Project description
A new path to synthetic life and a breakthrough for chemistry
A long-sought goal of engineering and chemistry has been the creation of synthetic life, yet engineers and chemists faced many obstacles. A major hurdle was the construction of life-inspired systems that can sense the environment, make autonomous decisions and extract energy and resources from the environment for cell growth and division (all processes controlled by enzymatic reaction networks). The EU-funded Life-Inspired project aims to construct life-inspired systems based on the design of living matter. To reach this goal, the project will focus on creating a set of complex systems based on programmable enzymatic reaction networks.
Objective
Many of the key functions typically associated with living systems, including sensing of the environment, autonomous decision making, and extracting energy and building blocks from the environment for cell growth and division, are all governed by enzymatic reaction networks. Constructing synthetic systems that capture some of these capabilities, i.e. life-inspired systems, would represent a truly disruptive development, as they challenge our notion of what differentiates living systems from synthetic, man-made devices. However, the ability create synthetic life-inspired systems remains an elusive goal. Despite impressive progress in systems chemistry, no clear engineering principles or methodologies exist for the bottom-up construction of functional complex molecular systems The translation of the design principles of living systems into programmable and functional life-inspired systems is one of the outstanding grand challenge in chemistry. The ultimate aim of this proposal is to construct life-inspired systems based on the design blueprints of living matter To achieve this aim, I propose a key breakthrough by presenting a completely new approach to functional complex systems based on programmable enzymatic reactions networks. The envisaged approach is modular and will allow for systematic increases in complexity. The core objectives of this proposal are: - establish a completely new approach to programmable enzymatic reaction networks - compartmentalize network motifs, and separate the small molecule ‘software’ from the enzyme ‘hardware’ - demonstrate modularity and increase the complexity via communication between compartments - develop robust methods to manage the maintenance of non-equilibrium conditions - design and construct complex life-inspired systems.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences computer and information sciences software
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-ADG - Advanced Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2018-ADG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
6525 XZ Nijmegen
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.