RESTORING CARDIAC MECHANICAL FUNCTION BY POLYMERIC ARTIFICIAL MUSCULAR TISSUE

Informacje na temat projektu

REPAIR

Identyfikator umowy o grant: 952166

DOI

10.3030/952166

Projekt został zamknięty

Data podpisania przez KE 22 Czerwca 2020

Data rozpoczęcia 1 Września 2020

Data zakończenia 31 Maja 2025

Finansowanie w ramach

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Koszt całkowity

€ 3 909 707,50

Wkład UE

€ 3 909 707,50

Koordynowany przez

UNIVERSITA DEGLI STUDI DI FIRENZE
Italy

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Websites, patent fillings, videos etc. (3)

Project Website
Preliminar Promotional material

Promotional material including updated results

Dissemination Kit for conferences and events

Dissemination Kit for conferences and events brochure summary explanantory videos

Open Research Data Pilot (2)

Data management plan.

Data management plan

Update of the data management plan

The data management plan will be updated

Publikacje

Peer reviewed articles (27)

Optical clearing in cardiac imaging: A comparative study

Autorzy: Olianti C, Giardini F, Lazzeri E, Costantini I, Silvestri L, Coppini R, Cerbai E, Pavone FS, Sacconi L.
Opublikowane w: PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 2022, ISSN 0079-6107
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.pbiomolbio.2021.07.012

Quantification of Myocyte Disarray in Human Cardiac Tissue

Autorzy: Giardini F, Lazzeri E, Vitale G, Ferrantini C, Costantini I, Pavone FS, Poggesi C, Bocchi L, Sacconi L.
Opublikowane w: Frontiers in Physiology, 2021, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.750364

Photoresponsive Polymer-Based Biomimetic ContractileUnits as Building Block for Artificial Muscles

Autorzy: Giulia Vitale, Bruno Grandinetti, Silvia Querceto, Daniele Martella, Chiara Tesi, Corrado Poggesi, Elisabetta Cerbai, Diederik S. Wiersma, Camilla Parmeggiani,* Cecilia Ferrantini,* and Leonardo Sacconi
Opublikowane w: Macromolecular Materials and Engineering, 2022, ISSN 1439-2054
Wydawca: Wiley
DOI: 10.1002/mame.202200187

Selecting repetitive focal and rotational activation patterns with the highest probability of being a source of atrial fibrillation

Autorzy: Ben J.M. Hermans, Ozan Özgül, Michael Wolf, Victor G. Marques, Arne van Hunnik, Sander Verheule, Sevasti-Maria Chaldoupi, Dominik Linz, Milad El Haddad, Mattias Duytschaever, Pietro Bonizzi, Kevin Vernooy, Sébastien Knecht, Stef Zeemering, Ulrich Schotten
Opublikowane w: Journal of Molecular and Cellular Cardiology Plus, Numer 7, 2025, Strona(/y) 100064, ISSN 2772-9761
Wydawca: Elsevier BV
DOI: 10.1016/j.jmccpl.2024.100064

Mesoscopic Optical Imaging of Whole Mouse Heart

Autorzy: Giardini F, Lazzeri E, Olianti C, Beconi G, Costantini I, Silvestri L, Cerbai E, Pavone FS, Sacconi L.
Opublikowane w: Journal of Visualized Experiments, 2021, ISSN 1940-087X
Wydawca: MYJoVE Corporation
DOI: 10.3791/62795

Electrophysiological Consequences of Cardiac Fibrosis

Autorzy: Sander Verheule, Ulrich Schotten
Opublikowane w: Cells, Numer 10, 2024, Strona(/y) 3220, ISSN 2073-4409
Wydawca: MDPI AG
DOI: 10.3390/cells10113220

Cardiac multiscale bioimaging: from nano- through micro- to mesoscales

Autorzy: Elen Tolstik, Stephan E. Lehnart, Christian Soeller, Kristina Lorenz, Leonardo Sacconi
Opublikowane w: Trends in Biotechnology, Numer 42, 2024, Strona(/y) 212-227, ISSN 0167-7799
Wydawca: Elsevier BV
DOI: 10.1016/j.tibtech.2023.08.007

Translation of pathophysiological mechanisms of atrial fibrosis into new diagnostic and therapeutic approaches

Autorzy: Ulrich Schotten, Andreas Goette, Sander Verheule
Opublikowane w: Nature Reviews Cardiology, Numer 22, 2025, Strona(/y) 225-240, ISSN 1759-5002
Wydawca: Nature Publishing Group
DOI: 10.1038/s41569-024-01088-w

Experimental study on the dynamic mechanical response of a blue light-stimulated acrylate side chain liquid crystal elastomer

Autorzy: Zichuan Li, Luutzen Wymenga, Jiajie Fan, Guoqi Zhang
Opublikowane w: Optics Letters, Numer 49, 2024, Strona(/y) 5248, ISSN 0146-9592
Wydawca: Optical Society of America
DOI: 10.1364/ol.533577

Heart Failure, Female Sex, and Atrial Fibrillation Are the Main Drivers of Human Atrial Cardiomyopathy: Results From the CATCH ME Consortium

Autorzy: Joris Winters, Aaron Isaacs, Stef Zeemering, Michal Kawczynski, Bart Maesen, Jos Maessen, Elham Bidar, Bas Boukens, Ben Hermans, Arne van Hunnik, Barbara Casadei, Larissa Fabritz, Winnie Chua, Laura Sommerfeld, Eduard Guasch, Luis Mont, Montserrat Batlle, Stephane Hatem, Paulus Kirchhof, Reza Wakili, Mortiz Sinner, Monica Stoll, Andreas Goette, Sander Verheule, Ulrich Schotten
Opublikowane w: Journal of the American Heart Association, Numer 12, 2024, ISSN 2047-9980
Wydawca: Wiley-Blackwell
DOI: 10.1161/jaha.123.031220

Disturbed atrial metabolism, shear stress, and cardiac load AF after ablation

Autorzy: Chua, Winnie; Khashaba, Alya; Canagarajah, Hansel; Nielsen, Jens Cosedis; di Biase, Luigi; Haeusler, Karl Georg; Hindricks, Gerhard; Mont, Lluis; Piccini, Jonathan; Schnabel, Renate B; Schotten, Ulrich; Wienhues-Thelen, Ursula-Henrike; Zeller, Tanja; Fabritz, Larissa; Kirchhof, Paulus
Opublikowane w: EP Europace, Numer 1, 2023, ISSN 1532-2092
Wydawca: University Oxford University Press

The Role of Crosslinker Molecular Structure on Mechanicaland Light-Actuation Properties in Liquid Crystalline Networks.

Autorzy: Simone Donato, Daniele Martella, Martina Salzano de Luna, Giulia Arecchi, Silvia Querceto, Cecilia Ferrantini, Leonardo Sacconi, Pierre-Louis Brient, Camille Chatard, Alain Graillot, Diederik S. Wiersma, Camilla Parmeggiani
Opublikowane w: Macromol. Rapid Commun., 2023, ISSN 1022-1336
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/marc.202200958

Coagulation Factor Xa Induces Proinflammatory Responses in Cardiac Fibroblasts via Activation of Protease-Activated Receptor-1

Autorzy: D’Alessandro, Elisa, Billy Scaf, Chantal Munts, Arne van Hunnik, Christopher J. Trevelyan, Sander Verheule, Henri M. H. Spronk, Neil A. Turner, Hugo ten Cate, Ulrich Schotten, and et al.
Opublikowane w: Cells, 2021, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells10112958

PITX2 deficiency leads to atrial mitochondrial dysfunction

Autorzy: Jasmeet S Reyat, Laura C Sommerfeld, Molly O’Reilly, Victor Roth Cardoso, Ellen Thiemann, Abdullah O Khan, Christopher O’Shea, Sönke Harder, Christian Müller, Jonathan Barlow, Rachel J Stapley, Winnie Chua, S Nashitha Kabir, Olivia Grech, Oliver Hummel, Norbert Hübner, Stefan Kääb, Lluis Mont, Stéphane N Hatem, Joris Winters, Stef Zeemering, Neil V Morgan, Julie Rayes, Katja Gehmlich, Mo
Opublikowane w: Cardiovascular Research, Numer 120, 2024, Strona(/y) 1907-1923, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvae169

The Complex Relation between Atrial Cardiomyopathy and Thrombogenesis

Autorzy: Elisa D’Alessandro, Joris Winters, Frans A. van Nieuwenhoven, Ulrich Schotten, Sander Verheule
Opublikowane w: Cells, Numer 11, 2025, Strona(/y) 2963, ISSN 2073-4409
Wydawca: MDPI AG
DOI: 10.3390/cells11192963

Thrombin generation by calibrated automated thrombography in goat plasma: Optimization of an assay

Autorzy: Elisa D'Alessandro, Billy Scaf, René van Oerle, Frans A. van Nieuwenhoven, Arne van Hunnik, Sander Verheule, Ulrich Schotten, Hugo ten Cate, Henri M.H. Spronk
Opublikowane w: Research and Practice in Thrombosis and Haemostasis, Numer 5, 2023, Strona(/y) e12620, ISSN 2475-0379
Wydawca: Elsevier BV
DOI: 10.1002/rth2.12620

Neuromuscular and cardiac organoids and assembloids: Advanced platforms for drug testing

Autorzy: Lorenzo Fontanelli, Noemi Nisini, Sergio Pirola, Fabio A. Recchia
Opublikowane w: Pharmacology & Therapeutics, Numer 272, 2025, Strona(/y) 108876, ISSN 0163-7258
Wydawca: Pergamon Press
DOI: 10.1016/j.pharmthera.2025.108876

Cell instructive Liquid Crystalline Networks for myotube formation

Autorzy: Daniele Martella, Michele Mannelli, Roberta Squecco, Rachele Garella, Eglantina Idrizaj, Diego Antonioli, Michele Laus, Diederik S. Wiersma, Tania Gamberi, Paolo Paoli, Camilla Parmeggiani, Tania Fiaschi
Opublikowane w: iScience, 2021, ISSN 2589-0042
Wydawca: CellPress
DOI: 10.1016/j.isci.2021.103077

Mesoscopic Optical Imaging of Whole Mouse Heart

Autorzy: Francesco Giardini, Erica Lazzeri, Camilla Olianti, Giada Beconi, Irene Costantini, Ludovico Silvestri, Elisabetta Cerbai, Francesco S. Pavone, Leonardo Sacconi
Opublikowane w: Journal of Visualized Experiments, 2024, ISSN 1940-087X
Wydawca: MYJoVE Corporation
DOI: 10.3791/62795-v

Management of patients with congenital bleeding disorders and cardiac indications for antithrombotic therapy

Autorzy: Dan Atar, Christophe Vandenbriele, Stefan Agewall, Bruna Gigante, Andreas Goette, Diana A Gorog, Pål A Holme, Konstantin A Krychtiuk, Bianca Rocca, Jolanta M Siller-Matula, Marco Valgimigli, Andrea Rubboli, Robert Klamroth
Opublikowane w: European Heart Journal - Cardiovascular Pharmacotherapy, Numer 11, 2025, Strona(/y) 275-289, ISSN 2055-6837
Wydawca: Oxford University Press (OUP)
DOI: 10.1093/ehjcvp/pvaf006

Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: the 8th AFNET/EHRA consensus conference

Autorzy: Renate B Schnabel, Elena Andreassi Marinelli, Elena Arbelo, Giuseppe Boriani, Serge Boveda, Claire M Buckley, A John Camm, Barbara Casadei, Winnie Chua, Nikolaos Dagres, Mirko de Melis, Lien Desteghe, Søren Zöga Diederichsen, David Duncker, Lars Eckardt, Christoph Eisert, Daniel Engler, Larissa Fabritz, Ben Freedman, Ludovic Gillet, Andreas Goette, Eduard Guasch, Jesper Hastrup Svendsen, Stépha
Opublikowane w: EP Europace, Numer 25, 2023, Strona(/y) 6-27, ISSN 1099-5129
Wydawca: Oxford University Press
DOI: 10.1093/europace/euac062

Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart

Autorzy: Jolanda van der Velden, Folkert W Asselbergs, Jeroen Bakkers, Sandor Batkai, Luc Bertrand, Connie R Bezzina, Ilze Bot, Bianca J J M Brundel, Lucie Carrier, Steven Chamuleau, Michele Ciccarelli, Dana Dawson, Sean M Davidson, Andreas Dendorfer, Dirk J Duncker, Thomas Eschenhagen, Larissa Fabritz, Ines Falcão-Pires, Péter Ferdinandy, Mauro Giacca, Henrique Girao, Can Gollmann-Tepeköylü, Mariann G
Opublikowane w: Cardiovascular Research, Numer 118, 2024, Strona(/y) 3016-3051, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvab370

Slower Calcium Handling Balances Faster Cross-Bridge Cycling in Human MYBPC3 HCM

Autorzy: Josè Manuel Pioner, Giulia Vitale, Sonette Steczina, Marianna Langione, Francesca Margara, Lorenzo Santini, Francesco Giardini, Erica Lazzeri, Nicoletta Piroddi, Beatrice Scellini, Chiara Palandri, Maike Schuldt, Valentina Spinelli, Francesca Girolami, Francesco Mazzarotto, Jolanda van der Velden, Elisabetta Cerbai, Chiara Tesi, Iacopo Olivotto, Alfonso Bueno-Orovio, Leonardo Sacconi, Raffaele Co
Opublikowane w: Circulation Research, 2023, ISSN 0009-7330
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.122.321956

Precision sampling of discrete sites identified during in-vivo functional testing in the mammalian heart

Autorzy: Dylan Vermoortele, Camilla Olianti, Matthew Amoni, Francesco Giardini, Stijn De Buck, Chandan K. Nagaraju, Rik Willems, H. Llewellyn Roderick, Karin R. Sipido, Leonardo Sacconi, Piet Claus
Opublikowane w: Communications Engineering, Numer 3, 2024, ISSN 2731-3395
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s44172-024-00307-z

Genotype-Driven Pathogenesis of Atrial Fibrillation in Hypertrophic Cardiomyopathy: The Case of Different TNNT2 Mutations

Autorzy: Josè Manuel Pioner, Giulia Vitale, Francesca Gentile, Beatrice Scellini, Nicoletta Piroddi, Elisabetta Cerbai, Iacopo Olivotto, Jil Tardiff, Raffaele Coppini, Chiara Tesi, Corrado Poggesi and Cecilia Ferrantini*
Opublikowane w: frontiers in physiology, 2022, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2022.864547

Optimal Threshold and Interpatient Variability in Left Atrial Ablation Scar Assessment by Dark-Blood LGE CMR

Autorzy: Geertruida Petronella Bijvoet, Ben J.M. Hermans, Dominik Linz, Justin G.L.M. Luermans, Bart Maesen, Robin Nijveldt, Casper Mihl, Kevin Vernooy, Joachim E. Wildberger, Rob J. Holtackers, Ulrich Schotten, Sevasti-Maria Chaldoupi
Opublikowane w: JACC: Clinical Electrophysiology, Numer 10, 2024, Strona(/y) 2186-2197, ISSN 2405-500X
Wydawca: Elsevier BV
DOI: 10.1016/j.jacep.2024.05.017

Disturbed atrial metabolism, shear stress, and cardiac load contribute to atrial fibrillation after ablation: AXAFA biomolecule study

Autorzy: Winnie Chua, Alya Khashaba, Hansel Canagarajah, Jens Cosedis Nielsen, Luigi di Biase, Karl Georg Haeusler, Gerhard Hindricks, Lluis Mont, Jonathan Piccini, Renate B Schnabel, Ulrich Schotten, Ursula-Henrike Wienhues-Thelen, Tanja Zeller, Larissa Fabritz, Paulus Kirchhof
Opublikowane w: Europace, Numer 26, 2024, ISSN 1099-5129
Wydawca: Oxford University Press
DOI: 10.1093/europace/euae028

Non-peer reviewed articles (1)

Correlating electrical dysfunctions and structural remodeling in Arrhythmogenic Mouse Hearts by advanced optical methods

Autorzy: F Giardini, C Olianti, V Biasci, G Arecchi, T Zaglia, M Mongillo, E Cerbai, C Zgierski-Johnston, P Kohl, L Sacconi
Opublikowane w: Cardiovascular Research, Numer 118, 2022, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvac066.114