Project description
Uncovering the hidden side of infectious diseases
The incubation period is the time interval between exposure to a disease-causing infectious agent and the onset of the first symptom. While it can vary amongst individuals, the rate of replication, as well as the type and length of suppressed symptoms, also varies considerably between pathogens. In this context, the EU-funded DCUBATION project will investigate the actual onset of the symptoms. Specifically, it will conduct real-time evaluation of the prior risk for respiratory infections by integrating transmission models with individual-level data from the electronic medical records of 4.5 million people. The project will identify micro-changes in patient behaviour during the early phase of an infection by analysing digital sensory data from wearable devices.
Objective
Infectious diseases pose one of the greatest risks for a global catastrophe. Just like controlling the spread of wildfires, an early detection of infectious diseases is instrumental to containing outbreaks. Nearly all infections start silently, and gradually progress until clinical symptoms appear. In this silent period, the incubation period (IP), pathogens inhibit major pathways of the innate immune system, allowing an extended period of unhindered replication. The rate of replication, as well as the type and length of suppressed symptoms vary considerably between pathogens, creating a unique signature for each pathogen. Thus, improved understanding of the IP is pivotal for early detection, prevention and control of infectious diseases. Previous studies estimating IPs have used aggregated retrospective data, and are subject to the biases of patient self-reporting. I hypothesise that the actual onset of clinical symptoms occurs earlier than previously known, can be identified more accurately, and can be used in real-time for patient empowerment. Focusing on respiratory infections, my methodological approach includes: 1) real-time evaluation of the prior risk for respiratory infections by integrating transmission models with individual-level data from electronic medical records of 4.5 Million individuals, 2) identification of micro-changes in patients’ behaviour during the early phase of an infection by prospectively analysing digital sensory data from wearable devices and mobile phones of 5000 selected participants, 3) early detection of the causing pathogen validated with self-swab kits that are tested using RT-PCR. Our preliminary work that combined an analysis of EMR and transmission modelling led to a change in public health policy in Israel. The proposed study has the potential to open new research directions on the hidden side of infectious diseases and to initiate a new era of personalized medicine through dramatic changes in patient-doctor interaction.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-STG - Starting Grant
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2020-STG
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
69978 Tel Aviv
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.