THERVACB: A THERAPEUTIC VACCINE TO CURE HEPATITIS B

Project Information

TherVacB

Grant agreement ID: 848223

DOI

10.3030/848223

EC signature date 6 December 2019

Start date 1 January 2020

End date 31 December 2026

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 10 425 686,21

EU contribution

€ 10 425 686,21

Coordinated by

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (4)

Synopsis and protocol of the patient registry

In close cooperation with all WP partners MHH will provide a short protocol as well as the study synopsis of the patient registry.

Cross-network SOPs for immunoassays

SOPs for centralized and decentralized immunoassays available and in place; initial cross-validation of decentralized immunoassays to ensure inter-lab precision finished

Agreement of sample storage

HMGU will provide an informed consent form and an SOPs for sample preparation and storage (plasma and PBMCs) for all participating centers

Incidental Findings Policy

Report on the Incidental Findings Policy

Websites, patent fillings, videos etc. (1)

THERVACB web site and the relevant social media

Overview of the objectives of the THERVACB public website as part of the dissemination strategy, and its main functionalities, as well as an outline of the THERVACB social media strategy.

Publications

Peer reviewed articles (11)

Perceptions of Stigma Among Patients With Hepatitis B in Germany: Cross-Sectional Survey

Author(s): Bettina M Zimmermann, Theresa Willem, Michael Rost, Nina Matthes, Alena Buyx
Published in: JMIR Formative Research, Issue 9, 2025, Page(s) e66379-e66379, ISSN 2561-326X
Publisher: JMIR Publications Inc.
DOI: 10.2196/66379

Social Media Recruitment as a Potential Trigger for Vulnerability: Multistakeholder Interview Study

Author(s): Nina Matthes, Theresa Willem, Alena Buyx, Bettina M Zimmermann
Published in: JMIR Human Factors, Issue 11, 2024, Page(s) e52448-e52448, ISSN 2292-9495
Publisher: JMIR Human Factors
DOI: 10.2196/52448

PD-L1 Silencing in Liver Using siRNAs Enhances Efficacy of Therapeutic Vaccination for Chronic Hepatitis B

Author(s): Till Bunse, Anna D Kosinska, Thomas Michler, Ulrike Protzer
Published in: Biomolecules, Issue 12(3):470, 2022, ISSN 2218-273X
Publisher: MDPI Open Access Journals
DOI: 10.3390/biom12030470

Practical Benefits, Challenges, and Recommendations on Social Media Recruitment: Multi-Stakeholder Interview Study

Author(s): Goldman N, Willem T, Buyx A, Zimmermann B
Published in: Journal of Medical Internet Research, Issue 25:e44587, 2023, ISSN 1438-8871
Publisher: Journal of medical Internet Research
DOI: 10.2196/44587

Acceptance of Social Media Recruitment for Clinical Studies Among Patients With Hepatitis B: Mixed Methods Study

Author(s): Theresa Willem, Bettina M Zimmermann, Nina Matthes, Michael Rost, Alena Buyx
Published in: Journal of Medical Internet Research, Issue 26, 2024, Page(s) e54034, ISSN 1438-8871
Publisher: Journal of medical Internet Research
DOI: 10.2196/54034

Social media advertising for clinical studies: Ethical and data protection implications of online targeting

Author(s): Rainer Mühlhoff, Theresa Willem
Published in: Big Data & Society, Issue 10, 2023, Page(s) 205395172311561, ISSN 2053-9517
Publisher: SAGE
DOI: 10.1177/20539517231156127

Ethical Issues in Social Media Recruitment for Clinical Studies: Ethical Analysis and Framework

Author(s): Zimmermann BM, Willem T, Bredthauer CJ, Buyx A
Published in: J Med Internet Res, Issue 24 (5), 2022, ISSN 1438-8871
Publisher: Journal of medical Internet Research
DOI: 10.2196/31231

Correction: Ethical Issues in Social Media Recruitment for Clinical Studies: Ethical Analysis and Framework

Author(s): Bettina M Zimmermann; Theresa Willem; Carl Justus Bredthauer; Alena Buyx
Published in: J Med Internet Res, 2022, ISSN 1438-8871
Publisher: Journal of medical Internet Research
DOI: 10.2196/40848

Immunogenicity and Antiviral Response of Therapeutic Hepatitis B Vaccination in a Mouse Model of HBeAg-Negative, Persistent HBV Infection

Author(s): Kosinska, A.D.; Festag, J.; Mück-Häusl, M.; Festag, M.M.; Asen, T.; Protzer, U.
Published in: Vaccines, Issue 9(8), 841, 2021, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9080841

Activation of CD4 T cells during prime immunization determines the success of a therapeutic hepatitis B vaccine in HBV-carrier mouse models

Author(s): Jinpeng Su, Livia Brunner, Edanur Ates Oz, Julia Sacherl, Geraldine Frank, Helene Anne Kerth, Frank Thiele, Marian Wiegand, Carolin Mogler, Julio Cesar Aguilar, Percy A. Knolle, Nicolas Collin, Anna D. Kosinska, Ulrike Protzer
Published in: Journal of Hepatology, 2023, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2022.12.013

Evaluation of the Effect of CD70 Co-Expression on CD8 T Cell Response in Protein-Prime MVA-Boost Vaccination in Mice

Author(s): Ann-Sophie Stephan; Anna D. Kosinska; Martin Mück-Häusl; Andreas Muschaweckh; Clemens Jäger; Natalie Röder; Mathias Heikenwälder; Claudia Dembek; Ulrike Protzer
Published in: Volume 11, Issue 1, 2023, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines11020245