 786630

DOI

10.3030/786630

Progetto chiuso

Data della firma CE 27 Giugno 2018

Data di avvio 1 Febbraio 2019

Data di completamento 31 Gennaio 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 471 095,00

Contributo UE

€ 2 471 095,00

Coordinato da

THE UNIVERSITY OF MANCHESTER
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (50)

Molecular Ratchets and Kinetic Asymmetry: Giving Chemistry Direction

Autori: S Borsley, D A Leigh and B M W Roberts
Pubblicato in: Angewandte Chemie International Edition, 2024, ISSN 1521-3773
Editore: Wiley
DOI: 10.1002/anie.202400495

Changing Liquid Crystal Helical Pitch with a Reversible Rotaxane Switch

Autori: Sujun Chen; Nathalie Katsonis; David A. Leigh; Manee Patanapongpibul; Alexander Ryabchun; Liang Zhang
Pubblicato in: Angewandte Chemie International Edition, Numero 3, 2024, ISSN 1521-3773
Editore: Wiley
DOI: 10.1002/anie.202401291

A Catalysis-Driven Dual Molecular Motor

Autori: Peng-Lai Wang, Enzo Olivieri, Stefan Borsley, George F. S. Whitehead, Avantika Hasija, David A. Leigh
Pubblicato in: Journal of the American Chemical Society, Numero 147, 2025, Pagina/e 10690-10697, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.5c01275

Switched “On” Transient Fluorescence Output from a Pulsed-Fuel Molecular Ratchet

Autori: A S Baluna, M Dommaschk, B Groh, S Kassem, D A Leigh, D J Tetlow, D Thomas and L V López
Pubblicato in: Journal of the American Chemical Society, 2023, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.3c11290

A Track-Based Molecular Synthesizer that Builds a Single-Sequence Oligomer through Iterative Carbon-Carbon Bond Formation

Autori: Charlie T. McTernan, Guillaume De Bo, David A. Leigh
Pubblicato in: Chem, Numero 6/11, 2020, Pagina/e 2964-2973, ISSN 2451-9294
Editore: Elsevier Inc.
DOI: 10.1016/j.chempr.2020.09.021

A catalysis-driven artificial molecular pump

Autori: Shuntaro Amano, Stephen D. P. Fielden, David A. Leigh
Pubblicato in: Nature, Numero 594/7864, 2021, Pagina/e 529-534, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-021-03575-3

Structural Influence of the Chemical Fueling System on a Catalysis-Driven Rotary Molecular Motor

Autori: Hua-Kui Liu, Toufic W. Mrad, Axel Troncossi, Stefan Borsley, Benjamin M. W. Roberts, Alexander Betts, David A. Leigh
Pubblicato in: Journal of the American Chemical Society, Numero 147, 2025, Pagina/e 8785-8795, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.5c00028

Stepwise Operation of a Molecular Rotary Motor Driven by an Appel Reaction

Autori: Patrick Zwick; Axel Troncossi; Stefan Borsley; Iñigo J. Vitorica-Yrezabal; David A. Leigh
Pubblicato in: Journal of the American Chemical Society, Numero 2, 2024, ISSN 1520-5126
Editore: ACS Publications
DOI: 10.1021/jacs.3c10266

A molecular endless (74) knot

Autori: David A. Leigh, Jonathan J. Danon, Stephen D. P. Fielden, Jean-François Lemonnier, George F. S. Whitehead, Steffen L. Woltering
Pubblicato in: Nature Chemistry, Numero 13/2, 2021, Pagina/e 117-122, ISSN 1755-4330
Editore: Nature Publishing Group
DOI: 10.1038/s41557-020-00594-x

Transducing chemical energy through catalysis by an artificial molecular motor

Autori: Peng-Lai Wang, Stefan Borsley, Martin J. Power, Alessandro Cavasso, Nicolas Giuseppone, David A. Leigh
Pubblicato in: Nature, Numero 637, 2025, Pagina/e 594-600, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-024-08288-x

Skeletal Editing of Mechanically Interlocked Molecules: Nitrogen Atom Deletion from Crown Ether-Dibenzylammonium Rotaxanes

Autori: Maxime Gauthier, Jessica B. M. Whittingham, Avantika Hasija, Daniel J. Tetlow, David A. Leigh
Pubblicato in: Journal of the American Chemical Society, Numero 146, 2024, Pagina/e 29496-29502, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.4c09066

Real-Time Fluctuations in Single-Molecule Rotaxane Experiments Reveal an Intermediate Weak Binding State during Shuttling

Autori: Damien Sluysmans, Perrine Lussis, Charles-André Fustin, Andrea Bertocco, David A. Leigh, Anne-Sophie Duwez
Pubblicato in: Journal of the American Chemical Society, Numero 143/5, 2021, Pagina/e 2348-2352, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.0c12161

Folding a Molecular Strand into a Trefoil Knot of Single Handedness with Co(II)/Co(III) Chaperones

Autori: Jiankang Zhong, Zhanhu Sun, Liang Zhang, George F. S. Whitehead, Iñigo J. Vitorica-Yrezabal, David A. Leigh
Pubblicato in: Journal of the American Chemical Society, Numero 146, 2024, Pagina/e 21762-21768, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.4c05953

Decorating polymer beads with 1014 inorganic-organic [2]rotaxanes as shown by spin counting.

Autori: D Asthana, D Thomas, S J Lockyer, A Brookfield, G A Timco, I J Vitorica-Yrezabal, G F S Whitehead, E J L McInnes, D Collison, D A Leigh and R E P Winpenny
Pubblicato in: Nature Communications Chemistry, 2022, ISSN 2399-3669
Editore: Springer Nature
DOI: 10.1038/s42004-022-00689-1

Effects of turn-structure on folding and entanglement in artificial molecular overhand knots

Autori: Yiwei Song, Fredrik Schaufelberger, Zoe Ashbridge, Lucian Pirvu, Iñigo J. Vitorica-Yrezabal, David A. Leigh
Pubblicato in: Chemical Science, Numero 12/5, 2021, Pagina/e 1826-1833, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/d0sc05897a

Active template synthesis

Autori: Romain Jamagne, Martin J. Power, Zhi-Hui Zhang, Germán Zango, Benjamin Gibber, David A. Leigh
Pubblicato in: Chemical Society Reviews, 2024, ISSN 0306-0012
Editore: Royal Society of Chemistry
DOI: 10.1039/d4cs00430b

Site-to-site peptide transport on a molecular platform using a small-molecule robotic arm

Autori: Salma Kassem, Alan T. L. Lee, David A. Leigh, Augustinas Markevicius, Daniel J. Tetlow, Naoyuki Toriumi
Pubblicato in: Chemical Science, Numero 12/6, 2021, Pagina/e 2065-2070, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/d0sc05906d

Compact Rotaxane Superbases

Autori: Martin J. Power, David T. J. Morris, Iigo J. Vitorica-Yrezabal, and David A. Leigh
Pubblicato in: Journal of the American Chemical Society, 2023, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.3c01202

Chemical fuels for molecular machinery

Autori: Borsley, S., Leigh, D.A. & Roberts, B.M.W.
Pubblicato in: Nature Chemistry, Numero 17554330, 2022, ISSN 1755-4330
Editore: Nature Publishing Group
DOI: 10.1038/s41557-022-00970-9

Social Self-Sorting Synthesis of Molecular Knots

Autori: Z Ashbridge, O M Knapp, E Kreidt, D A Leigh, L Pirvu and F Schaufelberger
Pubblicato in: Journal of the American Chemical Society, Numero 00027863, 2022, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.2c07682

Conformational selection accelerates catalysis by an organocatalytic molecular motor

Autori: J M Gallagher, B M W Roberts, S Borsley and D A Leigh
Pubblicato in: Chem, 2023, ISSN 2451-9294
Editore: Elsevier
DOI: 10.1016/j.chempr.2023.10.019

Tying different knots in a molecular strand

Autori: David A. Leigh, Fredrik Schaufelberger, Lucian Pirvu, Joakim Halldin Stenlid, David P. August, Julien Segard
Pubblicato in: Nature, Numero 584, 2021, Pagina/e 562-568, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-020-2614-0

Knotting a molecular strand can invert macroscopic effects of chirality

Autori: Nathalie Katsonis, Federico Lancia, David A. Leigh, Lucian Pirvu, Alexander Ryabchun, Fredrik Schaufelberger
Pubblicato in: Nature Chemistry, Numero 12, 2021, Pagina/e 939-944, ISSN 1755-4330
Editore: Nature Publishing Group
DOI: 10.1038/s41557-020-0517-1

Chemical engines: driving systems away from equilibrium through catalyst reaction cycles

Autori: Shuntaro Amano, Stefan Borsley, David A. Leigh, Zhanhu Sun
Pubblicato in: Nature Nanotechnology, Numero 16, 2024, Pagina/e 1057-1067, ISSN 1748-3387
Editore: Nature Publishing Group
DOI: 10.1038/s41565-021-00975-4

Sequence-Selective Decapeptide Synthesis by the Parallel Operation of Two Artificial Molecular Machines

Autori: Javier Echavarren, Malcolm A. Y. Gall, Adrian Haertsch, David A. Leigh, Justin T. J. Spence, Daniel J. Tetlow, Chong Tian
Pubblicato in: Journal of the American Chemical Society, Numero 143/13, 2021, Pagina/e 5158-5165, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.1c01234

Molecular weaving

Autori: Zhi-Hui Zhang, Björn J. Andreassen, David P. August, David A. Leigh, Liang Zhang
Pubblicato in: Nature Materials, Numero 21, 2022, Pagina/e 275-283, ISSN 1476-1122
Editore: Nature Publishing Group
DOI: 10.1038/s41563-021-01179-w

Transamidation-Driven Molecular Pumps

Autori: Lorna Binks, Chong Tian, Stephen D. P. Fielden, Iñigo J. Vitorica-yrezabal, David A. Leigh
Pubblicato in: Journal of the American Chemical Society, Numero 00027863, 2022, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.2c06807

Ratcheting synthesis

Autori: Stefan Borsley, James M. Gallagher, David A. Leigh & Benjamin M. W. Roberts
Pubblicato in: Nature Reviews Chemistry, 2023, ISSN 2397-3358
Editore: Nature Publishing Group
DOI: 10.1038/s41570-023-00558-y

A Chiral Cyclometalated Iridium Star of David [2]Catenane

Autori: David P. August, Javier Jaramillo-Garcia, David A. Leigh, Alberto Valero, Iñigo J. Vitorica-Yrezabal
Pubblicato in: Journal of the American Chemical Society, Numero 143/2, 2021, Pagina/e 1154-1161, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.0c12038

Using Catalysis to Drive Chemistry Away from Equilibrium: Relating Kinetic Asymmetry, Power Strokes, and the Curtin–Hammett Principle in Brownian Ratchets

Autori: S Amano, M Esposito, E Kreidt, D A Leigh, E Penocchio and B M W Roberts
Pubblicato in: Journal of the American Chemical Society, Numero 00027863, 2022, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.2c08723

Dynamic Control of Chiral Space Through Local Symmetry Breaking in a Rotaxane Organocatalyst

Autori: Marcel Dommaschk, Javier Echavarren, David A. Leigh, Vanesa Marcos, Thomas A. Singleton
Pubblicato in: Angewandte Chemie International Edition, 2019, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201908330

Self-Sorting Assembly of Molecular Trefoil Knots of Single Handedness

Autori: Jiankang Zhong, Liang Zhang, David P. August, George F. S. Whitehead, David A. Leigh
Pubblicato in: Journal of the American Chemical Society, Numero 141/36, 2019, Pagina/e 14249-14256, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.9b06127

Active template rotaxane synthesis through the Ni-catalyzed cross-coupling of alkylzinc reagents with redox-active esters

Autori: Javier Echavarren, Malcolm A. Y. Gall, Adrian Haertsch, David A. Leigh, Vanesa Marcos, Daniel J. Tetlow
Pubblicato in: Chemical Science, Numero 10/30, 2019, Pagina/e 7269-7273, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/c9sc02457c

Dissipative Catalysis with a Molecular Machine

Autori: Chiara Biagini, Stephen D. P. Fielden, David A. Leigh, Fredrik Schaufelberger, Stefano Di Stefano, Dean Thomas
Pubblicato in: Angewandte Chemie International Edition, Numero 58/29, 2019, Pagina/e 9876-9880, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201905250

Single-Step Enantioselective Synthesis of Mechanically Planar Chiral [2]Rotaxanes Using a Chiral Leaving Group Strategy

Autori: Chong Tian, Stephen D. P. Fielden, Borja Pérez-Saavedra, Iñigo J. Vitorica-Yrezabal, David A. Leigh
Pubblicato in: Journal of the American Chemical Society, Numero 142/21, 2020, Pagina/e 9803-9808, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.0c03447

Weak functional group interactions revealed through metal-free active template rotaxane synthesis

Autori: Chong Tian, Stephen D. P. Fielden, George F. S. Whitehead, Iñigo J. Vitorica-Yrezabal, David A. Leigh
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-14576-7

Transmembrane Ion Channels Formed by a Star of David [2]Catenane and a Molecular Pentafoil Knot

Autori: David P. August, Stefan Borsley, Scott L. Cockroft, Flavio della Sala, David A. Leigh, Simon J. Webb
Pubblicato in: Journal of the American Chemical Society, Numero 142/44, 2020, Pagina/e 18859-18865, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.0c07977

Knotting matters: orderly molecular entanglements

Autori: Z Ashbridge, S D P Fielden, D A Leigh, L Pirvu, F Schaufelberger and L Zhang
Pubblicato in: Chem. Soc. Rev., Numero 03060012, 2022, ISSN 0306-0012
Editore: Royal Society of Chemistry
DOI: 10.1039/d2cs00323f

Self-assembly of a layered two-dimensional molecularly woven fabric

Autori: David P. August, Robert A. W. Dryfe, Sarah J. Haigh, Paige R. C. Kent, David A. Leigh, Jean-François Lemonnier, Zheling Li, Christopher A. Muryn, Leoni I. Palmer, Yiwei Song, George F. S. Whitehead, Robert J. Young
Pubblicato in: Nature, Numero 588, 2023, Pagina/e 429-435, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-020-3019-9

A tape-reading molecular ratchet

Autori: Y Ren, R Jamagne, D J Tetlow and D A Leigh
Pubblicato in: Nature, Numero 00280836, 2022, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-022-05305-9

Autonomous fuelled directional rotation about a covalent single bond

Autori: S Borsley, E Kreidt, D A Leigh and B M W Roberts
Pubblicato in: Nature, 2022, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-022-04450-5

Mechanical scission of a knotted polymer.

Autori: M Zhang, R Nixon, F Schaufelberger, L Pirvu, G De Bo and D A Leigh
Pubblicato in: Nature Chemistry, 2024, ISSN 1755-4330
Editore: Nature Publishing Group
DOI: 10.1038/s41557-024-01510-3

A Doubly Kinetically-Gated Information Ratchet Autonomously Driven by Carbodiimide Hydration

Autori: Stefan Borsley, David A. Leigh, Benjamin M. W. Roberts
Pubblicato in: Journal of the American Chemical Society, Numero 143/11, 2021, Pagina/e 4414-4420, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.1c01172

Tuning the Force, Speed, and Efficiency of an Autonomous Chemically Fueled Information Ratchet

Autori: S Borsley, D A Leigh, B M W Roberts and I J Vitorica-Yrezabal
Pubblicato in: Journal of the American Chemical Society, Numero 00027863, 2022, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.2c07633

Endergonic synthesis driven by chemical fuelling

Autori: Enzo Olivieri; James M. Gallagher; Alexander Betts; Toufic W. Mrad; David A. Leigh
Pubblicato in: Nature Synthesis, Numero 3, 2024, ISSN 2731-0582
Editore: Springer Nature
DOI: 10.26434/chemrxiv-2023-6nqn3-v2

The role of kinetic asymmetry and power strokes in an information ratchet.

Autori: Lorna Binks, Stefan Borsley, Todd r. Gingrich, David Leigh, Emanuele Penocchio, Benjamin Roberts
Pubblicato in: Chem, 2023, ISSN 2451-9294
Editore: Elsevier
DOI: 10.1016/j.chempr.2023.05.035

Insights from an information thermodynamics analysis of a synthetic molecular motor

Autori: Amano, S., Esposito, M., Kreidt, E., Leigh, D. A., Penocchio, E. & Roberts, B. M. W.
Pubblicato in: Nature Chemistry, 2022, ISSN 1755-4330
Editore: Nature Publishing Group
DOI: 10.1038/s41557-022-00899-z

In Search of Wasserman’s Catenane

Autori: Andrei S. Baluna; Albano Galan; David A. Leigh; Gareth D. Smith; Justin T. J. Spence; Daniel J. Tetlow; Iñigo J. Vitorica-Yrezabal; Min Zhang
Pubblicato in: Journal of the American Chemical Society, 2023, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.3c01939

Macroscopic spiral rotation of microscopic objects induced by nanoscale rotaxane dynamics

Autori: A Ryabchun, R Jamagne, J Echavarren, M Patanapongpibul, L Zhang, N Katsonis and D A Leigh
Pubblicato in: Chem, 2024, ISSN 2451-9294
Editore: Science Direct Cell Press
DOI: 10.1016/j.chempr.2024.03.013

Pumping Between Phases With a Pulsed-Fuel Molecular Ratchet

Autori: D Thomas, D J Tetlow, Y Ren, S Kassem, U Karaca and D A Leigh
Pubblicato in: Nature Nanotechnology, 2022, ISSN 1748-3387
Editore: Nature Publishing Group
DOI: 10.1038/s41565-022-01097-1

Other (2)

Pumping Between Phases With a Pulsed-Fuel Molecular Ratchet

Autori: Dean Thomas, Daniel Tetlow, Yansong Ren, Salma Kassem, Ulvi Karaca, David Leigh
Pubblicato in: 2022
Editore: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv-2021-fl7tv

Transducing chemical energy through catalysis by an artificial molecular motor

Autori: Peng-Lai Wang, Stefan Borsley, Martin Power, Alessandro Cavasso, Nicolas Giuseppone, David Leigh
Pubblicato in: 2024
Editore: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv-2024-h6882

Non-peer reviewed articles (1)

Out-of-equilibrium compartments: Thinking inside the box

Autori: James M. Gallagher, Joaquin Baixeras Buye, David A. Leigh
Pubblicato in: Chem, Numero 10, 2024, Pagina/e 3526-3528, ISSN 2451-9294
Editore: Cell Press
DOI: 10.1016/j.chempr.2024.09.032