Ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Report on existing in vitro assays to detect MIEs and KEs in the qAOP networks on liver steatosis and cholestasis
Report on existing and novel in vitro assays to detect MIEs and KEs in the qAOP network on cognitive function defects
Report on existing in vitro assays to detect MIEs and KEs in the qAOP networks on tubular necrosis and crystallopathy
Report on the definition of and contact with target audiences

Project website

Computational model for neural tube closure defects

Publications

Computational Strategies for Assessing Adverse Outcome Pathways: Hepatic Steatosis as a Case Study

Author(s): Rita Ortega-Vallbona, Martina Palomino-Schätzlein, Laia Tolosa, Emilio Benfenati, Gerhard F. Ecker, Rafael Gozalbes, Eva Serrano-Candelas
Published in: International Journal of Molecular Sciences, Issue 25, 2024, Page(s) 11154, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms252011154

Safer chemicals using less animals: kick-off of the European ONTOX project

Author(s): Mathieu Vinken, Emilio Benfenati, François Busquet, José Castell, Djork-Arné Clevert, Theo M. de Kok, Hubert Dirven, Ellen Fritsche, Liesbet Geris, Rafael Gozalbes, Thomas Hartung, Danyel Jennen, Ramiro Jover, Helena Kandarova, Nynke Kramer, Cyrille Krul, Thomas Luechtefeld, Rosalinde Masereeuw, Erwin Roggen, Stephan Schaller, Tamara Vanhaecke, Chihae Yang, Aldert H. Piersma
Published in: Toxicology, Issue 458, 2021, Page(s) 152846, ISSN 0300-483X
Publisher: Elsevier BV
DOI: 10.1016/j.tox.2021.152846

Developmental neurotoxicity (DNT): A call for implementation of new approach methodologies for regulatory purposes: Summary of the 5th International Conference on DNT Testing

Author(s): Ivana Celardo, Michael Aschner, Randolph S. Ashton, Kelly E. Carstens, Andrea Cediel-Ulloa, Eike Cöllen, Kevin M. Crofton, Susan J. Debad, Nadine Dreser, Suzanne Fitzpatrick, Ellen Fritsche, Sebastian Gutsfeld, Barry Hardy, Thomas Hartung, Ellen Hessel, Harm Heusinkveld, Helena T. Hogberg, Jui-Hua Hsieh, Yasunari Kanda, Gavin T. Knight, Thomas Knudsen, Katharina Koch, Eliska Kuchovska, Iris Manga
Published in: ALTEX, Issue 42, 2025, Page(s) 323-349, ISSN 1868-8551
Publisher: ALTEX
DOI: 10.14573/altex.2503191

Unsupervised Representation Learning for Proteochemometric Modeling

Author(s): Kim, Paul T., Robin Winter, and Djork-Arné Clevert
Published in: International Journal of Molecular Sciences, Issue 22/23, 2021, Page(s) 12882, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222312882

A computational dynamic systems model for in silico prediction of neural tube closure defects

Author(s): Job H. Berkhout, James A. Glazier, Aldert H. Piersma, Julio M. Belmonte, Juliette Legler, Richard M. Spencer, Thomas B. Knudsen, Harm J. Heusinkveld
Published in: Current Research in Toxicology, Issue 8, 2025, Page(s) 100210, ISSN 2666-027X
Publisher: Elsevier BV
DOI: 10.1016/j.crtox.2024.100210

Scientific validation of human Neurosphere Assays for Developmental Neurotoxicity evaluation

Author(s): Koch K, Bartmann K, Hartmann J, Kapr J, Klose J, Kuchovská E, Pahl M, Schlüppmann K, Zühr E and Fritsche E
Published in: The Frontiers in toxicology/Section Neurotoxicology, Issue 4/816370, 2022, Page(s) 1-26, ISSN 2673-3080
Publisher: Frontiers Media S.A.
DOI: 10.3389/ftox.2022.816370

Biology-inspired dynamic microphysiological system approaches to revolutionize basic research, healthcare and animal welfare

Author(s): Uwe Marx, Sonja Beken, Zaozao Chen, E‑M Dehne, A Doherty, L Ewart, S C Fitzpatrick, L G Griffith, Z Gu, T Hartung, J Hickman, D E Ingber, S Ishida, J Jeong, M Leist, L Levin, D L Mendrick, G Pallocca, S Platz, M Raschke, L Smirnova, D A Tagle, M Trapecar, B W M van Balkom, J van den Eijnden‑van Raaij, A van der Meer,
Published in: ALTEX, Issue 42, 2025, Page(s) 204–223, ISSN 1868-596X
Publisher: ALTEX Edition
DOI: 10.14573/altex.2410112

Mapping physiology: A systems biology approach for the development of alternative methods in toxicology

Author(s): Bernard Staumont, Luiz Ladeira, Alessio Gamba, Harm J. Heusinkveld, Aldert Piersma, Ellen Fritsche, Rosalinde Masereeuw, Tamara Vanhaecke, Marc Teunis, Thomas H. Luechtefeld, Thomas Hartung, Ramiro Jover, Mathieu Vinken, Liesbet Geris
Published in: ALTEX, Issue Volume 42 (2), 2025, Page(s) 301–307, ISSN 1868-596X
Publisher: ALTEX Edition
DOI: 10.14573/altex.2412241

The SCAHT Adverse Outcome Pathway (AOP)_HUB: A hands-on platform for information exchange, sharing, and developing AOPs

Author(s): Emre Coerek, Eliska Kuchovska, Lidwina Gerner, Lihini Nilma, Dan Villeneuve and Ellen Fritsche
Published in: ALTEX, Issue 42, 2025, Page(s) 361-362, ISSN 1868-8551
Publisher: ALTEX
DOI: 10.14573/altex.2502051

Optimization of an adverse outcome pathway network on chemical-induced cholestasis using an artificial intelligence-assisted data collection and confidence level quantification approach

Author(s): Jonas van Ertvelde, Anouk Verhoeven, Amy Maerten, Axelle Cooreman, Bruna dos Santos Rodrigues, Julen Sanz-Serrano, Milos Mihajlovic, Ignacio Tripodi, Marc Teunis, Ramiro Jover, Thomas Luechtefeld, Tamara Vanhaecke, Jian Jiang, Mathieu Vinken
Published in: Journal of Biomedical Informatics, Issue Volume 145, September 2023, 2023, Page(s) 104465, ISSN 1532-0464
Publisher: Academic Press
DOI: 10.1016/j.jbi.2023.104465

Natural language processing in toxicology: Delineating adverse outcome pathways and guiding the application of new approach methodologies

Author(s): Marie Corradi, Alyanne de Haan, Bernard Staumont, Aldert Piersma, Liesbet Geris, Raymond Pieters, Cyrille Krul, Marc Teunis
Published in: Biosystems and Biomaterials, Issue 26665344, 2022, ISSN 2666-5344
Publisher: Elsevier BV
DOI: 10.1016/j.bbiosy.2022.100061

In vitro test battery for testing molecular initiating events in chemical-induced cholestasis

Author(s): Amy Maerten, Annika Drees, Jian Jiang, Julen Sanz-Serrano, Lindsey Devisscher, Mathieu Vinken
Published in: Toxicology, Issue 517, 2025, Page(s) 154210, ISSN 0300-483X
Publisher: Elsevier BV
DOI: 10.1016/j.tox.2025.154210

ToxAIcology - The evolving role of artificial intelligence in advancing toxicology and modernizing regulatory science

Author(s): Thomas Hartung
Published in: ALTEX, Issue 4/yr, 2023, Page(s) 559-570, ISSN 1868-8551
Publisher: Springer Spektrum
DOI: 10.14573/altex.2309191

A call for a Human Exposome Project.

Author(s): Thomas Hartung
Published in: ALTEX, Issue 4/yr, 2023, Page(s) 4–33, ISSN 1868-8551
Publisher: Springer Spektrum
DOI: 10.14573/altex.2301061

Transcriptomic characterization of 2D and 3D human induced pluripotent stem cell-based in vitro models as New Approach Methodologies for developmental neurotoxicity testing

Author(s): Malene Lislien, Eliska Kuchovska, Julia Kapr, Nur Duale, Jill Mari Andersen, Hubert Dirven, Oddvar Myhre, Ellen Fritsche, Katharina Koch, Marcin W. Wojewodzic
Published in: Toxicology, Issue 510, 2024, Page(s) 154000, ISSN 0300-483X
Publisher: Elsevier BV
DOI: 10.1016/j.tox.2024.154000

Unlocking liver physiology: comprehensive pathway maps for mechanistic understanding

Author(s): Luiz Ladeira, Anouk Verhoeven, Jonas van Ertvelde, Jian Jiang, Alessio Gamba, Julen Sanz-Serrano, Tamara Vanhaecke, Harm J. Heusinkveld, Ramiro Jover, Mathieu Vinken, Liesbet Geris, Bernard Staumont
Published in: Frontiers in Toxicology, Issue 7, 2025, Page(s) 1-10, ISSN 2673-3080
Publisher: Frontiers Media SA
DOI: 10.3389/ftox.2025.1619651

Img2Mol – accurate SMILES recognition from molecular graphical depictions

Author(s): Djork-Arné Clevert, Tuan Le, Robin Winter, Floriane Montanari
Published in: Chemical Science, Issue 12/42, 2021, Page(s) 14174-14181, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1sc01839f

Report of the First ONTOX Stakeholder Network Meeting: Digging Under the Surface of ONTOX Together With the Stakeholders

Author(s): Michael Diemar, Mathieu Vinken, Marc Teunis, Cyrille Krul, François Busquet, Julia Dominika Zajac, Helena Kandarova, Raffaella Corvi, Matteo Z. Russo, Anastasiia Kharina, Louise Bryndum, Michael Santillo, Denise Bloch, Olena Kucheryavenko, Demosthenes Panagiotakos, Vera Rogiers, Manon Beekhuijzen, Arianna Giusti, Abdulkarim Najjar, Carol CourageShow lessTorben Koenig, Susanne Kolle, Harrie Boonen
Published in: ATLA, Issue Jan, 2024, 2024, ISSN 0261-1929
Publisher: Fund for the Replacement of Animals in Medical Experiments
DOI: 10.1177/02611929231225730

Novel clinical phenotypes, drug categorization, and outcome prediction in drug-induced cholestasis: Analysis of a database of 432 patients developed by literature review and machine learning support

Author(s): Marta Moreno-Torres, Ernesto López-Pascual, Anna Rapisarda, Guillermo Quintás, Annika Drees, Inger-Lise Steffensen, Thomas Luechtefeld, Eva Serrano-Candelas, Marina Garcia de Lomana, Domenico Gadaleta, Hubert Dirven, Mathieu Vinken, Ramiro Jover
Published in: Biomedicine & Pharmacotherapy, Issue 174, 2024, Page(s) 116530, ISSN 0753-3322
Publisher: Elsevier Masson
DOI: 10.1016/j.biopha.2024.116530

Monte Carlo Models for Sub-Chronic Repeated-Dose Toxicity: Systemic and Organ-Specific Toxicity

Author(s): Gianluca Selvestrel, Giovanna J. Lavado, Alla P. Toropova, Andrey A. Toropov, Domenico Gadaleta, Marco Marzo, Diego Baderna and Emilio Benfenati
Published in: International Journal of Molecular Sciences, Issue 14220067, 2022, Page(s) 6615, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23126615

Mitochondria as the Target of Hepatotoxicity and Drug-Induced Liver Injury: Molecular Mechanisms and Detection Methods

Author(s): Mihajlović M and Vinken M
Published in: International Journal of Molecular Sciences, Issue 23(6), 3315, 2022, Page(s) 1-37, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23063315

In Vitro Liver Toxicity Testing of Chemicals: A Pragmatic Approach

Author(s): Andrés Tabernilla, Bruna dos Santos Rodrigues, Alanah Pieters, Anne Caufriez, Kaat Leroy, Raf Van Campenhout, Axelle Cooreman, Ana Rita Gomes, Emma Arnesdotter, Eva Gijbels, Mathieu Vinken
Published in: International Journal of Molecular Sciences, Issue 22/9, 2021, Page(s) 5038, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22095038

Accessible methods and tools to estimate chemical exposure in humans to support risk assessment: A systematic scoping review

Author(s): Maria E. Kalyva, Gunn E. Vist, Michael Guy Diemar, Graciela López-Soop, T.J. Bozada, Thomas Luechtefeld, Erwin L. Roggen, Hubert Dirven, Mathieu Vinken, Trine Husøy
Published in: Environmental Pollution, Issue 352, 2024, Page(s) 124109, ISSN 0269-7491
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2024.124109

Unraveling the mechanisms underlying drug-induced cholestatic liver injury: identifying key genes using machine learning techniques on human on in vitro data sets.

Author(s): Jian Jiang, Jonas van Ertvelde, Gökhan Ertaylan, Ralf Peeters, Danyel Jennen, Theo M. de Kok, Mathieu Vinken
Published in: Archives of Toxicology, Issue volume 91, 2023, 2023, Page(s) 2969-2981, ISSN 1432-0738
Publisher: Springer
DOI: 10.1007/s00204-023-03583-4

Comprehensive benchmarking of computational tools for predicting toxicokinetic and physicochemical properties of chemicals

Author(s): Domenico Gadaleta, Eva Serrano-Candelas, Rita Ortega-Vallbona, Erika Colombo, Marina Garcia de Lomana, Giada Biava, Pablo Aparicio-Sánchez, Alessandra Roncaglioni, Rafael Gozalbes, Emilio Benfenati
Published in: Journal of Cheminformatics, Issue 16, 2024, Page(s) 145, ISSN 1758-2946
Publisher: Chemistry Central
DOI: 10.1186/s13321-024-00931-z

Acceptance criteria for new approach methods in toxicology and human health-relevant life science research – part I

Author(s): Anna-Katharina Holzer
Published in: ALTEX, Issue 4/yr, 2023, Page(s) 706-712, ISSN 1868-596X
Publisher: Springer Spektrum
DOI: 10.14573/altex.2310021

The application of natural language processing for the extraction of mechanistic information in toxicology

Author(s): Marie Corradi, Thomas Luechtefeld, Alyanne M. de Haan, Raymond Pieters, Jonathan H. Freedman, Tamara Vanhaecke, Mathieu Vinken, Marc Teunis
Published in: Frontiers in Toxicology, Issue 6, 2024, ISSN 2673-3080
Publisher: Frontiers
DOI: 10.3389/ftox.2024.1393662

Machine learning classification of steatogenic compounds using toxicogenomics profiles

Author(s): Brian Bwanya, Saad Lodhi, Theo M. de Kok, Luiz Ladeira, Marcha CT Verheijen, Danyel GJ Jennen, Florian Caiment
Published in: Toxicology, Issue 517, 2025, Page(s) 154237, ISSN 0300-483X
Publisher: Elsevier BV
DOI: 10.1016/j.tox.2025.154237

Metabolomics in Preclinical Drug Safety Assessment: Current Status and Future Trends

Author(s): Fenna Sillé, Thomas Hartung
Published in: Metabolites, Issue 14(2), 98, 2024, ISSN 2218-1989
Publisher: MDPI
DOI: 10.3390/metabo14020098

Quantitative structure–activity relationships of chemical bioactivity toward proteins associated with molecular initiating events of organ-specific toxicity

Author(s): Domenico Gadaleta, Marina Garcia de Lomana, Eva Serrano-Candelas, Rita Ortega-Vallbona, Rafael Gozalbes, Alessandra Roncaglioni, Emilio Benfenati
Published in: Journal of Cheminformatics, Issue 16, 2024, ISSN 1758-2946
Publisher: Chemistry Central
DOI: 10.1186/s13321-024-00917-x

Predicting Liver-Related In Vitro Endpoints with Machine Learning to Support Early Detection of Drug-Induced Liver Injury

Author(s): Marina Garcia de Lomana, Domenico Gadaleta, Marian Raschke, Robert Fricke, Floriane Montanari
Published in: Chemical Research in Toxicology, Issue 38, 2025, Page(s) 656-671, ISSN 0893-228X
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrestox.4c00453

Using in silico tools to predict flame retardant metabolites for more informative exposomics-based approaches

Author(s): Breanne Kincaid, Przemyslaw Piechota, Emily Golden, Mikhail Maertens, Thomas Hartung, Alexandra Maertens
Published in: Frontiers in Toxicology, Issue 5, 2023, Page(s) 45307, ISSN 2673-3080
Publisher: Frontiers
DOI: 10.3389/ftox.2023.1216802

Alternative methods go green! Green toxicology as a sustainable approach for assessing chemical safety and designing safer chemicals

Author(s): Alexandra Maertens, Thomas Luechtefeld, Jean Knight, Thomas Hartung
Published in: ALTEX, Issue Vol. 41 No. 1, 2024, ISSN 1868-8551
Publisher: Springer International Publishing AG
DOI: 10.14573/altex.2312291

AI as the New Frontier in Chemical Risk Assessment

Author(s): Thomas Hartung
Published in: Frontiers in Artificial Intelligence, 2023, Page(s) 1-4, ISSN 0922-6389
Publisher: IOS Press
DOI: 10.3389/frai.2023.1269932

4.2 million and counting… The animal toll for REACH systemic toxicity studies

Author(s): Jean Knight, Thomas Hartung, Costanza Rovida
Published in: ALTEX, Issue 4/yr, 2023, Page(s) 389-407, ISSN 1868-8551
Publisher: Springer Spektrum
DOI: 10.14573/altex.2303201

The Development of a Non-Invasive Screening Method Based on Serum microRNAs to Quantify the Percentage of Liver Steatosis

Author(s): Polina Soluyanova, Guillermo Quintás, Álvaro Pérez-Rubio, Iván Rienda, Erika Moro, Marcel van Herwijnen, Marcha Verheijen, Florian Caiment, Judith Pérez-Rojas, Ramón Trullenque-Juan, Eugenia Pareja, Ramiro Jover
Published in: Biomolecules, Issue 14, 2025, Page(s) 1423, ISSN 2218-273X
Publisher: MDPI
DOI: 10.3390/biom14111423

Replacement of animal testing by integrated approaches to testingand assessment (IATA): a call for in vivitrosi

Author(s): Caloni F, De Angelis I, Hartung T
Published in: Archives of Toxicology, Issue 96, 2022, Page(s) 1935–1950, ISSN 0340-5761
Publisher: Springer Verlag
DOI: 10.1007/s00204-022-03299-x

The Good, The Bad, and The Perplexing: Structural Alerts and Read-Across for Predicting Skin Sensitization Using Human Data

Author(s): Emily Golden, Daniel C. Ukaegbu, Peter Ranslow, Robert H. Brown, Thomas Hartung, Alexandra Maertens
Published in: Chemical Research in Toxicology, Issue 36, 2023, Page(s) 734-746, ISSN 0893-228X
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrestox.2c00383

Prediction of the Neurotoxic Potential of Chemicals Based on Modelling of Molecular Initiating Events Upstream of the Adverse Outcome Pathways of (Developmental) Neurotoxicity

Author(s): Domenico Gadaleta, Nicoleta Spînu, Alessandra Roncaglioni, Mark T. D. Cronin, Emilio Benfenati
Published in: International Journal of Molecular Sciences, Issue 23(6), 2022, Page(s) 3053, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23063053

The effects of hexabromocyclododecane on the transcriptome and hepatic enzyme activity in three human HepaRG-based models

Author(s): Susana Proença, Nick van Sabben, Juliette Legler, Jorke H. Kamstra, Nynke I. Kramer
Published in: Toxicology, Issue Volume 485, February 2023, 153411, 2023, ISSN 0300-483X
Publisher: Elsevier BV
DOI: 10.1016/j.tox.2022.153411

G × E interactions as a basis for toxicological uncertainty

Author(s): Ilinca Suciu, David Pamies, Roberta Peruzzo, Petra H. Wirtz, Lena Smirnova, Giorgia Pallocca, Christof Hauck, Mark T. D. Cronin, Jan G. Hengstler, Thomas Brunner, Thomas Hartung, Ivano Amelio, and Marcel Leist
Published in: Archives of Toxicology, 2023, Page(s) 2035–2049, ISSN 0340-5761
Publisher: Springer Verlag
DOI: 10.1007/s00204-023-03500-9

Challenges and opportunities for validation of AI-based new approach methods

Author(s): Thomas Hartung, Nicole Kleinstreuer
Published in: ALTEX, Issue 42, 2025, Page(s) 1-21, ISSN 1868-596X
Publisher: ALTEX Edition
DOI: 10.14573/altex.2412291

From big data to smart decisions: artificial intelligence in kidney risk assessment

Author(s): Devon A. Barnes, Luiz Ladeira, Rosalinde Masereeuw
Published in: Nature Reviews Nephrology, Issue Monthly, 2025, ISSN 1759-5061
Publisher: Nature Publishing Group
DOI: 10.1038/s41581-025-00962-1

Artificial intelligence (AI)—it’s the end of the tox as we know it (and I feel fine)

Author(s): Nicole Kleinstreuer, Thomas Hartung
Published in: Archives of Toxicology, Issue Vol 98, 2024, Page(s) 735–754, ISSN 0340-5761
Publisher: Springer Verlag
DOI: 10.1007/s00204-023-03666-2

Predicting the Mitochondrial Toxicity of Small Molecules: Insights from Mechanistic Assays and Cell Painting Data

Author(s): Marina Garcia de Lomana, Paula Andrea Marin Zapata, and Floriane Montanari
Published in: Chemical Research in Toxicology, Issue Volume 36, issue 7, 2023, Page(s) 1107–1120, ISSN 0893-228X
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrestox.3c00086

DockTox: Targeting molecular initiating events in organ toxicity through molecular docking

Author(s): Rita Ortega-Vallbona, David Talavera-Cortés, Laureano E. Carpio, Jessica Coto Palacio, Alessandra Roncaglioni, Marina Garcia De Lomana, Domenico Gadaleta, Emilio Benfenati, Rafael Gozalbes, Eva Serrano-Candelas
Published in: Toxicology, Issue 515, 2025, Page(s) 154155, ISSN 0300-483X
Publisher: Elsevier BV
DOI: 10.1016/j.tox.2025.154155

Systematic evaluation of high-throughput PBK modelling strategies for the prediction of intravenous and oral pharmacokinetics in humans

Author(s): René Geci, Domenico Gadaleta, Marina García de Lomana, Rita Ortega-Vallbona, Erika Colombo, Eva Serrano-Candelas, Alicia Paini, Lars Kuepfer, Stephan Schaller
Published in: Archives of Toxicology, Issue 98, 2024, Page(s) 2659-2676, ISSN 0340-5761
Publisher: Springer Verlag
DOI: 10.1007/s00204-024-03764-9

REACH out-numbered! The future of REACH and animal numbers

Author(s): Costanza Rovida, Francois Busquet, Marcel Leist, Thomas Hartung
Published in: ALTEX, Issue 4/yr, 2023, Page(s) 367-388, ISSN 1868-8551
Publisher: Springer Spektrum
DOI: 10.14573/altex.2307121

From cellular perturbation to probabilistic risk assessments

Author(s): Alexandra Maertens, Breanne Kincaid, Eric Bridgeford, Celine Brochot, Arthur de Carvalho e Silva, Jean-Lou C. M. Dorne, Liesbet Geris, Trine Husøy, Nicole Kleinstreuer, Luiz C. M. Ladeira, Alistair Middleton, Joe Reynolds, Blanca Rodriguez, Erwin L. Roggen, Giulia Russo, Kris Thayer, Thomas Hartung
Published in: ALTEX, Issue Vol. 42 No. 3 (2025), 2025, Page(s) 413–434, ISSN 1868-596X
Publisher: ALTEX Edition
DOI: 10.14573/altex.2501291

Connexin-Based Channel Activity Is Not Specifically Altered by Hepatocarcinogenic Chemicals

Author(s): Kaat Leroy, Alanah Pieters, Axelle Cooreman, Raf Van Campenhout, Bruno Cogliati, Mathieu Vinken
Published in: International Journal of Molecular Sciences, Issue 22/21, 2021, Page(s) 11724, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222111724

A systematic review of in vitro models of drug-induced kidney injury

Author(s): Alasdair R. Irvine, Damiën van Berlo, Rawan Shekhani, Rosalinde Masereeuw
Published in: Current Opinion in Toxicology, Issue 27, 2021, Page(s) 18-26, ISSN 2468-2020
Publisher: Elsevier
DOI: 10.1016/j.cotox.2021.06.001

The probable future of toxicology - probabilistic risk assessment

Author(s): Alexandra Maertens, Eric Antignac, Emilio Benfenati, Denise Bloch, Ellen Fritsche, Sebastian Hoffmann, Joanna Jaworska, George Loizou, Kevin McNally, Przemyslaw Piechota, Erwin L. Roggen, Marc Teunis, Thomas Hartung
Published in: ALTEX, Issue N/A, 2024, Page(s) N/A, ISSN 1868-8551
Publisher: Springer International Publishing AG
DOI: 10.14573/altex.2310301

Primary Human Hepatocyte Spheroids as Tools to Study the Hepatotoxic Potential of Non-Pharmaceutical Chemicals

Author(s): Vânia Vilas-Boas, Eva Gijbels, Kaat Leroy, Alanah Pieters, Audrey Baze, Céline Parmentier, Mathieu Vinken
Published in: International Journal of Molecular Sciences, Issue 22/20, 2021, Page(s) 11005, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222011005

Development of an adverse outcome pathway network for nephrotoxicity

Author(s): D A Barnes, J W Firman, S J Belfield, M T D Cronin, M Vinken, M J Janssen, R Masereeuw
Published in: Archives of Toxicology, Issue Volume 98, 2024, Page(s) 929-942, ISSN 0340-5761
Publisher: Springer Verlag
DOI: 10.1007/s00204-023-03637-7

First steps for creating an ontology for cognitivefunction defects for regulatory application

Author(s): Eliska Kuchovska, Alessio Gamba, Luiz Carlos Maia Ladeira, Bernard Staumont, Raphaëlle Lesage, Inger-Lise Steffensen, Graciela Lopez Soop
Published in: 21st International Congress ESTIV Abstract Book, Issue annual, 2022, Page(s) 48-49, ISBN 978-80-969474-8-5
Publisher: ESTIV

P04-06 New approaches for evaluating kidney toxicity using physiological maps

Author(s): Alessio Gamba, Luiz Carlos Maia Ladeira, Raphaëlle Lesage, Devon Barnes, Daniël Roodzant, Marc Teunis, Manoe Janssen, Rosalinde Masereeuw, Liesbet Geris, Bernard Staumont
Published in: Toxicology Letters, Issue Volume 368, Supplement, 1 September 2022, 2022, Page(s) S101, ISSN 0378-4274
Publisher: ELSEVIER BV
DOI: 10.1016/j.toxlet.2022.07.290

Physiological Map to Study Kidney Toxicity in the ONTOX Project.

Author(s): Alessio Gamba, Luiz Carlos Maia Ladeira, Raphaëlle Lesage, Daniël Roodzant, Devon Barnes, Manoe Janssen, Marc Teunis, Rosalinde Masereeuw, Liesbet Geris, Bernard Staumont
Published in: 21st International Congress ESTIV Abstract Book, Issue annual, 2022, Page(s) 120-121, ISBN 978-80-969474-8-5
Publisher: ESTIV

Development of an Adverse Outcome Pathway for Kidney Tubular Necrosis

Author(s): Devon Barnes, Alasdair Irvine, Alessio Gamba, Luiz Carlos Maia Ladeira, Bernard Staumont, Huan Yang, Inger-Lise Steffensen, Liesbet Geris, Manoe Janssen, and Rosalinde Masereeuw
Published in: 21st International Congress ESTIV Abstract Book, Issue annual, 2022, Page(s) 186-187, ISBN 978-80-969474-8-5
Publisher: ESTIV

Protocol for a systematic scoping review

Author(s): Trine Husøy, Michael Guy Diemar, Erwin Roggen, Maria Kalyva, Hubert Dirven, Gunn Elisabeth Vist
Published in: Methods and tools for assessing chemical exposure in humans: protocol for a systematic scoping review - prosjektbeskrivelse, 2021
Publisher: NIPH

An AI supported case study applying in vitro studies using the ONTOX toolbox: Protocol for probabilistic risk assessment of perfluoroctanoic acid (PFOA)

Author(s): Trine Husøy (team leader) Camilla Svendsen Maria Kalyva Hubert Dirven Michael Guy Diemar Erwin L Roggen Devon A. Barnes Job Berkhout Maria Corradi Annika Drees Ellen Fritsche Domenico Gadeleta Thomas Hartung Ramiro Jover Nynke Kramer Eliska Kuchovska Luiz Carlos Maia Ladeira Thomas Luechtefeld Amy Maerten Alexandra Maertens Rosalinde Masereeuw Oddvar Myhre Rita Ortega Susana Proença Alessandra R
Published in: 2025
Publisher: Folkehelseinstituttet website

P17-07 Computational modelling of neural tube closure defects

Author(s): Job H Berkhout, Aldert H Piersma, Juliette Legler, Harm J Heusinkveld
Published in: Toxicology letters, Issue Volume 368, Supplement, 1 September 2022, 2022, Page(s) S229, ISSN 0378-4274
Publisher: ELSEVIER BV
DOI: 10.1016/j.toxlet.2022.07.617

P01-07 Development of an adverse outcome pathway for kidney tubular necrosis

Author(s): Devon Barnes, A. Irvine, Alessio Gamba, Bernard Staumont, Luiz C Maia Ladeira, Huan Yang, Inger-Lise Stffensen, Liesbet Geris, Manoe Janssen, Roos Masereeuw
Published in: Toxicology Letters, Issue Volume 368, Supplement, 1 September 2022, 2022, Page(s) S86-S87, ISSN 0378-4274
Publisher: ELSEVIER BV
DOI: 10.1016/j.toxlet.2022.07.251

Designing Physiological Maps as a Tool to Study Liver Toxicology

Author(s): Luiz Carlos Maia Ladeira, Alessio Gamba, Raphaëlle Lesage, Anouk Verhoeven, Jonas van Ertvelde, Jian Jiang, Daniël Roodzant, Marc Teunis, Ramiro Jover, Tamara Vanhaecke, Mathieu Vinken, Harm Heusinkveld, Liesbet Geris, Bernard Staumont.
Published in: 21st International Congress ESTIV Abstract Book, Issue annual, 2022, Page(s) 123-124, ISBN 978-80-969474-8-5
Publisher: ESTIV

Computational Modelling of Neural Tube Closure Defects

Author(s): Job Berkhout, Aldert Piersma, Juliette Legler, Alessio Gamba, Luiz Carlos Maia Ladeira, Bernard Staumont, Raphaëlle Lesage, Liesbet Geris, and Harm Heuseinkveld
Published in: 21st International Congress ESTIV Abstract Book, Issue annual, 2022, Page(s) 127, ISBN 978-80-969474-8-5
Publisher: ESTIV

P11-09 Physiology-based framework to study chemical-induced cholestasis

Author(s): Luiz Carlos Maia Ladeira, Alessio Gamba, Raphaëlle Lesage, Jonas van Ertvelde, Jian Jiang, Anouk Verhoeven, Daniël Roodzant, Marc Teunis, Ramiro Jover, Tamara Vanhaecke, Mathieu Vinken, Liesbet Geris, Bernard Staumont
Published in: Toxicology Letters, Issue Volume 368, Supplement, 1 September 2022, 2022, Page(s) S165-S166, ISSN 0378-4274
Publisher: ELSEVIER BV
DOI: 10.1016/j.toxlet.2022.07.459

SOC-VI-08 Physiological maps: a benchmark tool for adverse outcome pathways and a cornerstone for the development of disease ontologies

Author(s): Bernard Staumont, Luiz Carlos Maia Ladeira, Alessio Gamba, Raphaëlle Lesage, Anouk Verhoeven, Jian Jiang, Jonas van Ertvelde, Devon Barnes, Manoe Janssen, Eliska Kuchovska, Job Berkhout, Daniël Roodzant, Marc Teunis, Thomas Bozada Jr, Thomas Luechtefeld, Ramiro Jover, Tamara Vanhaecke, Mathieu Vinken, Rosalinde Masereeuw, Ellen Fritsche, Aldert Piersma, Harm Heusinkveld, Liesbet Geris
Published in: Toxicology Letters, Issue Volume 368, Supplement, 1 September 2022, 2022, Page(s) S77-S78, ISSN 0378-4274
Publisher: ELSEVIER BV
DOI: 10.1016/j.toxlet.2022.07.228

Multi-task Proteochemometric Modelling

Author(s): Anastasia Pentina, and Djork-Arné Clevert
Published in: ChemRxiv, 2022, ISSN 2573-2293
Publisher: Cambridge Open Engage
DOI: 10.26434/chemrxiv-2022-d5tzd

SKIG report 2023-2024

Author(s): Wittwehr, Clemens ; Audouze, Karine ; Burgdorf, Tanja ; Clerbaux, Laure-Alix ; Coerek, Emre ; Demuynck, Emmanuel ; Exner, Thomas ; Filipovska, Julija ; Fritsche, Ellen ; Geris, Liesbet ; Hench, Virginia ; Jeliazkova, Nina ; Karschnik, Travis ; Kuchovska, Eliska ; Maia Ladeira, Luiz Carlos ; Malinowska, Julia M ; Marinov, Evgeni ; Martens, Marvin ; Mertens, Birgit ; Nymark, Penny ; Schaffert, Alexa
Published in: EU publications, 2025, Page(s) 26665, ISSN 1831-9424
Publisher: Publications Office of the European Union
DOI: 10.2760/7749010

Report of the First ONTOX Hackathon: Hack to Save Lives and Avoid Animal Suffering. The Use of Artificial Intelligence in Toxicology — A Potential Driver for Reducing/Replacing Laboratory Animals in the Future

Author(s): Michael G. Diemar, Cyrille A.M. Krul, Marc Teunis, Francois Busquet, Helena Kandarova, Julia D. Zajac, Mathieu Vinken, Erwin L. Roggen
Published in: Alternatives to Laboratory Animals, Issue 53, 2025, Page(s) 42-61, ISSN 0261-1929
Publisher: Fund for the Replacement of Animals in Medical Experiments
DOI: 10.1177/02611929241305112

Probabilistic Risk Assessment –The Keystone for the Future of Toxicology

Author(s): Maertens A, Golden E, Luechtefeld T, Hoffmann S, Tsaioun K
Published in: Altex- Alternatives to animal experimentation, Issue 39/1, 2022, Page(s) 3–29, ISSN 1868-8551
Publisher: Springer-Spektrum
DOI: 10.14573/altex.2201081

Adverse outcome pathway networks as the basis for the development of new approach methodologies: Liver toxicity as a case study

Author(s): Mathieu Vinken
Published in: Current Opinion in Toxicology, Issue 40, 2024, Page(s) 100504, ISSN 2468-2020
Publisher: Elsevier
DOI: 10.1016/j.cotox.2024.100504

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