RESTORING CARDIAC MECHANICAL FUNCTION BY POLYMERIC ARTIFICIAL MUSCULAR TISSUE

Información del proyecto

REPAIR

Identificador del acuerdo de subvención: 952166

DOI

10.3030/952166

Proyecto cerrado

Fecha de la firma de la CE 22 Junio 2020

Fecha de inicio 1 Septiembre 2020

Fecha de finalización 31 Mayo 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Coste total

€ 3 909 707,50

Aportación de la UE

€ 3 909 707,50

Coordinado por

UNIVERSITA DEGLI STUDI DI FIRENZE
Italy

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (3)

Project Website
Preliminar Promotional material

Promotional material including updated results

Dissemination Kit for conferences and events

Dissemination Kit for conferences and events brochure summary explanantory videos

Open Research Data Pilot (2)

Data management plan.

Data management plan

Update of the data management plan

The data management plan will be updated

Publicaciones

Peer reviewed articles (27)

Optical clearing in cardiac imaging: A comparative study

Autores: Olianti C, Giardini F, Lazzeri E, Costantini I, Silvestri L, Coppini R, Cerbai E, Pavone FS, Sacconi L.
Publicado en: PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 2022, ISSN 0079-6107
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.pbiomolbio.2021.07.012

Quantification of Myocyte Disarray in Human Cardiac Tissue

Autores: Giardini F, Lazzeri E, Vitale G, Ferrantini C, Costantini I, Pavone FS, Poggesi C, Bocchi L, Sacconi L.
Publicado en: Frontiers in Physiology, 2021, ISSN 1664-042X
Editor: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.750364

Photoresponsive Polymer-Based Biomimetic ContractileUnits as Building Block for Artificial Muscles

Autores: Giulia Vitale, Bruno Grandinetti, Silvia Querceto, Daniele Martella, Chiara Tesi, Corrado Poggesi, Elisabetta Cerbai, Diederik S. Wiersma, Camilla Parmeggiani,* Cecilia Ferrantini,* and Leonardo Sacconi
Publicado en: Macromolecular Materials and Engineering, 2022, ISSN 1439-2054
Editor: Wiley
DOI: 10.1002/mame.202200187

Selecting repetitive focal and rotational activation patterns with the highest probability of being a source of atrial fibrillation

Autores: Ben J.M. Hermans, Ozan Özgül, Michael Wolf, Victor G. Marques, Arne van Hunnik, Sander Verheule, Sevasti-Maria Chaldoupi, Dominik Linz, Milad El Haddad, Mattias Duytschaever, Pietro Bonizzi, Kevin Vernooy, Sébastien Knecht, Stef Zeemering, Ulrich Schotten
Publicado en: Journal of Molecular and Cellular Cardiology Plus, Edición 7, 2025, Página(s) 100064, ISSN 2772-9761
Editor: Elsevier BV
DOI: 10.1016/j.jmccpl.2024.100064

Mesoscopic Optical Imaging of Whole Mouse Heart

Autores: Giardini F, Lazzeri E, Olianti C, Beconi G, Costantini I, Silvestri L, Cerbai E, Pavone FS, Sacconi L.
Publicado en: Journal of Visualized Experiments, 2021, ISSN 1940-087X
Editor: MYJoVE Corporation
DOI: 10.3791/62795

Electrophysiological Consequences of Cardiac Fibrosis

Autores: Sander Verheule, Ulrich Schotten
Publicado en: Cells, Edición 10, 2024, Página(s) 3220, ISSN 2073-4409
Editor: MDPI AG
DOI: 10.3390/cells10113220

Cardiac multiscale bioimaging: from nano- through micro- to mesoscales

Autores: Elen Tolstik, Stephan E. Lehnart, Christian Soeller, Kristina Lorenz, Leonardo Sacconi
Publicado en: Trends in Biotechnology, Edición 42, 2024, Página(s) 212-227, ISSN 0167-7799
Editor: Elsevier BV
DOI: 10.1016/j.tibtech.2023.08.007

Translation of pathophysiological mechanisms of atrial fibrosis into new diagnostic and therapeutic approaches

Autores: Ulrich Schotten, Andreas Goette, Sander Verheule
Publicado en: Nature Reviews Cardiology, Edición 22, 2025, Página(s) 225-240, ISSN 1759-5002
Editor: Nature Publishing Group
DOI: 10.1038/s41569-024-01088-w

Experimental study on the dynamic mechanical response of a blue light-stimulated acrylate side chain liquid crystal elastomer

Autores: Zichuan Li, Luutzen Wymenga, Jiajie Fan, Guoqi Zhang
Publicado en: Optics Letters, Edición 49, 2024, Página(s) 5248, ISSN 0146-9592
Editor: Optical Society of America
DOI: 10.1364/ol.533577

Heart Failure, Female Sex, and Atrial Fibrillation Are the Main Drivers of Human Atrial Cardiomyopathy: Results From the CATCH ME Consortium

Autores: Joris Winters, Aaron Isaacs, Stef Zeemering, Michal Kawczynski, Bart Maesen, Jos Maessen, Elham Bidar, Bas Boukens, Ben Hermans, Arne van Hunnik, Barbara Casadei, Larissa Fabritz, Winnie Chua, Laura Sommerfeld, Eduard Guasch, Luis Mont, Montserrat Batlle, Stephane Hatem, Paulus Kirchhof, Reza Wakili, Mortiz Sinner, Monica Stoll, Andreas Goette, Sander Verheule, Ulrich Schotten
Publicado en: Journal of the American Heart Association, Edición 12, 2024, ISSN 2047-9980
Editor: Wiley-Blackwell
DOI: 10.1161/jaha.123.031220

Disturbed atrial metabolism, shear stress, and cardiac load AF after ablation

Autores: Chua, Winnie; Khashaba, Alya; Canagarajah, Hansel; Nielsen, Jens Cosedis; di Biase, Luigi; Haeusler, Karl Georg; Hindricks, Gerhard; Mont, Lluis; Piccini, Jonathan; Schnabel, Renate B; Schotten, Ulrich; Wienhues-Thelen, Ursula-Henrike; Zeller, Tanja; Fabritz, Larissa; Kirchhof, Paulus
Publicado en: EP Europace, Edición 1, 2023, ISSN 1532-2092
Editor: University Oxford University Press

The Role of Crosslinker Molecular Structure on Mechanicaland Light-Actuation Properties in Liquid Crystalline Networks.

Autores: Simone Donato, Daniele Martella, Martina Salzano de Luna, Giulia Arecchi, Silvia Querceto, Cecilia Ferrantini, Leonardo Sacconi, Pierre-Louis Brient, Camille Chatard, Alain Graillot, Diederik S. Wiersma, Camilla Parmeggiani
Publicado en: Macromol. Rapid Commun., 2023, ISSN 1022-1336
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/marc.202200958

Coagulation Factor Xa Induces Proinflammatory Responses in Cardiac Fibroblasts via Activation of Protease-Activated Receptor-1

Autores: D’Alessandro, Elisa, Billy Scaf, Chantal Munts, Arne van Hunnik, Christopher J. Trevelyan, Sander Verheule, Henri M. H. Spronk, Neil A. Turner, Hugo ten Cate, Ulrich Schotten, and et al.
Publicado en: Cells, 2021, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells10112958

PITX2 deficiency leads to atrial mitochondrial dysfunction

Autores: Jasmeet S Reyat, Laura C Sommerfeld, Molly O’Reilly, Victor Roth Cardoso, Ellen Thiemann, Abdullah O Khan, Christopher O’Shea, Sönke Harder, Christian Müller, Jonathan Barlow, Rachel J Stapley, Winnie Chua, S Nashitha Kabir, Olivia Grech, Oliver Hummel, Norbert Hübner, Stefan Kääb, Lluis Mont, Stéphane N Hatem, Joris Winters, Stef Zeemering, Neil V Morgan, Julie Rayes, Katja Gehmlich, Mo
Publicado en: Cardiovascular Research, Edición 120, 2024, Página(s) 1907-1923, ISSN 0008-6363
Editor: Elsevier BV
DOI: 10.1093/cvr/cvae169

The Complex Relation between Atrial Cardiomyopathy and Thrombogenesis

Autores: Elisa D’Alessandro, Joris Winters, Frans A. van Nieuwenhoven, Ulrich Schotten, Sander Verheule
Publicado en: Cells, Edición 11, 2025, Página(s) 2963, ISSN 2073-4409
Editor: MDPI AG
DOI: 10.3390/cells11192963

Thrombin generation by calibrated automated thrombography in goat plasma: Optimization of an assay

Autores: Elisa D'Alessandro, Billy Scaf, René van Oerle, Frans A. van Nieuwenhoven, Arne van Hunnik, Sander Verheule, Ulrich Schotten, Hugo ten Cate, Henri M.H. Spronk
Publicado en: Research and Practice in Thrombosis and Haemostasis, Edición 5, 2023, Página(s) e12620, ISSN 2475-0379
Editor: Elsevier BV
DOI: 10.1002/rth2.12620

Neuromuscular and cardiac organoids and assembloids: Advanced platforms for drug testing

Autores: Lorenzo Fontanelli, Noemi Nisini, Sergio Pirola, Fabio A. Recchia
Publicado en: Pharmacology & Therapeutics, Edición 272, 2025, Página(s) 108876, ISSN 0163-7258
Editor: Pergamon Press
DOI: 10.1016/j.pharmthera.2025.108876

Cell instructive Liquid Crystalline Networks for myotube formation

Autores: Daniele Martella, Michele Mannelli, Roberta Squecco, Rachele Garella, Eglantina Idrizaj, Diego Antonioli, Michele Laus, Diederik S. Wiersma, Tania Gamberi, Paolo Paoli, Camilla Parmeggiani, Tania Fiaschi
Publicado en: iScience, 2021, ISSN 2589-0042
Editor: CellPress
DOI: 10.1016/j.isci.2021.103077

Mesoscopic Optical Imaging of Whole Mouse Heart

Autores: Francesco Giardini, Erica Lazzeri, Camilla Olianti, Giada Beconi, Irene Costantini, Ludovico Silvestri, Elisabetta Cerbai, Francesco S. Pavone, Leonardo Sacconi
Publicado en: Journal of Visualized Experiments, 2024, ISSN 1940-087X
Editor: MYJoVE Corporation
DOI: 10.3791/62795-v

Management of patients with congenital bleeding disorders and cardiac indications for antithrombotic therapy

Autores: Dan Atar, Christophe Vandenbriele, Stefan Agewall, Bruna Gigante, Andreas Goette, Diana A Gorog, Pål A Holme, Konstantin A Krychtiuk, Bianca Rocca, Jolanta M Siller-Matula, Marco Valgimigli, Andrea Rubboli, Robert Klamroth
Publicado en: European Heart Journal - Cardiovascular Pharmacotherapy, Edición 11, 2025, Página(s) 275-289, ISSN 2055-6837
Editor: Oxford University Press (OUP)
DOI: 10.1093/ehjcvp/pvaf006

Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: the 8th AFNET/EHRA consensus conference

Autores: Renate B Schnabel, Elena Andreassi Marinelli, Elena Arbelo, Giuseppe Boriani, Serge Boveda, Claire M Buckley, A John Camm, Barbara Casadei, Winnie Chua, Nikolaos Dagres, Mirko de Melis, Lien Desteghe, Søren Zöga Diederichsen, David Duncker, Lars Eckardt, Christoph Eisert, Daniel Engler, Larissa Fabritz, Ben Freedman, Ludovic Gillet, Andreas Goette, Eduard Guasch, Jesper Hastrup Svendsen, Stépha
Publicado en: EP Europace, Edición 25, 2023, Página(s) 6-27, ISSN 1099-5129
Editor: Oxford University Press
DOI: 10.1093/europace/euac062

Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart

Autores: Jolanda van der Velden, Folkert W Asselbergs, Jeroen Bakkers, Sandor Batkai, Luc Bertrand, Connie R Bezzina, Ilze Bot, Bianca J J M Brundel, Lucie Carrier, Steven Chamuleau, Michele Ciccarelli, Dana Dawson, Sean M Davidson, Andreas Dendorfer, Dirk J Duncker, Thomas Eschenhagen, Larissa Fabritz, Ines Falcão-Pires, Péter Ferdinandy, Mauro Giacca, Henrique Girao, Can Gollmann-Tepeköylü, Mariann G
Publicado en: Cardiovascular Research, Edición 118, 2024, Página(s) 3016-3051, ISSN 0008-6363
Editor: Elsevier BV
DOI: 10.1093/cvr/cvab370

Slower Calcium Handling Balances Faster Cross-Bridge Cycling in Human MYBPC3 HCM

Autores: Josè Manuel Pioner, Giulia Vitale, Sonette Steczina, Marianna Langione, Francesca Margara, Lorenzo Santini, Francesco Giardini, Erica Lazzeri, Nicoletta Piroddi, Beatrice Scellini, Chiara Palandri, Maike Schuldt, Valentina Spinelli, Francesca Girolami, Francesco Mazzarotto, Jolanda van der Velden, Elisabetta Cerbai, Chiara Tesi, Iacopo Olivotto, Alfonso Bueno-Orovio, Leonardo Sacconi, Raffaele Co
Publicado en: Circulation Research, 2023, ISSN 0009-7330
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.122.321956

Precision sampling of discrete sites identified during in-vivo functional testing in the mammalian heart

Autores: Dylan Vermoortele, Camilla Olianti, Matthew Amoni, Francesco Giardini, Stijn De Buck, Chandan K. Nagaraju, Rik Willems, H. Llewellyn Roderick, Karin R. Sipido, Leonardo Sacconi, Piet Claus
Publicado en: Communications Engineering, Edición 3, 2024, ISSN 2731-3395
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s44172-024-00307-z

Genotype-Driven Pathogenesis of Atrial Fibrillation in Hypertrophic Cardiomyopathy: The Case of Different TNNT2 Mutations

Autores: Josè Manuel Pioner, Giulia Vitale, Francesca Gentile, Beatrice Scellini, Nicoletta Piroddi, Elisabetta Cerbai, Iacopo Olivotto, Jil Tardiff, Raffaele Coppini, Chiara Tesi, Corrado Poggesi and Cecilia Ferrantini*
Publicado en: frontiers in physiology, 2022, ISSN 1664-042X
Editor: Frontiers Research Foundation
DOI: 10.3389/fphys.2022.864547

Optimal Threshold and Interpatient Variability in Left Atrial Ablation Scar Assessment by Dark-Blood LGE CMR

Autores: Geertruida Petronella Bijvoet, Ben J.M. Hermans, Dominik Linz, Justin G.L.M. Luermans, Bart Maesen, Robin Nijveldt, Casper Mihl, Kevin Vernooy, Joachim E. Wildberger, Rob J. Holtackers, Ulrich Schotten, Sevasti-Maria Chaldoupi
Publicado en: JACC: Clinical Electrophysiology, Edición 10, 2024, Página(s) 2186-2197, ISSN 2405-500X
Editor: Elsevier BV
DOI: 10.1016/j.jacep.2024.05.017

Disturbed atrial metabolism, shear stress, and cardiac load contribute to atrial fibrillation after ablation: AXAFA biomolecule study

Autores: Winnie Chua, Alya Khashaba, Hansel Canagarajah, Jens Cosedis Nielsen, Luigi di Biase, Karl Georg Haeusler, Gerhard Hindricks, Lluis Mont, Jonathan Piccini, Renate B Schnabel, Ulrich Schotten, Ursula-Henrike Wienhues-Thelen, Tanja Zeller, Larissa Fabritz, Paulus Kirchhof
Publicado en: Europace, Edición 26, 2024, ISSN 1099-5129
Editor: Oxford University Press
DOI: 10.1093/europace/euae028

Non-peer reviewed articles (1)

Correlating electrical dysfunctions and structural remodeling in Arrhythmogenic Mouse Hearts by advanced optical methods

Autores: F Giardini, C Olianti, V Biasci, G Arecchi, T Zaglia, M Mongillo, E Cerbai, C Zgierski-Johnston, P Kohl, L Sacconi
Publicado en: Cardiovascular Research, Edición 118, 2022, ISSN 0008-6363
Editor: Elsevier BV
DOI: 10.1093/cvr/cvac066.114