Predicting Routes Of Tumour Evolution driven by Unstable genomes and Selection

Informazioni relative al progetto

PROTEUS

ID dell’accordo di sovvenzione: 835297

DOI

10.3030/835297

Progetto chiuso

Data della firma CE 14 Maggio 2019

Data di avvio 1 Giugno 2019

Data di completamento 30 Novembre 2024

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 500 000,00

Contributo UE

€ 2 500 000,00

Coordinato da

THE FRANCIS CRICK INSTITUTE LIMITED
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (14)

Representation of genomic intratumor heterogeneity in multi-region non-small cell lung cancer patient-derived xenograft models

Autori: Robert E. Hynds, Ariana Huebner, David R. Pearce, Mark S. Hill, Ayse U. Akarca, David A. Moore, Sophia Ward, Kate H. C. Gowers, Takahiro Karasaki, Maise Al Bakir, Gareth A. Wilson, Oriol Pich, Carlos Martínez-Ruiz, A. S. Md Mukarram Hossain, Simon P. Pearce, Monica Sivakumar, Assma Ben Aissa, Eva Grönroos, Deepak Chandrasekharan, Krishna K. Kolluri, Rebecca Towns, Kaiwen Wang, Daniel E. Cook, Le
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-47547-3

TRACERx analysis identifies a role for FAT1 in regulating chromosomal instability and whole-genome doubling via Hippo signalling

Autori: Wei-Ting Lu, Lykourgos-Panagiotis Zalmas, Chris Bailey, James R. M. Black, Carlos Martinez-Ruiz, Oriol Pich, Francisco Gimeno-Valiente, Ieva Usaite, Alastair Magness, Kerstin Thol, Thomas A. Webber, Ming Jiang, Rebecca E. Saunders, Yun-Hsin Liu, Dhruva Biswas, Esther O. Ige, Birgit Aerne, Eva Grönroos, Subramanian Venkatesan, Georgia Stavrou, Takahiro Karasaki, Maise Al Bakir, Matthew Renshaw, Ha
Pubblicato in: Nature Cell Biology, Numero 27, 2025, Pagina/e 154-168, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/s41556-024-01558-w

Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution

Autori: Subramanian Venkatesan, Mihaela Angelova, Clare Puttick, Haoran Zhai, Deborah R. Caswell, Wei-Ting Lu, Michelle Dietzen, Panagiotis Galanos, Konstantinos Evangelou, Roberto Bellelli, Emilia L. Lim, Thomas B.K. Watkins, Andrew Rowan, Vitor H. Teixeira, Yue Zhao, Haiquan Chen, Bryan Ngo, Lykourgos-Panagiotis Zalmas, Maise Al Bakir, Sebastijan Hobor, Eva Grönroos, Adam Pennycuick, Ersilia Nigro, Bri
Pubblicato in: Cancer Discovery, 2020, ISSN 2159-8274
Editore: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-20-0725

Pervasive chromosomal instability and karyotype order in tumour evolution

Autori: Thomas B. K. Watkins, Emilia L. Lim, Marina Petkovic, Sergi Elizalde, Nicolai J. Birkbak, Gareth A. Wilson, David A. Moore, Eva Grönroos, Andrew Rowan, Sally M. Dewhurst, Jonas Demeulemeester, Stefan C. Dentro, Stuart Horswell, Lewis Au, Kerstin Haase, Mickael Escudero, Rachel Rosenthal, Maise Al Bakir, Hang Xu, Kevin Litchfield, Wei Ting Lu, Thanos P. Mourikis, Michelle Dietzen, Lavinia Spain, G
Pubblicato in: Nature, 2020, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-020-2698-6

The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance

Autori: Deborah R. Caswell, Philippe Gui, Manasi K. Mayekar, Emily K. Law, Oriol Pich, Chris Bailey, Jesse Boumelha, D. Lucas Kerr, Collin M. Blakely, Tadashi Manabe, Carlos Martinez-Ruiz, Bjorn Bakker, Juan De Dios Palomino Villcas, Natalie I. Vokes, Michelle Dietzen, Mihaela Angelova, Beatrice Gini, Whitney Tamaki, Paul Allegakoen, Wei Wu, Timothy J. Humpton, William Hill, Mona Tomaschko, Wei-Ting Lu, F
Pubblicato in: Nature Genetics, Numero 56, 2024, Pagina/e 60-73, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-023-01592-8

Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling

Autori: Sebastijan Hobor, Maise Al Bakir, Crispin T. Hiley, Marcin Skrzypski, Alexander M. Frankell, Bjorn Bakker, Thomas B. K. Watkins, Aleksandra Markovets, Jonathan R. Dry, Andrew P. Brown, Jasper van der Aart, Hilda van den Bos, Diana Spierings, Dahmane Oukrif, Marco Novelli, Turja Chakrabarti, Adam H. Rabinowitz, Laila Ait Hassou, Saskia Litière, D. Lucas Kerr, Lisa Tan, Gavin Kelly, David A. Moore,
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-47606-9

Impact of risk factors on early cancer evolution

Autori: Clare E. Weeden, William Hill, Emilia L. Lim, Eva Grönroos, Charles Swanton
Pubblicato in: Cell, 2023, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2023.03.013

Lung adenocarcinoma promotion by air pollutants

Autori: William Hill, Emilia L Lim, Clare E Weeden, Claudia Lee, Marcellus Augustine, Kezhong Chen, Feng-Che Kuan, Fabio Marongiu, Edward J Evans Jr, David A Moore, Felipe S Rodrigues, Oriol Pich, Bjorn Bakker, Hongui Cha, Renelle Myers, Febe van Maldegem, Jesse Boumelha, Selvaraju Veeriah, Andrew Rowan, Cristina Naceur-Lombardelli, Takahiro Karasaki, Monica Sivakumar, Swapnanil De, Deborah R Caswell, Ai
Pubblicato in: Nature, 2023, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-023-05874-3

A functional taxonomy of tumor suppression in oncogenic KRAS-driven lung cancer

Autori: Hongchen Cai; Su Kit Chew; Chuan Li; Min K. Tsai; Laura Andrejka; Christopher W. Murray; Nicholas W. Hughes; Emily G. Shuldiner; Emily L. Ashkin; Rui Tang; King L. Hung; Leo C Chen; Shi Ya C. Lee; Maryam Yousefi; Wen-Yang Lin; Christian A. Kunder; Le Cong; Christopher D. McFarland; Dmitri A. Petrov; Charles Swanton; Monte M. Winslow
Pubblicato in: Cancer Discovery, vol 11, iss 7, Numero 1, 2021, Pagina/e 1754–1773, ISSN 2159-8290
Editore: AACR
DOI: 10.1158/2159-8290.cd-20-1325

Combinatorial Inactivation of Tumor Suppressors Efficiently Initiates Lung Adenocarcinoma with Therapeutic Vulnerabilities

Autori: Maryam Yousefi, Gábor Boross, Carly Weiss, Christopher W. Murray, Jess D. Hebert, Hongchen Cai, Emily L. Ashkin, Saswati Karmakar, Laura Andrejka, Leo Chen, Minwei Wang, Min K. Tsai, Wen-Yang Lin, Chuan Li, Pegah Yakhchalian, Caterina I. Colón, Su-Kit Chew, Pauline Chu, Charles Swanton, Christian A. Kunder, Dmitri A. Petrov, Monte M. Winslow
Pubblicato in: Cancer Research, Numero 82, 2022, Pagina/e 1589-1602, ISSN 0008-5472
Editore: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-22-0059

CKS1 inhibition depletes leukemic stem cells and protects healthy hematopoietic stem cells in acute myeloid leukemia

Autori: William Grey, Ana Rio-Machin, Pedro Casado, Eva Grönroos, Sara Ali, Juho J. Miettinen, Findlay Bewicke-Copley, Alun Parsons, Caroline A. Heckman, Charles Swanton, Pedro R. Cutillas, John Gribben, Jude Fitzgibbon, Dominique Bonnet
Pubblicato in: Science Translational Medicine, Numero 14, 2024, ISSN 1946-6234
Editore: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abn3248

ALDH1L2 regulation of formate, formyl-methionine, and ROS controls cancer cell migration and metastasis

Autori: Marc Hennequart; Steven E. Pilley; Christiaan F. Labuschagne; Jack Coomes; Loic Mervant; Paul C. Driscoll; Nathalie M. Legrave; Younghwan Lee; Peter Kreuzaler; Benedict Macintyre; Yulia Panina; Julianna Blagih; David Stevenson; Douglas Strathdee; Deborah Schneider-Luftman; Eva Grönroos; Eric C. Cheung; Mariia Yuneva; Charles Swanton; Karen H. Vousden
Pubblicato in: Crossref, Numero 3, 2023, Pagina/e 1-18, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2023.112562

Progress towards non-small-cell lung cancer models that represent clinical evolutionary trajectories

Autori: Robert E. Hynds, Kristopher K. Frese, David R. Pearce, Eva Grönroos, Caroline Dive, Charles Swanton
Pubblicato in: Open Biology, 2021, ISSN 2046-2441
Editore: Royal Society Publishing
DOI: 10.1098/rsob.200247

Kinome profiling reveals pathogenic variant specific protein signalling networks in MEN2 children with Medullary Thyroid Cancer

Autori: B. Rix, R. Chauhan, Z. Masoumi, E. Grönroos, C. E. Brain, O. K. Ogunbiyi, K. Swarbrick, C. Swanton, D. Bonnet, T. R. Kurzawinski, L. Izatt, N. Q. McDonald, W. Grey
Pubblicato in: npj Precision Oncology, Numero 9, 2025, ISSN 2397-768X
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41698-025-00919-4