Management of chronic cardiometabolic disease and treatment discontinuity in adult ADHD patients

Informazioni relative al progetto

TIMESPAN

ID dell’accordo di sovvenzione: 965381

DOI

10.3030/965381

Data della firma CE 25 Gennaio 2021

Data di avvio 1 Aprile 2021

Data di completamento 31 Marzo 2026

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 6 811 451,00

Contributo UE

€ 5 999 986,00

Coordinato da

OREBRO UNIVERSITY
Sweden

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (5)

Report on Ethics Monitoring Strategy

D71 Report on Ethics Monitoring Strategy Month 3

Systematic review covering the available evidence on ADHD and cardiometabolic disease

Systematic review covering the available evidence on ADHD and cardiometabolic disease (Month 24)

EDMB report (incl. EDAC feedback) on TIMESPAN ethics and data management implementation (incl. evaluation of the independent ethics advisor) (Month 18)

1) EDMB report (incl. EDAC feedback) on TIMESPAN ethics and data management implementation 2) Prevention of misuse of research participant’s data (data security measures to prevent unauthorized access and data breach, anonymization techniques, encryption, secure data transfer, controllerprocessor agreement ensuring high security standards (for the remote collection)). Such measures will mitigate the possible risks for the research participants 3) Ethical considerations in relation to AI applications (terms of fairness, discrimination, inequality, avoidance of harm, conflicts of autonomy, beneficence, non-maleficence, justice, the “black box” problem in AI, and accountability)4) The entire report will be evaluated by an independent ethics advisor

Communication and Outreach plan

Communication and Outreach plan Month 6

EDB report (incl. EDAC feedback) on TIMESPAN ethics and data management implementation (Month 36)

EDMB report (incl. EDAC feedback) on TIMESPAN ethics and data management implementation (Month 36)

Other (2)

DLNN algorithms (freely available via GitHub) (Task 4)

D62 DLNN algorithms freely available via GitHub Task 4 Month 15

DLNN algorithms (freely available via GitHub) (Task 1)

D6.1: DLNN algorithms (freely available via GitHub) (Task 1) (Month 6)

Websites, patent fillings, videos etc. (5)

Training course in pharmaco-epidemiological analyses using real-world data for relevant stakeholders

Training course in pharmaco-epidemiological analyses using real-world data for relevant stakeholders (Month 48)

Project brochure and professional templates

Project brochure and professional templates Month 6

Patient and layman event

Patient and layman event (Month 50)

Go-online of the public project website (Month 04)

Goonline of the public project website Month 04

Go-online of the public project website

Goonline of the public project website Month 4

Pubblicazioni

Peer reviewed articles (34)

Predicting childhood and adolescent attention-deficit/hyperactivity disorder onset: a nationwide deep learning approach

Autori: Miguel Garcia-Argibay, Yanli Zhang-James, Samuele Cortese, Paul Lichtenstein, Henrik Larsson & Stephen V. Faraone
Pubblicato in: Molecular Psychiatry, Numero 28, 2022, Pagina/e 1232–1239, ISSN 1476-5578
Editore: Springer Nature
DOI: 10.1038/s41380-022-01918-8

Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs

Autori: Adrienne Y. L. Chan, Le Gao, Miyuki Hsing-Chun Hsieh, Lars J. Kjerpeseth, Raquel Avelar, Tobias Banaschewski, Amy Hai Yan Chan, David Coghill, Jacqueline M. Cohen, Mika Gissler, Jeff Harrison, Patrick Ip, Øystein Karlstad, Wallis C. Y. Lau, Maarit K. Leinonen, Wing Cheong Leung, Tzu-Chi Liao, Johan Reutfors, Shih-Chieh Shao, Emily Simonoff, Kathryn Choon Beng Tan, Katja Taxis, Andrew Tomlin, Caro
Pubblicato in: Nature Medicine, Numero 30, 2024, Pagina/e 1416-1423, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/s41591-024-02917-8

Cardiovascular risk factors in attention-deficit/hyperactivity disorder: A family design study of Swedish conscripts

Autori: Larsson H, Garcia-Argibay M, Du Rietz E, Hartman CA, Lichtenstein P, Chang Z, Fava C, Cortese S
Pubblicato in: International Journal of Methods in Psychiatric Research, Numero 10498931, 2022, ISSN 1049-8931
Editore: Whurr Publishers Ltd.
DOI: 10.1002/mpr.1930

Psychiatric comorbidities in women with cardiometabolic conditions with and without ADHD: a population-based study

Autori: Jakobsdottir Smari U, Valdimarsdottir UA Aspelund T, Hauksdottir A, Thordardottir EB, Hartman CA, Andell P, Henrik Larsson H, Zoega H
Pubblicato in: BMC Medicine, 2023, ISSN 1741-7015
Editore: BioMed Central
DOI: 10.1186/s12916-023-03160-7

Nonlinear associations between insomnia symptoms and circadian preferences in the general population: Symptom-specific and lifespan differences in men and women

Autori: Sarsembayeva, D., Hartman, C. A., Cardoso Melo, R. D., & Schreuder, M. J.
Pubblicato in: Sleep health, 2023, ISSN 2352-7218
Editore: Elsevier Inc.
DOI: 10.1016/j.sleh.2023.10.008

The role of ADHD genetic risk in mid-to-late life somatic health conditions

Autori: Brikell I, Garcia-Argibay M, du Rietz E, Lu Y, Martin J, Haan E, Lehto K, Bergen SE, Lichtenstein P, Larsson H
Pubblicato in: Translational Psychiatry, Numero 21583188, 2022, ISSN 2158-3188
Editore: Nature Publishing Group
DOI: 10.1038/s41398-022-01933-x

Somatic burden of attention‐deficit/hyperactivity disorder across the lifecourse

Autori: Berit Libutzki, Benno Neukirch, Andreas Reif, Catharina A. Hartman
Pubblicato in: Acta Psychiatrica Scandinavica, Numero 150, 2025, Pagina/e 105-117, ISSN 0001-690X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/acps.13694

The contribution of attention-deficit/hyperactivity disorder polygenic load to metabolic and cardiovascular health outcomes: a large-scale population and sibling study

Autori: Ebba Du Rietz, Tian Xie, Rujia Wang, Rosa Cheesman, Miguel Garcia-Argibay, Zihan Dong, Jia Zhang, Jacobien Niebuur, Melissa Vos, Harold Snieder, Henrik Larsson, Catharina A. Hartman
Pubblicato in: Translational Psychiatry, Numero 14, 2024, ISSN 2158-3188
Editore: Nature Publishing Group
DOI: 10.1038/s41398-024-03178-2

Association of ADHD symptoms with type 2 diabetes and cardiovascular comorbidities in adults receiving outpatient diabetes care.

Autori: A. Z. Dehnavi, Y. Zhang-James, D. Draytsel, B. Carguello, S.V. Faraone and R. S. Weinstock
Pubblicato in: Journal of Clinical & Translational Endocrinology, Numero 32, 2023, ISSN 2214-6237
Editore: Elsevier
DOI: 10.1016/j.jcte.2023.100318

Expanded access to publicly subsidised lisdexamfetamine treatment for adults with attention-deficit/hyperactivity disorder: An interrupted time-series analysis

Autori: Bruno C, Zoega H, Gillies MB, et al.
Pubblicato in: The Australian and New Zealand Journal of Psychiatry, Numero 57(7):1073-1076, 2023, ISSN 1440-1614
Editore: Australian and New Zealand journal of psychiatry
DOI: 10.1177/00048674231170556

Distal-to-proximal etiologically relevant variables associated with the general (p) and specific factors of psychopathology

Autori: Ormel, J., Vos, M., Laceulle, O. M., Vrijen, C., van der Laan, C. M., Nolte, I. M., & Hartman, C. A.
Pubblicato in: Journal of Child Psychology and Psychiatry, 2024, ISSN 1469-7610
Editore: Wiley-Blackwell
DOI: 10.1111/jcpp.13979

Attention-Deficit/Hyperactivity Disorder Medications and Long-Term Risk of Cardiovascular Diseases

Autori: Le Zhang, Lin Li, Pontus Andell, Miguel Garcia-Argibay, Patrick D. Quinn, Brian M. D’Onofrio, Isabell Brikell, Ralf Kuja-Halkola, Paul Lichtenstein, Kristina Johnell, Henrik Larsson, Zheng Chang
Pubblicato in: JAMA psychiatry, 2022, ISSN 1538-3636
Editore: American Medical Association (USA)
DOI: 10.1001/jamapsychiatry.2023.4294

Attention-Deficit/Hyperactivity Disorder and Major Depressive Disorder: Evidence From Multiple Genetically Informed Designs

Autori: Garcia Argibay, M., Isabell Brikell, Anita Thapar, Paul Lichtenstein, Sebastian Lundström, Ditte Demontis, Henrik Larsson
Pubblicato in: Biological Psychiatry, Numero Volume 95, ISSUE 5, 2023, Pagina/e P444-452, ISSN 1873-2402
Editore: Biological Psychiatry
DOI: 10.1016/j.biopsych.2023.07.017

The association between type 2 diabetes and attention- deficit/hyperactivity disorder: A systematic review, meta-analysis, and population-based sibling study

Autori: Miguel Garcia-Argibay, Lin Li, Ebba Du Rietz, Le Zhang, Honghui Yao, Johan Jendle, Josep A. Ramos-Quiroga, Marta Ribasés, Zheng Chang, Isabell Brikell, Samuele Cortese, Henrik Larsson
Pubblicato in: Neuroscience & Biobehavioral Reviews, Numero Volume 147, 105076, 2023, ISSN 0149-7634
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2023.105076

Attention-deficit/hyperactivity disorder as a risk factor for cardiovascular diseases: a nationwide population-based cohort study

Autori: Larsson H, Li L, Chang Z, Sun J, Garcia-Argibay M, Du Rietz E, Dobrosavljevic M, Brikell I, Jernberg T, Solmi M, Cortese S
Pubblicato in: World Psychiatry, Numero 17238617, 2022, Pagina/e 452-459, ISSN 1723-8617
Editore: Masson Italia Periodici
DOI: 10.1002/wps.21020

ADHD Remote Technology study of cardiometabolic risk factors and medication adherence (ART-CARMA): a multi-centre prospective cohort study protocol

Autori: Denyer H, Ramos-Quiroga JA, Folarin A, Ramos C, Nemeth P, Bilbow A, Woodward E, Whitwell S, Müller-Sedgwick U, Larsson H, Dobson RJB, Kuntsi J.
Pubblicato in: BMC Psychiatry, Numero 22, 2022, Pagina/e 813, ISSN 1471-244X
Editore: BioMed Central
DOI: 10.1186/s12888-022-04429-6

Methylphenidate and Short-Term Cardiovascular Risk

Autori: Miguel Garcia-Argibay, Paul-Christian Bürkner, Paul Lichtenstein, Le Zhang, Brian M. D’Onofrio, Pontus Andell, Zheng Chang, Samuele Cortese, Henrik Larsson
Pubblicato in: JAMA Network Open, Numero 2024;7(3):e241349, 2024, ISSN 2574-3805
Editore: Jama Network Open
DOI: 10.1001/jamanetworkopen.2024.1349

Association Between ADHD and COVID-19 Infection and Clinical Outcomes: A Retrospective Cohort Study From Electronic Medical Records

Autori: Kathaleen Heslin, Aminat Haruna, Regina A George, Shiyu Chen, Ishak Nobel, Kathryn B Anderson, Stephen V Faraone and Yanli Zhang-James
Pubblicato in: Journal of Attention Disorders, 2022, ISSN 1087-0547
Editore: SAGE Publications
DOI: 10.1177/10870547221129305

Risk of cardiovascular diseases associated with medications used in attention-deficit/hyperactivity disorder: A systematic review and meta-analysis

Autori: Zheng Chang, Le Zhang, Honghui Yao, Lin Li, Ebba Du Rietz, Pontus Andell, Miguel Garcia-Argibay, Brian M. D’Onofrio, Samuele Cortese, Henrik Larsson
Pubblicato in: JAMA Network Open / Psychiatry, 2022, ISSN 2168-622X
Editore: American Medical Association
DOI: 10.1001/jamanetworkopen.2022.43597

Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals

Autori: Zhou, H., Kember, R.L., Deak, J.D. et al.
Pubblicato in: Nature Medicine, Numero 29, 3184–3192, 2023, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/s41591-023-02653-5

Association between Attention Deficit Hyperactivity Disorder and outcomes after metabolic and bariatric surgery: a nationwide propensity matched cohort study

Autori: Erik Stenberg, Henrik Larsson, Richard Marsk, Yang Cao, Magnus Sundbom, Erik Näslund
Pubblicato in: Surgery for Obesity and Related Diseases, 2022, ISSN 1550-7289
Editore: Elsevier BV
DOI: 10.1016/j.soard.2022.10.028

Effects of ADHD and ADHD treatment on glycemic management in type 1 diabetes: A systematic review and meta-analysis of observational studies.

Autori: A. Zare Dehnavi, I. Elmitwalli, H. O. H. Alsharif, A. Shervin Razavi, T. A. Gumpel, A. Smith, R. S. Weinstock, S.V. Faraone, Y. Zhang-James
Pubblicato in: Diabetes Research and Clinical Practice, 2024, Pagina/e 111566, ISSN 1872-8227
Editore: Diabetes research and clinical practice.
DOI: 10.1016/j.diabres.2024.111566

26. THE IMPACT OF GENETIC FACTORS ON STIMULANT MEDICATION TREATMENT IN ADHD

Autori: Janne Thirstrup, Jinjie Duan, Anders Børglum, Isabell Brikell, Ditte Demontis
Pubblicato in: European Neuropsychopharmacology, Numero 87, 2024, Pagina/e 61-62, ISSN 0924-977X
Editore: Elsevier BV
DOI: 10.1016/j.euroneuro.2024.08.140

Risk prediction model for cardiovascular diseases in adults initiating pharmacological treatment for attention-deficit/hyperactivity disorder

Autori: Maja Dobrosavljevic; Seena Fazel; Ebba Du Rietz; Lin Li; Le Zhang; Zheng Chang; Tomas Jernberg; Stephen V Faraone; Johan Jendle; Qi Chen; Isabell Brikell; Henrik Larsson
Pubblicato in: Evid Based Ment Health, Numero 13620347, 2022, ISSN 1362-0347
Editore: BMJ Publishing Group
DOI: 10.1136/ebmental-2022-300492

Attention-deficit/hyperactivity disorder and cardiometabolic risk profile in patients with acute myocardial infarction: data from the SWEDEHEART registry

Autori: Honghui Yao, Isabell Brikell, Henrik Larsson, Lin Li, Ebba Du Rietz, Catharina A Hartman, Tomas Jernberg, Pontus Andell, Zheng Chang
Pubblicato in: European Journal of Preventive Cardiology, 2025, ISSN 2047-4873
Editore: SAGE Publications Ltd
DOI: 10.1093/eurjpc/zwaf151

How can we improve the management of individuals with attention deficit hyperactivity disorders and co-occurring cardiometabolic disease?

Autori: Henrik Larsson
Pubblicato in: Expert Review of Cardiovascular Therapy, 2023, Pagina/e Pages 725-728, ISSN 1477-9072
Editore: Future Drugs Ltd.
DOI: 10.1080/14779072.2023.2279608

Genetic Architecture of ADHD and Overlap With Other Psychiatric Disorders And Cognition-Related Phenotypes.

Autori: Ribasés, M., Mitjans, M., Hartman, C. A., Soler Artigas, M., Demontis, D., Larsson, H., Ramos-Quiroga, J. A., Kuntsi, J., Faraone, S. V., Børglum, A. D., Reif, A., Franke, B., & Cormand, B.
Pubblicato in: Neuroscience and Biobehavioral Reviews, Numero 153, Article 105313, 2023, ISSN 1873-7528
Editore: Elsevier
DOI: 10.1016/j.neubiorev.2023.105313

Associations between attention-deficit hyperactivity disorder genetic liability and ICD-10 medical conditions in adults: utilizing electronic health records in a Phenome-Wide Association Study.

Autori: Haan E, Krebs K, Võsa U, Brikell I, Larsson H, Lehto K.
Pubblicato in: Psychological Medicine., 2024, ISSN 1469-8978
Editore: Cambridge University Press
DOI: 10.1017/s0033291724000606

Cumulative ADHD medication use and risk of type 2 diabetes in adults: a Swedish Register study

Autori: Zihan Dong, Le Zhang, Lin Li, Shengxin Liu, Isabell Brikell, Ralf Kuja-Halkola, Brian M D’Onofrio, Agnieszka Butwicka, Soffia Gudbjornsdottir, Henrik Larsson, Zheng Chang, Ebba Du Rietz
Pubblicato in: BMJ Mental Health, Numero 27, 2025, Pagina/e e301195, ISSN 2755-9734
Editore: BMJ
DOI: 10.1136/bmjment-2024-301195

Mediating pathways between attention deficit hyperactivity disorder and type 2 diabetes mellitus: evidence from a two-step and multivariable Mendelian randomization study

Autori: J. Zhang, Z. K. Chen, R. D. Triatin, H. Snieder, C. H. L. Thio, C. A. Hartman
Pubblicato in: Epidemiology and Psychiatric Sciences, Numero 33, 2024, ISSN 2045-7960
Editore: Cambridge University Press
DOI: 10.1017/s2045796024000593

Rare coding variants in ten genes confer substantial risk for schizophrenia.

Autori: M.J. Daly, Singh, T., T. Poterba, D. Curtis, H. Akil, M. Al Eissa, J. D. Barchas, N. Bass, T. B. Bigdeli, G. Breen, E. J. Bromet, P. F. Buckley, W. E. Bunney, J. Bybjerg-Grauholm, W. F. Byerley, S. B. Chapman, W. J. Chen, C. Churchhouse, N. Craddock, C. M. Cusick, L. DeLisi, S. Dodge, M. A. Escamilla, S. Eskelinen, A. H. Fanous, S.V. Faraone, A. Fiorentino, L. Francioli, S. B. Gabriel, D. Gage, S.
Pubblicato in: Nature, Numero 00280836, 2022, Pagina/e 509–516, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-022-04556-w

"Polygenic resilience scores capture protective genetic effects for Alzheimer's disease."""

Autori: Hou, J., J. L. Hess, N. Armstrong, J. C. Bis, B. Grenier-Boley, I. K. Karlsson, G. Leonenko, K. Numbers, E. K. O'Brien, A. Shadrin, A. Thalamuthu, Q. Yang, O. A. Andreassen, H. Brodaty, M. Gatz, N. A. Kochan, J. C. Lambert, S. M. Laws, C. L. Masters, K. A. Mather, N. L. Pedersen, D. Posthuma, P. S. Sachdev, J. Williams, C. C. Fan, S. V. Faraone, C. Fennema-Notestine, S. J. Lin, V. Escott-Price, P.
Pubblicato in: Transl Psychiatry, Numero 21583188, 2022, ISSN 2158-3188
Editore: Nature Publishing Group
DOI: 10.1038/s41398-022-02055-0

Attention-deficit/hyperactivity disorder is associated with increased risk of cardiovascular diseases: A systematic review and meta-analysis

Autori: Lin Li, Honghui Yao, Le Zhang, Miguel Garcia-Argibay, Ebba Du Rietz, Isabell Brikell, Marco Solmi, Samuele Cortese, J. Antoni Ramos-Quiroga, Marta Ribasés, Zheng Chang, Henrik Larsson
Pubblicato in: JCPP Advances, 2023, ISSN 2692-9384
Editore: JCPP advances
DOI: 10.1002/jcv2.12158

Patterns of attention deficit hyperactivity disorder medicine use in the era of new non-stimulant medicines: A population-based study among Australian children and adults (2013–2020)

Autori: Bruno C, Alys Havard, Malcolm B Gillies, David Coghill, Jonathan Brett, Adam J Guastella, Sallie-Anne Pearson, Helga Zoega
Pubblicato in: Australia N Z J Psychiatry, 2022, ISSN 0004-8674
Editore: Blackwell Publishing Inc.
DOI: 10.1177/00048674221114782

Other (3)

Attention-deficit/hyperactivity disorder medication use and cardiometabolic conditions in pregnancy: A population-based cohort study

Autori: Andrea Sit, Claudia Bruno, Masako Araki, Malcolm Gillies, Helga Zoega
Pubblicato in: 2024
Editore: Authorea, Inc.
DOI: 10.22541/au.172742419.94824081/v1

Using Genomic Context Informed Genotype Data and Within‐model Ancestry Adjustment to Classify Type 2 Diabetes

Autori: Eric J Barnett, Yanli Zhang-James, Jonathan Hess, Stephen J Glatt, Stephen V Faraone
Pubblicato in: 2024
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.09.12.24313579

Adhd Symptoms are Common and Associated with Worse Glycemic Control in Adults with Type 1 Diabetes

Autori: Yanli Zhang-James, Dan Draytsel, Ben Carguello, Stephen V. Faraone, Ruth S. Weinstock
Pubblicato in: Journal of Clinical Medicine (in revision; preprint is published on SSRN), 2024
Editore: Elsevier BV
DOI: 10.2139/ssrn.4856029

Thesis and dissertations (2)

Using real-world data to generate evidence to improve quality use of psychotropic medicines in priority populations.

Autori: Bruno, Claudia
Pubblicato in: 2023
Editore: University of New South Wales
DOI: 10.26190/unsworks/25402

Cardiovascular medicine use in adults with ADHD: A nationwide study in Australia

Autori: Masako Araki
Pubblicato in: 2023
Editore: Research Gate

Conference proceedings (1)

ABSTRACTS of the 2024 ISPE Annual Meeting, Berlin, Germany, 24–28 August 2024

Autori: Araki M., Zoega H., Gillies M.B., Falster M., Peirs D., Larsson H., Costa J.
Pubblicato in: Pharmacoepidemiology and Drug Safety, Numero 33, 2024, ISSN 1053-8569
Editore: John Wiley & Sons Inc.
DOI: 10.1002/pds.5891