Brain metastases: Deciphering tumor-stroma interactions in three dimensions for the rational design of nanomedicines

Project Information

3DBrainStrom

Grant agreement ID: 835227

DOI

10.3030/835227

Project closed

EC signature date 23 May 2019

Start date 1 April 2019

End date 31 March 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 353 125,00

EU contribution

€ 2 353 125,00

Coordinated by

TEL AVIV UNIVERSITY
Israel

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (24)

Potent antitumor activity of anti-HER2 antibody-topoisomerase I inhibitor conjugate based on self-immolative dendritic dimeric-linker

Author(s): Yulia Liubomirski, Galia Tiram, Anna Scomparin, Samer Gnaim, Sayantan Das, Sachin Gholap, Liang Ge, Eilam Yeini, Omri Shelef, Arie Zauberman, Nir Berger, Doron Kalimi, Mira Toister-Achituv, Christian Schröter, Stephan Dickgiesser, Jason Tonillo, Min Shan, Carl Deutsch, Stanley Sweeney-Lasch, Doron Shabat, Ronit Satchi-Fainaro
Published in: Journal of Controlled Release, Issue 367, 2024, Page(s) 148-157, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2024.01.025

Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators

Author(s): João Conniot, Anna Scomparin, Carina Peres, Eilam Yeini, Sabina Pozzi, Ana I. Matos, Ron Kleiner, Liane I. F. Moura, Eva Zupančič, Ana S. Viana, Hila Doron, Pedro M. P. Gois, Neta Erez, Steffen Jung, Ronit Satchi-Fainaro, Helena F. Florindo
Published in: Nature Nanotechnology, Issue 14, 2023, Page(s) 891-901, ISSN 1748-3387
Publisher: Nature Publishing Group
DOI: 10.1038/s41565-019-0512-0

Immune-mediated approaches against COVID-19

Author(s): Helena F. Florindo, Ron Kleiner, Daniella Vaskovich-Koubi, Rita C. Acúrcio, Barbara Carreira, Eilam Yeini, Galia Tiram, Yulia Liubomirski, Ronit Satchi-Fainaro
Published in: Nature Nanotechnology, Issue 15/8, 2020, Page(s) 630-645, ISSN 1748-3387
Publisher: Nature Publishing Group
DOI: 10.1038/s41565-020-0732-3

Deoxyhypusine hydroxylase: A novel therapeutic target differentially expressed in short‐term vs long‐term survivors of glioblastoma

Author(s): Paula Ofek, Eilam Yeini, Gali Arad, Artem Danilevsky, Sabina Pozzi, Christian Burgos Luna, Sahar Israeli Dangoor, Rachel Grossman, Zvi Ram, Noam Shomron, Henry Brem, Thomas M. Hyde, Tamar Geiger, Ronit Satchi‐Fainaro
Published in: International Journal of Cancer, Issue 153, 2023, Page(s) 654-668, ISSN 0020-7136
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ijc.34545

Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment

Author(s): Rita C. Acúrcio, Sabina Pozzi, Barbara Carreira, Marta Pojo, Nuria Gómez-Cebrián, Sandra Casimiro, Adelaide Fernandes, Andreia Barateiro, Vitor Farricha, Joaquim Brito, Ana Paula Leandro, Jorge A R Salvador, Luís Graça, Leonor Puchades-Carrasco, Luís Costa, Ronit Satchi-Fainaro, Rita C. Guedes, Helena F. Florindo
Published in: Journal for ImmunoTherapy of Cancer, Issue 10, 2024, Page(s) e004695, ISSN 2051-1426
Publisher: BMJ
DOI: 10.1136/jitc-2022-004695

interFLOW: maximum flow framework for the identification of factors mediating the signaling convergence of multiple receptors

Author(s): Ron Sheinin, Koren Salomon, Eilam Yeini, Shai Dulberg, Ayelet Kaminitz, Ronit Satchi-Fainaro, Roded Sharan, Asaf Madi
Published in: npj Systems Biology and Applications, Issue 10, 2024, ISSN 2056-7189
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41540-024-00391-z

Rational Design of Polyglutamic Acid Delivering an Optimized Combination of Drugs Targeting Mutated BRAF and MEK in Melanoma

Author(s): Evgeni Pisarevsky, Rachel Blau, Yana Epshtein, Dikla Ben‐Shushan, Anat Eldar‐Boock, Galia Tiram, Shani Koshrovski‐Michael, Anna Scomparin, Sabina Pozzi, Adva Krivitsky, Gal Shenbach‐Koltin, Eilam Yeini, Lidar Fridrich, Richard White, Ronit Satchi‐Fainaro
Published in: Advanced Therapeutics, Issue 3/8, 2020, Page(s) 2000028, ISSN 2366-3987
Publisher: Wile Online Library
DOI: 10.1002/adtp.202000028

Two-in-one nanoparticle platform induces a strong therapeutic effect of targeted therapies in P-selectin–expressing cancers

Author(s): Shani Koshrovski-Michael, Daniel Rodriguez Ajamil, Pradip Dey, Ron Kleiner, Shahar Tevet, Yana Epshtein, Marina Green Buzhor, Rami Khoury, Sabina Pozzi, Gal Shenbach-Koltin, Eilam Yeini, Laura Woythe, Rachel Blau, Anna Scomparin, Iris Barshack, Helena F. Florindo, Shlomi Lazar, Lorenzo Albertazzi, Roey J. Amir, Ronit Satchi-Fainaro
Published in: Science Advances, Issue 10, 2024, ISSN 2375-2548
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.adr4762

Sulfonated Amphiphilic Poly(α)glutamate Amine—A Potential siRNA Nanocarrier for the Treatment of Both Chemo-Sensitive and Chemo-Resistant Glioblastoma Tumors

Author(s): Adva Krivitsky, Sabina Pozzi, Eilam Yeini, Sahar Israeli Dangoor, Tal Zur, Sapir Golan, Vadim Krivitsky, Nitzan Albeck, Evgeny Pisarevsky, Paula Ofek, Asaf Madi, Ronit Satchi-Fainaro
Published in: Pharmaceutics, Issue 13, 2024, Page(s) 2199, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13122199

Polyglutamate-based nanoconjugates for image-guided surgery and post-operative melanoma metastases prevention

Author(s): Yana Epshtein, Rachel Blau, Evgeni Pisarevsky, Shani Koshrovski-Michael, Dikla Ben-Shushan, Sabina Pozzi, Gal Shenbach-Koltin, Lidar Fridrich, Marina Buzhor, Adva Krivitsky, Pradip Dey, Ronit Satchi-Fainaro
Published in: Theranostics, Issue 12, 2022, Page(s) 6339-6362, ISSN 1838-7640
Publisher: Ivyspring International Publisher
DOI: 10.7150/thno.72941

Proteogenomics of glioblastoma associates molecular patterns with survival

Author(s): Gali Yanovich-Arad, Paula Ofek, Eilam Yeini, Mariya Mardamshina, Artem Danilevsky, Noam Shomron, Rachel Grossman, Ronit Satchi-Fainaro, Tamar Geiger
Published in: Cell Reports, Issue 34, 2022, Page(s) 108787, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.108787

Polyoxazoline‐Based Nanovaccine Synergizes with Tumor‐Associated Macrophage Targeting and Anti‐PD‐1 Immunotherapy against Solid Tumors

Author(s): Ana I. Matos, Carina Peres, Barbara Carreira, Liane I. F. Moura, Rita C. Acúrcio, Theresa Vogel, Erik Wegener, Filipa Ribeiro, Marta B. Afonso, Fábio M. F. Santos, Águeda Martínez‐Barriocanal, Diego Arango, Ana S. Viana, Pedro M. P. Góis, Liana C. Silva, Cecília M. P. Rodrigues, Luis Graca, Rainer Jordan, Ronit Satchi‐Fainaro, Helena F. Florindo
Published in: Advanced Science, Issue 10, 2023, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202300299

Meet me halfway: Are in vitro 3D cancer models on the way to replace in vivo models for nanomedicine development?

Author(s): Sabina Pozzi, Anna Scomparin, Sahar Israeli Dangoor, Daniel Rodriguez Ajamil, Paula Ofek, Lena Neufeld, Adva Krivitsky, Daniella Vaskovich-Koubi, Ron Kleiner, Pradip Dey, Shani Koshrovski-Michael, Noa Reisman, Ronit Satchi-Fainaro
Published in: Advanced Drug Delivery Reviews, Issue 175, 2021, Page(s) 113760, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2021.04.001

3D bioprinted cancer models: from basic biology to drug development

Author(s): Lena Neufeld, Eilam Yeini, Sabina Pozzi, Ronit Satchi-Fainaro
Published in: Nature Reviews Cancer, Issue 22, 2022, Page(s) 679-692, ISSN 1474-175X
Publisher: Nature Publishing Group
DOI: 10.1038/s41568-022-00514-w

Chemiluminescent probes in cancer biology

Author(s): Rachel Blau, Omri Shelef, Doron Shabat, Ronit Satchi-Fainaro
Published in: Nature Reviews Bioengineering, Issue 1, 2023, Page(s) 648-664, ISSN 2731-6092
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s44222-023-00074-0

CCL2 blockade combined with PD-1/P-selectin immunomodulators impedes breast cancer brain metastasis

Author(s): Sahar Israeli Dangoor, Rami Khoury, Koren Salomon, Sabina Pozzi, Shir Shahar, Adan Miari, Yael Leichtmann-Bardoogo, Neta Bar-Hai, Neta Frommer, Eilam Yeini, Tom Winkler, Nora Balint Lahat, Iris Kamer, Ori Hadad, Kathrin Laue, Henry Brem, Thomas M Hyde, Jair Bar, Iris Barshack, Uri Ben-David, Dana Ishay-Ronen, Ben M Maoz, Ronit Satchi-Fainaro
Published in: Brain, Issue 148, 2025, Page(s) 1740-1756, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awae347

Better, Faster, Stronger: Accelerating <scp>mRNA</scp>‐Based Immunotherapies With Nanocarriers

Author(s): Henrique M. B. Carvalho, Tiago A. S. Fidalgo, Rita C. Acúrcio, Ana I. Matos, Ronit Satchi‐Fainaro, Helena F. Florindo
Published in: WIREs Nanomedicine and Nanobiotechnology, Issue 16, 2025, ISSN 1939-0041
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/wnan.2017

Intranasal Multiepitope PD‐L1‐siRNA‐Based Nanovaccine: The Next‐Gen COVID‐19 Immunotherapy

Author(s): Rita C. Acúrcio, Ron Kleiner, Daniella Vaskovich‐Koubi, Bárbara Carreira, Yulia Liubomirski, Carolina Palma, Adva Yeheskel, Eilam Yeini, Ana S. Viana, Vera Ferreira, Carlos Araújo, Michael Mor, Natalia T. Freund, Eran Bacharach, João Gonçalves, Mira Toister‐Achituv, Manon Fabregue, Solene Matthieu, Capucine Guerry, Ana Zarubica, Sarit Aviel‐Ronen, Helena F. Florindo, Ronit Satchi‐Fain
Published in: Advanced Science, Issue 11, 2024, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202404159

Microengineered perfusable 3D-bioprinted glioblastoma model for in vivo mimicry of tumor microenvironment

Author(s): Lena Neufeld, Eilam Yeini, Noa Reisman, Yael Shtilerman, Dikla Ben-Shushan, Sabina Pozzi, Asaf Madi, Galia Tiram, Anat Eldar-Boock, Shiran Ferber, Rachel Grossman, Zvi Ram, Ronit Satchi-Fainaro
Published in: Science Advances, Issue 7/34, 2021, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.abi9119

Nanomedicines as Multifunctional Modulators of Melanoma Immune Microenvironment

Author(s): Barbara Carreira, Rita C. Acúrcio, Ana I. Matos, Carina Peres, Sabina Pozzi, Daniella Vaskovich‐Koubi, Ron Kleiner, Mariana Bento, Ronit Satchi‐Fainaro, Helena F. Florindo
Published in: Advanced Therapeutics, Issue 4, 2024, ISSN 2366-3987
Publisher: Wiley
DOI: 10.1002/adtp.202000147

Microengineered perfusable 3D-bioprinted glioblastoma model for in vivo mimicry of tumor microenvironment

Author(s): Lena Neufeld, Eilam Yeini, Noa Reisman, Yael Shtilerman, Dikla Ben-Shushan, Sabina Pozzi, Asaf Madi, Galia Tiram, Anat Eldar-Boock, Shiran Ferber, Rachel Grossman, Zvi Ram, Ronit Satchi-Fainaro
Published in: Science Advances, Issue 7, 2024, ISSN 2375-2548
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.abi9119

P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression

Author(s): Eilam Yeini, Paula Ofek, Sabina Pozzi, Nitzan Albeck, Dikla Ben-Shushan, Galia Tiram, Sapir Golan, Ron Kleiner, Ron Sheinin, Sahar Israeli Dangoor, Shlomit Reich-Zeliger, Rachel Grossman, Zvi Ram, Henry Brem, Thomas M. Hyde, Prerna Magod, Dinorah Friedmann-Morvinski, Asaf Madi, Ronit Satchi-Fainaro
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-22186-0

Thymidine Phosphodiester Chemiluminescent Probe for Sensitive and Selective Detection of Ectonucleotide Pyrophosphatase 1

Author(s): Omri Shelef, Sara Gutkin, Molhm Nassir, Anne Krinsky, Ronit Satchi-Fainaro, Phil S. Baran, Doron Shabat
Published in: Bioconjugate Chemistry, Issue 36, 2025, Page(s) 152-159, ISSN 1043-1802
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.4c00454

MCP-1/CCR2 axis inhibition sensitizes the brain microenvironment against melanoma brain metastasis progression

Author(s): Sabina Pozzi, Anna Scomparin, Dikla Ben-Shushan, Eilam Yeini, Paula Ofek, Alessio D. Nahmad, Shelly Soffer, Ariel Ionescu, Antonella Ruggiero, Adi Barzel, Henry Brem, Thomas M. Hyde, Iris Barshack, Sanju Sinha, Eytan Ruppin, Tomer Weiss, Asaf Madi, Eran Perlson, Inna Slutsky, Helena F. Florindo, Ronit Satchi-Fainaro
Published in: JCI Insight, Issue 7, 2023, ISSN 2379-3708
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.154804