Structural basis of controlling the membrane attack complex

Project Information

Controlling MAC

Grant agreement ID: 864751

DOI

10.3030/864751

Project closed

EC signature date 31 January 2020

Start date 1 July 2020

End date 30 June 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 990,00

EU contribution

€ 1 999 990,00

Coordinated by

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (6)

Macrocyclic Peptide Probes for Immunomodulatory Protein CD59: Potent Modulators of Bacterial Toxin Activity and Antibody‐Dependent Cytotoxicity

Author(s): Jasmine K. Bickel, Ammar. I. S. Ahmed, Aidan B. Pidd, Rhodri M. Morgan, Tom E. McAllister, Sam Horrell, Emma C. Couves, Hemavathi Nagaraj, Edward J. Bartlett, Kamel El Omari, Akane Kawamura, Doryen Bubeck, Edward W. Tate
Published in: Angewandte Chemie, Issue 137, 2025, ISSN 0044-8249
Publisher: Wiley
DOI: 10.1002/ange.202422673

Structural basis for membrane attack complex inhibition by CD59

Author(s): Emma C. Couves, Scott Gardner, Tomas B. Voisin, Jasmine K. Bickel, Phillip J. Stansfeld, Edward W. Tate, Doryen Bubeck
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-36441-z

Structural basis of soluble membrane attack complex packaging for clearance

Author(s): Anaïs Menny, Marie V Lukassen, Emma C Couves, Vojtech Franc, Albert J R Heck, Doryen Bubeck
Published in: Nature Communications, Issue Oct 19;12(1):6086, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26366-w

Soluble Membrane Attack Complex: Biochemistry and Immunobiology

Author(s): Scott R Barnum, Doryen Bubeck, Theresa N Schein
Published in: Frontiers in Immunology, Issue 11:585108, 2020, ISSN 1664-3224
Publisher: Frontiers in Immunology
DOI: 10.3389/fimmu.2020.585108

Dynamics and Molecular Interactions of GPI-Anchored CD59

Author(s): Tomas B. Voisin, Emma C. Couves, Edward W. Tate, Doryen Bubeck
Published in: Toxins, Issue 15, 2023, Page(s) 430, ISSN 2072-6651
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins15070430

Capturing pore-forming intermediates of MACPF and binary toxin assemblies by cryoEM

Author(s): Emma C Couves, Doryen Bubeck
Published in: Current Opinion in Structural Biology, Issue June 11; 75:102401, 2022, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2022.102401

Other (2)

Structural basis for how sMAC is packaged for clearance

Author(s): Anaïs Menny, Marie V. Lukassen, Emma C. Couves, Vojtech Franc, Albert J.R. Heck, Doryen Bubeck
Published in: Biorxiv, 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.04.06.438592

Structural basis for membrane attack complex inhibition by CD59

Author(s): Emma C. Couves, Scott Gardner, Tomas B. Voisin, Jasmine K. Bickel, Phillip J. Stansfeld, Edward W. Tate, Doryen Bubeck
Published in: Biorxiv preprint, 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.09.05.506672