Predicting Routes Of Tumour Evolution driven by Unstable genomes and Selection

Project Information

PROTEUS

Grant agreement ID: 835297

DOI

10.3030/835297

Project closed

EC signature date 14 May 2019

Start date 1 June 2019

End date 30 November 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

THE FRANCIS CRICK INSTITUTE LIMITED
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (14)

Representation of genomic intratumor heterogeneity in multi-region non-small cell lung cancer patient-derived xenograft models

Author(s): Robert E. Hynds, Ariana Huebner, David R. Pearce, Mark S. Hill, Ayse U. Akarca, David A. Moore, Sophia Ward, Kate H. C. Gowers, Takahiro Karasaki, Maise Al Bakir, Gareth A. Wilson, Oriol Pich, Carlos Martínez-Ruiz, A. S. Md Mukarram Hossain, Simon P. Pearce, Monica Sivakumar, Assma Ben Aissa, Eva Grönroos, Deepak Chandrasekharan, Krishna K. Kolluri, Rebecca Towns, Kaiwen Wang, Daniel E. Cook, Le
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-47547-3

TRACERx analysis identifies a role for FAT1 in regulating chromosomal instability and whole-genome doubling via Hippo signalling

Author(s): Wei-Ting Lu, Lykourgos-Panagiotis Zalmas, Chris Bailey, James R. M. Black, Carlos Martinez-Ruiz, Oriol Pich, Francisco Gimeno-Valiente, Ieva Usaite, Alastair Magness, Kerstin Thol, Thomas A. Webber, Ming Jiang, Rebecca E. Saunders, Yun-Hsin Liu, Dhruva Biswas, Esther O. Ige, Birgit Aerne, Eva Grönroos, Subramanian Venkatesan, Georgia Stavrou, Takahiro Karasaki, Maise Al Bakir, Matthew Renshaw, Ha
Published in: Nature Cell Biology, Issue 27, 2025, Page(s) 154-168, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-024-01558-w

Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution

Author(s): Subramanian Venkatesan, Mihaela Angelova, Clare Puttick, Haoran Zhai, Deborah R. Caswell, Wei-Ting Lu, Michelle Dietzen, Panagiotis Galanos, Konstantinos Evangelou, Roberto Bellelli, Emilia L. Lim, Thomas B.K. Watkins, Andrew Rowan, Vitor H. Teixeira, Yue Zhao, Haiquan Chen, Bryan Ngo, Lykourgos-Panagiotis Zalmas, Maise Al Bakir, Sebastijan Hobor, Eva Grönroos, Adam Pennycuick, Ersilia Nigro, Bri
Published in: Cancer Discovery, 2020, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-20-0725

Pervasive chromosomal instability and karyotype order in tumour evolution

Author(s): Thomas B. K. Watkins, Emilia L. Lim, Marina Petkovic, Sergi Elizalde, Nicolai J. Birkbak, Gareth A. Wilson, David A. Moore, Eva Grönroos, Andrew Rowan, Sally M. Dewhurst, Jonas Demeulemeester, Stefan C. Dentro, Stuart Horswell, Lewis Au, Kerstin Haase, Mickael Escudero, Rachel Rosenthal, Maise Al Bakir, Hang Xu, Kevin Litchfield, Wei Ting Lu, Thanos P. Mourikis, Michelle Dietzen, Lavinia Spain, G
Published in: Nature, 2020, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2698-6

The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance

Author(s): Deborah R. Caswell, Philippe Gui, Manasi K. Mayekar, Emily K. Law, Oriol Pich, Chris Bailey, Jesse Boumelha, D. Lucas Kerr, Collin M. Blakely, Tadashi Manabe, Carlos Martinez-Ruiz, Bjorn Bakker, Juan De Dios Palomino Villcas, Natalie I. Vokes, Michelle Dietzen, Mihaela Angelova, Beatrice Gini, Whitney Tamaki, Paul Allegakoen, Wei Wu, Timothy J. Humpton, William Hill, Mona Tomaschko, Wei-Ting Lu, F
Published in: Nature Genetics, Issue 56, 2024, Page(s) 60-73, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-023-01592-8

Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling

Author(s): Sebastijan Hobor, Maise Al Bakir, Crispin T. Hiley, Marcin Skrzypski, Alexander M. Frankell, Bjorn Bakker, Thomas B. K. Watkins, Aleksandra Markovets, Jonathan R. Dry, Andrew P. Brown, Jasper van der Aart, Hilda van den Bos, Diana Spierings, Dahmane Oukrif, Marco Novelli, Turja Chakrabarti, Adam H. Rabinowitz, Laila Ait Hassou, Saskia Litière, D. Lucas Kerr, Lisa Tan, Gavin Kelly, David A. Moore,
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-47606-9

Impact of risk factors on early cancer evolution

Author(s): Clare E. Weeden, William Hill, Emilia L. Lim, Eva Grönroos, Charles Swanton
Published in: Cell, 2023, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2023.03.013

Lung adenocarcinoma promotion by air pollutants

Author(s): William Hill, Emilia L Lim, Clare E Weeden, Claudia Lee, Marcellus Augustine, Kezhong Chen, Feng-Che Kuan, Fabio Marongiu, Edward J Evans Jr, David A Moore, Felipe S Rodrigues, Oriol Pich, Bjorn Bakker, Hongui Cha, Renelle Myers, Febe van Maldegem, Jesse Boumelha, Selvaraju Veeriah, Andrew Rowan, Cristina Naceur-Lombardelli, Takahiro Karasaki, Monica Sivakumar, Swapnanil De, Deborah R Caswell, Ai
Published in: Nature, 2023, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-023-05874-3

A functional taxonomy of tumor suppression in oncogenic KRAS-driven lung cancer

Author(s): Hongchen Cai; Su Kit Chew; Chuan Li; Min K. Tsai; Laura Andrejka; Christopher W. Murray; Nicholas W. Hughes; Emily G. Shuldiner; Emily L. Ashkin; Rui Tang; King L. Hung; Leo C Chen; Shi Ya C. Lee; Maryam Yousefi; Wen-Yang Lin; Christian A. Kunder; Le Cong; Christopher D. McFarland; Dmitri A. Petrov; Charles Swanton; Monte M. Winslow
Published in: Cancer Discovery, vol 11, iss 7, Issue 1, 2021, Page(s) 1754–1773, ISSN 2159-8290
Publisher: AACR
DOI: 10.1158/2159-8290.cd-20-1325

Combinatorial Inactivation of Tumor Suppressors Efficiently Initiates Lung Adenocarcinoma with Therapeutic Vulnerabilities

Author(s): Maryam Yousefi, Gábor Boross, Carly Weiss, Christopher W. Murray, Jess D. Hebert, Hongchen Cai, Emily L. Ashkin, Saswati Karmakar, Laura Andrejka, Leo Chen, Minwei Wang, Min K. Tsai, Wen-Yang Lin, Chuan Li, Pegah Yakhchalian, Caterina I. Colón, Su-Kit Chew, Pauline Chu, Charles Swanton, Christian A. Kunder, Dmitri A. Petrov, Monte M. Winslow
Published in: Cancer Research, Issue 82, 2022, Page(s) 1589-1602, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-22-0059

CKS1 inhibition depletes leukemic stem cells and protects healthy hematopoietic stem cells in acute myeloid leukemia

Author(s): William Grey, Ana Rio-Machin, Pedro Casado, Eva Grönroos, Sara Ali, Juho J. Miettinen, Findlay Bewicke-Copley, Alun Parsons, Caroline A. Heckman, Charles Swanton, Pedro R. Cutillas, John Gribben, Jude Fitzgibbon, Dominique Bonnet
Published in: Science Translational Medicine, Issue 14, 2024, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abn3248

ALDH1L2 regulation of formate, formyl-methionine, and ROS controls cancer cell migration and metastasis

Author(s): Marc Hennequart; Steven E. Pilley; Christiaan F. Labuschagne; Jack Coomes; Loic Mervant; Paul C. Driscoll; Nathalie M. Legrave; Younghwan Lee; Peter Kreuzaler; Benedict Macintyre; Yulia Panina; Julianna Blagih; David Stevenson; Douglas Strathdee; Deborah Schneider-Luftman; Eva Grönroos; Eric C. Cheung; Mariia Yuneva; Charles Swanton; Karen H. Vousden
Published in: Crossref, Issue 3, 2023, Page(s) 1-18, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2023.112562

Progress towards non-small-cell lung cancer models that represent clinical evolutionary trajectories

Author(s): Robert E. Hynds, Kristopher K. Frese, David R. Pearce, Eva Grönroos, Caroline Dive, Charles Swanton
Published in: Open Biology, 2021, ISSN 2046-2441
Publisher: Royal Society Publishing
DOI: 10.1098/rsob.200247

Kinome profiling reveals pathogenic variant specific protein signalling networks in MEN2 children with Medullary Thyroid Cancer

Author(s): B. Rix, R. Chauhan, Z. Masoumi, E. Grönroos, C. E. Brain, O. K. Ogunbiyi, K. Swarbrick, C. Swanton, D. Bonnet, T. R. Kurzawinski, L. Izatt, N. Q. McDonald, W. Grey
Published in: npj Precision Oncology, Issue 9, 2025, ISSN 2397-768X
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41698-025-00919-4