Management of chronic cardiometabolic disease and treatment discontinuity in adult ADHD patients

Informacje na temat projektu

TIMESPAN

Identyfikator umowy o grant: 965381

DOI

10.3030/965381

Data podpisania przez KE 25 Stycznia 2021

Data rozpoczęcia 1 Kwietnia 2021

Data zakończenia 31 Marca 2026

Finansowanie w ramach

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Koszt całkowity

€ 6 811 451,00

Wkład UE

€ 5 999 986,00

Koordynowany przez

OREBRO UNIVERSITY
Sweden

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Documents, reports (5)

Report on Ethics Monitoring Strategy

D71 Report on Ethics Monitoring Strategy Month 3

Systematic review covering the available evidence on ADHD and cardiometabolic disease

Systematic review covering the available evidence on ADHD and cardiometabolic disease (Month 24)

EDMB report (incl. EDAC feedback) on TIMESPAN ethics and data management implementation (incl. evaluation of the independent ethics advisor) (Month 18)

1) EDMB report (incl. EDAC feedback) on TIMESPAN ethics and data management implementation 2) Prevention of misuse of research participant’s data (data security measures to prevent unauthorized access and data breach, anonymization techniques, encryption, secure data transfer, controllerprocessor agreement ensuring high security standards (for the remote collection)). Such measures will mitigate the possible risks for the research participants 3) Ethical considerations in relation to AI applications (terms of fairness, discrimination, inequality, avoidance of harm, conflicts of autonomy, beneficence, non-maleficence, justice, the “black box” problem in AI, and accountability)4) The entire report will be evaluated by an independent ethics advisor

Communication and Outreach plan

Communication and Outreach plan Month 6

EDB report (incl. EDAC feedback) on TIMESPAN ethics and data management implementation (Month 36)

EDMB report (incl. EDAC feedback) on TIMESPAN ethics and data management implementation (Month 36)

Other (2)

DLNN algorithms (freely available via GitHub) (Task 4)

D62 DLNN algorithms freely available via GitHub Task 4 Month 15

DLNN algorithms (freely available via GitHub) (Task 1)

D6.1: DLNN algorithms (freely available via GitHub) (Task 1) (Month 6)

Websites, patent fillings, videos etc. (5)

Training course in pharmaco-epidemiological analyses using real-world data for relevant stakeholders

Training course in pharmaco-epidemiological analyses using real-world data for relevant stakeholders (Month 48)

Project brochure and professional templates

Project brochure and professional templates Month 6

Patient and layman event

Patient and layman event (Month 50)

Go-online of the public project website (Month 04)

Goonline of the public project website Month 04

Go-online of the public project website

Goonline of the public project website Month 4

Publikacje

Peer reviewed articles (34)

Predicting childhood and adolescent attention-deficit/hyperactivity disorder onset: a nationwide deep learning approach

Autorzy: Miguel Garcia-Argibay, Yanli Zhang-James, Samuele Cortese, Paul Lichtenstein, Henrik Larsson & Stephen V. Faraone
Opublikowane w: Molecular Psychiatry, Numer 28, 2022, Strona(/y) 1232–1239, ISSN 1476-5578
Wydawca: Springer Nature
DOI: 10.1038/s41380-022-01918-8

Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs

Autorzy: Adrienne Y. L. Chan, Le Gao, Miyuki Hsing-Chun Hsieh, Lars J. Kjerpeseth, Raquel Avelar, Tobias Banaschewski, Amy Hai Yan Chan, David Coghill, Jacqueline M. Cohen, Mika Gissler, Jeff Harrison, Patrick Ip, Øystein Karlstad, Wallis C. Y. Lau, Maarit K. Leinonen, Wing Cheong Leung, Tzu-Chi Liao, Johan Reutfors, Shih-Chieh Shao, Emily Simonoff, Kathryn Choon Beng Tan, Katja Taxis, Andrew Tomlin, Caro
Opublikowane w: Nature Medicine, Numer 30, 2024, Strona(/y) 1416-1423, ISSN 1078-8956
Wydawca: Nature Publishing Group
DOI: 10.1038/s41591-024-02917-8

Cardiovascular risk factors in attention-deficit/hyperactivity disorder: A family design study of Swedish conscripts

Autorzy: Larsson H, Garcia-Argibay M, Du Rietz E, Hartman CA, Lichtenstein P, Chang Z, Fava C, Cortese S
Opublikowane w: International Journal of Methods in Psychiatric Research, Numer 10498931, 2022, ISSN 1049-8931
Wydawca: Whurr Publishers Ltd.
DOI: 10.1002/mpr.1930

Psychiatric comorbidities in women with cardiometabolic conditions with and without ADHD: a population-based study

Autorzy: Jakobsdottir Smari U, Valdimarsdottir UA Aspelund T, Hauksdottir A, Thordardottir EB, Hartman CA, Andell P, Henrik Larsson H, Zoega H
Opublikowane w: BMC Medicine, 2023, ISSN 1741-7015
Wydawca: BioMed Central
DOI: 10.1186/s12916-023-03160-7

Nonlinear associations between insomnia symptoms and circadian preferences in the general population: Symptom-specific and lifespan differences in men and women

Autorzy: Sarsembayeva, D., Hartman, C. A., Cardoso Melo, R. D., & Schreuder, M. J.
Opublikowane w: Sleep health, 2023, ISSN 2352-7218
Wydawca: Elsevier Inc.
DOI: 10.1016/j.sleh.2023.10.008

The role of ADHD genetic risk in mid-to-late life somatic health conditions

Autorzy: Brikell I, Garcia-Argibay M, du Rietz E, Lu Y, Martin J, Haan E, Lehto K, Bergen SE, Lichtenstein P, Larsson H
Opublikowane w: Translational Psychiatry, Numer 21583188, 2022, ISSN 2158-3188
Wydawca: Nature Publishing Group
DOI: 10.1038/s41398-022-01933-x

Somatic burden of attention‐deficit/hyperactivity disorder across the lifecourse

Autorzy: Berit Libutzki, Benno Neukirch, Andreas Reif, Catharina A. Hartman
Opublikowane w: Acta Psychiatrica Scandinavica, Numer 150, 2025, Strona(/y) 105-117, ISSN 0001-690X
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/acps.13694

The contribution of attention-deficit/hyperactivity disorder polygenic load to metabolic and cardiovascular health outcomes: a large-scale population and sibling study

Autorzy: Ebba Du Rietz, Tian Xie, Rujia Wang, Rosa Cheesman, Miguel Garcia-Argibay, Zihan Dong, Jia Zhang, Jacobien Niebuur, Melissa Vos, Harold Snieder, Henrik Larsson, Catharina A. Hartman
Opublikowane w: Translational Psychiatry, Numer 14, 2024, ISSN 2158-3188
Wydawca: Nature Publishing Group
DOI: 10.1038/s41398-024-03178-2

Association of ADHD symptoms with type 2 diabetes and cardiovascular comorbidities in adults receiving outpatient diabetes care.

Autorzy: A. Z. Dehnavi, Y. Zhang-James, D. Draytsel, B. Carguello, S.V. Faraone and R. S. Weinstock
Opublikowane w: Journal of Clinical & Translational Endocrinology, Numer 32, 2023, ISSN 2214-6237
Wydawca: Elsevier
DOI: 10.1016/j.jcte.2023.100318

Expanded access to publicly subsidised lisdexamfetamine treatment for adults with attention-deficit/hyperactivity disorder: An interrupted time-series analysis

Autorzy: Bruno C, Zoega H, Gillies MB, et al.
Opublikowane w: The Australian and New Zealand Journal of Psychiatry, Numer 57(7):1073-1076, 2023, ISSN 1440-1614
Wydawca: Australian and New Zealand journal of psychiatry
DOI: 10.1177/00048674231170556

Distal-to-proximal etiologically relevant variables associated with the general (p) and specific factors of psychopathology

Autorzy: Ormel, J., Vos, M., Laceulle, O. M., Vrijen, C., van der Laan, C. M., Nolte, I. M., & Hartman, C. A.
Opublikowane w: Journal of Child Psychology and Psychiatry, 2024, ISSN 1469-7610
Wydawca: Wiley-Blackwell
DOI: 10.1111/jcpp.13979

Attention-Deficit/Hyperactivity Disorder Medications and Long-Term Risk of Cardiovascular Diseases

Autorzy: Le Zhang, Lin Li, Pontus Andell, Miguel Garcia-Argibay, Patrick D. Quinn, Brian M. D’Onofrio, Isabell Brikell, Ralf Kuja-Halkola, Paul Lichtenstein, Kristina Johnell, Henrik Larsson, Zheng Chang
Opublikowane w: JAMA psychiatry, 2022, ISSN 1538-3636
Wydawca: American Medical Association (USA)
DOI: 10.1001/jamapsychiatry.2023.4294

Attention-Deficit/Hyperactivity Disorder and Major Depressive Disorder: Evidence From Multiple Genetically Informed Designs

Autorzy: Garcia Argibay, M., Isabell Brikell, Anita Thapar, Paul Lichtenstein, Sebastian Lundström, Ditte Demontis, Henrik Larsson
Opublikowane w: Biological Psychiatry, Numer Volume 95, ISSUE 5, 2023, Strona(/y) P444-452, ISSN 1873-2402
Wydawca: Biological Psychiatry
DOI: 10.1016/j.biopsych.2023.07.017

The association between type 2 diabetes and attention- deficit/hyperactivity disorder: A systematic review, meta-analysis, and population-based sibling study

Autorzy: Miguel Garcia-Argibay, Lin Li, Ebba Du Rietz, Le Zhang, Honghui Yao, Johan Jendle, Josep A. Ramos-Quiroga, Marta Ribasés, Zheng Chang, Isabell Brikell, Samuele Cortese, Henrik Larsson
Opublikowane w: Neuroscience & Biobehavioral Reviews, Numer Volume 147, 105076, 2023, ISSN 0149-7634
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2023.105076

Attention-deficit/hyperactivity disorder as a risk factor for cardiovascular diseases: a nationwide population-based cohort study

Autorzy: Larsson H, Li L, Chang Z, Sun J, Garcia-Argibay M, Du Rietz E, Dobrosavljevic M, Brikell I, Jernberg T, Solmi M, Cortese S
Opublikowane w: World Psychiatry, Numer 17238617, 2022, Strona(/y) 452-459, ISSN 1723-8617
Wydawca: Masson Italia Periodici
DOI: 10.1002/wps.21020

ADHD Remote Technology study of cardiometabolic risk factors and medication adherence (ART-CARMA): a multi-centre prospective cohort study protocol

Autorzy: Denyer H, Ramos-Quiroga JA, Folarin A, Ramos C, Nemeth P, Bilbow A, Woodward E, Whitwell S, Müller-Sedgwick U, Larsson H, Dobson RJB, Kuntsi J.
Opublikowane w: BMC Psychiatry, Numer 22, 2022, Strona(/y) 813, ISSN 1471-244X
Wydawca: BioMed Central
DOI: 10.1186/s12888-022-04429-6

Methylphenidate and Short-Term Cardiovascular Risk

Autorzy: Miguel Garcia-Argibay, Paul-Christian Bürkner, Paul Lichtenstein, Le Zhang, Brian M. D’Onofrio, Pontus Andell, Zheng Chang, Samuele Cortese, Henrik Larsson
Opublikowane w: JAMA Network Open, Numer 2024;7(3):e241349, 2024, ISSN 2574-3805
Wydawca: Jama Network Open
DOI: 10.1001/jamanetworkopen.2024.1349

Association Between ADHD and COVID-19 Infection and Clinical Outcomes: A Retrospective Cohort Study From Electronic Medical Records

Autorzy: Kathaleen Heslin, Aminat Haruna, Regina A George, Shiyu Chen, Ishak Nobel, Kathryn B Anderson, Stephen V Faraone and Yanli Zhang-James
Opublikowane w: Journal of Attention Disorders, 2022, ISSN 1087-0547
Wydawca: SAGE Publications
DOI: 10.1177/10870547221129305

Risk of cardiovascular diseases associated with medications used in attention-deficit/hyperactivity disorder: A systematic review and meta-analysis

Autorzy: Zheng Chang, Le Zhang, Honghui Yao, Lin Li, Ebba Du Rietz, Pontus Andell, Miguel Garcia-Argibay, Brian M. D’Onofrio, Samuele Cortese, Henrik Larsson
Opublikowane w: JAMA Network Open / Psychiatry, 2022, ISSN 2168-622X
Wydawca: American Medical Association
DOI: 10.1001/jamanetworkopen.2022.43597

Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals

Autorzy: Zhou, H., Kember, R.L., Deak, J.D. et al.
Opublikowane w: Nature Medicine, Numer 29, 3184–3192, 2023, ISSN 1078-8956
Wydawca: Nature Publishing Group
DOI: 10.1038/s41591-023-02653-5

Association between Attention Deficit Hyperactivity Disorder and outcomes after metabolic and bariatric surgery: a nationwide propensity matched cohort study

Autorzy: Erik Stenberg, Henrik Larsson, Richard Marsk, Yang Cao, Magnus Sundbom, Erik Näslund
Opublikowane w: Surgery for Obesity and Related Diseases, 2022, ISSN 1550-7289
Wydawca: Elsevier BV
DOI: 10.1016/j.soard.2022.10.028

Effects of ADHD and ADHD treatment on glycemic management in type 1 diabetes: A systematic review and meta-analysis of observational studies.

Autorzy: A. Zare Dehnavi, I. Elmitwalli, H. O. H. Alsharif, A. Shervin Razavi, T. A. Gumpel, A. Smith, R. S. Weinstock, S.V. Faraone, Y. Zhang-James
Opublikowane w: Diabetes Research and Clinical Practice, 2024, Strona(/y) 111566, ISSN 1872-8227
Wydawca: Diabetes research and clinical practice.
DOI: 10.1016/j.diabres.2024.111566

26. THE IMPACT OF GENETIC FACTORS ON STIMULANT MEDICATION TREATMENT IN ADHD

Autorzy: Janne Thirstrup, Jinjie Duan, Anders Børglum, Isabell Brikell, Ditte Demontis
Opublikowane w: European Neuropsychopharmacology, Numer 87, 2024, Strona(/y) 61-62, ISSN 0924-977X
Wydawca: Elsevier BV
DOI: 10.1016/j.euroneuro.2024.08.140

Risk prediction model for cardiovascular diseases in adults initiating pharmacological treatment for attention-deficit/hyperactivity disorder

Autorzy: Maja Dobrosavljevic; Seena Fazel; Ebba Du Rietz; Lin Li; Le Zhang; Zheng Chang; Tomas Jernberg; Stephen V Faraone; Johan Jendle; Qi Chen; Isabell Brikell; Henrik Larsson
Opublikowane w: Evid Based Ment Health, Numer 13620347, 2022, ISSN 1362-0347
Wydawca: BMJ Publishing Group
DOI: 10.1136/ebmental-2022-300492

Attention-deficit/hyperactivity disorder and cardiometabolic risk profile in patients with acute myocardial infarction: data from the SWEDEHEART registry

Autorzy: Honghui Yao, Isabell Brikell, Henrik Larsson, Lin Li, Ebba Du Rietz, Catharina A Hartman, Tomas Jernberg, Pontus Andell, Zheng Chang
Opublikowane w: European Journal of Preventive Cardiology, 2025, ISSN 2047-4873
Wydawca: SAGE Publications Ltd
DOI: 10.1093/eurjpc/zwaf151

How can we improve the management of individuals with attention deficit hyperactivity disorders and co-occurring cardiometabolic disease?

Autorzy: Henrik Larsson
Opublikowane w: Expert Review of Cardiovascular Therapy, 2023, Strona(/y) Pages 725-728, ISSN 1477-9072
Wydawca: Future Drugs Ltd.
DOI: 10.1080/14779072.2023.2279608

Genetic Architecture of ADHD and Overlap With Other Psychiatric Disorders And Cognition-Related Phenotypes.

Autorzy: Ribasés, M., Mitjans, M., Hartman, C. A., Soler Artigas, M., Demontis, D., Larsson, H., Ramos-Quiroga, J. A., Kuntsi, J., Faraone, S. V., Børglum, A. D., Reif, A., Franke, B., & Cormand, B.
Opublikowane w: Neuroscience and Biobehavioral Reviews, Numer 153, Article 105313, 2023, ISSN 1873-7528
Wydawca: Elsevier
DOI: 10.1016/j.neubiorev.2023.105313

Associations between attention-deficit hyperactivity disorder genetic liability and ICD-10 medical conditions in adults: utilizing electronic health records in a Phenome-Wide Association Study.

Autorzy: Haan E, Krebs K, Võsa U, Brikell I, Larsson H, Lehto K.
Opublikowane w: Psychological Medicine., 2024, ISSN 1469-8978
Wydawca: Cambridge University Press
DOI: 10.1017/s0033291724000606

Cumulative ADHD medication use and risk of type 2 diabetes in adults: a Swedish Register study

Autorzy: Zihan Dong, Le Zhang, Lin Li, Shengxin Liu, Isabell Brikell, Ralf Kuja-Halkola, Brian M D’Onofrio, Agnieszka Butwicka, Soffia Gudbjornsdottir, Henrik Larsson, Zheng Chang, Ebba Du Rietz
Opublikowane w: BMJ Mental Health, Numer 27, 2025, Strona(/y) e301195, ISSN 2755-9734
Wydawca: BMJ
DOI: 10.1136/bmjment-2024-301195

Mediating pathways between attention deficit hyperactivity disorder and type 2 diabetes mellitus: evidence from a two-step and multivariable Mendelian randomization study

Autorzy: J. Zhang, Z. K. Chen, R. D. Triatin, H. Snieder, C. H. L. Thio, C. A. Hartman
Opublikowane w: Epidemiology and Psychiatric Sciences, Numer 33, 2024, ISSN 2045-7960
Wydawca: Cambridge University Press
DOI: 10.1017/s2045796024000593

Rare coding variants in ten genes confer substantial risk for schizophrenia.

Autorzy: M.J. Daly, Singh, T., T. Poterba, D. Curtis, H. Akil, M. Al Eissa, J. D. Barchas, N. Bass, T. B. Bigdeli, G. Breen, E. J. Bromet, P. F. Buckley, W. E. Bunney, J. Bybjerg-Grauholm, W. F. Byerley, S. B. Chapman, W. J. Chen, C. Churchhouse, N. Craddock, C. M. Cusick, L. DeLisi, S. Dodge, M. A. Escamilla, S. Eskelinen, A. H. Fanous, S.V. Faraone, A. Fiorentino, L. Francioli, S. B. Gabriel, D. Gage, S.
Opublikowane w: Nature, Numer 00280836, 2022, Strona(/y) 509–516, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/s41586-022-04556-w

"Polygenic resilience scores capture protective genetic effects for Alzheimer's disease."""

Autorzy: Hou, J., J. L. Hess, N. Armstrong, J. C. Bis, B. Grenier-Boley, I. K. Karlsson, G. Leonenko, K. Numbers, E. K. O'Brien, A. Shadrin, A. Thalamuthu, Q. Yang, O. A. Andreassen, H. Brodaty, M. Gatz, N. A. Kochan, J. C. Lambert, S. M. Laws, C. L. Masters, K. A. Mather, N. L. Pedersen, D. Posthuma, P. S. Sachdev, J. Williams, C. C. Fan, S. V. Faraone, C. Fennema-Notestine, S. J. Lin, V. Escott-Price, P.
Opublikowane w: Transl Psychiatry, Numer 21583188, 2022, ISSN 2158-3188
Wydawca: Nature Publishing Group
DOI: 10.1038/s41398-022-02055-0

Attention-deficit/hyperactivity disorder is associated with increased risk of cardiovascular diseases: A systematic review and meta-analysis

Autorzy: Lin Li, Honghui Yao, Le Zhang, Miguel Garcia-Argibay, Ebba Du Rietz, Isabell Brikell, Marco Solmi, Samuele Cortese, J. Antoni Ramos-Quiroga, Marta Ribasés, Zheng Chang, Henrik Larsson
Opublikowane w: JCPP Advances, 2023, ISSN 2692-9384
Wydawca: JCPP advances
DOI: 10.1002/jcv2.12158

Patterns of attention deficit hyperactivity disorder medicine use in the era of new non-stimulant medicines: A population-based study among Australian children and adults (2013–2020)

Autorzy: Bruno C, Alys Havard, Malcolm B Gillies, David Coghill, Jonathan Brett, Adam J Guastella, Sallie-Anne Pearson, Helga Zoega
Opublikowane w: Australia N Z J Psychiatry, 2022, ISSN 0004-8674
Wydawca: Blackwell Publishing Inc.
DOI: 10.1177/00048674221114782

Other (3)

Attention-deficit/hyperactivity disorder medication use and cardiometabolic conditions in pregnancy: A population-based cohort study

Autorzy: Andrea Sit, Claudia Bruno, Masako Araki, Malcolm Gillies, Helga Zoega
Opublikowane w: 2024
Wydawca: Authorea, Inc.
DOI: 10.22541/au.172742419.94824081/v1

Using Genomic Context Informed Genotype Data and Within‐model Ancestry Adjustment to Classify Type 2 Diabetes

Autorzy: Eric J Barnett, Yanli Zhang-James, Jonathan Hess, Stephen J Glatt, Stephen V Faraone
Opublikowane w: 2024
Wydawca: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.09.12.24313579

Adhd Symptoms are Common and Associated with Worse Glycemic Control in Adults with Type 1 Diabetes

Autorzy: Yanli Zhang-James, Dan Draytsel, Ben Carguello, Stephen V. Faraone, Ruth S. Weinstock
Opublikowane w: Journal of Clinical Medicine (in revision; preprint is published on SSRN), 2024
Wydawca: Elsevier BV
DOI: 10.2139/ssrn.4856029

Thesis and dissertations (2)

Using real-world data to generate evidence to improve quality use of psychotropic medicines in priority populations.

Autorzy: Bruno, Claudia
Opublikowane w: 2023
Wydawca: University of New South Wales
DOI: 10.26190/unsworks/25402

Cardiovascular medicine use in adults with ADHD: A nationwide study in Australia

Autorzy: Masako Araki
Opublikowane w: 2023
Wydawca: Research Gate

Conference proceedings (1)

ABSTRACTS of the 2024 ISPE Annual Meeting, Berlin, Germany, 24–28 August 2024

Autorzy: Araki M., Zoega H., Gillies M.B., Falster M., Peirs D., Larsson H., Costa J.
Opublikowane w: Pharmacoepidemiology and Drug Safety, Numer 33, 2024, ISSN 1053-8569
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/pds.5891