RESTORING CARDIAC MECHANICAL FUNCTION BY POLYMERIC ARTIFICIAL MUSCULAR TISSUE

Project Information

REPAIR

Grant agreement ID: 952166

DOI

10.3030/952166

Project closed

EC signature date 22 June 2020

Start date 1 September 2020

End date 31 May 2025

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost

€ 3 909 707,50

EU contribution

€ 3 909 707,50

Coordinated by

UNIVERSITA DEGLI STUDI DI FIRENZE
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (3)

Project Website
Preliminar Promotional material

Promotional material including updated results

Dissemination Kit for conferences and events

Dissemination Kit for conferences and events brochure summary explanantory videos

Open Research Data Pilot (2)

Data management plan.

Data management plan

Update of the data management plan

The data management plan will be updated

Publications

Peer reviewed articles (27)

Optical clearing in cardiac imaging: A comparative study

Author(s): Olianti C, Giardini F, Lazzeri E, Costantini I, Silvestri L, Coppini R, Cerbai E, Pavone FS, Sacconi L.
Published in: PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 2022, ISSN 0079-6107
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.pbiomolbio.2021.07.012

Quantification of Myocyte Disarray in Human Cardiac Tissue

Author(s): Giardini F, Lazzeri E, Vitale G, Ferrantini C, Costantini I, Pavone FS, Poggesi C, Bocchi L, Sacconi L.
Published in: Frontiers in Physiology, 2021, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.750364

Photoresponsive Polymer-Based Biomimetic ContractileUnits as Building Block for Artificial Muscles

Author(s): Giulia Vitale, Bruno Grandinetti, Silvia Querceto, Daniele Martella, Chiara Tesi, Corrado Poggesi, Elisabetta Cerbai, Diederik S. Wiersma, Camilla Parmeggiani,* Cecilia Ferrantini,* and Leonardo Sacconi
Published in: Macromolecular Materials and Engineering, 2022, ISSN 1439-2054
Publisher: Wiley
DOI: 10.1002/mame.202200187

Selecting repetitive focal and rotational activation patterns with the highest probability of being a source of atrial fibrillation

Author(s): Ben J.M. Hermans, Ozan Özgül, Michael Wolf, Victor G. Marques, Arne van Hunnik, Sander Verheule, Sevasti-Maria Chaldoupi, Dominik Linz, Milad El Haddad, Mattias Duytschaever, Pietro Bonizzi, Kevin Vernooy, Sébastien Knecht, Stef Zeemering, Ulrich Schotten
Published in: Journal of Molecular and Cellular Cardiology Plus, Issue 7, 2025, Page(s) 100064, ISSN 2772-9761
Publisher: Elsevier BV
DOI: 10.1016/j.jmccpl.2024.100064

Mesoscopic Optical Imaging of Whole Mouse Heart

Author(s): Giardini F, Lazzeri E, Olianti C, Beconi G, Costantini I, Silvestri L, Cerbai E, Pavone FS, Sacconi L.
Published in: Journal of Visualized Experiments, 2021, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/62795

Electrophysiological Consequences of Cardiac Fibrosis

Author(s): Sander Verheule, Ulrich Schotten
Published in: Cells, Issue 10, 2024, Page(s) 3220, ISSN 2073-4409
Publisher: MDPI AG
DOI: 10.3390/cells10113220

Cardiac multiscale bioimaging: from nano- through micro- to mesoscales

Author(s): Elen Tolstik, Stephan E. Lehnart, Christian Soeller, Kristina Lorenz, Leonardo Sacconi
Published in: Trends in Biotechnology, Issue 42, 2024, Page(s) 212-227, ISSN 0167-7799
Publisher: Elsevier BV
DOI: 10.1016/j.tibtech.2023.08.007

Translation of pathophysiological mechanisms of atrial fibrosis into new diagnostic and therapeutic approaches

Author(s): Ulrich Schotten, Andreas Goette, Sander Verheule
Published in: Nature Reviews Cardiology, Issue 22, 2025, Page(s) 225-240, ISSN 1759-5002
Publisher: Nature Publishing Group
DOI: 10.1038/s41569-024-01088-w

Experimental study on the dynamic mechanical response of a blue light-stimulated acrylate side chain liquid crystal elastomer

Author(s): Zichuan Li, Luutzen Wymenga, Jiajie Fan, Guoqi Zhang
Published in: Optics Letters, Issue 49, 2024, Page(s) 5248, ISSN 0146-9592
Publisher: Optical Society of America
DOI: 10.1364/ol.533577

Heart Failure, Female Sex, and Atrial Fibrillation Are the Main Drivers of Human Atrial Cardiomyopathy: Results From the CATCH ME Consortium

Author(s): Joris Winters, Aaron Isaacs, Stef Zeemering, Michal Kawczynski, Bart Maesen, Jos Maessen, Elham Bidar, Bas Boukens, Ben Hermans, Arne van Hunnik, Barbara Casadei, Larissa Fabritz, Winnie Chua, Laura Sommerfeld, Eduard Guasch, Luis Mont, Montserrat Batlle, Stephane Hatem, Paulus Kirchhof, Reza Wakili, Mortiz Sinner, Monica Stoll, Andreas Goette, Sander Verheule, Ulrich Schotten
Published in: Journal of the American Heart Association, Issue 12, 2024, ISSN 2047-9980
Publisher: Wiley-Blackwell
DOI: 10.1161/jaha.123.031220

Disturbed atrial metabolism, shear stress, and cardiac load AF after ablation

Author(s): Chua, Winnie; Khashaba, Alya; Canagarajah, Hansel; Nielsen, Jens Cosedis; di Biase, Luigi; Haeusler, Karl Georg; Hindricks, Gerhard; Mont, Lluis; Piccini, Jonathan; Schnabel, Renate B; Schotten, Ulrich; Wienhues-Thelen, Ursula-Henrike; Zeller, Tanja; Fabritz, Larissa; Kirchhof, Paulus
Published in: EP Europace, Issue 1, 2023, ISSN 1532-2092
Publisher: University Oxford University Press

The Role of Crosslinker Molecular Structure on Mechanicaland Light-Actuation Properties in Liquid Crystalline Networks.

Author(s): Simone Donato, Daniele Martella, Martina Salzano de Luna, Giulia Arecchi, Silvia Querceto, Cecilia Ferrantini, Leonardo Sacconi, Pierre-Louis Brient, Camille Chatard, Alain Graillot, Diederik S. Wiersma, Camilla Parmeggiani
Published in: Macromol. Rapid Commun., 2023, ISSN 1022-1336
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/marc.202200958

Coagulation Factor Xa Induces Proinflammatory Responses in Cardiac Fibroblasts via Activation of Protease-Activated Receptor-1

Author(s): D’Alessandro, Elisa, Billy Scaf, Chantal Munts, Arne van Hunnik, Christopher J. Trevelyan, Sander Verheule, Henri M. H. Spronk, Neil A. Turner, Hugo ten Cate, Ulrich Schotten, and et al.
Published in: Cells, 2021, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10112958

PITX2 deficiency leads to atrial mitochondrial dysfunction

Author(s): Jasmeet S Reyat, Laura C Sommerfeld, Molly O’Reilly, Victor Roth Cardoso, Ellen Thiemann, Abdullah O Khan, Christopher O’Shea, Sönke Harder, Christian Müller, Jonathan Barlow, Rachel J Stapley, Winnie Chua, S Nashitha Kabir, Olivia Grech, Oliver Hummel, Norbert Hübner, Stefan Kääb, Lluis Mont, Stéphane N Hatem, Joris Winters, Stef Zeemering, Neil V Morgan, Julie Rayes, Katja Gehmlich, Mo
Published in: Cardiovascular Research, Issue 120, 2024, Page(s) 1907-1923, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvae169

The Complex Relation between Atrial Cardiomyopathy and Thrombogenesis

Author(s): Elisa D’Alessandro, Joris Winters, Frans A. van Nieuwenhoven, Ulrich Schotten, Sander Verheule
Published in: Cells, Issue 11, 2025, Page(s) 2963, ISSN 2073-4409
Publisher: MDPI AG
DOI: 10.3390/cells11192963

Thrombin generation by calibrated automated thrombography in goat plasma: Optimization of an assay

Author(s): Elisa D'Alessandro, Billy Scaf, René van Oerle, Frans A. van Nieuwenhoven, Arne van Hunnik, Sander Verheule, Ulrich Schotten, Hugo ten Cate, Henri M.H. Spronk
Published in: Research and Practice in Thrombosis and Haemostasis, Issue 5, 2023, Page(s) e12620, ISSN 2475-0379
Publisher: Elsevier BV
DOI: 10.1002/rth2.12620

Neuromuscular and cardiac organoids and assembloids: Advanced platforms for drug testing

Author(s): Lorenzo Fontanelli, Noemi Nisini, Sergio Pirola, Fabio A. Recchia
Published in: Pharmacology & Therapeutics, Issue 272, 2025, Page(s) 108876, ISSN 0163-7258
Publisher: Pergamon Press
DOI: 10.1016/j.pharmthera.2025.108876

Cell instructive Liquid Crystalline Networks for myotube formation

Author(s): Daniele Martella, Michele Mannelli, Roberta Squecco, Rachele Garella, Eglantina Idrizaj, Diego Antonioli, Michele Laus, Diederik S. Wiersma, Tania Gamberi, Paolo Paoli, Camilla Parmeggiani, Tania Fiaschi
Published in: iScience, 2021, ISSN 2589-0042
Publisher: CellPress
DOI: 10.1016/j.isci.2021.103077

Mesoscopic Optical Imaging of Whole Mouse Heart

Author(s): Francesco Giardini, Erica Lazzeri, Camilla Olianti, Giada Beconi, Irene Costantini, Ludovico Silvestri, Elisabetta Cerbai, Francesco S. Pavone, Leonardo Sacconi
Published in: Journal of Visualized Experiments, 2024, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/62795-v

Management of patients with congenital bleeding disorders and cardiac indications for antithrombotic therapy

Author(s): Dan Atar, Christophe Vandenbriele, Stefan Agewall, Bruna Gigante, Andreas Goette, Diana A Gorog, Pål A Holme, Konstantin A Krychtiuk, Bianca Rocca, Jolanta M Siller-Matula, Marco Valgimigli, Andrea Rubboli, Robert Klamroth
Published in: European Heart Journal - Cardiovascular Pharmacotherapy, Issue 11, 2025, Page(s) 275-289, ISSN 2055-6837
Publisher: Oxford University Press (OUP)
DOI: 10.1093/ehjcvp/pvaf006

Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: the 8th AFNET/EHRA consensus conference

Author(s): Renate B Schnabel, Elena Andreassi Marinelli, Elena Arbelo, Giuseppe Boriani, Serge Boveda, Claire M Buckley, A John Camm, Barbara Casadei, Winnie Chua, Nikolaos Dagres, Mirko de Melis, Lien Desteghe, Søren Zöga Diederichsen, David Duncker, Lars Eckardt, Christoph Eisert, Daniel Engler, Larissa Fabritz, Ben Freedman, Ludovic Gillet, Andreas Goette, Eduard Guasch, Jesper Hastrup Svendsen, Stépha
Published in: EP Europace, Issue 25, 2023, Page(s) 6-27, ISSN 1099-5129
Publisher: Oxford University Press
DOI: 10.1093/europace/euac062

Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart

Author(s): Jolanda van der Velden, Folkert W Asselbergs, Jeroen Bakkers, Sandor Batkai, Luc Bertrand, Connie R Bezzina, Ilze Bot, Bianca J J M Brundel, Lucie Carrier, Steven Chamuleau, Michele Ciccarelli, Dana Dawson, Sean M Davidson, Andreas Dendorfer, Dirk J Duncker, Thomas Eschenhagen, Larissa Fabritz, Ines Falcão-Pires, Péter Ferdinandy, Mauro Giacca, Henrique Girao, Can Gollmann-Tepeköylü, Mariann G
Published in: Cardiovascular Research, Issue 118, 2024, Page(s) 3016-3051, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvab370

Slower Calcium Handling Balances Faster Cross-Bridge Cycling in Human MYBPC3 HCM

Author(s): Josè Manuel Pioner, Giulia Vitale, Sonette Steczina, Marianna Langione, Francesca Margara, Lorenzo Santini, Francesco Giardini, Erica Lazzeri, Nicoletta Piroddi, Beatrice Scellini, Chiara Palandri, Maike Schuldt, Valentina Spinelli, Francesca Girolami, Francesco Mazzarotto, Jolanda van der Velden, Elisabetta Cerbai, Chiara Tesi, Iacopo Olivotto, Alfonso Bueno-Orovio, Leonardo Sacconi, Raffaele Co
Published in: Circulation Research, 2023, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.122.321956

Precision sampling of discrete sites identified during in-vivo functional testing in the mammalian heart

Author(s): Dylan Vermoortele, Camilla Olianti, Matthew Amoni, Francesco Giardini, Stijn De Buck, Chandan K. Nagaraju, Rik Willems, H. Llewellyn Roderick, Karin R. Sipido, Leonardo Sacconi, Piet Claus
Published in: Communications Engineering, Issue 3, 2024, ISSN 2731-3395
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s44172-024-00307-z

Genotype-Driven Pathogenesis of Atrial Fibrillation in Hypertrophic Cardiomyopathy: The Case of Different TNNT2 Mutations

Author(s): Josè Manuel Pioner, Giulia Vitale, Francesca Gentile, Beatrice Scellini, Nicoletta Piroddi, Elisabetta Cerbai, Iacopo Olivotto, Jil Tardiff, Raffaele Coppini, Chiara Tesi, Corrado Poggesi and Cecilia Ferrantini*
Published in: frontiers in physiology, 2022, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2022.864547

Optimal Threshold and Interpatient Variability in Left Atrial Ablation Scar Assessment by Dark-Blood LGE CMR

Author(s): Geertruida Petronella Bijvoet, Ben J.M. Hermans, Dominik Linz, Justin G.L.M. Luermans, Bart Maesen, Robin Nijveldt, Casper Mihl, Kevin Vernooy, Joachim E. Wildberger, Rob J. Holtackers, Ulrich Schotten, Sevasti-Maria Chaldoupi
Published in: JACC: Clinical Electrophysiology, Issue 10, 2024, Page(s) 2186-2197, ISSN 2405-500X
Publisher: Elsevier BV
DOI: 10.1016/j.jacep.2024.05.017

Disturbed atrial metabolism, shear stress, and cardiac load contribute to atrial fibrillation after ablation: AXAFA biomolecule study

Author(s): Winnie Chua, Alya Khashaba, Hansel Canagarajah, Jens Cosedis Nielsen, Luigi di Biase, Karl Georg Haeusler, Gerhard Hindricks, Lluis Mont, Jonathan Piccini, Renate B Schnabel, Ulrich Schotten, Ursula-Henrike Wienhues-Thelen, Tanja Zeller, Larissa Fabritz, Paulus Kirchhof
Published in: Europace, Issue 26, 2024, ISSN 1099-5129
Publisher: Oxford University Press
DOI: 10.1093/europace/euae028

Non-peer reviewed articles (1)

Correlating electrical dysfunctions and structural remodeling in Arrhythmogenic Mouse Hearts by advanced optical methods

Author(s): F Giardini, C Olianti, V Biasci, G Arecchi, T Zaglia, M Mongillo, E Cerbai, C Zgierski-Johnston, P Kohl, L Sacconi
Published in: Cardiovascular Research, Issue 118, 2022, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvac066.114