Development, dIagnostic and prevention of gender-related Somatic and mental COmorbitiEs in iRritable bowel syndrome In Europe

Informazioni relative al progetto

DISCOvERIE

ID dell’accordo di sovvenzione: 848228

DOI

10.3030/848228

Progetto chiuso

Data della firma CE 13 Dicembre 2019

Data di avvio 1 Gennaio 2020

Data di completamento 31 Maggio 2025

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 6 000 000,00

Contributo UE

€ 6 000 000,00

Coordinato da

FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA
Spain

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (13)

Mechanistically-oriented sex-specific molecular signature of IBS comorbidities following animal and human microbiota transfer

Mechanistically-oriented sex-specific molecular signature of IBS comorbidities following animal and human microbiota transfer (M40).

Report on IBS pattern comorbidities in retrospective cohorts

Report on IBS pattern comorbidities in retrospective cohorts (M16).

Report on candidate mechanisms for comorbid development and mechanistic biomarkers from existing data

Report on candidate mechanisms for comorbid development and mechanistic biomarkers from existing data (M18).

Report on candidate mechanisms and biomarkers for comorbid IBS

Report on candidate mechanisms and biomarkers for comorbid IBS (M48).

Report on effect of approved drugs on candidate mechanisms

Report on effect of approved drugs on candidate mechanisms (M48).

To integrate the data provided by ESM app and HumanITcare platform with data from WP2-6 and to feed the repository

To integrate the data provided by ESM app and HumanITcare platform with data from WP2-6 and to feed the repository (M40).

Intestinal mucosal profiling of mechanisms of barrier dysfunction that differentiate IBS from comorbid IBS

Intestinal mucosal profiling of mechanisms of barrier dysfunction that differentiate IBS from comorbid IBS (M36).

Report on fecal sampling and transport of IBS cohorts in the project and the quantitative microbiome profiling

Report on fecal sampling and transport of IBS cohorts in the project and the quantitativemicrobiome profiling (M30).

Report on IBS pattern comorbidities in prospectively deeply phenotyped cohorts

Report on IBS pattern comorbidities in prospectively deeply phenotyped cohorts (M36).

Confirmation of transfer of comorbid IBS phenotypes from animal models and from human samples

Confirmation of transfer of comorbid IBS phenotypes from animal models and from humansamples (M40).

Identification of common genetic variants involved in IBS and comorbidities

Identification of common genetic variants involved in IBS and comorbidities (M36).

"Profiling of ""gut-to-brain"" and ""brain-to-gut"" mechanisms associated with comorbidities development in IBS"

Profiling of “gut-to-brain” and “brain-to-gut” mechanisms associated with comorbiditiesdevelopment in IBS (M36).

Report on microbiome and metabolome profiling in IBS and comorbid IBS

Report on microbiome and metabolome profiling in IBS and comorbid IBS (M31).

Websites, patent fillings, videos etc. (1)

Launch project identity, brochure and public website

Launch project identity, brochure and public website (M6).

Pubblicazioni

Peer reviewed articles (9)

Gut microbiota composition links to variation in functional domains across psychiatric disorders

Autori: Danique Mulder, Babette Jakobi, Yingjie Shi, Peter Mulders, Josina D. Kist, Rose M. Collard, Janna N. Vrijsen, Phillip van Eijndhoven, Indira Tendolkar, Mirjam Bloemendaal, Alejandro Arias Vasquez
Pubblicato in: Brain, Behavior, and Immunity, Numero 120, 2024, Pagina/e 275-287, ISSN 0889-1591
Editore: Academic Press
DOI: 10.1016/j.bbi.2024.05.037

Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new genetic hits

Autori: Silvia Alemany; María Soler Artigas; Judit Cabana; Dana Salim Fakhreddine; Natalia Llonga; Laura Vilar-Ribó; Amanda Rodríguez-Urrutia; Judit Palacio; Ana María González-Castro; Beatriz Lobo; Carmen Alonso-Cotoner; Magnus Simrén; Javier Santos; Josep Antoni Ramos-Quiroga; Marta Ribasés
Pubblicato in: Journal of Transnational Medicine, Numero 3, 2023, ISSN 1479-5876
Editore: BioMed Central
DOI: 10.1101/2023.01.30.23285080

The effect of expectancy versus actual gluten intake on gastrointestinal and extra-intestinal symptoms in non-coeliac gluten sensitivity: a randomised, double-blind, placebo-controlled, international, multicentre study

Autori: Marlijne C G de Graaf, Clare L Lawton, Fiona Croden, Agnieszka Smolinska, Bjorn Winkens, Martine A M Hesselink, Gonny van Rooy, Peter L Weegels, Peter R Shewry, Peter D Mooney, Lesley A Houghton, Ben J M Witteman, Daniel Keszthelyi, Fred J P H Brouns, Louise Dye, Daisy M A E Jonkers
Pubblicato in: The Lancet Gastroenterology & Hepatology, Numero 9, 2025, Pagina/e 110-123, ISSN 2468-1253
Editore: Elsevier BV
DOI: 10.1016/s2468-1253(23)00317-5

Sex specific gut-microbiota signatures of resilient and comorbid gut-brain phenotypes induced by early life stress

Autori: Lars Wilmes, Valentina Caputi, Thomaz F.S. Bastiaanssen, James M. Collins, Fiona Crispie, Paul D. Cotter, Timothy G. Dinan, John F. Cryan, Gerard Clarke, Siobhain M. O'Mahony
Pubblicato in: Neurobiology of Stress, Numero 33, 2024, Pagina/e 100686, ISSN 2352-2895
Editore: Elsevier BV
DOI: 10.1016/j.ynstr.2024.100686

Refining physical exercise training studies in patients with inflammatory bowel disease: patient selection and assessment of physical fitness changes

Autori: Karlijn Demers, Bart C. Bongers, Daisy M. A. E. Jonkers, Marieke J. Pierik, Laurents P. S. Stassen
Pubblicato in: Trials, Numero 25, 2024, ISSN 1745-6215
Editore: BioMed Central
DOI: 10.1186/s13063-024-08163-0

Of bowels, brain and behavior: A role for the gut microbiota in psychiatric comorbidities in irritable bowel syndrome

Autori: Lars Wilmes, James M. Collins, Kenneth J. O'Riordan, Siobhain M. O’Mahony, John F. Cryan, Gerard Clarke
Pubblicato in: Neurogastroenterology & Motility, Numero 33/3, 2021, ISSN 1350-1925
Editore: Blackwell Publishing Inc.
DOI: 10.1111/nmo.14095

Investigating causality with fecal microbiota transplantation in rodents: applications, recommendations and pitfalls.

Autori: Cassandra E. Gheorghe; Nathaniel L. Ritz; Jason A. Martin; Hannah R. Wardill; John F. Cryan; Gerard Clarke
Pubblicato in: Gut Microbes, Vol 13, Iss 1 (2021), Numero 3, 2021, ISSN 1949-0984
Editore: Gut Microbes (Taylor & Francis Group)
DOI: 10.1080/19490976.2021.1941711

Criterion Validity of Screening Tools and Field-Based Tests for Health-Related Physical Fitness in Inflammatory Bowel Disease

Autori: Karlijn Demers, Bart C. Bongers, Sander M. J. van Kuijk, Guy Plasqui, Daisy M. A. E. Jonkers, Marieke J. Pierik, Laurents P. S. Stassen
Pubblicato in: Digestive Diseases and Sciences, Numero 69, 2024, Pagina/e 4072-4088, ISSN 0163-2116
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10620-024-08682-5

A trial‐based economic evaluation of peppermint oil for the treatment of irritable bowel syndrome

Autori: Zsa Zsa R. M. Weerts, Brigitte A. B. Essers, Daisy M. A. E. Jonkers, Jeresa I. A. Willems, Deborah J. P. A. Janssen, Ben J. M. Witteman, Cees H. M. Clemens, Audrey Westendorp, Ad A. M. Masclee, Daniel Keszthelyi
Pubblicato in: United European Gastroenterology Journal, Numero 9, 2023, Pagina/e 997-1006, ISSN 2050-6406
Editore: Wiley
DOI: 10.1002/ueg2.12134