Predicting Routes Of Tumour Evolution driven by Unstable genomes and Selection

Información del proyecto

PROTEUS

Identificador del acuerdo de subvención: 835297

DOI

10.3030/835297

Proyecto cerrado

Fecha de la firma de la CE 14 Mayo 2019

Fecha de inicio 1 Junio 2019

Fecha de finalización 30 Noviembre 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 500 000,00

Aportación de la UE

€ 2 500 000,00

Coordinado por

THE FRANCIS CRICK INSTITUTE LIMITED
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (14)

Representation of genomic intratumor heterogeneity in multi-region non-small cell lung cancer patient-derived xenograft models

Autores: Robert E. Hynds, Ariana Huebner, David R. Pearce, Mark S. Hill, Ayse U. Akarca, David A. Moore, Sophia Ward, Kate H. C. Gowers, Takahiro Karasaki, Maise Al Bakir, Gareth A. Wilson, Oriol Pich, Carlos Martínez-Ruiz, A. S. Md Mukarram Hossain, Simon P. Pearce, Monica Sivakumar, Assma Ben Aissa, Eva Grönroos, Deepak Chandrasekharan, Krishna K. Kolluri, Rebecca Towns, Kaiwen Wang, Daniel E. Cook, Le
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-47547-3

TRACERx analysis identifies a role for FAT1 in regulating chromosomal instability and whole-genome doubling via Hippo signalling

Autores: Wei-Ting Lu, Lykourgos-Panagiotis Zalmas, Chris Bailey, James R. M. Black, Carlos Martinez-Ruiz, Oriol Pich, Francisco Gimeno-Valiente, Ieva Usaite, Alastair Magness, Kerstin Thol, Thomas A. Webber, Ming Jiang, Rebecca E. Saunders, Yun-Hsin Liu, Dhruva Biswas, Esther O. Ige, Birgit Aerne, Eva Grönroos, Subramanian Venkatesan, Georgia Stavrou, Takahiro Karasaki, Maise Al Bakir, Matthew Renshaw, Ha
Publicado en: Nature Cell Biology, Edición 27, 2025, Página(s) 154-168, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/s41556-024-01558-w

Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution

Autores: Subramanian Venkatesan, Mihaela Angelova, Clare Puttick, Haoran Zhai, Deborah R. Caswell, Wei-Ting Lu, Michelle Dietzen, Panagiotis Galanos, Konstantinos Evangelou, Roberto Bellelli, Emilia L. Lim, Thomas B.K. Watkins, Andrew Rowan, Vitor H. Teixeira, Yue Zhao, Haiquan Chen, Bryan Ngo, Lykourgos-Panagiotis Zalmas, Maise Al Bakir, Sebastijan Hobor, Eva Grönroos, Adam Pennycuick, Ersilia Nigro, Bri
Publicado en: Cancer Discovery, 2020, ISSN 2159-8274
Editor: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-20-0725

Pervasive chromosomal instability and karyotype order in tumour evolution

Autores: Thomas B. K. Watkins, Emilia L. Lim, Marina Petkovic, Sergi Elizalde, Nicolai J. Birkbak, Gareth A. Wilson, David A. Moore, Eva Grönroos, Andrew Rowan, Sally M. Dewhurst, Jonas Demeulemeester, Stefan C. Dentro, Stuart Horswell, Lewis Au, Kerstin Haase, Mickael Escudero, Rachel Rosenthal, Maise Al Bakir, Hang Xu, Kevin Litchfield, Wei Ting Lu, Thanos P. Mourikis, Michelle Dietzen, Lavinia Spain, G
Publicado en: Nature, 2020, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-020-2698-6

The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance

Autores: Deborah R. Caswell, Philippe Gui, Manasi K. Mayekar, Emily K. Law, Oriol Pich, Chris Bailey, Jesse Boumelha, D. Lucas Kerr, Collin M. Blakely, Tadashi Manabe, Carlos Martinez-Ruiz, Bjorn Bakker, Juan De Dios Palomino Villcas, Natalie I. Vokes, Michelle Dietzen, Mihaela Angelova, Beatrice Gini, Whitney Tamaki, Paul Allegakoen, Wei Wu, Timothy J. Humpton, William Hill, Mona Tomaschko, Wei-Ting Lu, F
Publicado en: Nature Genetics, Edición 56, 2024, Página(s) 60-73, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/s41588-023-01592-8

Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling

Autores: Sebastijan Hobor, Maise Al Bakir, Crispin T. Hiley, Marcin Skrzypski, Alexander M. Frankell, Bjorn Bakker, Thomas B. K. Watkins, Aleksandra Markovets, Jonathan R. Dry, Andrew P. Brown, Jasper van der Aart, Hilda van den Bos, Diana Spierings, Dahmane Oukrif, Marco Novelli, Turja Chakrabarti, Adam H. Rabinowitz, Laila Ait Hassou, Saskia Litière, D. Lucas Kerr, Lisa Tan, Gavin Kelly, David A. Moore,
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-47606-9

Impact of risk factors on early cancer evolution

Autores: Clare E. Weeden, William Hill, Emilia L. Lim, Eva Grönroos, Charles Swanton
Publicado en: Cell, 2023, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2023.03.013

Lung adenocarcinoma promotion by air pollutants

Autores: William Hill, Emilia L Lim, Clare E Weeden, Claudia Lee, Marcellus Augustine, Kezhong Chen, Feng-Che Kuan, Fabio Marongiu, Edward J Evans Jr, David A Moore, Felipe S Rodrigues, Oriol Pich, Bjorn Bakker, Hongui Cha, Renelle Myers, Febe van Maldegem, Jesse Boumelha, Selvaraju Veeriah, Andrew Rowan, Cristina Naceur-Lombardelli, Takahiro Karasaki, Monica Sivakumar, Swapnanil De, Deborah R Caswell, Ai
Publicado en: Nature, 2023, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-023-05874-3

A functional taxonomy of tumor suppression in oncogenic KRAS-driven lung cancer

Autores: Hongchen Cai; Su Kit Chew; Chuan Li; Min K. Tsai; Laura Andrejka; Christopher W. Murray; Nicholas W. Hughes; Emily G. Shuldiner; Emily L. Ashkin; Rui Tang; King L. Hung; Leo C Chen; Shi Ya C. Lee; Maryam Yousefi; Wen-Yang Lin; Christian A. Kunder; Le Cong; Christopher D. McFarland; Dmitri A. Petrov; Charles Swanton; Monte M. Winslow
Publicado en: Cancer Discovery, vol 11, iss 7, Edición 1, 2021, Página(s) 1754–1773, ISSN 2159-8290
Editor: AACR
DOI: 10.1158/2159-8290.cd-20-1325

Combinatorial Inactivation of Tumor Suppressors Efficiently Initiates Lung Adenocarcinoma with Therapeutic Vulnerabilities

Autores: Maryam Yousefi, Gábor Boross, Carly Weiss, Christopher W. Murray, Jess D. Hebert, Hongchen Cai, Emily L. Ashkin, Saswati Karmakar, Laura Andrejka, Leo Chen, Minwei Wang, Min K. Tsai, Wen-Yang Lin, Chuan Li, Pegah Yakhchalian, Caterina I. Colón, Su-Kit Chew, Pauline Chu, Charles Swanton, Christian A. Kunder, Dmitri A. Petrov, Monte M. Winslow
Publicado en: Cancer Research, Edición 82, 2022, Página(s) 1589-1602, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-22-0059

CKS1 inhibition depletes leukemic stem cells and protects healthy hematopoietic stem cells in acute myeloid leukemia

Autores: William Grey, Ana Rio-Machin, Pedro Casado, Eva Grönroos, Sara Ali, Juho J. Miettinen, Findlay Bewicke-Copley, Alun Parsons, Caroline A. Heckman, Charles Swanton, Pedro R. Cutillas, John Gribben, Jude Fitzgibbon, Dominique Bonnet
Publicado en: Science Translational Medicine, Edición 14, 2024, ISSN 1946-6234
Editor: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abn3248

ALDH1L2 regulation of formate, formyl-methionine, and ROS controls cancer cell migration and metastasis

Autores: Marc Hennequart; Steven E. Pilley; Christiaan F. Labuschagne; Jack Coomes; Loic Mervant; Paul C. Driscoll; Nathalie M. Legrave; Younghwan Lee; Peter Kreuzaler; Benedict Macintyre; Yulia Panina; Julianna Blagih; David Stevenson; Douglas Strathdee; Deborah Schneider-Luftman; Eva Grönroos; Eric C. Cheung; Mariia Yuneva; Charles Swanton; Karen H. Vousden
Publicado en: Crossref, Edición 3, 2023, Página(s) 1-18, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2023.112562

Progress towards non-small-cell lung cancer models that represent clinical evolutionary trajectories

Autores: Robert E. Hynds, Kristopher K. Frese, David R. Pearce, Eva Grönroos, Caroline Dive, Charles Swanton
Publicado en: Open Biology, 2021, ISSN 2046-2441
Editor: Royal Society Publishing
DOI: 10.1098/rsob.200247

Kinome profiling reveals pathogenic variant specific protein signalling networks in MEN2 children with Medullary Thyroid Cancer

Autores: B. Rix, R. Chauhan, Z. Masoumi, E. Grönroos, C. E. Brain, O. K. Ogunbiyi, K. Swarbrick, C. Swanton, D. Bonnet, T. R. Kurzawinski, L. Izatt, N. Q. McDonald, W. Grey
Publicado en: npj Precision Oncology, Edición 9, 2025, ISSN 2397-768X
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41698-025-00919-4