Predicting comorbid cardiovascular disease in individuals with mental disorder by decoding disease mechanisms

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Quality Management Plan
Genotyped (chipped) and long range phased Nordic citizens

Genotyped chippeed and long range phased more than one million Nordic citizens M18

Report on dissemination towards industry
Identify interplay between rare and common variants associated with CVD comorbidity in mental illness
Identified rare gene risk variants associated with mental disorders and comorbid CVD
Innovation Management Plan
Report overlap of CVD-mental illness risk genes with body fatty tissue age
Protocols for distributed data analyses

Protocols for distributed data analyses in compliance with ethical, privacy, and GDPR regulations, with scalable technology.

Define non-inherited factors of lifestyle and behaviour
Genes, common/rare variants and pathways/networks associated with CVD-related side effects of antipsychotics/SSRIs

Genes, common/rare variants and pathways/networks associated with CVD-related side effects of antipsychotics/SSRIs.This is a combination of the two deliverables from the original proposal:D5.3 Genes and common/rare variants associated with CVD-related side effects of antipsychotics/SSRIsD5.4 Pathways/networks associated with CVD-related side effects of antipsychotics/SSRIsSince they were similar in scope they were merged in agreement with the Project Officer.

Analysis of a) medication influence and genetic influenc

Analysis of a) medication influence on CVD trajectories for mental disorder patients and b) genetic influence on trajectories in mental disorders and CVD

Report on scientific outreach activities and public outreach activities - M12

Report on scientific outreach activities and public outreach activities. Including information on CoMorMent 6-monthly newsletters.

Validation of stratification tools in re-phenotyped samples

Validation of stratification tools in re-phenotyped samples. A brief description of the achievement.

Report on scientific outreach activities and public outreach activities - M24

Report on scientific outreach activities and public outreach activitiesIncluding information on CoMorMent 6monthly newsletters

Report pharmaceutical targets
IP/Knowledge Management Plan
Dissemination, Exploitation and Communication Plan

Dissemination, Exploitation and Communication Plan and yearly updates. Including a description of CoMorMent website and Social Media channels operational.

Report overlap of CVD-mental illness risk genes with brain age and its genetic architecture

Report overlap of CVDmental illness risk genes with brain age and its genetic architecture

Report of functional mechanisms

A comprehensive report of functional mechanisms

Risk Management Plan
CoMorMent Coordination team established
Analysis of downstream trajectories

Analysis of downstream trajectories in individuals first diagnosed with a mental disorders or b CVD

Report on scientific outreach activities and public outreach activities - M48

Report on scientific outreach activities and public outreach activities - M24.Including information on CoMorMent 6-monthly newsletters.

Definition and harmonization of phenotypic and trajectories data from registries

Infrastructure for coordinated analysis of individual genotypes and phenotypes

Infrastructure for coordinated analysis of individual genotypes and phenotypes from more than one million participants

Analytical tools for imputation and large-scale genotype-phenotype analysis

State-of-the-art analytical tools for imputation and large-scale genotype-phenotype analysis

Data platform for distributed data analysis

A secure data platform for distributed data analysis, including secure computing clusters for each country.

Presentations from the workshop directed at clinical researchers
CoMorMent website and Social Media channels

The CoMorMent website is the key hub for providing detailed dissemination and communication material. The site will feature e.g. abstracts and lay summaries of scientific papers, newsletters, links to articles in popular science publications, and other material as outlined in Sections 2.2.1 and 2.2.5. CoMorMent will exploit social media for both dissemination and communication (Twitter, LinkedIn, Facebook, YouTube) purposes and to direct traffic to the project website. This task entails establishing the project website, Twitter, LinkedIn, Facebook accounts and a YouTube channel. All partners will provide material to be published. The partners will author a lay summary of the partner’s scientific articles for posting on the project website.

Data Management Plan

Tools and code openly available

Make tools and code openly available, incl. documentation for reproducibility

Annual Project Meeting - Y2

Meeting at DECODE Agenda+minutes

Final Project Meeting

Organized by UiO, in BrusselsAgenda + minutes

Annual Project Meeting - Y4

Meeting organized at REGHAgenda+minutes

Annual Project Meeting - Y3

Meeting at UTartuAgenda+minutes

Pubblicazioni

Cardiovascular-related deaths at the beginning of the COVID-19 outbreak: a prospective analysis based on the UK Biobank

Autori: Wang J, Zhu J, Yang H, Hu Y, Sun Y, Ying Z, Qu Y, Valdimarsdottir U, Fang F, Song H.
Pubblicato in: BMJ open, Numero 114;5, 2021, ISSN 2044-6055
Editore: BMJ Publishing Group
DOI: 10.1136/bmjopen-2020-046931

Mental illness and COVID-19 vaccination: a multinational investigation of observational & register-based data

Autori: Mary M. Barker, Kadri Kõiv, Ingibjörg Magnúsdóttir, Hannah Milbourn, Bin Wang, Xinkai Du, Gillian Murphy, Eva Herweijer, Elísabet U. Gísladóttir, Huiqi Li, Anikó Lovik, Anna K. Kähler, Archie Campbell, Maria Feychting, Arna Hauksdóttir, Emily E. Joyce, Edda Bjork Thordardottir, Emma M. Frans, Asle Hoffart, Reedik Mägi, Gunnar Tómasson, Kristjana Ásbjörnsdóttir, Jóhanna Jakobsdótti
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-52342-1

Characterising the shared genetic determinants of bipolar disorder, schizophrenia and risk-taking.

Autori: Guy Hindley; Guy Hindley; Shahram Bahrami; Nils Eiel Steen; Kevin S. O’Connell; Oleksandr Frei; Oleksandr Frei; Alexey A. Shadrin; Francesco Bettella; Linn Rødevand; Chun Chieh Fan; Chun Chieh Fan; Anders M. Dale; Srdjan Djurovic; Srdjan Djurovic; Olav B. Smeland; Ole A. Andreassen
Pubblicato in: Translational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021), Numero 20, 2021, ISSN 2158-3188
Editore: Nature Publishing Group
DOI: 10.1038/s41398-021-01576-4

Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality

Autori: Asmundur Oddsson, Patrick Sulem, Gardar Sveinbjornsson, Gudny A. Arnadottir, Valgerdur Steinthorsdottir, Gisli H. Halldorsson, Bjarni A. Atlason, Gudjon R. Oskarsson, Hannes Helgason, Henriette Svarre Nielsen, David Westergaard, Juha M. Karjalainen, Hildigunnur Katrinardottir, Run Fridriksdottir, Brynjar O. Jensson, Vinicius Tragante, Egil Ferkingstad, Hakon Jonsson, Sigurjon A. Gudjonsson, Doruk
Pubblicato in: Nature Communications, Numero 14, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-38951-2

Disease trajectories and mortality among individuals diagnosed with depression: a community-based cohort study in UK Biobank

Autori: Xin Han, Can Hou, Huazhen Yang, Wenwen Chen, Zhiye Ying, Yao Hu, Yajing Sun, Yuanyuan Qu, Lei Yang, Unnur A. Valdimarsdóttir, Wei Zhang, Haomin Yang, Fang Fang, Huan Song
Pubblicato in: Molecular Psychiatry, 2021, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-021-01170-6

Thirty novel sequence variants impacting human intracranial volume

Autori: Muhammad Sulaman Nawaz, Gudmundur Einarsson, Mariana Bustamante, Rosa S Gisladottir, G Bragi Walters, Gudrun A Jonsdottir, Astros Th Skuladottir, Gyda Bjornsdottir, Sigurdur H Magnusson, Bergrun Asbjornsdottir, Unnur Unnsteinsdottir, Engilbert Sigurdsson, Palmi V Jonsson, Vala Kolbrun Palmadottir, Sigurjon A Gudjonsson, Gisli H Halldorsson, Egil Ferkingstad, Ingileif Jonsdottir, Gudmar Thorleifsso
Pubblicato in: BRAIN COMMUNICATIONS, Numero Volume 4, Numero 6, 2022, Pagina/e 1 to 14, ISSN 2632-1297
Editore: Oxford academic press
DOI: 10.1093/braincomms/fcac271

Genetic Stratification of Age‐Dependent Parkinson's Disease Risk by Polygenic Hazard Score

Autori: Lasse Pihlstrøm, Chun C. Fan, Oleksandr Frei, Manuela Tan, Roshan A. Karunamuni, Cornelis Blauwendraat, Sara Bandres‐Ciga, Ziv Gan‐Or, Donald G. Grosset, null null, Anders M. Dale, Tyler M. Seibert, Ole A. Andreassen
Pubblicato in: Movement Disorders, Numero 37, 2023, Pagina/e 62-69, ISSN 0885-3185
Editore: John Wiley & Sons Inc.
DOI: 10.1002/mds.28808

Pre-pandemic psychiatric disorders and risk of COVID-19: a UK Biobank cohort analysis

Autori: Huazhen Yang, Wenwen Chen, Yao Hu, Yilong Chen, Yu Zeng, Yajing Sun, Zhiye Ying, Junhui He, Yuanyuan Qu, Donghao Lu, Fang Fang, Unnur A Valdimarsdóttir, Huan Song
Pubblicato in: The Lancet Healthy longevity, Numero 1, 2020, ISSN 2666-7568
Editore: Elsevier
DOI: 10.1016/s2666-7568(20)30013-1

Greater male than female variability in regional brain structure across the lifespan

Autori: Lara M. Wierenga; Gaelle E. Doucet; Gaelle E. Doucet; Danai Dima; Danai Dima; Ingrid Agartz; Ingrid Agartz; Moji Aghajani; Moji Aghajani; Theophilus N. Akudjedu; Theophilus N. Akudjedu; Anton Albajes-Eizagirre; Dag Alnæs; Dag Alnæs; Kathryn I. Alpert; Ole A. Andreassen; Ole A. Andreassen; Alan Anticevic; Philip Asherson; Tobias Banaschewski; Núria Bargalló; Sarah Baumeister; Ramona Baur-Streub
Pubblicato in: Human Brain Mapping, Numero 31, 2022, Pagina/e reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, ISSN 1065-9471
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hbm.25204

Developmental manifestations of polygenic risk for bipolar disorder from infancy to middle childhood

Autori: Ragna Bugge Askeland, Laurie J. Hannigan, Kevin S. O’Connell, Elizabeth C. Corfield, Oleksandr Frei, Anita Thapar, George Davey Smith, Ted Reichborn-Kjennerud, Ole A. Andreassen, Helga Ask, Alexandra Havdahl
Pubblicato in: Translational Psychiatry, Numero 13, 2023, ISSN 2158-3188
Editore: Nature Publishing Group
DOI: 10.1038/s41398-023-02522-2

Sex‐ and age‐specific associations between cardiometabolic risk and white matter brain age in the UK Biobank cohort

Autori: Sivaniya Subramaniapillai; Sana Suri; Claudia Barth; Ivan I. Maximov; Irene Voldsbekk; Dennis van der Meer; Tiril P. Gurholt; Dani Beck; Bogdan Draganski; Ole A. Andreassen; Klaus P. Ebmeier; Lars T. Westlye; Ann‐Marie G. de Lange
Pubblicato in: HBM, Numero 29, 2022, ISSN 1065-9471
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hbm.25882

Cohort Profile: COVIDMENT: COVID-19 cohorts on mental health across six nations

Autori: Anna Bára Unnarsdóttir, Anikó Lovik, Chloe Fawns-Ritchie, Helga Ask, Kadri Kõiv, Kristen Hagen, Maria Didriksen, Lea Arregui Nordahl Christoffersen, Alexander Berg Garðarsson, Andrew McIntosh, Anna K Kähler, Archie Campbell, Arna Hauksdóttir, Christian Erikstrup, Dorte Helenius Mikkelsen, Drew Altschul, Edda Bjork Thordardottir, Emma Maria Frans, Gerd Kvale, Gunnar Tómasson, Hanna Maria Ka
Pubblicato in: Intl Jnl Epidemiology, Numero 3, 2021, Pagina/e e108–e122, ISSN 1464-3685
Editore: Oxford University Press
DOI: 10.1093/ije/dyab234

Metabolic Profile and Long-Term Risk of Depression, Anxiety, and Stress-Related Disorders

Autori: Charilaos Chourpiliadis, Yu Zeng, Anikó Lovik, Dang Wei, Unnur Valdimarsdóttir, Huan Song, Niklas Hammar, Fang Fang
Pubblicato in: JAMA Network Open, Numero 7, 2024, Pagina/e e244525, ISSN 2574-3805
Editore: JAMA
DOI: 10.1001/jamanetworkopen.2024.4525

Lessons Learned From Neuroimaging Studies of Copy Number Variants: A Systematic Review.

Autori: Claudia Modenato; Sandra Martin-Brevet; Clara A. Moreau; Borja Rodriguez-Herreros; Kuldeep Kumar; Bogdan Draganski; Ida E Sønderby; Sébastien Jacquemont
Pubblicato in: "Biological Psychiatry, Elsevier, 2021, 90 (9), pp.596-610. ⟨10.1016/j.biopsych.2021.05.028⟩", Numero 4, 2021, ISSN 0006-3223
Editore: Elsevier BV
DOI: 10.1016/j.biopsych.2021.05.028

Cardiometabolic risk factors associated with brain age and accelerate brain ageing

Autori: Dani Beck; Dani Beck; Ann-Marie Glasø de Lange; Ann-Marie Glasø de Lange; Ann-Marie Glasø de Lange; Mads Lund Pedersen; Mads Lund Pedersen; Dag Alnæs; Dag Alnæs; Ivan I. Maximov; Ivan I. Maximov; Ivan I. Maximov; Irene Voldsbekk; Irene Voldsbekk; Geneviève Richard; Anne-Marthe Sanders; Anne-Marthe Sanders; Kristine Moe Ulrichsen; Kristine Moe Ulrichsen; Erlend S. Dørum; Erlend S. Dørum; Kn
Pubblicato in: HBM, Numero 19, 2021, Pagina/e 1-21, ISSN 1065-9471
Editore: John Wiley & Sons Inc.
DOI: 10.1101/2021.02.25.21252272

Shared genetic architecture between neuroticism, coronary artery disease and cardiovascular risk factors

Autori: Kristin Torgersen, Shahram Bahrami, Oleksandr Frei, Alexey Shadrin, Kevin S. O’ Connell, Olav B. Smeland, John Munkhaugen, Srdjan Djurovic, Toril Dammen, Ole A. Andreassen
Pubblicato in: Translational Psychiatry, Numero 11, 2022, ISSN 2158-3188
Editore: Nature Publishing Group
DOI: 10.1038/s41398-021-01466-9

Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease

Autori: Jacob Bergstedt, Joëlle A. Pasman, Ziyan Ma, Arvid Harder, Shuyang Yao, Nadine Parker, Jorien L. Treur, Dirk J. A. Smit, Oleksandr Frei, Alexey A. Shadrin, Joeri J. Meijsen, Qing Shen, Sara Hägg, Per Tornvall, Alfonso Buil, Thomas Werge, Jens Hjerling-Leffler, Thomas D. Als, Anders D. Børglum, Cathryn M. Lewis, Andrew M. McIntosh, Unnur A. Valdimarsdóttir, Ole A. Andreassen, Patrick F. Sulliva
Pubblicato in: Nature Cardiovascular Research, Numero 3, 2024, Pagina/e 754-769, ISSN 2731-0590
Editore: Springer Nature
DOI: 10.1038/s44161-024-00488-y

Associations between abdominal adipose tissue, reproductive span, and brain characteristics in post-menopausal women

Autori: Louise S. Schindler, Sivaniya Subramaniapillai, Claudia Barth, Dennis van der Meer, Mads L. Pedersen, Tobias Kaufmann, Ivan I. Maximov, Jennifer Linge, Olof Dahlqvist Leinhard, Dani Beck, Tiril P. Gurholt, Irene Voldsbekk, Sana Suri, Klaus P. Ebmeier, Bogdan Draganski, Ole A. Andreassen, Lars T. Westlye, Ann-Marie G. de Lange
Pubblicato in: NeuroImage: clinical, 2022, ISSN 2213-1582
Editore: Elsevier BV
DOI: 10.1016/j.nicl.2022.103239

Phenotypically independent profiles relevant to mental health are genetically correlated

Autori: Daniel Roelfs, Dag Alnæs, Oleksandr Frei, Dennis van der Meer, Olav B. Smeland, Ole A. Andreassen, Lars T. Westlye, Tobias Kaufmann
Pubblicato in: Translational Psychiatry, Numero 11/1, 2021, ISSN 2158-3188
Editore: Nature Publishing Group
DOI: 10.1038/s41398-021-01313-x

COSGAP: COntainerized Statistical Genetics Analysis Pipelines

Autori: Bayram Cevdet Akdeniz, Oleksandr Frei, Espen Hagen, Tahir Tekin Filiz, Sandeep Karthikeyan, Joëlle Pasman, Andreas Jangmo, Jacob Bergstedt, John R Shorter, Richard Zetterberg, Joeri Meijsen, Ida Elken Sønderby, Alfonso Buil, Martin Tesli, Yi Lu, Patrick Sullivan, Ole A Andreassen, Eivind Hovig
Pubblicato in: Bioinformatics Advances, Numero 4, 2024, ISSN 2635-0041
Editore: Oxford Academic
DOI: 10.1093/bioadv/vbae067

Poor muscle health and cardiometabolic risks associated with antidepressant treatment

Autori: Patrik Andersson, Jennifer Linge, Tiril P. Gurholt, Ida E. Sønderby, Guy Hindley, Ole A. Andreassen, Olof Dahlqvist Leinhard
Pubblicato in: Obesity, Numero 32, 2024, Pagina/e 1857-1869, ISSN 1930-7381
Editore: Wiley-Blackwell
DOI: 10.1002/oby.24085

Patient satisfaction with mental and physical health services: Findings from a UK-wide online survey

Autori: Elizabeth J. Kirkham; Sue Fletcher-Watson; Iona Beange; Stella W.Y. Chan; Stephen M. Lawrie
Pubblicato in: Wellcome Open Research, Numero 14, 2022, ISSN 1936-1521
Editore: Taylor & Francis
DOI: 10.12688/wellcomeopenres.17973.1

Genetic predisposition and antipsychotic treatment effect on metabolic syndrome in schizophrenia: a ten-year follow-up study using the Estonian Biobank

Autori: Maris Alver, Silva Kasela, Liina Haring, Laura Birgit Luitva, Krista Fischer, Märt Möls, Lili Milani
Pubblicato in: The Lancet Regional Health - Europe, Numero 41, 2024, Pagina/e 100914, ISSN 2666-7762
Editore: Elsevier
DOI: 10.1016/j.lanepe.2024.100914

Familial factors, diet, and risk of cardiovascular disease: a cohort analysis of the UK Biobank

Autori: Hanyue Zhang, Yu Zeng, Huazhen Yang, Yihan Hu, Yao Hu, Wenwen Chen, Zhiye Ying, Yajing Sun, Yuanyuan Qu, Qian Li, Unnur A Valdimarsdóttir, Huan Song,
Pubblicato in: The American Journal of Clinical Nutrition, Numero 114;5, 2021, Pagina/e 1837-1846, ISSN 0002-9165
Editore: American Society for Clinical Nutrition, Inc.
DOI: 10.1093/ajcn/nqab261

No signs of neurodegenerative effects in 15q11.2 BP1-BP2 copy number variant carriers in the UK Biobank

Autori: Rune Boen, Tobias Kaufmann, Oleksandr Frei, Dennis van der Meer, Srdjan Djurovic, Ole A. Andreassen, Kaja K. Selmer, Dag Alnæs, Ida E. Sønderby
Pubblicato in: Translational Psychiatry, Numero 13, 2023, ISSN 2158-3188
Editore: Nature Publishing Group
DOI: 10.1038/s41398-023-02358-w

Genetic liability for schizophrenia and childhood psychopathology in the general population

Autori: Laurie J. Hannigan; Ragna Bugge Askeland; Helga Ask; Martin Tesli; Martin Tesli; Elizabeth Corfield; Ziada Ayorech; Øyvind Helgeland; Øyvind Helgeland; Per Magnus; Per Magnus; Pål R. Njølstad; Pål R. Njølstad; Anne-Siri Øyen; Camilla Stoltenberg; Camilla Stoltenberg; Ole A. Andreassen; Ole A. Andreassen; George Davey Smith; Ted Reichborn-Kjennerud; Ted Reichborn-Kjennerud; Alexandra Havdahl
Pubblicato in: Schizophrenia Bulletin, Numero 26, 2021, ISSN 0586-7614
Editore: Oxford University Press
DOI: 10.1093/schbul/sbaa193

The genetic architecture of the human thalamus and its overlap with ten common brain disorders

Autori: Torbjørn Elvsåshagen, Alexey Shadrin, Oleksandr Frei, Dennis van der Meer, Shahram Bahrami, Vinod Jangir Kumar, Olav Smeland, Lars T. Westlye, Ole A. Andreassen, Tobias Kaufmann
Pubblicato in: Nature Communications, Numero 12, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-23175-z

A comprehensive map of genetic relationships among diagnostic categories based on 48.6 million relative pairs from the Danish genealogy

Autori: Georgios Athanasiadis, Joeri J Meijsen, Dorte Helenius, Andrew J Schork, Andrés Ingason, Wesley K Thompson, Daniel H Geschwind, Thomas Werge, Alfonso Buil
Pubblicato in: PNAS, Numero 119, 2022, ISSN 1091-6490
Editore: US national academy of sciences
DOI: 10.1073/pnas.2118688119

Finemap-MiXeR: A variational Bayesian approach for genetic finemapping

Autori: Bayram Cevdet Akdeniz, Oleksandr Frei, Alexey Shadrin, Dmitry Vetrov, Dmitry Kropotov, Eivind Hovig, Ole A. Andreassen, Anders M. Dale
Pubblicato in: PLOS Genetics, Numero 20, 2024, Pagina/e e1011372, ISSN 1553-7404
Editore: Public Library of Science
DOI: 10.1371/journal.pgen.1011372

Psychometric Properties and Diagnostic Associations of the Short-Form Community Assessment of Psychic Experiences in a Population-Based Sample of 29 021 Adult Men

Autori: Viktoria Birkenæs, Nora Refsum Bakken, Evgeniia Frei, Piotr Jaholkowski, Olav B Smeland, Markos Tesfaye, Ingrid Agartz, Ezra Susser, Michaeline Bresnahan, Espen Røysamb, Kjetil Nordbø Jørgensen, Ragnar Nesvåg, Alexandra Havdahl, Ole A Andreassen, Ida Elken Sønderby
Pubblicato in: Schizophrenia Bulletin, Numero 49, 2023, Pagina/e 1229-1238, ISSN 0586-7614
Editore: Oxford University Press
DOI: 10.1093/schbul/sbad074

Mental health indicators in Sweden over a 12-month period during the COVID-19 pandemic – Baseline data of the Omtanke2020 Study

Autori: Anikó Lovik; Juan González-Hijón; Anna K. Kähler; Unnur A. Valdimarsdóttir; Emma M. Frans; Patrik K.E. Magnusson; Nancy L. Pedersen; Per Hall; Kamila Czene; Patrick F. Sullivan; Fang Fang
Pubblicato in: Journal of Affective Disorders, Numero 10, 2023, ISSN 0165-0327
Editore: Elsevier BV
DOI: 10.1016/j.jad.2022.11.004

Plasma Levels of the Cytokines B Cell-Activating Factor (BAFF) and A Proliferation-Inducing Ligand (APRIL) in Schizophrenia, Bipolar, and Major Depressive Disorder: A Cross Sectional, Multisite Study.

Autori: John Abel Engh; Thor Ueland; Thor Ueland; Thor Ueland; Ingrid Agartz; Ingrid Agartz; Dimitrios Andreou; Dimitrios Andreou; Pål Aukrust; Pål Aukrust; Birgitte Boye; Birgitte Boye; Erlend Bøen; Ole Kristian Drange; Torbjørn Elvsåshagen; Sigrun Hope; Margrethe Collier Høegh; Inge Joa; Inge Joa; Erik Johnsen; Erik Johnsen; Rune A. Kroken; Rune A. Kroken; Trine Vik Lagerberg; Tove Lekva; Ulrik Fr
Pubblicato in: 10, Numero 1, 2022, ISSN 0586-7614
Editore: Oxford University Press
DOI: 10.1093/schbul/sbab106

Metabolomic Investigation of Major Depressive Disorder Identifies a Potentially Causal Association With Polyunsaturated Fatty Acids

Autori: Eleanor Davyson, Xueyi Shen, Danni A. Gadd, Elena Bernabeu, Robert F. Hillary, Daniel L. McCartney, Mark Adams, Riccardo Marioni, Andrew M. McIntosh
Pubblicato in: Biological Psychiatry, Numero 94, 2024, Pagina/e 630-639, ISSN 0006-3223
Editore: Elsevier BV
DOI: 10.1016/j.biopsych.2023.01.027

Linking sarcopenia, brain structure and cognitive performance: a large-scale UK Biobank study

Autori: Tiril P Gurholt, Miguel Germán Borda, Nadine Parker, Vera Fominykh, Rikka Kjelkenes, Jennifer Linge, Dennis van der Meer, Ida E Sønderby, Gustavo Duque, Lars T Westlye, Dag Aarsland, Ole A Andreassen
Pubblicato in: Brain Communications, Numero 6, 2024, ISSN 2632-1297
Editore: Oxford Academic
DOI: 10.1093/braincomms/fcae083

Additional file 1 of Genetic predispositions to psychiatric disorders and the risk of COVID-19

Autori: Chen, Wenwen; Zeng, Yu; Suo, Chen; Yang, Huazhen; Chen, Yilong; Hou, Can; Hu, Yao; Ying, Zhiye; Sun, Yajing; Qu, Yuanyuan; Lu, Donghao; Fang, Fang; Valdimarsdóttir, Unnur A.; Song, Huan
Pubblicato in: BMC Medicine, Numero 6, 2022, ISSN 1741-7015
Editore: BioMed Central
DOI: 10.6084/m9.figshare.20579734.v1

How important are parents in the development of child anxiety and depression? A genomic analysis of parent-offspring trios in the Norwegian Mother Father and Child Cohort Study (MoBa)

Autori: Rosa Cheesman; Espen Moen Eilertsen; Yasmin I. Ahmadzadeh; Line C. Gjerde; Line C. Gjerde; Laurie J. Hannigan; Alexandra Havdahl; Alexander I. Young; Alexander I. Young; Thalia C. Eley; Pål R. Njølstad; Pål R. Njølstad; Per Magnus; Ole A. Andreassen; Ole A. Andreassen; Eivind Ystrom; Eivind Ystrom; Tom A. McAdams; Tom A. McAdams
Pubblicato in: BMC Medicine, Vol 18, Iss 1, Pp 1-11 (2020), Numero 27, 2020, ISSN 1741-7015
Editore: BioMed Central
DOI: 10.1101/2020.04.14.20064782

Genetic predispositions to psychiatric disorders and the risk of COVID-19

Autori: Wenwen Chen; Yu Zeng; Chen Suo; Huazhen Yang; Yilong Chen; Can Hou; Yao Hu; Zhiye Ying; Yajing Sun; Yuanyuan Qu; Donghao Lu; Fang Fang; Unnur A. Valdimarsdóttir; Huan Song
Pubblicato in: BMC Medicine, Numero 5, 2022, ISSN 1741-7015
Editore: BioMed Central
DOI: 10.1186/s12916-022-02520-z

Polygenic risk for schizophrenia and bipolar disorder in relation to cardiovascular biomarkers

Autori: Elina J. Reponen, Thor Ueland, Jaroslav Rokicki, Francesco Bettella, Monica Aas, Maren C. F. Werner, Ingrid Dieset, Nils E. Steen, Ole A. Andreassen, Martin Tesli
Pubblicato in: European Archives of Psychiatry and Clinical Neuroscience, Numero 274, 2024, Pagina/e 1223-1230, ISSN 0940-1334
Editore: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00406-023-01591-0

Considerations on brain age predictions from repeatedly sampled data across time

Autori: Max Korbmacher, Meng-Yun Wang, Rune Eikeland, Ralph Buchert, Ole A. Andreassen, Thomas Espeseth, Esten Leonardsen, Lars T. Westlye, Ivan I. Maximov, Karsten Specht
Pubblicato in: Brain and Behaviour, 2024, ISSN 2162-3279
Editore: Wiley
DOI: 10.1101/2023.03.31.535038

How important are parents in the development of child anxiety and depression? A genomic analysis of parent-offspring trios in the Norwegian Mother Father and Child Cohort Study (MoBa)

Autori: Rosa Cheesman, Espen Moen Eilertsen, Yasmin I. Ahmadzadeh, Line C. Gjerde, Laurie J. Hannigan, Alexandra Havdahl, Alexander I. Young, Thalia C. Eley, Pål R. Njølstad, Per Magnus, Ole A. Andreassen, Eivind Ystrom, Tom A. McAdams
Pubblicato in: BMC Medicine, Numero 18, 2021, ISSN 1741-7015
Editore: BioMed Central
DOI: 10.1186/s12916-020-01760-1

Heart rate variability is associated with disease severity in psychosis spectrum disorders.

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Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation.

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Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms

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Genome-by-Trauma Exposure Interactions in Adults With Depression in the UK Biobank

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Characterizing the polygenic overlap and shared loci between rheumatoid arthritis and cardiovascular diseases

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Cohort Profile Update: Mental Health Online Survey in the Estonian Biobank (EstBB MHoS)

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The role of genetic predisposition in cardiovascular risk after cancer diagnosis: a matched cohort study of the UK Biobank

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Depressive symptom trajectories among general population during the COVID-19 pandemic in Iceland: a prospective cohort study (2020–2023)

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Using Polygenic Hazard Scores to Predict Age at Onset of Alzheimer’s Disease in Nordic Populations

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Boosting Schizophrenia Genetics by Utilizing Genetic Overlap With Brain Morphology

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The Effect of School Bullying on Pupils' Perceived Stress and Wellbeing During the Covid-19 Pandemic:A Longitudinal Study

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Extensive brain structural heterogeneity in individuals with schizophrenia and bipolar disorder

Autori: Wolfers, Thomas; Rokicki, Jaroslav; Alnaes, Dag; Agartz, Ingrid; Kia, Seyed Mostafa; Kaufmann, Tobias; Zabihi, Mariam; Moberget, Torgeir; Melle, Ingrid; Beckmann, Christian F; Andreassen, Ole A; Marquand, Andre F; Westlye, Lars T
Pubblicato in: HBM, Numero 23, 2021, ISSN 1065-9471
Editore: John Wiley & Sons Inc.
DOI: 10.1101/2020.05.08.20095091

1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans

Autori: Ida E. Sønderby, Dennis van der Meer, Clara Moreau, Tobias Kaufmann, G. Bragi Walters, Maria Ellegaard, Abdel Abdellaoui, David Ames, Katrin Amunts, Micael Andersson, Nicola J. Armstrong, Manon Bernard, Nicholas B. Blackburn, John Blangero, Dorret I. Boomsma, Henry Brodaty, Rachel M. Brouwer, Robin Bülow, Rune Bøen, Wiepke Cahn, Vince D. Calhoun, Svenja Caspers, Christopher R. K. Ching, Sven Ci
Pubblicato in: Translational Psychiatry, Numero 11/1, 2021, ISSN 2158-3188
Editore: Nature Publishing Group
DOI: 10.1038/s41398-021-01213-0

Adverse muscle composition predicts all-cause mortality in the UK Biobank imaging study.

Autori: Jennifer Linge; Mikael Petersson; Mikael Forsgren; Arun J. Sanyal; Olof Dahlqvist Leinhard
Pubblicato in: Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 6, Pp 1513-1526 (2021), Numero 16, 2021, ISSN 2190-5991
Editore: Springer Verlag
DOI: 10.1002/jcsm.12834

Bio-psycho-social factors’ associations with brain age: a large-scale UK Biobank diffusion study of 35,749 participants

Autori: Max Korbmacher, Tiril P. Gurholt, Ann-Marie G. de Lange, Dennis van der Meer, Dani Beck, Eli Eikefjord, Arvid Lundervold, Ole A. Andreassen, Lars T. Westlye, Ivan I. Maximov
Pubblicato in: Frontiers in Psychology, Numero 14, 2023, ISSN 1664-1078
Editore: Frontiers Research Foundation
DOI: 10.3389/fpsyg.2023.1117732

Psychiatric disorders and subsequent risk of cardiovascular disease: a longitudinal matched cohort study across three countries

Autori: Qing Shen, Dorte Helenius Mikkelsen, Laura Birgit Luitva, Huan Song, Silva Kasela, Thor Aspelund, Jacob Bergstedt, Yi Lu, Patrick F. Sullivan, Weimin Ye, Katja Fall, Per Tornvall, Yudi Pawitan, Ole A. Andreassen, Alfonso Buil, Lili Milani, Fang Fang, Unnur Valdimarsdóttir
Pubblicato in: eClinicalMedicine, Numero 61, 2023, Pagina/e 102063, ISSN 2589-5370
Editore: The Lancet
DOI: 10.1016/j.eclinm.2023.102063

Shared genetic loci between depression and cardiometabolic traits

Autori: Kristin Torgersen, Zillur Rahman, Shahram Bahrami, Guy Frederick Lanyon Hindley, Nadine Parker, Oleksandr Frei, Alexey Shadrin, Kevin S. O’Connell, Martin Tesli, Olav B. Smeland, John Munkhaugen, Srdjan Djurovic, Toril Dammen, Ole A. Andreassen
Pubblicato in: PLOS Genetics, Numero 18, 2022, Pagina/e e1010161, ISSN 1553-7404
Editore: Open Access publisher
DOI: 10.1371/journal.pgen.1010161

Shared genetic architecture between mental health and the brain functional connectome in the UK Biobank

Autori: Daniel Roelfs, Oleksandr Frei, Dennis van der Meer, Elleke Tissink, Alexey Shadrin, Dag Alnaes, Ole A. Andreassen, Lars T. Westlye, Tobias Kaufmann
Pubblicato in: BMC Psychiatry, Numero 23, 2023, ISSN 1471-244X
Editore: BioMed Central
DOI: 10.1186/s12888-023-04905-7

Incidence Trajectories of Psychiatric Disorders After Assault, Injury, and Bereavement

Autori: Yufeng Chen, Qing Shen, Paul Lichtenstein, Jaimie L. Gradus, Filip K. Arnberg, Henrik Larsson, Brian M. D’Onofrio, Fang Fang, Huan Song, Unnur A. Valdimarsdottir
Pubblicato in: JAMA Psychiatry, Numero 81, 2024, Pagina/e 374, ISSN 2168-622X
Editore: American Medical Association
DOI: 10.1001/jamapsychiatry.2023.5156

Genetic Association Between Schizophrenia and Cortical Brain Surface Area and Thickness

Autori: Weiqiu Cheng, Oleksandr Frei, Dennis van der Meer, Yunpeng Wang, Kevin S. O’Connell, Yunhan Chu, Shahram Bahrami, Alexey A. Shadrin, Dag Alnæs, Guy F. L. Hindley, Aihua Lin, Naz Karadag, Chun-Chieh Fan, Lars T. Westlye, Tobias Kaufmann, Espen Molden, Anders M. Dale, Srdjan Djurovic, Olav B. Smeland, Ole A. Andreassen
Pubblicato in: JAMA Psychiatry, Numero 78, 2021, Pagina/e 1020, ISSN 2168-622X
Editore: American Medical Association
DOI: 10.1001/jamapsychiatry.2021.1435

COGEDAP: A COmprehensive GEnomic Data Analysis Platform

Autori: Bayram Cevdet Akdeniz, Oleksandr Frei, Espen Hagen, Tahir Tekin Filiz, Sandeep Karthikeyan, Joelle Pasman, Andreas Jangmo, Jacob Bergsted, John R. Shorter, Richard Zetterberg, Joeri Meijsen, Ida Elken Sonderby, Alfonso Buil, Martin Tesli, Yi Lu, Patrick Sullivan, Ole Andreassen, Eivind Hovig
Pubblicato in: Arxiv, 2022
Editore: Cornell University
DOI: 10.48550/arxiv.2212.14103

Pleiotropic and sex-specific genetic architecture of circulating metabolic markers

Autori: Dennis van der Meer, Zillur Rahman, Aigar Ottas, Pravesh Parekh, Gleda Kutrolli, Sara Stinson, Maria Koromina, Jaroslav Rokicki, Ida Sonderby, Nadine Parker, Markos Tesfaye, Guy Hindley, Linn Rodevand, Elise Koch, Nils Steen, Jens Berg, Kevin O'Connell, Olav Smeland, Oleksandr Frei, Anders Dale, Srdjan Djurovic, Kelli Lehto, Maris Alver, Lili Milani, Alexey Shadrin, Ole Andreassen
Pubblicato in: 2024, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.07.30.24311254

Efficient meta-analysis of multivariate genome-wide association studies with Meta-MOSTest

Autori: Aihua Lin, Alexey Shadrin, Dennis van der Meer, Guy Hindley, Weiqiu Cheng, Ida Elken Sønderby, Shahram Bahrami, Kevin S O’Connell, Zillur Rahman, Nadine Parker, Olav B Smeland, Chun C. Fan, Dominic Holland, Anders M Dale, Ole A Andreassen, Oleksandr Frei
Pubblicato in: 2022
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.08.18.504383

The Norwegian Mother, Father, and Child cohort study (MoBa) genotyping data resource: MoBaPsychGen pipeline v.1

Autori: Elizabeth C. Corfield, Oleksandr Frei, Alexey A. Shadrin, Zillur Rahman, Aihua Lin, Lavinia Athanasiu, Bayram Cevdet Akdeniz, Laurie Hannigan, Robyn E. Wootton, Chloe Austerberry, Amanda Hughes, Martin Tesli, Lars T. Westlye, Hreinn Stefánsson, Kári Stefánsson, Pål R. Njølstad, Per Magnus, Neil M. Davies, Vivek Appadurai, Gibran Hemani, Eivind Hovig, Tetyana Zayats, Helga Ask, Ted Reichbo
Pubblicato in: bioRxiv, 2022
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.06.23.496289

Finemap-MiXeR: A variational Bayesian approach for genetic finemapping

Autori: Bayram Cevdet Akdeniz, Oleksandr Frei, Alexey Shadrin, Dmitry Vetrov, Dmitry Kropotov, Eivind Hovig, Ole A. Andreassen, Anders M. Dale
Pubblicato in: Biorxiv, 2023
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.11.30.518509

Acute COVID-19 severity and mental health morbidity trajectories in patient populations of six nations: an observational study

Autori: Magnúsdóttir et al
Pubblicato in: The Lancet Public Health, 2022, ISSN 2468-2667
Editore: [Oxford] : Elsevier, Ltd., [2016]-
DOI: 10.1016/s2468-2667(22)00042-1

Better treatment response in people with obsessive-compulsive disorder is associated with more use of a planning-focused coping style

Autori: Elizabeth Kirkham, Yintao Cao, Martyna Król
Pubblicato in: Open Research Europe, Numero 4, 2024, Pagina/e 57, ISSN 2732-5121
Editore: https://open-research-europe.ec.europa.eu/articles/4-57
DOI: 10.12688/openreseurope.17056.1

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