Molecular Machines with Integrated Parts

Project Information

MolMacIP

Grant agreement ID: 786630

DOI

10.3030/786630

Project closed

EC signature date 27 June 2018

Start date 1 February 2019

End date 31 January 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 471 095,00

EU contribution

€ 2 471 095,00

Coordinated by

THE UNIVERSITY OF MANCHESTER
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (50)

Molecular Ratchets and Kinetic Asymmetry: Giving Chemistry Direction

Author(s): S Borsley, D A Leigh and B M W Roberts
Published in: Angewandte Chemie International Edition, 2024, ISSN 1521-3773
Publisher: Wiley
DOI: 10.1002/anie.202400495

Changing Liquid Crystal Helical Pitch with a Reversible Rotaxane Switch

Author(s): Sujun Chen; Nathalie Katsonis; David A. Leigh; Manee Patanapongpibul; Alexander Ryabchun; Liang Zhang
Published in: Angewandte Chemie International Edition, Issue 3, 2024, ISSN 1521-3773
Publisher: Wiley
DOI: 10.1002/anie.202401291

A Catalysis-Driven Dual Molecular Motor

Author(s): Peng-Lai Wang, Enzo Olivieri, Stefan Borsley, George F. S. Whitehead, Avantika Hasija, David A. Leigh
Published in: Journal of the American Chemical Society, Issue 147, 2025, Page(s) 10690-10697, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.5c01275

Switched “On” Transient Fluorescence Output from a Pulsed-Fuel Molecular Ratchet

Author(s): A S Baluna, M Dommaschk, B Groh, S Kassem, D A Leigh, D J Tetlow, D Thomas and L V López
Published in: Journal of the American Chemical Society, 2023, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c11290

A Track-Based Molecular Synthesizer that Builds a Single-Sequence Oligomer through Iterative Carbon-Carbon Bond Formation

Author(s): Charlie T. McTernan, Guillaume De Bo, David A. Leigh
Published in: Chem, Issue 6/11, 2020, Page(s) 2964-2973, ISSN 2451-9294
Publisher: Elsevier Inc.
DOI: 10.1016/j.chempr.2020.09.021

A catalysis-driven artificial molecular pump

Author(s): Shuntaro Amano, Stephen D. P. Fielden, David A. Leigh
Published in: Nature, Issue 594/7864, 2021, Page(s) 529-534, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-03575-3

Structural Influence of the Chemical Fueling System on a Catalysis-Driven Rotary Molecular Motor

Author(s): Hua-Kui Liu, Toufic W. Mrad, Axel Troncossi, Stefan Borsley, Benjamin M. W. Roberts, Alexander Betts, David A. Leigh
Published in: Journal of the American Chemical Society, Issue 147, 2025, Page(s) 8785-8795, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.5c00028

Stepwise Operation of a Molecular Rotary Motor Driven by an Appel Reaction

Author(s): Patrick Zwick; Axel Troncossi; Stefan Borsley; Iñigo J. Vitorica-Yrezabal; David A. Leigh
Published in: Journal of the American Chemical Society, Issue 2, 2024, ISSN 1520-5126
Publisher: ACS Publications
DOI: 10.1021/jacs.3c10266

A molecular endless (74) knot

Author(s): David A. Leigh, Jonathan J. Danon, Stephen D. P. Fielden, Jean-François Lemonnier, George F. S. Whitehead, Steffen L. Woltering
Published in: Nature Chemistry, Issue 13/2, 2021, Page(s) 117-122, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-020-00594-x

Transducing chemical energy through catalysis by an artificial molecular motor

Author(s): Peng-Lai Wang, Stefan Borsley, Martin J. Power, Alessandro Cavasso, Nicolas Giuseppone, David A. Leigh
Published in: Nature, Issue 637, 2025, Page(s) 594-600, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-024-08288-x

Skeletal Editing of Mechanically Interlocked Molecules: Nitrogen Atom Deletion from Crown Ether-Dibenzylammonium Rotaxanes

Author(s): Maxime Gauthier, Jessica B. M. Whittingham, Avantika Hasija, Daniel J. Tetlow, David A. Leigh
Published in: Journal of the American Chemical Society, Issue 146, 2024, Page(s) 29496-29502, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.4c09066

Real-Time Fluctuations in Single-Molecule Rotaxane Experiments Reveal an Intermediate Weak Binding State during Shuttling

Author(s): Damien Sluysmans, Perrine Lussis, Charles-André Fustin, Andrea Bertocco, David A. Leigh, Anne-Sophie Duwez
Published in: Journal of the American Chemical Society, Issue 143/5, 2021, Page(s) 2348-2352, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.0c12161

Folding a Molecular Strand into a Trefoil Knot of Single Handedness with Co(II)/Co(III) Chaperones

Author(s): Jiankang Zhong, Zhanhu Sun, Liang Zhang, George F. S. Whitehead, Iñigo J. Vitorica-Yrezabal, David A. Leigh
Published in: Journal of the American Chemical Society, Issue 146, 2024, Page(s) 21762-21768, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.4c05953

Decorating polymer beads with 1014 inorganic-organic [2]rotaxanes as shown by spin counting.

Author(s): D Asthana, D Thomas, S J Lockyer, A Brookfield, G A Timco, I J Vitorica-Yrezabal, G F S Whitehead, E J L McInnes, D Collison, D A Leigh and R E P Winpenny
Published in: Nature Communications Chemistry, 2022, ISSN 2399-3669
Publisher: Springer Nature
DOI: 10.1038/s42004-022-00689-1

Effects of turn-structure on folding and entanglement in artificial molecular overhand knots

Author(s): Yiwei Song, Fredrik Schaufelberger, Zoe Ashbridge, Lucian Pirvu, Iñigo J. Vitorica-Yrezabal, David A. Leigh
Published in: Chemical Science, Issue 12/5, 2021, Page(s) 1826-1833, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sc05897a

Active template synthesis

Author(s): Romain Jamagne, Martin J. Power, Zhi-Hui Zhang, Germán Zango, Benjamin Gibber, David A. Leigh
Published in: Chemical Society Reviews, 2024, ISSN 0306-0012
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4cs00430b

Site-to-site peptide transport on a molecular platform using a small-molecule robotic arm

Author(s): Salma Kassem, Alan T. L. Lee, David A. Leigh, Augustinas Markevicius, Daniel J. Tetlow, Naoyuki Toriumi
Published in: Chemical Science, Issue 12/6, 2021, Page(s) 2065-2070, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sc05906d

Compact Rotaxane Superbases

Author(s): Martin J. Power, David T. J. Morris, Iigo J. Vitorica-Yrezabal, and David A. Leigh
Published in: Journal of the American Chemical Society, 2023, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c01202

Chemical fuels for molecular machinery

Author(s): Borsley, S., Leigh, D.A. & Roberts, B.M.W.
Published in: Nature Chemistry, Issue 17554330, 2022, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-022-00970-9

Social Self-Sorting Synthesis of Molecular Knots

Author(s): Z Ashbridge, O M Knapp, E Kreidt, D A Leigh, L Pirvu and F Schaufelberger
Published in: Journal of the American Chemical Society, Issue 00027863, 2022, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.2c07682

Conformational selection accelerates catalysis by an organocatalytic molecular motor

Author(s): J M Gallagher, B M W Roberts, S Borsley and D A Leigh
Published in: Chem, 2023, ISSN 2451-9294
Publisher: Elsevier
DOI: 10.1016/j.chempr.2023.10.019

Tying different knots in a molecular strand

Author(s): David A. Leigh, Fredrik Schaufelberger, Lucian Pirvu, Joakim Halldin Stenlid, David P. August, Julien Segard
Published in: Nature, Issue 584, 2021, Page(s) 562-568, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2614-0

Knotting a molecular strand can invert macroscopic effects of chirality

Author(s): Nathalie Katsonis, Federico Lancia, David A. Leigh, Lucian Pirvu, Alexander Ryabchun, Fredrik Schaufelberger
Published in: Nature Chemistry, Issue 12, 2021, Page(s) 939-944, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-020-0517-1

Chemical engines: driving systems away from equilibrium through catalyst reaction cycles

Author(s): Shuntaro Amano, Stefan Borsley, David A. Leigh, Zhanhu Sun
Published in: Nature Nanotechnology, Issue 16, 2024, Page(s) 1057-1067, ISSN 1748-3387
Publisher: Nature Publishing Group
DOI: 10.1038/s41565-021-00975-4

Sequence-Selective Decapeptide Synthesis by the Parallel Operation of Two Artificial Molecular Machines

Author(s): Javier Echavarren, Malcolm A. Y. Gall, Adrian Haertsch, David A. Leigh, Justin T. J. Spence, Daniel J. Tetlow, Chong Tian
Published in: Journal of the American Chemical Society, Issue 143/13, 2021, Page(s) 5158-5165, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.1c01234

Molecular weaving

Author(s): Zhi-Hui Zhang, Björn J. Andreassen, David P. August, David A. Leigh, Liang Zhang
Published in: Nature Materials, Issue 21, 2022, Page(s) 275-283, ISSN 1476-1122
Publisher: Nature Publishing Group
DOI: 10.1038/s41563-021-01179-w

Transamidation-Driven Molecular Pumps

Author(s): Lorna Binks, Chong Tian, Stephen D. P. Fielden, Iñigo J. Vitorica-yrezabal, David A. Leigh
Published in: Journal of the American Chemical Society, Issue 00027863, 2022, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.2c06807

Ratcheting synthesis

Author(s): Stefan Borsley, James M. Gallagher, David A. Leigh & Benjamin M. W. Roberts
Published in: Nature Reviews Chemistry, 2023, ISSN 2397-3358
Publisher: Nature Publishing Group
DOI: 10.1038/s41570-023-00558-y

A Chiral Cyclometalated Iridium Star of David [2]Catenane

Author(s): David P. August, Javier Jaramillo-Garcia, David A. Leigh, Alberto Valero, Iñigo J. Vitorica-Yrezabal
Published in: Journal of the American Chemical Society, Issue 143/2, 2021, Page(s) 1154-1161, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.0c12038

Using Catalysis to Drive Chemistry Away from Equilibrium: Relating Kinetic Asymmetry, Power Strokes, and the Curtin–Hammett Principle in Brownian Ratchets

Author(s): S Amano, M Esposito, E Kreidt, D A Leigh, E Penocchio and B M W Roberts
Published in: Journal of the American Chemical Society, Issue 00027863, 2022, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.2c08723

Dynamic Control of Chiral Space Through Local Symmetry Breaking in a Rotaxane Organocatalyst

Author(s): Marcel Dommaschk, Javier Echavarren, David A. Leigh, Vanesa Marcos, Thomas A. Singleton
Published in: Angewandte Chemie International Edition, 2019, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201908330

Self-Sorting Assembly of Molecular Trefoil Knots of Single Handedness

Author(s): Jiankang Zhong, Liang Zhang, David P. August, George F. S. Whitehead, David A. Leigh
Published in: Journal of the American Chemical Society, Issue 141/36, 2019, Page(s) 14249-14256, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.9b06127

Active template rotaxane synthesis through the Ni-catalyzed cross-coupling of alkylzinc reagents with redox-active esters

Author(s): Javier Echavarren, Malcolm A. Y. Gall, Adrian Haertsch, David A. Leigh, Vanesa Marcos, Daniel J. Tetlow
Published in: Chemical Science, Issue 10/30, 2019, Page(s) 7269-7273, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9sc02457c

Dissipative Catalysis with a Molecular Machine

Author(s): Chiara Biagini, Stephen D. P. Fielden, David A. Leigh, Fredrik Schaufelberger, Stefano Di Stefano, Dean Thomas
Published in: Angewandte Chemie International Edition, Issue 58/29, 2019, Page(s) 9876-9880, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201905250

Single-Step Enantioselective Synthesis of Mechanically Planar Chiral [2]Rotaxanes Using a Chiral Leaving Group Strategy

Author(s): Chong Tian, Stephen D. P. Fielden, Borja Pérez-Saavedra, Iñigo J. Vitorica-Yrezabal, David A. Leigh
Published in: Journal of the American Chemical Society, Issue 142/21, 2020, Page(s) 9803-9808, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.0c03447

Weak functional group interactions revealed through metal-free active template rotaxane synthesis

Author(s): Chong Tian, Stephen D. P. Fielden, George F. S. Whitehead, Iñigo J. Vitorica-Yrezabal, David A. Leigh
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-14576-7

Transmembrane Ion Channels Formed by a Star of David [2]Catenane and a Molecular Pentafoil Knot

Author(s): David P. August, Stefan Borsley, Scott L. Cockroft, Flavio della Sala, David A. Leigh, Simon J. Webb
Published in: Journal of the American Chemical Society, Issue 142/44, 2020, Page(s) 18859-18865, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.0c07977

Knotting matters: orderly molecular entanglements

Author(s): Z Ashbridge, S D P Fielden, D A Leigh, L Pirvu, F Schaufelberger and L Zhang
Published in: Chem. Soc. Rev., Issue 03060012, 2022, ISSN 0306-0012
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2cs00323f

Self-assembly of a layered two-dimensional molecularly woven fabric

Author(s): David P. August, Robert A. W. Dryfe, Sarah J. Haigh, Paige R. C. Kent, David A. Leigh, Jean-François Lemonnier, Zheling Li, Christopher A. Muryn, Leoni I. Palmer, Yiwei Song, George F. S. Whitehead, Robert J. Young
Published in: Nature, Issue 588, 2023, Page(s) 429-435, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-3019-9

A tape-reading molecular ratchet

Author(s): Y Ren, R Jamagne, D J Tetlow and D A Leigh
Published in: Nature, Issue 00280836, 2022, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-05305-9

Autonomous fuelled directional rotation about a covalent single bond

Author(s): S Borsley, E Kreidt, D A Leigh and B M W Roberts
Published in: Nature, 2022, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-04450-5

Mechanical scission of a knotted polymer.

Author(s): M Zhang, R Nixon, F Schaufelberger, L Pirvu, G De Bo and D A Leigh
Published in: Nature Chemistry, 2024, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-024-01510-3

A Doubly Kinetically-Gated Information Ratchet Autonomously Driven by Carbodiimide Hydration

Author(s): Stefan Borsley, David A. Leigh, Benjamin M. W. Roberts
Published in: Journal of the American Chemical Society, Issue 143/11, 2021, Page(s) 4414-4420, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.1c01172

Tuning the Force, Speed, and Efficiency of an Autonomous Chemically Fueled Information Ratchet

Author(s): S Borsley, D A Leigh, B M W Roberts and I J Vitorica-Yrezabal
Published in: Journal of the American Chemical Society, Issue 00027863, 2022, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.2c07633

Endergonic synthesis driven by chemical fuelling

Author(s): Enzo Olivieri; James M. Gallagher; Alexander Betts; Toufic W. Mrad; David A. Leigh
Published in: Nature Synthesis, Issue 3, 2024, ISSN 2731-0582
Publisher: Springer Nature
DOI: 10.26434/chemrxiv-2023-6nqn3-v2

The role of kinetic asymmetry and power strokes in an information ratchet.

Author(s): Lorna Binks, Stefan Borsley, Todd r. Gingrich, David Leigh, Emanuele Penocchio, Benjamin Roberts
Published in: Chem, 2023, ISSN 2451-9294
Publisher: Elsevier
DOI: 10.1016/j.chempr.2023.05.035

Insights from an information thermodynamics analysis of a synthetic molecular motor

Author(s): Amano, S., Esposito, M., Kreidt, E., Leigh, D. A., Penocchio, E. & Roberts, B. M. W.
Published in: Nature Chemistry, 2022, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-022-00899-z

In Search of Wasserman’s Catenane

Author(s): Andrei S. Baluna; Albano Galan; David A. Leigh; Gareth D. Smith; Justin T. J. Spence; Daniel J. Tetlow; Iñigo J. Vitorica-Yrezabal; Min Zhang
Published in: Journal of the American Chemical Society, 2023, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c01939

Macroscopic spiral rotation of microscopic objects induced by nanoscale rotaxane dynamics

Author(s): A Ryabchun, R Jamagne, J Echavarren, M Patanapongpibul, L Zhang, N Katsonis and D A Leigh
Published in: Chem, 2024, ISSN 2451-9294
Publisher: Science Direct Cell Press
DOI: 10.1016/j.chempr.2024.03.013

Pumping Between Phases With a Pulsed-Fuel Molecular Ratchet

Author(s): D Thomas, D J Tetlow, Y Ren, S Kassem, U Karaca and D A Leigh
Published in: Nature Nanotechnology, 2022, ISSN 1748-3387
Publisher: Nature Publishing Group
DOI: 10.1038/s41565-022-01097-1

Other (2)

Pumping Between Phases With a Pulsed-Fuel Molecular Ratchet

Author(s): Dean Thomas, Daniel Tetlow, Yansong Ren, Salma Kassem, Ulvi Karaca, David Leigh
Published in: 2022
Publisher: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv-2021-fl7tv

Transducing chemical energy through catalysis by an artificial molecular motor

Author(s): Peng-Lai Wang, Stefan Borsley, Martin Power, Alessandro Cavasso, Nicolas Giuseppone, David Leigh
Published in: 2024
Publisher: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv-2024-h6882

Non-peer reviewed articles (1)

Out-of-equilibrium compartments: Thinking inside the box

Author(s): James M. Gallagher, Joaquin Baixeras Buye, David A. Leigh
Published in: Chem, Issue 10, 2024, Page(s) 3526-3528, ISSN 2451-9294
Publisher: Cell Press
DOI: 10.1016/j.chempr.2024.09.032