Management of chronic cardiometabolic disease and treatment discontinuity in adult ADHD patients

Projektinformationen

TIMESPAN

ID Finanzhilfevereinbarung: 965381

DOI

10.3030/965381

EK-Unterschriftsdatum 25 Januar 2021

Startdatum 1 April 2021

Enddatum 31 März 2026

Finanziert unter

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Gesamtkosten

€ 6 811 451,00

EU-Beitrag

€ 5 999 986,00

Koordiniert durch

OREBRO UNIVERSITY
Sweden

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Documents, reports (5)

Report on Ethics Monitoring Strategy

D71 Report on Ethics Monitoring Strategy Month 3

Systematic review covering the available evidence on ADHD and cardiometabolic disease

Systematic review covering the available evidence on ADHD and cardiometabolic disease (Month 24)

EDMB report (incl. EDAC feedback) on TIMESPAN ethics and data management implementation (incl. evaluation of the independent ethics advisor) (Month 18)

1) EDMB report (incl. EDAC feedback) on TIMESPAN ethics and data management implementation 2) Prevention of misuse of research participant’s data (data security measures to prevent unauthorized access and data breach, anonymization techniques, encryption, secure data transfer, controllerprocessor agreement ensuring high security standards (for the remote collection)). Such measures will mitigate the possible risks for the research participants 3) Ethical considerations in relation to AI applications (terms of fairness, discrimination, inequality, avoidance of harm, conflicts of autonomy, beneficence, non-maleficence, justice, the “black box” problem in AI, and accountability)4) The entire report will be evaluated by an independent ethics advisor

Communication and Outreach plan

Communication and Outreach plan Month 6

EDB report (incl. EDAC feedback) on TIMESPAN ethics and data management implementation (Month 36)

EDMB report (incl. EDAC feedback) on TIMESPAN ethics and data management implementation (Month 36)

Other (2)

DLNN algorithms (freely available via GitHub) (Task 4)

D62 DLNN algorithms freely available via GitHub Task 4 Month 15

DLNN algorithms (freely available via GitHub) (Task 1)

D6.1: DLNN algorithms (freely available via GitHub) (Task 1) (Month 6)

Websites, patent fillings, videos etc. (5)

Training course in pharmaco-epidemiological analyses using real-world data for relevant stakeholders

Training course in pharmaco-epidemiological analyses using real-world data for relevant stakeholders (Month 48)

Project brochure and professional templates

Project brochure and professional templates Month 6

Patient and layman event

Patient and layman event (Month 50)

Go-online of the public project website (Month 04)

Goonline of the public project website Month 04

Go-online of the public project website

Goonline of the public project website Month 4

Veröffentlichungen

Peer reviewed articles (34)

Predicting childhood and adolescent attention-deficit/hyperactivity disorder onset: a nationwide deep learning approach

Autoren: Miguel Garcia-Argibay, Yanli Zhang-James, Samuele Cortese, Paul Lichtenstein, Henrik Larsson & Stephen V. Faraone
Veröffentlicht in: Molecular Psychiatry, Ausgabe 28, 2022, Seite(n) 1232–1239, ISSN 1476-5578
Herausgeber: Springer Nature
DOI: 10.1038/s41380-022-01918-8

Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs

Autoren: Adrienne Y. L. Chan, Le Gao, Miyuki Hsing-Chun Hsieh, Lars J. Kjerpeseth, Raquel Avelar, Tobias Banaschewski, Amy Hai Yan Chan, David Coghill, Jacqueline M. Cohen, Mika Gissler, Jeff Harrison, Patrick Ip, Øystein Karlstad, Wallis C. Y. Lau, Maarit K. Leinonen, Wing Cheong Leung, Tzu-Chi Liao, Johan Reutfors, Shih-Chieh Shao, Emily Simonoff, Kathryn Choon Beng Tan, Katja Taxis, Andrew Tomlin, Caro
Veröffentlicht in: Nature Medicine, Ausgabe 30, 2024, Seite(n) 1416-1423, ISSN 1078-8956
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41591-024-02917-8

Cardiovascular risk factors in attention-deficit/hyperactivity disorder: A family design study of Swedish conscripts

Autoren: Larsson H, Garcia-Argibay M, Du Rietz E, Hartman CA, Lichtenstein P, Chang Z, Fava C, Cortese S
Veröffentlicht in: International Journal of Methods in Psychiatric Research, Ausgabe 10498931, 2022, ISSN 1049-8931
Herausgeber: Whurr Publishers Ltd.
DOI: 10.1002/mpr.1930

Psychiatric comorbidities in women with cardiometabolic conditions with and without ADHD: a population-based study

Autoren: Jakobsdottir Smari U, Valdimarsdottir UA Aspelund T, Hauksdottir A, Thordardottir EB, Hartman CA, Andell P, Henrik Larsson H, Zoega H
Veröffentlicht in: BMC Medicine, 2023, ISSN 1741-7015
Herausgeber: BioMed Central
DOI: 10.1186/s12916-023-03160-7

Nonlinear associations between insomnia symptoms and circadian preferences in the general population: Symptom-specific and lifespan differences in men and women

Autoren: Sarsembayeva, D., Hartman, C. A., Cardoso Melo, R. D., & Schreuder, M. J.
Veröffentlicht in: Sleep health, 2023, ISSN 2352-7218
Herausgeber: Elsevier Inc.
DOI: 10.1016/j.sleh.2023.10.008

The role of ADHD genetic risk in mid-to-late life somatic health conditions

Autoren: Brikell I, Garcia-Argibay M, du Rietz E, Lu Y, Martin J, Haan E, Lehto K, Bergen SE, Lichtenstein P, Larsson H
Veröffentlicht in: Translational Psychiatry, Ausgabe 21583188, 2022, ISSN 2158-3188
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41398-022-01933-x

Somatic burden of attention‐deficit/hyperactivity disorder across the lifecourse

Autoren: Berit Libutzki, Benno Neukirch, Andreas Reif, Catharina A. Hartman
Veröffentlicht in: Acta Psychiatrica Scandinavica, Ausgabe 150, 2025, Seite(n) 105-117, ISSN 0001-690X
Herausgeber: Blackwell Publishing Inc.
DOI: 10.1111/acps.13694

The contribution of attention-deficit/hyperactivity disorder polygenic load to metabolic and cardiovascular health outcomes: a large-scale population and sibling study

Autoren: Ebba Du Rietz, Tian Xie, Rujia Wang, Rosa Cheesman, Miguel Garcia-Argibay, Zihan Dong, Jia Zhang, Jacobien Niebuur, Melissa Vos, Harold Snieder, Henrik Larsson, Catharina A. Hartman
Veröffentlicht in: Translational Psychiatry, Ausgabe 14, 2024, ISSN 2158-3188
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41398-024-03178-2

Association of ADHD symptoms with type 2 diabetes and cardiovascular comorbidities in adults receiving outpatient diabetes care.

Autoren: A. Z. Dehnavi, Y. Zhang-James, D. Draytsel, B. Carguello, S.V. Faraone and R. S. Weinstock
Veröffentlicht in: Journal of Clinical & Translational Endocrinology, Ausgabe 32, 2023, ISSN 2214-6237
Herausgeber: Elsevier
DOI: 10.1016/j.jcte.2023.100318

Expanded access to publicly subsidised lisdexamfetamine treatment for adults with attention-deficit/hyperactivity disorder: An interrupted time-series analysis

Autoren: Bruno C, Zoega H, Gillies MB, et al.
Veröffentlicht in: The Australian and New Zealand Journal of Psychiatry, Ausgabe 57(7):1073-1076, 2023, ISSN 1440-1614
Herausgeber: Australian and New Zealand journal of psychiatry
DOI: 10.1177/00048674231170556

Distal-to-proximal etiologically relevant variables associated with the general (p) and specific factors of psychopathology

Autoren: Ormel, J., Vos, M., Laceulle, O. M., Vrijen, C., van der Laan, C. M., Nolte, I. M., & Hartman, C. A.
Veröffentlicht in: Journal of Child Psychology and Psychiatry, 2024, ISSN 1469-7610
Herausgeber: Wiley-Blackwell
DOI: 10.1111/jcpp.13979

Attention-Deficit/Hyperactivity Disorder Medications and Long-Term Risk of Cardiovascular Diseases

Autoren: Le Zhang, Lin Li, Pontus Andell, Miguel Garcia-Argibay, Patrick D. Quinn, Brian M. D’Onofrio, Isabell Brikell, Ralf Kuja-Halkola, Paul Lichtenstein, Kristina Johnell, Henrik Larsson, Zheng Chang
Veröffentlicht in: JAMA psychiatry, 2022, ISSN 1538-3636
Herausgeber: American Medical Association (USA)
DOI: 10.1001/jamapsychiatry.2023.4294

Attention-Deficit/Hyperactivity Disorder and Major Depressive Disorder: Evidence From Multiple Genetically Informed Designs

Autoren: Garcia Argibay, M., Isabell Brikell, Anita Thapar, Paul Lichtenstein, Sebastian Lundström, Ditte Demontis, Henrik Larsson
Veröffentlicht in: Biological Psychiatry, Ausgabe Volume 95, ISSUE 5, 2023, Seite(n) P444-452, ISSN 1873-2402
Herausgeber: Biological Psychiatry
DOI: 10.1016/j.biopsych.2023.07.017

The association between type 2 diabetes and attention- deficit/hyperactivity disorder: A systematic review, meta-analysis, and population-based sibling study

Autoren: Miguel Garcia-Argibay, Lin Li, Ebba Du Rietz, Le Zhang, Honghui Yao, Johan Jendle, Josep A. Ramos-Quiroga, Marta Ribasés, Zheng Chang, Isabell Brikell, Samuele Cortese, Henrik Larsson
Veröffentlicht in: Neuroscience & Biobehavioral Reviews, Ausgabe Volume 147, 105076, 2023, ISSN 0149-7634
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2023.105076

Attention-deficit/hyperactivity disorder as a risk factor for cardiovascular diseases: a nationwide population-based cohort study

Autoren: Larsson H, Li L, Chang Z, Sun J, Garcia-Argibay M, Du Rietz E, Dobrosavljevic M, Brikell I, Jernberg T, Solmi M, Cortese S
Veröffentlicht in: World Psychiatry, Ausgabe 17238617, 2022, Seite(n) 452-459, ISSN 1723-8617
Herausgeber: Masson Italia Periodici
DOI: 10.1002/wps.21020

ADHD Remote Technology study of cardiometabolic risk factors and medication adherence (ART-CARMA): a multi-centre prospective cohort study protocol

Autoren: Denyer H, Ramos-Quiroga JA, Folarin A, Ramos C, Nemeth P, Bilbow A, Woodward E, Whitwell S, Müller-Sedgwick U, Larsson H, Dobson RJB, Kuntsi J.
Veröffentlicht in: BMC Psychiatry, Ausgabe 22, 2022, Seite(n) 813, ISSN 1471-244X
Herausgeber: BioMed Central
DOI: 10.1186/s12888-022-04429-6

Methylphenidate and Short-Term Cardiovascular Risk

Autoren: Miguel Garcia-Argibay, Paul-Christian Bürkner, Paul Lichtenstein, Le Zhang, Brian M. D’Onofrio, Pontus Andell, Zheng Chang, Samuele Cortese, Henrik Larsson
Veröffentlicht in: JAMA Network Open, Ausgabe 2024;7(3):e241349, 2024, ISSN 2574-3805
Herausgeber: Jama Network Open
DOI: 10.1001/jamanetworkopen.2024.1349

Association Between ADHD and COVID-19 Infection and Clinical Outcomes: A Retrospective Cohort Study From Electronic Medical Records

Autoren: Kathaleen Heslin, Aminat Haruna, Regina A George, Shiyu Chen, Ishak Nobel, Kathryn B Anderson, Stephen V Faraone and Yanli Zhang-James
Veröffentlicht in: Journal of Attention Disorders, 2022, ISSN 1087-0547
Herausgeber: SAGE Publications
DOI: 10.1177/10870547221129305

Risk of cardiovascular diseases associated with medications used in attention-deficit/hyperactivity disorder: A systematic review and meta-analysis

Autoren: Zheng Chang, Le Zhang, Honghui Yao, Lin Li, Ebba Du Rietz, Pontus Andell, Miguel Garcia-Argibay, Brian M. D’Onofrio, Samuele Cortese, Henrik Larsson
Veröffentlicht in: JAMA Network Open / Psychiatry, 2022, ISSN 2168-622X
Herausgeber: American Medical Association
DOI: 10.1001/jamanetworkopen.2022.43597

Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals

Autoren: Zhou, H., Kember, R.L., Deak, J.D. et al.
Veröffentlicht in: Nature Medicine, Ausgabe 29, 3184–3192, 2023, ISSN 1078-8956
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41591-023-02653-5

Association between Attention Deficit Hyperactivity Disorder and outcomes after metabolic and bariatric surgery: a nationwide propensity matched cohort study

Autoren: Erik Stenberg, Henrik Larsson, Richard Marsk, Yang Cao, Magnus Sundbom, Erik Näslund
Veröffentlicht in: Surgery for Obesity and Related Diseases, 2022, ISSN 1550-7289
Herausgeber: Elsevier BV
DOI: 10.1016/j.soard.2022.10.028

Effects of ADHD and ADHD treatment on glycemic management in type 1 diabetes: A systematic review and meta-analysis of observational studies.

Autoren: A. Zare Dehnavi, I. Elmitwalli, H. O. H. Alsharif, A. Shervin Razavi, T. A. Gumpel, A. Smith, R. S. Weinstock, S.V. Faraone, Y. Zhang-James
Veröffentlicht in: Diabetes Research and Clinical Practice, 2024, Seite(n) 111566, ISSN 1872-8227
Herausgeber: Diabetes research and clinical practice.
DOI: 10.1016/j.diabres.2024.111566

26. THE IMPACT OF GENETIC FACTORS ON STIMULANT MEDICATION TREATMENT IN ADHD

Autoren: Janne Thirstrup, Jinjie Duan, Anders Børglum, Isabell Brikell, Ditte Demontis
Veröffentlicht in: European Neuropsychopharmacology, Ausgabe 87, 2024, Seite(n) 61-62, ISSN 0924-977X
Herausgeber: Elsevier BV
DOI: 10.1016/j.euroneuro.2024.08.140

Risk prediction model for cardiovascular diseases in adults initiating pharmacological treatment for attention-deficit/hyperactivity disorder

Autoren: Maja Dobrosavljevic; Seena Fazel; Ebba Du Rietz; Lin Li; Le Zhang; Zheng Chang; Tomas Jernberg; Stephen V Faraone; Johan Jendle; Qi Chen; Isabell Brikell; Henrik Larsson
Veröffentlicht in: Evid Based Ment Health, Ausgabe 13620347, 2022, ISSN 1362-0347
Herausgeber: BMJ Publishing Group
DOI: 10.1136/ebmental-2022-300492

Attention-deficit/hyperactivity disorder and cardiometabolic risk profile in patients with acute myocardial infarction: data from the SWEDEHEART registry

Autoren: Honghui Yao, Isabell Brikell, Henrik Larsson, Lin Li, Ebba Du Rietz, Catharina A Hartman, Tomas Jernberg, Pontus Andell, Zheng Chang
Veröffentlicht in: European Journal of Preventive Cardiology, 2025, ISSN 2047-4873
Herausgeber: SAGE Publications Ltd
DOI: 10.1093/eurjpc/zwaf151

How can we improve the management of individuals with attention deficit hyperactivity disorders and co-occurring cardiometabolic disease?

Autoren: Henrik Larsson
Veröffentlicht in: Expert Review of Cardiovascular Therapy, 2023, Seite(n) Pages 725-728, ISSN 1477-9072
Herausgeber: Future Drugs Ltd.
DOI: 10.1080/14779072.2023.2279608

Genetic Architecture of ADHD and Overlap With Other Psychiatric Disorders And Cognition-Related Phenotypes.

Autoren: Ribasés, M., Mitjans, M., Hartman, C. A., Soler Artigas, M., Demontis, D., Larsson, H., Ramos-Quiroga, J. A., Kuntsi, J., Faraone, S. V., Børglum, A. D., Reif, A., Franke, B., & Cormand, B.
Veröffentlicht in: Neuroscience and Biobehavioral Reviews, Ausgabe 153, Article 105313, 2023, ISSN 1873-7528
Herausgeber: Elsevier
DOI: 10.1016/j.neubiorev.2023.105313

Associations between attention-deficit hyperactivity disorder genetic liability and ICD-10 medical conditions in adults: utilizing electronic health records in a Phenome-Wide Association Study.

Autoren: Haan E, Krebs K, Võsa U, Brikell I, Larsson H, Lehto K.
Veröffentlicht in: Psychological Medicine., 2024, ISSN 1469-8978
Herausgeber: Cambridge University Press
DOI: 10.1017/s0033291724000606

Cumulative ADHD medication use and risk of type 2 diabetes in adults: a Swedish Register study

Autoren: Zihan Dong, Le Zhang, Lin Li, Shengxin Liu, Isabell Brikell, Ralf Kuja-Halkola, Brian M D’Onofrio, Agnieszka Butwicka, Soffia Gudbjornsdottir, Henrik Larsson, Zheng Chang, Ebba Du Rietz
Veröffentlicht in: BMJ Mental Health, Ausgabe 27, 2025, Seite(n) e301195, ISSN 2755-9734
Herausgeber: BMJ
DOI: 10.1136/bmjment-2024-301195

Mediating pathways between attention deficit hyperactivity disorder and type 2 diabetes mellitus: evidence from a two-step and multivariable Mendelian randomization study

Autoren: J. Zhang, Z. K. Chen, R. D. Triatin, H. Snieder, C. H. L. Thio, C. A. Hartman
Veröffentlicht in: Epidemiology and Psychiatric Sciences, Ausgabe 33, 2024, ISSN 2045-7960
Herausgeber: Cambridge University Press
DOI: 10.1017/s2045796024000593

Rare coding variants in ten genes confer substantial risk for schizophrenia.

Autoren: M.J. Daly, Singh, T., T. Poterba, D. Curtis, H. Akil, M. Al Eissa, J. D. Barchas, N. Bass, T. B. Bigdeli, G. Breen, E. J. Bromet, P. F. Buckley, W. E. Bunney, J. Bybjerg-Grauholm, W. F. Byerley, S. B. Chapman, W. J. Chen, C. Churchhouse, N. Craddock, C. M. Cusick, L. DeLisi, S. Dodge, M. A. Escamilla, S. Eskelinen, A. H. Fanous, S.V. Faraone, A. Fiorentino, L. Francioli, S. B. Gabriel, D. Gage, S.
Veröffentlicht in: Nature, Ausgabe 00280836, 2022, Seite(n) 509–516, ISSN 0028-0836
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41586-022-04556-w

"Polygenic resilience scores capture protective genetic effects for Alzheimer's disease."""

Autoren: Hou, J., J. L. Hess, N. Armstrong, J. C. Bis, B. Grenier-Boley, I. K. Karlsson, G. Leonenko, K. Numbers, E. K. O'Brien, A. Shadrin, A. Thalamuthu, Q. Yang, O. A. Andreassen, H. Brodaty, M. Gatz, N. A. Kochan, J. C. Lambert, S. M. Laws, C. L. Masters, K. A. Mather, N. L. Pedersen, D. Posthuma, P. S. Sachdev, J. Williams, C. C. Fan, S. V. Faraone, C. Fennema-Notestine, S. J. Lin, V. Escott-Price, P.
Veröffentlicht in: Transl Psychiatry, Ausgabe 21583188, 2022, ISSN 2158-3188
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41398-022-02055-0

Attention-deficit/hyperactivity disorder is associated with increased risk of cardiovascular diseases: A systematic review and meta-analysis

Autoren: Lin Li, Honghui Yao, Le Zhang, Miguel Garcia-Argibay, Ebba Du Rietz, Isabell Brikell, Marco Solmi, Samuele Cortese, J. Antoni Ramos-Quiroga, Marta Ribasés, Zheng Chang, Henrik Larsson
Veröffentlicht in: JCPP Advances, 2023, ISSN 2692-9384
Herausgeber: JCPP advances
DOI: 10.1002/jcv2.12158

Patterns of attention deficit hyperactivity disorder medicine use in the era of new non-stimulant medicines: A population-based study among Australian children and adults (2013–2020)

Autoren: Bruno C, Alys Havard, Malcolm B Gillies, David Coghill, Jonathan Brett, Adam J Guastella, Sallie-Anne Pearson, Helga Zoega
Veröffentlicht in: Australia N Z J Psychiatry, 2022, ISSN 0004-8674
Herausgeber: Blackwell Publishing Inc.
DOI: 10.1177/00048674221114782

Other (3)

Attention-deficit/hyperactivity disorder medication use and cardiometabolic conditions in pregnancy: A population-based cohort study

Autoren: Andrea Sit, Claudia Bruno, Masako Araki, Malcolm Gillies, Helga Zoega
Veröffentlicht in: 2024
Herausgeber: Authorea, Inc.
DOI: 10.22541/au.172742419.94824081/v1

Using Genomic Context Informed Genotype Data and Within‐model Ancestry Adjustment to Classify Type 2 Diabetes

Autoren: Eric J Barnett, Yanli Zhang-James, Jonathan Hess, Stephen J Glatt, Stephen V Faraone
Veröffentlicht in: 2024
Herausgeber: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.09.12.24313579

Adhd Symptoms are Common and Associated with Worse Glycemic Control in Adults with Type 1 Diabetes

Autoren: Yanli Zhang-James, Dan Draytsel, Ben Carguello, Stephen V. Faraone, Ruth S. Weinstock
Veröffentlicht in: Journal of Clinical Medicine (in revision; preprint is published on SSRN), 2024
Herausgeber: Elsevier BV
DOI: 10.2139/ssrn.4856029

Thesis and dissertations (2)

Using real-world data to generate evidence to improve quality use of psychotropic medicines in priority populations.

Autoren: Bruno, Claudia
Veröffentlicht in: 2023
Herausgeber: University of New South Wales
DOI: 10.26190/unsworks/25402

Cardiovascular medicine use in adults with ADHD: A nationwide study in Australia

Autoren: Masako Araki
Veröffentlicht in: 2023
Herausgeber: Research Gate

Conference proceedings (1)

ABSTRACTS of the 2024 ISPE Annual Meeting, Berlin, Germany, 24–28 August 2024

Autoren: Araki M., Zoega H., Gillies M.B., Falster M., Peirs D., Larsson H., Costa J.
Veröffentlicht in: Pharmacoepidemiology and Drug Safety, Ausgabe 33, 2024, ISSN 1053-8569
Herausgeber: John Wiley & Sons Inc.
DOI: 10.1002/pds.5891