Synthetic Active Droplets Inspired by Life

Project Information

ActiDrops

Grant agreement ID: 852187

DOI

10.3030/852187

Project closed

EC signature date 14 October 2019

Start date 1 February 2020

End date 31 January 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 491 350,00

EU contribution

€ 1 491 350,00

Coordinated by

TECHNISCHE UNIVERSITAET MUENCHEN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (26)

Design rules for reciprocal coupling in chemically fueled assembly

Author(s): Xiaoyao Chen, Brigitte A. K. Kriebisch, Alexander M. Bergmann, Job Boekhoven
Published in: Chemical Science, Issue 14, 2024, Page(s) 10176-10183, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3sc02062b

Active coacervate droplets as a model for membraneless organelles and protocells

Author(s): Carsten Donau, Fabian Späth, Marilyne Sosson, Brigitte A. K. Kriebisch, Fabian Schnitter, Marta Tena-Solsona, Hyun-Seo Kang, Elia Salibi, Michael Sattler, Hannes Mutschler, Job Boekhoven
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-18815-9

Chemically fueled materials with a self-immolative mechanism: transient materials with a fast on/off response

Author(s): Patrick S. Schwarz, Laura Tebcharani, Julian E. Heger, Peter Müller-Buschbaum, Job Boekhoven
Published in: Chemical Science, Issue 12/29, 2021, Page(s) 9969-9976, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1sc02561a

Fuel-Driven Dynamic Combinatorial Libraries

Author(s): Christine M. E. Kriebisch, Alexander M. Bergmann, Job Boekhoven
Published in: Journal of the American Chemical Society, Issue 143/20, 2021, Page(s) 7719-7725, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.1c01616

Synthesis and characterization of chemically fueled supramolecular materials driven by carbodiimide-based fuels

Author(s): Fabian Schnitter, Alexander M. Bergmann, Benjamin Winkeljann, Jennifer Rodon Fores, Oliver Lieleg, Job Boekhoven
Published in: Nature Protocols, Issue 16, 2021, Page(s) 3901-3932, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-021-00563-9

Liquid spherical shells are a non-equilibrium steady state of active droplets

Author(s): Alexander M. Bergmann, Jonathan Bauermann, Giacomo Bartolucci, Carsten Donau, Michele Stasi, Anna-Lena Holtmannspötter, Frank Jülicher, Christoph A. Weber, Job Boekhoven
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-42344-w

Regulating Nucleic Acid Catalysis Using Active Droplets

Author(s): Anna‐Lena Holtmannspötter, Corbin Machatzke, Christian Begemann, Elia Salibi, Carsten Donau, Fabian Späth, Job Boekhoven, Hannes Mutschler
Published in: Angewandte Chemie International Edition, Issue 63, 2024, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202412534

Chemically Driven Division of Protocells by Membrane Budding

Author(s): Pablo Zambrano, Xiaoyao Chen, Christine M. E. Kriebisch, Brigitte A. K. Kriebisch, Oleksii Zozulia, Job Boekhoven
Published in: Journal of the American Chemical Society, Issue 146, 2024, Page(s) 33359-33367, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.4c08226

Carbodiimide-fueled catalytic reaction cycles to regulate supramolecular processes

Author(s): Patrick S. Schwarz; Marta Tena-Solsona; Kun Dai; Job Boekhoven
Published in: Chemical Communications, Issue 3, 2022, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1cc06428b

Acyl Phosphates as Chemically Fueled Building Blocks for Self‐Sustaining Protocells

Author(s): Oleksii Zozulia, Christine M. E. Kriebisch, Brigitte A. K. Kriebisch, Héctor Soria‐Carrera, Kingu Rici Ryadi, Juliana Steck, Job Boekhoven
Published in: Angewandte Chemie, Issue 136, 2025, ISSN 0044-8249
Publisher: Wiley
DOI: 10.1002/ange.202406094

The Multifunctional Role of Templates in Chemically Fueled Dynamic Combinatorial Libraries

Author(s): Christine M. E. Kriebisch, Brigitte A. K. Kriebisch, Juliette Langlais, Anton S. Maier, Bernhard Rieger, Dieter Braun, Job Boekhoven
Published in: ChemSystemsChem, 2025, ISSN 2570-4206
Publisher: ChemSystemsChem
DOI: 10.1002/syst.202400087

Evolution and Single-Droplet Analysis of Fuel-Driven Compartments by Droplet-Based Microfluidics

Author(s): Alexander M. Bergmann, Carsten Donau, Fabian Späth,Kevin Jahnke, Kerstin Göpfrich,Job Boekhoven
Published in: Angewandte Chemie, Issue 15213773, 2022, ISSN 1521-3773
Publisher: Wiley
DOI: 10.1002/anie.202203928

A chemically fueled supramolecular glue for self-healing gels

Author(s): Jennifer Rodon-Fores, Michaela A. Würbser, Martin Kretschmer, Benedikt Rieß , Alexander M. Bergmann, Oliver Lieleg, Job Boekhoven
Published in: Chemical Science, Issue 20416539, 2022, ISSN 2041-6539
Publisher: Royal Society
DOI: 10.1039/d2sc03691f

Template-based copying in chemically fuelled dynamic combinatorial libraries

Author(s): Christine M. E. Kriebisch, Ludwig Burger, Oleksii Zozulia, Michele Stasi, Alexander Floroni, Dieter Braun, Ulrich Gerland, Job Boekhoven
Published in: Nature Chemistry, Issue 16, 2024, Page(s) 1240-1249, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-024-01570-5

Molecular Design of Chemically Fueled Peptide–Polyelectrolyte Coacervate-Based Assemblies

Author(s): Fabian Späth, Carsten Donau, Alexander M. Bergmann, Moritz Kränzlein, Christopher V. Synatschke, Bernhard Rieger, Job Boekhoven
Published in: Journal of the American Chemical Society, Issue 143/12, 2021, Page(s) 4782-4789, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.1c01148

Chemically Fueled Block Copolymer Self‐Assembly into Transient Nanoreactors**

Author(s): Michaela A. Würbser, Patrick S. Schwarz, Jonas Heckel, Alexander M. Bergmann, Andreas Walther, Job Boekhoven
Published in: ChemSystemsChem, 2021, ISSN 2570-4206
Publisher: Chem Systems Chem
DOI: 10.1002/syst.202100015

Active droplets through enzyme-free, dynamic phosphorylation

Author(s): Simone M. Poprawa, Michele Stasi, Brigitte A. K. Kriebisch, Monika Wenisch, Judit Sastre, Job Boekhoven
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-48571-z

Phase Transitions in Chemically Fueled, Multiphase Complex Coacervate Droplets

Author(s): Carsten Donau, Fabian Späth, Michele Stasi, Alexander M. Bergmann, Job Boekhoven
Published in: Angewandte Chemie, Issue 15213773, 2022, ISSN 1521-3773
Publisher: Wiley
DOI: 10.1002/anie.202211905

Regulating DNA-Hybridization Using a Chemically Fueled Reaction Cycle

Author(s): Michele Stasi, Alba Monferrer, Leon Babl, Sreekar Wunnava, Christina Felicitas Dirscherl, Dieter Braun, Petra Schwille, Hendrik Dietz, Job Boekhoven
Published in: Journal of the American Chemical Society, Issue 144, 2023, Page(s) 21939-21947, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.2c08463

Morphological transitions in chemically fueled self-assembly

Author(s): Kun Dai; Marta Tena-Solsona; Jennifer Rodon Fores; Alexander M. Bergmann; Job Boekhoven
Published in: Nanoscale, Issue 4, 2022, ISSN 2040-3372
Publisher: Royal Society for Chemistry
DOI: 10.1039/d1nr04954b

Size control and oscillations of active droplets in synthetic cells

Author(s): Judit Sastre, Advait Thatte, Alexander M. Bergmann, Michele Stasi, Marta Tena-Solsona, Christoph A. Weber, Job Boekhoven
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-57240-8

A Carbodiimide-Fueled Reaction Cycle That Forms Transient 5(4<i>H</i>)-Oxazolones

Author(s): Xiaoyao Chen, Michele Stasi, Jennifer Rodon-Fores, Paula F. Großmann, Alexander M. Bergmann, Kun Dai, Marta Tena-Solsona, Bernhard Rieger, Job Boekhoven
Published in: Journal of the American Chemical Society, Issue 145, 2023, Page(s) 6880-6887, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c00273

Accelerated Ripening in Chemically Fueled Emulsions**

Author(s): Marta Tena‐Solsona, Jacqueline Janssen, Caren Wanzke, Fabian Schnitter, Hansol Park, Benedikt Rieß, Julianne M. Gibbs, Christoph A. Weber, Job Boekhoven
Published in: ChemSystemsChem, Issue 3/2, 2021, ISSN 2570-4206
Publisher: ChemSystemsChem
DOI: 10.1002/syst.202000034

Reciprocal Coupling in Chemically Fueled Assembly: A Reaction Cycle Regulates Self-Assembly and Vice Versa

Author(s): Brigitte A. K. Kriebisch, Alexander Jussupow, Alexander M. Bergmann, Fabian Kohler, Hendrik Dietz, Ville R. I. Kaila, Job Boekhoven
Published in: Journal of the American Chemical Society, Issue 142/49, 2020, Page(s) 20837-20844, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.0c10486

Parasitic behavior in competing chemically fueled reaction cycles

Author(s): Patrick S. Schwarz, Sudarshana Laha, Jacqueline Janssen, Tabea Huss, Job Boekhoven, Christoph A. Weber
Published in: Chemical Science, Issue 12/21, 2021, Page(s) 7554-7560, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1sc01106e

The Role of Chemically Innocent Polyanions in Active, Chemically Fueled Complex Coacervate Droplets

Author(s): Fabian Späth, Anton S. Maier, Michele Stasi, Alexander M. Bergmann, Kerstin Halama, Monika Wenisch, Bernhard Rieger, Job Boekhoven
Published in: Angewandte Chemie International Edition, Issue 62, 2023, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202309318